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Amato J. Giaccia
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Journal Articles

Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone

Available to Purchase
Chun-Lung Chiu, Dalin Zhang, Hongjuan Zhao, Yi Wei, Alexandra Lapat Polasko, Mikkel Thy Thomsen, Vanessa Yang, Kasie Kexin Yang, Spencer Hauck, Eric E. Peterson, Ru M. Wen, Zhengyuan Qiu, Eva Corey, Yu Rebecca Miao, Erinn B. Rankin, Donna M. Peehl, Jiaoti Huang, Amato J. Giaccia, James D. Brooks
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (7): 1346–1358.
https://doi.org/10.1158/1078-0432.CCR-24-3028
Published: 01 April 2025
View article titled, Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone
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Includes: Supplementary data
Journal Articles

Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer

Open Access
Yu Rebecca Miao, Kaushik N. Thakkar, Jin Qian, Mihalis S. Kariolis, Wei Huang, Saravanan Nandagopal, Teddy Tat Chi Yang, Anh N. Diep, Gerald Maxwell Cherf, Yu Xu, Eui Jung Moon, Yiren Xiao, Haizea Alemany, Tiane Li, Wenhua Yu, Bo Wei, Erinn B. Rankin, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4435–4448.
https://doi.org/10.1158/1078-0432.CCR-20-0482
Published: 01 August 2021
View article titled, Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations

Available to Purchase
Todd A. Aguilera, Eslam A. Elghonaimy, Hussein Shehade, Marjan Rafat, Laura Castellini, Dadi Jiang, Mihalis Kariolis, Albert C. Koong, Quynh-Thu Le, Lesley G. Ellies, Erinn B. Rankin, Edward E. Graves, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12): 2972–2985.
https://doi.org/10.1158/1078-0432.CCR-19-4220
Published: 15 June 2020
View article titled, Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations
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Includes: Supplementary data
Journal Articles

Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO–AACR Research Workshop

Free
Heather M. McGee, Dadi Jiang, David R. Soto-Pantoja, Avinoam Nevler, Amato J. Giaccia, Wendy A. Woodward
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 2969–2974.
https://doi.org/10.1158/1078-0432.CCR-18-3781
Published: 15 May 2019
View article titled, Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO–AACR Research Workshop
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Journal Articles

Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion—A New Role for the AXL Receptor Tyrosine Kinase

Free
Todd A. Aguilera, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): 2928–2933.
https://doi.org/10.1158/1078-0432.CCR-17-0189
Published: 14 June 2017
View article titled, Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion—A New Role for the AXL Receptor Tyrosine Kinase
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Journal Articles

Abstract AS19: The role of the receptor tyrosine kinase AXL in an immunocompetent mouse model of invasive endometrioid ovarian cancer

Free
Katherine Fuh, Erinn Rankin, Colleen Wu, Anh Diep, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): AS19.
https://doi.org/10.1158/1557-3265.OVCASYMP14-AS19
Published: 15 August 2015
View article titled, Abstract AS19: The role of the receptor tyrosine kinase AXL in an immunocompetent mouse model of invasive endometrioid ovarian cancer
Journal Articles

Emerging Treatment Paradigms in Radiation Oncology

Free
Quynh-Thu Le, Hiroki Shirato, Amato J. Giaccia, Albert C. Koong
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (15): 3393–3401.
https://doi.org/10.1158/1078-0432.CCR-14-1191
Published: 02 August 2015
View article titled, Emerging Treatment Paradigms in Radiation Oncology
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Includes: Supplementary data
Journal Articles

Galectin-1 Mediates Radiation-Related Lymphopenia and Attenuates NSCLC Radiation Response

Free
Peiwen Kuo, Scott V. Bratman, David B. Shultz, Rie von Eyben, Cato Chan, Ziwei Wang, Carmen Say, Aparna Gupta, Bill W. Loo, Jr, Amato J. Giaccia, Albert C. Koong, Maximilian Diehn, Quynh-Thu Le
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (21): 5558–5569.
https://doi.org/10.1158/1078-0432.CCR-14-1138
Published: 30 October 2014
View article titled, Galectin-1 Mediates Radiation-Related Lymphopenia and Attenuates NSCLC Radiation Response
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Includes: Supplementary data
Journal Articles

Hypoxia in Models of Lung Cancer: Implications for Targeted Therapeutics

Free
Edward E. Graves, Marta Vilalta, Ivana K. Cecic, Janine T. Erler, Phuoc T. Tran, Dean Felsher, Leanne Sayles, Alejandro Sweet-Cordero, Quynh-Thu Le, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (19): 4843–4852.
https://doi.org/10.1158/1078-0432.CCR-10-1206
Published: 29 September 2010
View article titled, Hypoxia in Models of Lung Cancer: Implications for Targeted Therapeutics
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Includes: Supplementary data
Journal Articles

Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104

Free
Rob A. Cairns, Kevin L. Bennewith, Edward E. Graves, Amato J. Giaccia, Daniel T. Chang, Nicholas C. Denko
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (23): 7170–7174.
https://doi.org/10.1158/1078-0432.CCR-09-1676
Published: 30 November 2009
View article titled, Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104
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Includes: Supplementary data
Journal Articles

Hypoxia-Inducible Factor-1 and p53: Friends, Acquaintances, or Strangers?

Free
Ester M. Hammond, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (17): 5007–5009.
https://doi.org/10.1158/1078-0432.CCR-06-0613
Published: 01 September 2006
View article titled, Hypoxia-Inducible Factor-1 and p53: Friends, Acquaintances, or Strangers?
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Journal Articles

An Evaluation of Tumor Oxygenation and Gene Expression in Patients with Early Stage Non–Small Cell Lung Cancers

Free
Quynh-Thu Le, Eunice Chen, Ali Salim, Hongbin Cao, Christina S. Kong, Richard Whyte, Jessica Donington, Walter Cannon, Heather Wakelee, Robert Tibshirani, John D. Mitchell, Donna Richardson, Ken J. O'Byrne, Albert C. Koong, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (5): 1507–1514.
https://doi.org/10.1158/1078-0432.CCR-05-2049
Published: 06 March 2006
View article titled, An Evaluation of Tumor Oxygenation and Gene Expression in Patients with Early Stage Non–Small Cell Lung Cancers
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Journal Articles

Therapeutic Exploitation of the Physiological and Molecular Genetic Alterations in Head and Neck Cancer

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Quynh-Thu Le, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (12): 4287–4295.
Published: 10 October 2003
View article titled, Therapeutic Exploitation of the Physiological and Molecular Genetic Alterations in Head and Neck Cancer
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Journal Articles

HIF-α, a Gender Independent Transcription Factor

Free
Quynh-Thu Le, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (7): 2391–2393.
Published: 01 July 2003
View article titled, HIF-α, a Gender Independent Transcription Factor
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Journal Articles

Identification of Osteopontin as a Prognostic Plasma Marker for Head and Neck Squamous Cell Carcinomas

Free
Quynh-Thu Le, Patrick D. Sutphin, Soumya Raychaudhuri, Sheue Ching T. Yu, David J. Terris, Ho Sheng Lin, Bert Lum, Harlan A Pinto, Albert C. Koong, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 59–67.
Published: 01 January 2003
View article titled, Identification of Osteopontin as a Prognostic Plasma Marker for Head and Neck Squamous Cell Carcinomas
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Journal Articles

Opposing Effects of Hypoxia on Expression of the Angiogenic Inhibitor Thrombospondin 1 and the Angiogenic Inducer Vascular Endothelial Growth Factor

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Keith R. Laderoute, Rodolfo M. Alarcon, Michael D. Brody, Joy M. Calaoagan, Eunice Y. Chen, A. Merrill Knapp, Zhong Yun, Nicholas C. Denko, Amato J. Giaccia
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (7): 2941–2950.
Published: 01 July 2000
View article titled, Opposing Effects of Hypoxia on Expression of the Angiogenic Inhibitor Thrombospondin 1 and the Angiogenic Inducer Vascular Endothelial Growth Factor
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