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Alexander J. Lazar
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Journal Articles

The Landscape of Alterations from 1407 Ultra-Rare Sarcomas from the AACR GENIE Database: Clinical Implications

Ryan A. Denu, Justin T. Moyers, Mohamed A. Gouda, Anthony P. Conley, Alexander J. Lazar, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (22): 4669–4678.
https://doi.org/10.1158/1078-0432.CCR-23-0876
Published: 14 November 2023
View article titled, The Landscape of Alterations from 1407 Ultra-Rare Sarcomas from the AACR GENIE Database: Clinical Implications
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Includes: Supplementary data
Journal Articles

Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome

Nan Deng, Laura Reyes-Uribe, Johannes F. Fahrmann, Whittney S. Thoman, Mark F. Munsell, Jennifer B. Dennison, Eunice Murage, Ranran Wu, Ernest T. Hawk, Selvi Thirumurthi, Patrick M. Lynch, Christina M. Dieli-Conwright, Alexander J. Lazar, Sonali Jindal, Khoi Chu, Manoj Chelvanambi, Karen Basen-Engquist, Yisheng Li, Jennifer A. Wargo, Florencia McAllister, James P. Allison, Padmanee Sharma, Krishna M. Sinha, Samir Hanash, Susan C. Gilchrist, Eduardo Vilar
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4361–4372.
https://doi.org/10.1158/1078-0432.CCR-23-0088
Published: 01 November 2023
View article titled, Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome
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Includes: Supplementary data
Journal Articles

Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes

Ryan A. Denu, Richard K. Yang, Alexander J. Lazar, Shalin S. Patel, Valerae O. Lewis, Jason Roszik, J. Andrew Livingston, Wei-Lien Wang, Kenna R. Shaw, Ravin Ratan, Maria A. Zarzour, Justin Bird, Shaan Raza, Kadir C. Akdemir, Jordi Rodon Ahnert, Vivek Subbiah, Shreyaskumar Patel, Anthony P. Conley
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF9.
https://doi.org/10.1158/1078-0432.CCR-23-1703
Published: 17 October 2023
View article titled, Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals <em>TP53</em> Mutation to Be Associated with Worse Outcomes
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Includes: Supplementary data
Journal Articles

Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101)

Roberto Carmagnani Pestana, Justin T. Moyers, Jason Roszik, Shiraj Sen, David S. Hong, Aung Naing, Cynthia E. Herzog, Siqing Fu, Sarina A. Piha-Paul, Jordi Rodon, Timothy A. Yap, Daniel D. Karp, Apostolia M. Tsimberidou, Shubham Pant, Maria A. Zarzour, Ravin Ratan, Vinod Ravi, Robert S. Benjamin, Alexander J. Lazar, Wei-Lien Wang, Najat Daw, Jonathan B. Gill, Douglas J. Harrison, Valerae O. Lewis, Christina L. Roland, Shreyaskumar R. Patel, J. Andrew Livingston, Neeta Somaiah, Joseph A. Ludwig, Anthony P. Conley, Nelson Hamerschlak, Richard Gorlick, Funda Meric-Bernstam, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (9): 1708–1718.
https://doi.org/10.1158/1078-0432.CCR-22-3629
Published: 01 May 2023
View article titled, Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101)
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Includes: Supplementary data
Journal Articles

Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma

Andrew W. Hahn, Ashley V. Menk, Dayana B. Rivadeneira, Ryan C. Augustin, Mingchu Xu, Jun Li, Xiaogang Wu, Aditya K. Mishra, Tuba N. Gide, Camelia Quek, Yan Zang, Christine N. Spencer, Alexander M. Menzies, Carrie R. Daniel, Courtney W. Hudgens, Theodore Nowicki, Lauren E. Haydu, M.A. Wadud Khan, Vancheswaran Gopalakrishnan, Elizabeth M. Burton, Jared Malke, Julie M. Simon, Chantale Bernatchez, Nagireddy Putluri, Scott E. Woodman, Y.N. Vashisht Gopal, Renato Guerrieri, Grant M. Fischer, Jian Wang, Khalida M. Wani, John F. Thompson, Jeffrey E. Lee, Patrick Hwu, Nadim Ajami, Jeffrey E. Gershenwald, Georgina V. Long, Richard A. Scolyer, Michael T. Tetzlaff, Alexander J. Lazar, Dirk Schadendorf, Jennifer A. Wargo, John M. Kirkwood, Ralph J. DeBerardinis, Han Liang, Andrew Futreal, Jianhua Zhang, James S. Wilmott, Weiyi Peng, Michael A. Davies, Greg M. Delgoffe, Yana G. Najjar, Jennifer L. McQuade
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (1): 154–164.
https://doi.org/10.1158/1078-0432.CCR-22-2661
Published: 04 January 2023
View article titled, Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

Abstract A023: Identifying new therapeutic indications for afamitresgene autoleucel (“afami-cel” [formerly ADP-A2M4]) in adult and pediatric sarcomas using MAGE-A4 immunohistochemistry

Swethajit Biswas, Caddie Laberiano, Khalida Wani, Davis Ingram, Wei Lu, Rossana Lazcano, Wei-Lien Wang, Yao Chen, Dennis Williams, Cheryl McAlpine, Alexander J. Lazar, Luisa M. Solis Soto
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): A023.
https://doi.org/10.1158/1557-3265.SARCOMAS22-A023
Published: 15 September 2022
View article titled, Abstract A023: Identifying new therapeutic indications for afamitresgene autoleucel (“afami-cel” [formerly ADP-A2M4]) in adult and pediatric sarcomas using MAGE-A4 immunohistochemistry
Journal Articles

Abstract PR002: Antigen presentation and processing pathway is associated with early relapse after neoadjuvant immune checkpoint blockade (ICB) in dedifferentiated liposarcomas (DDLPS)

Elise F. Nassif, Chia-Chin Wu, Kadir Akdemir, Russell G. Witt, Raymond Traweek, Brandon Cope, Prapassorn Thirasastr, Taylor Tate, Grace Mathew, Shadarra Crosby, Randy Chu, Mohammad Mohammad, Kenna Shaw, Ingram Davis, Khalida Wani, Alexander J. Lazar, Wei-Lien Wang, Sheila Duncan, Ashleigh B. Guadagnolo, Andrew J. Bishop, Valerae Lewis, Justin E. Bird, Keila E. Torres, Kelly K. Hunt, Barry W. Feig, Christopher P. Scally, Ravin Ratan, Shreyaskumar Patel, Robert S. Benjamin, Robert Satcher, Kevin McBride, Wolf H. Fridman, Ignacio Wistuba, Andrew Futreal, Jennifer A. Wargo, Neeta Somaiah, Christina L. Roland, Emily Z. Keung
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): PR002.
https://doi.org/10.1158/1557-3265.SARCOMAS22-PR002
Published: 15 September 2022
View article titled, Abstract PR002: Antigen presentation and processing pathway is associated with early relapse after neoadjuvant immune checkpoint blockade (ICB) in dedifferentiated liposarcomas (DDLPS)
Journal Articles

Systemic Chemotherapies Retain Antitumor Activity in Desmoid Tumors Independent of Specific Mutations in CTNNB1 or APC: A Multi-institutional Retrospective Study

Michael J. Nathenson, Junxiao Hu, Ravin Ratan, Neeta Somaiah, Robert Hsu, Peter J. DeMaria, Heath W. Catoe, Angela Pang, Ty K. Subhawong, Behrang Amini, Kevin Sweet, Katharina Feister, Karan Malik, Jyothi Jagannathan, Marta Braschi-Amirfarzan, Jamie Sheren, Yupanqui Caldas, Cristiam Moreno Tellez, Andrew E. Rosenberg, Alexander J. Lazar, Robert G. Maki, Pasquale Benedetto, Jonathan Cohen, Jonathan C. Trent, Vinod Ravi, Shreyaskumar Patel, Breelyn A. Wilky
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18): 4092–4104.
https://doi.org/10.1158/1078-0432.CCR-21-4504
Published: 15 September 2022
View article titled, Systemic Chemotherapies Retain Antitumor Activity in Desmoid Tumors Independent of Specific Mutations in <em>CTNNB1</em> or <em>APC</em>: A Multi-institutional Retrospective Study
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Includes: Supplementary data
Journal Articles

Correction: SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma

Kate Lynn J. Bill, Jeannine Garnett, Isabelle Meaux, XiaoYen Ma, Chad J. Creighton, Svetlana Bolshakov, Cedric Barriere, Laurent Debussche, Alexander J. Lazar, Bethany C. Prudner, Lucia Casadei, Danielle Braggio, Gonzalo Lopez, Abbie Zewdu, Hemant Bid, Lev Dina, Raphael E. Pollock
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 431.
https://doi.org/10.1158/1078-0432.CCR-21-4243
Published: 19 January 2022
View article titled, Correction: SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma
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Journal Articles

Correlative Analyses of the SARC028 Trial Reveal an Association Between Sarcoma-Associated Immune Infiltrate and Response to Pembrolizumab

Emily Z. Keung, Melissa Burgess, Ruth Salazar, Edwin R. Parra, Jaime Rodrigues-Canales, Vanessa Bolejack, Brian A. Van Tine, Scott M. Schuetze, Steven Attia, Richard F. Riedel, James Hu, Scott H. Okuno, Dennis A. Priebat, Sujana Movva, Lara E. Davis, Damon R. Reed, Alexandre Reuben, Christina L. Roland, Denise Reinke, Alexander J. Lazar, Wei-Lien Wang, Jennifer A. Wargo, Hussein A. Tawbi
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1258–1266.
https://doi.org/10.1158/1078-0432.CCR-19-1824
Published: 13 March 2020
View article titled, Correlative Analyses of the SARC028 Trial Reveal an Association Between Sarcoma-Associated Immune Infiltrate and Response to Pembrolizumab
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Includes: Supplementary data
Journal Articles

B7-H3 Expression in Merkel Cell Carcinoma–Associated Endothelial Cells Correlates with Locally Aggressive Primary Tumor Features and Increased Vascular Density

Phyu P. Aung, Edwin Roger Parra, Souptik Barua, Dawen Sui, Jing Ning, Barbara Mino, Debora Alejandra Ledesma, Jonathan L. Curry, Priyadharsini Nagarajan, Carlos A. Torres-Cabala, Eleni Efstathiou, Anh G. Hoang, Michael K. Wong, Jennifer A. Wargo, Alexander J. Lazar, Arvind Rao, Victor G. Prieto, Ignacio Wistuba, Michael T. Tetzlaff
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (11): 3455–3467.
https://doi.org/10.1158/1078-0432.CCR-18-2355
Published: 03 June 2019
View article titled, B7-H3 Expression in Merkel Cell Carcinoma–Associated Endothelial Cells Correlates with Locally Aggressive Primary Tumor Features and Increased Vascular Density
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Includes: Supplementary data
Journal Articles

Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival

Vivek Subbiah, Salah-Eddine Lamhamedi-Cherradi, Branko Cuglievan, Brian A. Menegaz, Pamela Camacho, Winston Huh, Vandhana Ramamoorthy, Pete M. Anderson, Raphael E. Pollock, Dina C. Lev, Wei Qiao, Mary Frances McAleer, Robert S. Benjamin, Shreyaskumar Patel, Cynthia E. Herzog, Najat C. Daw, Barry W. Feig, Alexander J. Lazar, Andrea Hayes-Jordan, Joseph A. Ludwig
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (19): 4865–4873.
https://doi.org/10.1158/1078-0432.CCR-18-0202
Published: 01 October 2018
View article titled, Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival
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Includes: Supplementary data
Journal Articles

Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma

Vladimir Bezrookove, Mehdi Nosrati, James R. Miller, III, David De Semir, Altaf A. Dar, Elham Vosoughi, Edith Vaquero, Antje Sucker, Alexander J. Lazar, Jeffrey E. Gershenwald, Michael A. Davies, Dirk Schadendorf, Mohammed Kashani-Sabet
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17): 4119–4125.
https://doi.org/10.1158/1078-0432.CCR-18-0791
Published: 04 September 2018
View article titled, Role of Elevated <em>PHIP</em> Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma
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Includes: Supplementary data
Journal Articles

Abstract PR11: SSX-mediated chromatin engagement and targeting of BAF complexes activates oncogenic transcription in synovial sarcoma

Matthew J. McBride, John L. Pulice, Robert T. Nakayama, Nazar Mashtalir, Davis R. Ingram, Jacob D. Jaffe, Jack F. Shern, Javed Khan, Jason L. Hornick, Alexander J. Lazar, Cigall Kadoch
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2_Supplement): PR11.
https://doi.org/10.1158/1557-3265.SARCOMAS17-PR11
Published: 15 January 2018
View article titled, Abstract PR11: SSX-mediated chromatin engagement and targeting of BAF complexes activates oncogenic transcription in synovial sarcoma
Journal Articles

SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma

Kate Lynn J. Bill, Jeannine Garnett, Isabelle Meaux, XiaoYen Ma, Chad J. Creighton, Svetlana Bolshakov, Cedric Barriere, Laurent Debussche, Alexander J. Lazar, Bethany C. Prudner, Lucia Casadei, Danielle Braggio, Gonzalo Lopez, Abbie Zewdu, Hemant Bid, Dina Lev, Raphael E. Pollock
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (5): 1150–1160.
https://doi.org/10.1158/1078-0432.CCR-15-1522
Published: 01 March 2016
View article titled, SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma
Open the PDF for SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma in another window
Includes: Supplementary data
Journal Articles

Hotspot Mutation Panel Testing Reveals Clonal Evolution in a Study of 265 Paired Primary and Metastatic Tumors

Rashmi S. Goswami, Keyur P. Patel, Rajesh R. Singh, Funda Meric-Bernstam, E. Scott Kopetz, Vivek Subbiah, Ricardo H. Alvarez, Michael A. Davies, Kausar J. Jabbar, Sinchita Roy-Chowdhuri, Alexander J. Lazar, L. Jeffrey Medeiros, Russell R. Broaddus, Rajyalakshmi Luthra, Mark J. Routbort
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (11): 2644–2651.
https://doi.org/10.1158/1078-0432.CCR-14-2391
Published: 31 May 2015
View article titled, Hotspot Mutation Panel Testing Reveals Clonal Evolution in a Study of 265 Paired Primary and Metastatic Tumors
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Includes: Supplementary data
Journal Articles

New, Tolerable γ-Secretase Inhibitor Takes Desmoid Down a Notch

Dennis P.M. Hughes, Shivaani Kummar, Alexander J. Lazar
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (1): 7–9.
https://doi.org/10.1158/1078-0432.CCR-14-1660
Published: 05 January 2015
View article titled, New, Tolerable γ-Secretase Inhibitor Takes Desmoid Down a Notch
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Journal Articles

Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target

Guo Chen, Nitin Chakravarti, Kimberly Aardalen, Alexander J. Lazar, Michael T. Tetzlaff, Bradley Wubbenhorst, Sang-Bae Kim, Scott Kopetz, Alicia A. Ledoux, Y.N. Vashisht Gopal, Cristiano Goncalves Pereira, Wanleng Deng, Ju-Seog Lee, Katherine L. Nathanson, Kenneth D. Aldape, Victor G. Prieto, Darrin Stuart, Michael A. Davies
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (21): 5537–5546.
https://doi.org/10.1158/1078-0432.CCR-13-3003
Published: 30 October 2014
View article titled, Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target
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Includes: Supplementary data
Journal Articles

Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with BRAFV600 Mutations

Amanda D. Bucheit, Guo Chen, Alan Siroy, Michael Tetzlaff, Russell Broaddus, Denai Milton, Patricia Fox, Roland Bassett, Patrick Hwu, Jeffrey E. Gershenwald, Alexander J. Lazar, Michael A. Davies
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (21): 5527–5536.
https://doi.org/10.1158/1078-0432.CCR-14-1027
Published: 30 October 2014
View article titled, Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with <em>BRAF</em><sup>V600</sup> Mutations
Open the PDF for Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with <em>BRAF</em><sup>V600</sup> Mutations in another window
Includes: Supplementary data
Journal Articles

Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine Leiomyosarcoma

Kari J. Brewer Savannah, Elizabeth G. Demicco, Kristelle Lusby, Markus PH. Ghadimi, Roman Belousov, Eric Young, Yiqun Zhang, Kai-Lieh Huang, Alexander J. Lazar, Kelly K. Hunt, Raphael E. Pollock, Chad J. Creighton, Matthew L. Anderson, Dina Lev
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (17): 4633–4645.
https://doi.org/10.1158/1078-0432.CCR-12-0436
Published: 30 August 2012
View article titled, Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine Leiomyosarcoma
Open the PDF for Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine Leiomyosarcoma in another window
Includes: Supplementary data