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Alexander I. Spira
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Journal Articles

Early Changes in Circulating Cell-Free KRAS G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients

Cloud P. Paweletz, Grace A. Heavey, Yanan Kuang, Emily Durlacher, Thian Kheoh, Richard C. Chao, Alexander I. Spira, Konstantinos Leventakos, Melissa L. Johnson, Sai-Hong Ignatius Ou, Gregory J. Riely, Kenna Anderes, Wenjing Yang, James G. Christensen, Pasi A. Jänne
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (16): 3074–3080.
https://doi.org/10.1158/1078-0432.CCR-23-0795
Published: 15 August 2023
View article titled, Early Changes in Circulating Cell-Free <em>KRAS</em> G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients
Open the PDF for Early Changes in Circulating Cell-Free <em>KRAS</em> G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients in another window
Includes: Supplementary data
Journal Articles

Has the Enemy “MET” Its Match? Subgroup Analysis Results from VISION Study

Samuel Rosner, Alexander I. Spira
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (6): 1055–1057.
https://doi.org/10.1158/1078-0432.CCR-21-4109
Published: 14 March 2022
View article titled, Has the Enemy “MET” Its Match? Subgroup Analysis Results from VISION Study
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Journal Articles

Phase II, Randomized Study of Spartalizumab (PDR001), an Anti–PD-1 Antibody, versus Chemotherapy in Patients with Recurrent/Metastatic Nasopharyngeal Cancer

Caroline Even, Hung-Ming Wang, Shau-Hsuan Li, Roger K-C Ngan, Arunee Dechaphunkul, Li Zhang, Chia-Jui Yen, Po Chung Chan, Somvilai Chakrabandhu, Brigette B.Y. Ma, Suebpong Tanasanvimon, Victor H.F. Lee, Pei-Jen Lou, Zujun Li, Alexander I. Spira, Ammar Sukari, Joël Guigay, Steven McCune, Juan Gonzalez-Maffe, Sebastian Szpakowski, Yao Yao, Hongzi Liang, Jennifer Mataraza, Romain Séchaud, Luigi Manenti, Darren W-T. Lim
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6413–6423.
https://doi.org/10.1158/1078-0432.CCR-21-0822
Published: 01 December 2021
View article titled, Phase II, Randomized Study of Spartalizumab (PDR001), an Anti–PD-1 Antibody, versus Chemotherapy in Patients with Recurrent/Metastatic Nasopharyngeal Cancer
Open the PDF for Phase II, Randomized Study of Spartalizumab (PDR001), an Anti–PD-1 Antibody, versus Chemotherapy in Patients with Recurrent/Metastatic Nasopharyngeal Cancer in another window
Includes: Supplementary data
Journal Articles

A Phase Ib Open-Label, Multicenter Study of Inhaled DV281, a TLR9 Agonist, in Combination with Nivolumab in Patients with Advanced or Metastatic Non–small Cell Lung Cancer

Edward B. Garon, Alexander I. Spira, Melissa Johnson, Lyudmila Bazhenova, Joseph Leach, Amy L. Cummings, Albert Candia, Robert L. Coffman, Mary J. Janatpour, Robert Janssen, Erick Gamelin, Laura Q.M. Chow
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4566–4573.
https://doi.org/10.1158/1078-0432.CCR-21-0263
Published: 15 August 2021
View article titled, A Phase Ib Open-Label, Multicenter Study of Inhaled DV281, a TLR9 Agonist, in Combination with Nivolumab in Patients with Advanced or Metastatic Non–small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

A Phase Ib/II Study of Pepinemab in Combination with Avelumab in Advanced Non–Small Cell Lung Cancer

Michael R. Shafique, Terrence L. Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae E. Pastore, Crystal L. Mallow, Ernest Smith, Vikas Mishra, Andreas Schröder, Kevin M. Chin, Joseph T. Beck, Megan A. Baumgart, Ramaswamy Govindan, Nashat Y. Gabrail, Alexander I. Spira, Nagashree Seetharamu, Yanyan Lou, Aaron S. Mansfield, Rachel E. Sanborn, Jonathan W. Goldman, Maurice Zauderer
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (13): 3630–3640.
https://doi.org/10.1158/1078-0432.CCR-20-4792
Published: 01 July 2021
View article titled, A Phase Ib/II Study of Pepinemab in Combination with Avelumab in Advanced Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors

George D. Demetri, Jason J. Luke, Antoine Hollebecque, John D. Powderly, II, Alexander I. Spira, Vivek Subbiah, Louie Naumovski, Chris Chen, Hua Fang, Dominic W. Lai, Huibin Yue, Akshanth R. Polepally, James W. Purcell, Randy Robinson, Padmanee Sharma, James P. Allison, Anthony Tolcher, Victor M. Villalobos
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (13): 3556–3566.
https://doi.org/10.1158/1078-0432.CCR-20-4513
Published: 01 July 2021
View article titled, First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Laboratory Reference Ranges and Testing Intervals Work Group

Alexander I. Spira, Mark D. Stewart, Suzanne Jones, Elaine Chang, Anitra Fielding, Nicole Richie, Laura S. Wood, Michael A. Thompson, Lee Jones, Abhilasha Nair, Brandon A. Mahal, David E. Gerber
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2416–2423.
https://doi.org/10.1158/1078-0432.CCR-20-3853
Published: 01 May 2021
View article titled, Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Laboratory Reference Ranges and Testing Intervals Work Group
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Includes: Supplementary data
Journal Articles

A Phase Ib Study of Onvansertib, a Novel Oral PLK1 Inhibitor, in Combination Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia

Amer M. Zeidan, Maya Ridinger, Tara L. Lin, Pamela S. Becker, Gary J. Schiller, Prapti A. Patel, Alexander I. Spira, Michaela L. Tsai, Errin Samuëlsz, Sandra L. Silberman, Mark Erlander, Eunice S. Wang
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (23): 6132–6140.
https://doi.org/10.1158/1078-0432.CCR-20-2586
Published: 01 December 2020
View article titled, A Phase Ib Study of Onvansertib, a Novel Oral PLK1 Inhibitor, in Combination Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Detection of NRG1 Gene Fusions in Solid Tumors

Sushma Jonna, Rebecca A. Feldman, Jeffrey Swensen, Zoran Gatalica, Wolfgang M. Korn, Hossein Borghaei, Patrick C. Ma, Jorge J. Nieva, Alexander I. Spira, Ari M. Vanderwalde, Antoinette J. Wozniak, Edward S. Kim, Stephen V. Liu
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (16): 4966–4972.
https://doi.org/10.1158/1078-0432.CCR-19-0160
Published: 15 August 2019
View article titled, Detection of NRG1 Gene Fusions in Solid Tumors
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Includes: Supplementary data