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Alexander Drilon
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Journal Articles

Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets

Monica F. Chen, Soo-Ryum Yang, Jessica J. Tao, Antoine Desilets, Eli L. Diamond, Clare Wilhelm, Ezra Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J. Young, Romel Somwar, Helena A. Yu, Mark G. Kris, Gregory J. Riely, Maria E. Arcila, Marc Ladanyi, Mark T.A. Donoghue, Neal Rosen, Rona Yaeger, Alexander Drilon, Yonina R. Murciano-Goroff, Michael Offin
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (17): 3812–3823.
https://doi.org/10.1158/1078-0432.CCR-23-3981
Published: 03 September 2024
View article titled, Tumor-Agnostic Genomic and Clinical Analysis of <em>BRAF</em> Fusions Identifies Actionable Targets
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Includes: Supplementary data
Journal Articles

Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers

Julia Rotow, Jyoti D. Patel, Matthew P. Hanley, Helena Yu, Mark Awad, Jonathan W. Goldman, Hovav Nechushtan, Matthias Scheffler, Chih-Hsi S. Kuo, Senthil Rajappa, Guilherme Harada, Sarah Clifford, Alison Santucci, Laura Silva, Rebecca Tupper, Geoffrey R. Oxnard, Jennifer Kherani, Alexander Drilon
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (16): 2979–2987.
https://doi.org/10.1158/1078-0432.CCR-22-2189
Published: 15 August 2023
View article titled, Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of <em>EGFR</em>-Mutant and <em>RET</em> Fusion-Positive Lung Cancers
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Includes: Supplementary data
Journal Articles

Bioinformatically Expanded Next-Generation Sequencing Analysis Optimizes Identification of Therapeutically Relevant MET Copy Number Alterations in >50,000 Tumors

James P. Solomon, Soo-Ryum Yang, Noura J. Choudhury, Ryan N. Ptashkin, Nasrin Eslamdoost, Christina J. Falcon, Axel Martin, Andrew Plodkowski, Clare Wilhelm, Ronglai Shen, Marc Ladanyi, Michael Berger, Yanming Zhang, Alexander Drilon, Maria E. Arcila
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4649–4659.
https://doi.org/10.1158/1078-0432.CCR-22-1321
Published: 01 November 2022
View article titled, Bioinformatically Expanded Next-Generation Sequencing Analysis Optimizes Identification of Therapeutically Relevant <em>MET</em> Copy Number Alterations in &gt;50,000 Tumors
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Includes: Supplementary data
Journal Articles

An Ascendant Challenge: Central Nervous System Metastases in ALK+ Lung Cancers

Yonina R. Murciano-Goroff, Guilherme Harada, Alexander Drilon
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (12): 2477–2479.
https://doi.org/10.1158/1078-0432.CCR-22-0341
Published: 13 June 2022
View article titled, An Ascendant Challenge: Central Nervous System Metastases in <em>ALK</em><sup>+</sup> Lung Cancers
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Journal Articles

Correction: Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients with NTRK Fusion–Positive Solid Tumors

George D. Demetri, Filippo De Braud, Alexander Drilon, Salvatore Siena, Manish R. Patel, Byoung Chul Cho, Stephen V. Liu, Myung-Ju Ahn, Chao-Hua Chiu, Jessica J. Lin, Koichi Goto, Jeeyun Lee, Lyudmila Bazhenova, Thomas John, Marwan Fakih, Sant P. Chawla, Rafal Dziadziuszko, Takashi Seto, Sebastian Heinzmann, Bethany Pitcher, David Chen, Timothy R. Wilson, Christian Rolfo
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (10): 2196.
https://doi.org/10.1158/1078-0432.CCR-22-1108
Published: 13 May 2022
View article titled, Correction: Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients with <em>NTRK</em> Fusion–Positive Solid Tumors
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Journal Articles

Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients With NTRK Fusion-Positive Solid Tumors

George D. Demetri, Filippo De Braud, Alexander Drilon, Salvatore Siena, Manish R. Patel, Byoung Chul Cho, Stephen V. Liu, Myung-Ju Ahn, Chao-Hua Chiu, Jessica J. Lin, Koichi Goto, Jeeyun Lee, Lyudmila Bazhenova, Thomas John, Marwan Fakih, Sant P. Chawla, Rafal Dziadziuszko, Takashi Seto, Sebastian Heinzmann, Bethany Pitcher, David Chen, Timothy R. Wilson, Christian Rolfo
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (7): 1302–1312.
https://doi.org/10.1158/1078-0432.CCR-21-3597
Published: 01 April 2022
View article titled, Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients With <em>NTRK</em> Fusion-Positive Solid Tumors
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Includes: Supplementary data
Journal Articles

Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial

Vivek Subbiah, Justin F. Gainor, Geoffrey R. Oxnard, Daniel S.W. Tan, Dwight H. Owen, Byoung Chul Cho, Herbert H. Loong, Caroline E. McCoach, Jared Weiss, Yu Jung Kim, Lyudmila Bazhenova, Keunchil Park, Haruko Daga, Benjamin Besse, Oliver Gautschi, Christian Rolfo, Edward Y. Zhu, Jennifer F. Kherani, Xin Huang, Suhyun Kang, Alexander Drilon
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4160–4167.
https://doi.org/10.1158/1078-0432.CCR-21-0800
Published: 01 August 2021
View article titled, Intracranial Efficacy of Selpercatinib in <em>RET</em> Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial
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Includes: Supplementary data
Journal Articles

Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes

Jason C. Chang, Michael Offin, Christina Falcon, David Brown, Brian R. Houck-Loomis, Fanli Meng, Vasilisa A. Rudneva, Helen H. Won, Sharon Amir, Joseph Montecalvo, Patrice Desmeules, Kyuichi Kadota, Prasad S. Adusumilli, Valerie W. Rusch, Sarah Teed, Joshua K. Sabari, Ryma Benayed, Khedoudja Nafa, Laetitia Borsu, Bob T. Li, Alison M. Schram, Maria E. Arcila, William D. Travis, Marc Ladanyi, Alexander Drilon, Natasha Rekhtman
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4066–4076.
https://doi.org/10.1158/1078-0432.CCR-21-0423
Published: 15 July 2021
View article titled, Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes
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Includes: Supplementary data
Journal Articles

Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion–Positive Lung Cancer

Jessica J. Lin, Noura J. Choudhury, Satoshi Yoda, Viola W. Zhu, Ted W. Johnson, Ramin Sakhtemani, Ibiayi Dagogo-Jack, Subba R. Digumarthy, Charlotte Lee, Andrew Do, Jennifer Peterson, Kylie Prutisto-Chang, Wafa Malik, Harper G. Hubbeling, Adam Langenbucher, Adam J. Schoenfeld, Christina J. Falcon, Jennifer S. Temel, Lecia V. Sequist, Beow Y. Yeap, Jochen K. Lennerz, Alice T. Shaw, Michael S. Lawrence, Sai-Hong Ignatius Ou, Aaron N. Hata, Alexander Drilon, Justin F. Gainor
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2899–2909.
https://doi.org/10.1158/1078-0432.CCR-21-0032
Published: 15 May 2021
View article titled, Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in <em>ROS1</em> Fusion–Positive Lung Cancer
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Includes: Supplementary data
Journal Articles

KRASG12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma

Gregory D. Jones, Raul Caso, Kay See Tan, Brooke Mastrogiacomo, Francisco Sanchez-Vega, Yuan Liu, James G. Connolly, Yonina R. Murciano-Goroff, Matthew J. Bott, Prasad S. Adusumilli, Daniela Molena, Gaetano Rocco, Valerie W. Rusch, Smita Sihag, Sandra Misale, Rona Yaeger, Alexander Drilon, Kathryn C. Arbour, Gregory J. Riely, Neal Rosen, Piro Lito, Haiying Zhang, David C. Lyden, Charles M. Rudin, David R. Jones, Bob T. Li, James M. Isbell
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2604–2612.
https://doi.org/10.1158/1078-0432.CCR-20-4772
Published: 01 May 2021
View article titled, <em>KRAS</em><sup>G12C</sup> Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

A Performance Comparison of Commonly Used Assays to Detect RET Fusions

Soo-Ryum Yang, Umut Aypar, Ezra Y. Rosen, Douglas A. Mata, Ryma Benayed, Kerry Mullaney, Gowtham Jayakumaran, Yanming Zhang, Denise Frosina, Alexander Drilon, Marc Ladanyi, Achim A. Jungbluth, Natasha Rekhtman, Jaclyn F. Hechtman
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1316–1328.
https://doi.org/10.1158/1078-0432.CCR-20-3208
Published: 01 March 2021
View article titled, A Performance Comparison of Commonly Used Assays to Detect RET Fusions
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Includes: Supplementary data
Journal Articles

MET Exon 14–altered Lung Cancers and MET Inhibitor Resistance

Robin Guo, Michael Offin, A. Rose Brannon, Jason Chang, Andrew Chow, Lukas Delasos, Jeffrey Girshman, Olivia Wilkins, Caroline G. McCarthy, Alex Makhnin, Christina Falcon, Kerry Scott, Yuan Tian, Fabiola Cecchi, Todd Hembrough, Deepu Alex, Ronglai Shen, Ryma Benayed, Bob T. Li, Charles M. Rudin, Mark G. Kris, Maria E. Arcila, Natasha Rekhtman, Paul Paik, Ahmet Zehir, Alexander Drilon
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3): 799–806.
https://doi.org/10.1158/1078-0432.CCR-20-2861
Published: 01 February 2021
View article titled, <em>MET</em> Exon 14–altered Lung Cancers and MET Inhibitor Resistance
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Includes: Supplementary data
Journal Articles

Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib

Ezra Y. Rosen, Melissa L. Johnson, Sarah E. Clifford, Romel Somwar, Jennifer F. Kherani, Jieun Son, Arrien A. Bertram, Monika A. Davare, Eric Gladstone, Elena V. Ivanova, Dahlia N. Henry, Elaine M. Kelley, Mika Lin, Marina S.D. Milan, Binoj C. Nair, Elizabeth A. Olek, Jenna E. Scanlon, Morana Vojnic, Kevin Ebata, Jaclyn F. Hechtman, Bob T. Li, Lynette M. Sholl, Barry S. Taylor, Marc Ladanyi, Pasi A. Jänne, S. Michael Rothenberg, Alexander Drilon, Geoffrey R. Oxnard
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 34–42.
https://doi.org/10.1158/1078-0432.CCR-20-2278
Published: 04 January 2021
View article titled, Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
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Includes: Supplementary data
Journal Articles

Progresses Toward Precision Medicine in RET-altered Solid Tumors

Carmen Belli, Santosh Anand, Justin F. Gainor, Frederique Penault-Llorca, Vivek Subbiah, Alexander Drilon, Fabrice Andrè, Giuseppe Curigliano
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6102–6111.
https://doi.org/10.1158/1078-0432.CCR-20-1587
Published: 01 December 2020
View article titled, Progresses Toward Precision Medicine in <em>RET</em>-altered Solid Tumors
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Journal Articles

Repotrectinib Exhibits Potent Antitumor Activity in Treatment-Naïve and Solvent-Front–Mutant ROS1-Rearranged Non–Small Cell Lung Cancer

Mi Ran Yun, Dong Hwi Kim, Seok-Young Kim, Hyeong-Seok Joo, You Won Lee, Hun Mi Choi, Chae Won Park, Seong Gu Heo, Han Na Kang, Sung Sook Lee, Adam J. Schoenfeld, Alexander Drilon, Seok-Gu Kang, Hyo Sup Shim, Min Hee Hong, J. Jean Cui, Hye Ryun Kim, Byoung Chul Cho
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (13): 3287–3295.
https://doi.org/10.1158/1078-0432.CCR-19-2777
Published: 01 July 2020
View article titled, Repotrectinib Exhibits Potent Antitumor Activity in Treatment-Naïve and Solvent-Front–Mutant ROS1-Rearranged Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract 16: Landscape and outcome of TRK fusion-positive Cancers

Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_1): 16.
https://doi.org/10.1158/1557-3265.ADVPRECMED20-16
Published: 15 June 2020
View article titled, Abstract 16: Landscape and outcome of TRK fusion-positive Cancers
Journal Articles

MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions

Hiroki Sato, Adam J. Schoenfeld, Evan Siau, Yue Christine Lu, Huichun Tai, Ken Suzawa, Daisuke Kubota, Allan J.W. Lui, Besnik Qeriqi, Marissa Mattar, Michael Offin, Masakiyo Sakaguchi, Shinichi Toyooka, Alexander Drilon, Neal X. Rosen, Mark G. Kris, David Solit, Elisa De Stanchina, Monika A. Davare, Gregory J. Riely, Marc Ladanyi, Romel Somwar
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12): 2932–2945.
https://doi.org/10.1158/1078-0432.CCR-19-3321
Published: 15 June 2020
View article titled, MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by <em>ROS1</em> Fusions
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Includes: Supplementary data
Journal Articles

TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations

Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (7): 1624–1632.
https://doi.org/10.1158/1078-0432.CCR-19-3165
Published: 01 April 2020
View article titled, TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations
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Includes: Supplementary data
Journal Articles

A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer

James J. Harding, Andrew X. Zhu, Todd M. Bauer, Toni K. Choueiri, Alexander Drilon, Martin H. Voss, Charles S. Fuchs, Ghassan K. Abou-Alfa, Sameera R. Wijayawardana, Xuejing Aimee Wang, Brian A. Moser, Arantxa Uruñuela, Volker Wacheck, Johanna C. Bendell
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (17): 5202–5211.
https://doi.org/10.1158/1078-0432.CCR-18-4010
Published: 03 September 2019
View article titled, A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer
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Includes: Supplementary data
Journal Articles

High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden

Ryma Benayed, Michael Offin, Kerry Mullaney, Purvil Sukhadia, Kelly Rios, Patrice Desmeules, Ryan Ptashkin, Helen Won, Jason Chang, Darragh Halpenny, Alison M. Schram, Charles M. Rudin, David M. Hyman, Maria E. Arcila, Michael F. Berger, Ahmet Zehir, Mark G. Kris, Alexander Drilon, Marc Ladanyi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4712–4722.
https://doi.org/10.1158/1078-0432.CCR-19-0225
Published: 01 August 2019
View article titled, High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden
Open the PDF for High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden in another window
Includes: Supplementary data