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Alex Sparreboom
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Journal Articles

Unique Cabozantinib Dosing Considerations in People Living with HIV and Cancer

Eric D. Eisenmann, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (24): 4999–5001.
https://doi.org/10.1158/1078-0432.CCR-23-2351
Published: 15 December 2023
View articletitled, Unique Cabozantinib Dosing Considerations in People Living with HIV and Cancer
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Journal Articles

Precision Dosing of Targeted Therapies Is Ready for Prime Time

Stefanie L. Groenland, Remy B. Verheijen, Markus Joerger, Ron H.J. Mathijssen, Alex Sparreboom, Jos H. Beijnen, Jan H. Beumer, Neeltje Steeghs, Alwin D.R. Huitema
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (24): 6644–6652.
https://doi.org/10.1158/1078-0432.CCR-20-4555
Published: 15 December 2021
View articletitled, Precision Dosing of Targeted Therapies Is Ready for Prime Time
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Journal Articles

Regulation of OATP1B1 Function by Tyrosine Kinase–mediated Phosphorylation

Elizabeth R. Hayden, Mingqing Chen, Kyle Z. Pasquariello, Alice A. Gibson, James J. Petti, Shichen Shen, Jun Qu, Su Sien Ong, Taosheng Chen, Yan Jin, Muhammad Erfan Uddin, Kevin M. Huang, Aviv Paz, Alex Sparreboom, Shuiying Hu, Jason A. Sprowl
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4301–4310.
https://doi.org/10.1158/1078-0432.CCR-21-0023
Published: 01 August 2021
View articletitled, Regulation of OATP1B1 Function by Tyrosine Kinase–mediated Phosphorylation
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Includes: Supplementary data
Journal Articles

Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors

Florence Atrafi, Ruben A.G. van Eerden, Marte A.M van Hylckama Vlieg, Esther Oomen-de Hoop, Peter de Bruijn, Martijn P. Lolkema, Adriaan Moelker, Cristianne J. Rijcken, Rob Hanssen, Alex Sparreboom, Ferry A.L.M. Eskens, Ron H.J. Mathijssen, Stijn L.W. Koolen
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3537–3545.
https://doi.org/10.1158/1078-0432.CCR-20-0008
Published: 15 July 2020
View articletitled, Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors
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Includes: Supplementary data
Journal Articles

Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach

Jing Li, Jianmei Wu, Xun Bao, Norissa Honea, Youming Xie, Seongho Kim, Alex Sparreboom, Nader Sanai
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24): 7454–7466.
https://doi.org/10.1158/1078-0432.CCR-17-0983
Published: 14 December 2017
View articletitled, Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach
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Includes: Supplementary data
Journal Articles

CCR 20th Anniversary Commentary: BMS-247550—Microtubule Stabilization as Successful Targeted Therapy

Navjotsingh Pabla, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (6): 1237–1239.
https://doi.org/10.1158/1078-0432.CCR-14-2551
Published: 12 March 2015
View articletitled, CCR 20th Anniversary Commentary: BMS-247550—Microtubule Stabilization as Successful Targeted Therapy
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Journal Articles

Hepatic Uptake Transporters and Docetaxel Disposition in Mice—Letter

Alex Sparreboom, Ron H. J. Mathijssen
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (15): 4167.
https://doi.org/10.1158/1078-0432.CCR-14-0949
Published: 31 July 2014
View articletitled, Hepatic Uptake Transporters and Docetaxel Disposition in Mice—Letter
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Journal Articles

Cisplatin-Induced Renal Injury Is Independently Mediated by OCT2 and p53

Jason A. Sprowl, Cynthia S. Lancaster, Navjotsingh Pabla, Edwin Hermann, Ashley M. Kosloske, Alice A. Gibson, Lie Li, Dorothea Zeeh, Eberhard Schlatter, Laura J. Janke, Giuliano Ciarimboli, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (15): 4026–4035.
https://doi.org/10.1158/1078-0432.CCR-14-0319
Published: 31 July 2014
View articletitled, Cisplatin-Induced Renal Injury Is Independently Mediated by OCT2 and p53
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Includes: Supplementary data
Journal Articles

Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)

Anne T. Nies, Elke Schaeffeler, Heiko van der Kuip, Ingolf Cascorbi, Oliver Bruhn, Michael Kneba, Christiane Pott, Ute Hofmann, Christopher Volk, Shuiying Hu, Sharyn D. Baker, Alex Sparreboom, Peter Ruth, Hermann Koepsell, Matthias Schwab
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (4): 985–994.
https://doi.org/10.1158/1078-0432.CCR-13-1999
Published: 16 February 2014
View articletitled, Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)
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Includes: Supplementary data
Journal Articles

A Pharmacogenetic Predictive Model for Paclitaxel Clearance Based on the DMET Platform

Anne-Joy M. de Graan, Laure Elens, Marcel Smid, John W. Martens, Alex Sparreboom, Annemieke J.M. Nieuweboer, Lena E. Friberg, Samira Elbouazzaoui, Erik A.C. Wiemer, Bronno van der Holt, Jaap Verweij, Ron H.N. van Schaik, Ron H.J. Mathijssen
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (18): 5210–5217.
https://doi.org/10.1158/1078-0432.CCR-13-0487
Published: 16 September 2013
View articletitled, A Pharmacogenetic Predictive Model for Paclitaxel Clearance Based on the DMET Platform
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Journal Articles

Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

Brian D. Furmanski, Shuiying Hu, Ken-ichi Fujita, Lie Li, Alice A. Gibson, Laura J. Janke, Richard T. Williams, John D. Schuetz, Alex Sparreboom, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (16): 4359–4370.
https://doi.org/10.1158/1078-0432.CCR-13-0980
Published: 13 August 2013
View articletitled, Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib
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Includes: Supplementary data
Journal Articles

CYP3A4*22 Genotype and Systemic Exposure Affect Paclitaxel-Induced Neurotoxicity

Anne-Joy M. de Graan, Laure Elens, Jason A. Sprowl, Alex Sparreboom, Lena E. Friberg, Bronno van der Holt, Pleun J. de Raaf, Peter de Bruijn, Frederike K. Engels, Ferry A.L.M. Eskens, Erik A.C. Wiemer, Jaap Verweij, Ron H.J. Mathijssen, Ron H.N. van Schaik
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (12): 3316–3324.
https://doi.org/10.1158/1078-0432.CCR-12-3786
Published: 13 June 2013
View articletitled, CYP3A4*22 Genotype and Systemic Exposure Affect Paclitaxel-Induced Neurotoxicity
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Includes: Supplementary data
Journal Articles

Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide

Eric I. Zimmerman, Shuiying Hu, Justin L. Roberts, Alice A. Gibson, Shelley J. Orwick, Lie Li, Alex Sparreboom, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1458–1466.
https://doi.org/10.1158/1078-0432.CCR-12-3306
Published: 14 March 2013
View articletitled, Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
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Includes: Supplementary data
Journal Articles

Long-term Prospective Population PK Study in GIST Patients—Response

Ron H.J. Mathijssen, Peter de Bruijn, Karel Eechoute, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (4): 950.
https://doi.org/10.1158/1078-0432.CCR-12-3807
Published: 14 February 2013
View articletitled, Long-term Prospective Population PK Study in GIST Patients—Response
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Journal Articles

A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients

Karel Eechoute, Martin N. Fransson, An K. Reyners, Floris A. de Jong, Alex Sparreboom, Winette T.A. van der Graaf, Lena E. Friberg, Gaia Schiavon, Erik A.C. Wiemer, Jaap Verweij, Walter J. Loos, Ron H.J. Mathijssen, Ugo De Giorgi
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (20): 5780–5787.
https://doi.org/10.1158/1078-0432.CCR-12-0490
Published: 14 October 2012
View articletitled, A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients
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Includes: Supplementary data
Journal Articles

Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel

Anne-Joy M. de Graan, Cynthia S. Lancaster, Amanda Obaidat, Bruno Hagenbuch, Laure Elens, Lena E. Friberg, Peter de Bruijn, Shuiying Hu, Alice A. Gibson, Gitte H. Bruun, Thomas J. Corydon, Torben S. Mikkelsen, Aisha L. Walker, Guoqing Du, Walter J. Loos, Ron H. N. van Schaik, Sharyn D. Baker, Ron H. J. Mathijssen, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (16): 4433–4440.
https://doi.org/10.1158/1078-0432.CCR-12-0761
Published: 14 August 2012
View articletitled, Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel
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Includes: Supplementary data
Journal Articles

Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients

Giuliano Ciarimboli, Cynthia S. Lancaster, Eberhard Schlatter, Ryan M. Franke, Jason A. Sprowl, Hermann Pavenstädt, Vivian Massmann, Denise Guckel, Ron H. J. Mathijssen, Wenjian Yang, Ching-Hon Pui, Mary V. Relling, Edwin Herrmann, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (4): 1101–1108.
https://doi.org/10.1158/1078-0432.CCR-11-2503
Published: 14 February 2012
View articletitled, Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients
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Includes: Supplementary data
Journal Articles

Impact of ABCB1 Allelic Variants on QTc Interval Prolongation

Tristan M. Sissung, Erin R. Gardner, Richard L. Piekarz, Reuben Howden, Xiaohong Chen, Sukyung Woo, Ryan Franke, James A. Clark, Laura Miller-DeGraff, Seth M. Steinberg, David Venzon, David Liewehr, Steven R. Kleeberger, Susan E. Bates, Douglas K. Price, Douglas R. Rosing, Christopher Cabell, Alex Sparreboom, William D. Figg
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (4): 937–946.
https://doi.org/10.1158/1078-0432.CCR-10-0925
Published: 15 February 2011
View articletitled, Impact of ABCB1 Allelic Variants on QTc Interval Prolongation
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Includes: Supplementary data
Journal Articles

Drug Transporters and Imatinib Treatment: Implications for Clinical Practice

Karel Eechoute, Alex Sparreboom, Herman Burger, Ryan M. Franke, Gaia Schiavon, Jaap Verweij, Walter J. Loos, Erik A.C. Wiemer, Ron H.J. Mathijssen
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (3): 406–415.
https://doi.org/10.1158/1078-0432.CCR-10-2250
Published: 01 February 2011
View articletitled, Drug Transporters and Imatinib Treatment: Implications for Clinical Practice
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Journal Articles

Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting

Cynthia S. Lancaster, Chaoxin Hu, Ryan M. Franke, Kelly K. Filipski, Shelley J. Orwick, Zhaoyuan Chen, Zhili Zuo, Walter J. Loos, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (19): 4789–4799.
https://doi.org/10.1158/1078-0432.CCR-10-1239
Published: 29 September 2010
View articletitled, Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting
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