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Journal Articles

Abstract P1-10-05: Real-World Molecular Profiling After CDK4/6 Inhibition in Advanced Breast Cancer: Analysis of the SOLTI-1903 HOPE Study

Free
Elia Segui, Rubén Olivera-Salguero, Juan Miguel Cejalvo, Mafalda OliveiraPablo Tolosa, Pablo Tolosa, Maria Vidal, Marcos Malumbres, Joaquín Gavilá, Cristina Saura, Sonia Pernas, Rafael López, Mireia Margelí, Judith Balmaña, Montserrat Muñoz, Isabel Blancas, Valentina Boni, Eva Ciruelos, Elena Galve, Antonia Perelló, Raquel Gómez-Bravo, Isabel García-Fructuoso, Susana de la Cruz, Miguel de la Hoya, Teresa Manchón, Juan Manuel Ferrero-Cafiero, Helena Masanas, Rosa Olmos, Gema Rodríguez, Amparo Medina, Maria José Prieto, Aleix Prat, Ana Casas, Tomás Pascual
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P1-10-05.
https://doi.org/10.1158/1557-3265.SABCS24-P1-10-05
Published: 13 June 2025
View articletitled, Abstract P1-10-05: Real-World Molecular Profiling After CDK4/6 Inhibition in Advanced Breast Cancer: Analysis of the SOLTI-1903 HOPE Study
Journal Articles

Abstract P2-07-29: DNADX in advanced hormone receptor-positive and HER2-negative (HR+/HER2-) breast cancer following endocrine therapy with or without palbociclib: a correlative analysis from the GEICAM/2014-12 FLIPPER phase II randomized trial

Free
Joan Albanell, Aleix Prat, Maria Teresa Martinez, Guillermo Villacampa, Lorena Paris, Sandra Cobo, Miriam O' Connor, Rosario Vega, Luis de la Cruz-Merino, Fara Brasó-Maristany, Ana Santaballa Bertrán, Francisco Pardo, Noelia Martínez-Jañez, Patricia Galván, Fernando Moreno, Oleguer Castillo, Isaura Fernández, Laia Paré, Jesús Alarcón, Judit Matito, Juan Antonio Virizuela, Juan de la Haba-Rodríguez, Pedro Sánchez-Rovira, Lucía González-Cortijo, Mireia Margelí, Alfonso Sánchez-Muñoz, Iria González Maeso, Antonio Antón, Juan Guerra, Ariadna Tibau, Manuel Ruíz-Borrego, Cinta Rosa Albacar, Coralia Bueno, Andrés García-Palomo, Yolanda Fernández, Sonia González, María Rodríguez de la Borbolla, Vega Iranzo, Catherine M Kelly, Maccon M Keane, Patrick G Morris, Conleth G Murphy, Charles M Perou, Jesús Herranz, Joel S Parker, Marta Portela, Patricia Villagrasa, Rosalia Caballero, Ana Vivancos, Federico Rojo
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P2-07-29.
https://doi.org/10.1158/1557-3265.SABCS24-P2-07-29
Published: 13 June 2025
View articletitled, Abstract P2-07-29: DNADX in advanced hormone receptor-positive and HER2-negative (HR+/HER2-) breast cancer following endocrine therapy with or without palbociclib: a correlative analysis from the GEICAM/2014-12 FLIPPER phase II randomized trial
Journal Articles

Abstract P5-07-18: HER2DX assay in HER2-positive (HER2+) breast ductal carcinoma in situ (DCIS)

Free
Esther Sanfeliu, Anabel Martinez-Romero, Mercedes Marín-Aguilera, Vicente Marco, Felip Garcia, Vicente Peg, Blanca González-Farré, Ivonne Vazquez, Patricia Galván, Oleguer Castillo, Paula Blasco, Valeria Sirenko, Angela Aguirre, Laia Paré, Guillermo Villacampa, Antonio Martínez, Jesus Soberino, Aleix Prat, Fara Brasó-Maristany
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P5-07-18.
https://doi.org/10.1158/1557-3265.SABCS24-P5-07-18
Published: 13 June 2025
View articletitled, Abstract P5-07-18: HER2DX assay in HER2-positive (HER2+) breast ductal carcinoma in situ (DCIS)
Journal Articles

Abstract RF1-07: Multifactor analysis for pathologic complete response (pCR) in a chemotherapy-free regimen of durvalumab, trastuzumab, and pertuzumab (DTP Trial) in HER2-enriched early breast cancer

Free
Polly Niravath, Mailin Li, Jian Guan, Wei Qian, Fotis Nikolo, Jenying Deng, Xen Ping Hoi, Tiffany Sheu, Susan L Haley, Mary Schwartz, Sunil Mathur, Kai Sun, Hahn Mai, Keith S. Chan, Steven T. C. Wong, Aleix Prat, Jenny C Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): RF1-07.
https://doi.org/10.1158/1557-3265.SABCS24-RF1-07
Published: 13 June 2025
View articletitled, Abstract RF1-07: Multifactor analysis for pathologic complete response (pCR) in a chemotherapy-free regimen of durvalumab, trastuzumab, and pertuzumab (DTP Trial) in HER2-enriched early breast cancer
Journal Articles

Abstract P4-03-19: Plasma-based prediction of prognosis, receptor status and organ involvement among patients receiving antibody-drug conjugates for metastatic breast cancer

Free
Paolo Tarantino, Morganti, Rosario Vega, Francisco Pardo, Sandra Cobo, Melissa E. Hughes, Ross Kusmick, Kalie Smith, Guillermo Villacampa, Fara Brasó-Maristany, Mercedes Marín-Aguilera, Georgia Suggs, Molly Skeffington, Simone Buck, Kerry Sendrick, Abigail Recko, Katherine Junkins, Hajer Rahoo, Oleguer Castillo, Sarah Sammons, Antonio Giordano, Ana Garrido-Castro, Nabihah Tayob, Charles M. Perou, Joel S. Parker, Patricia Villagrasa, Laia Paré, Nancy U. Lin, Heather Parsons, Ana Vivancos, Aleix Prat, Sara M. Tolaney
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P4-03-19.
https://doi.org/10.1158/1557-3265.SABCS24-P4-03-19
Published: 13 June 2025
View articletitled, Abstract P4-03-19: Plasma-based prediction of prognosis, receptor status and organ involvement among patients receiving antibody-drug conjugates for metastatic breast cancer
Journal Articles

Abstract P2-03-25: Characterization of patritumab deruxtecan activity in breast cancer (BC) patient-derived xenograft (PDX) models

Free
Andreu Òdena, Laia Monserrat, Fara Brasó-Maristany, Cristina Molina-Guitiérrez, Marta Guzmán, Olga Rodríguez, Sarat Chandarlapaty, Fumitaka Suto, Pang-Dian Fan, Mafalda Oliveira, Aleix Prat, Violeta Serra
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P2-03-25.
https://doi.org/10.1158/1557-3265.SABCS24-P2-03-25
Published: 13 June 2025
View articletitled, Abstract P2-03-25: Characterization of patritumab deruxtecan activity in breast cancer (BC) patient-derived xenograft (PDX) models
Journal Articles

Abstract P1-03-01: Towards Universal Germline Screening for Breast Cancer, Planning for a Sustainable Future: A Single-Center Retrospective Analysis

Free
Adela Rodriguez Hernandez Barbara Adamo, Fara Brasó-Maristany, Benedetta Conte, Olga Martínez-Sáez, Miriam Potrony, Lorena Moreno, Elia Grau, Esther Sanfeliu, Raquel Gómez, Isabel García, Beatrice Fatrini, Elia Segui, Maria Vidal, Montserrat Muñoz, Teresa Ramón y Cajal, Francesc Balaguer, Aleix Prat, Barbara Adamo
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P1-03-01.
https://doi.org/10.1158/1557-3265.SABCS24-P1-03-01
Published: 13 June 2025
View articletitled, Abstract P1-03-01: Towards Universal Germline Screening for Breast Cancer, Planning for a Sustainable Future: A Single-Center Retrospective Analysis
Journal Articles

Abstract P2-05-18: Molecular effects of short pre-operative endocrine therapy in hormone receptor-positive and HER2-negative early breast cancer

Free
Raquel Gómez-Bravo, Barbara Adamo, Benjamin Walbaum, Esther Sanfeliu, Blanca González-Farré, Francesco Schettini, Olga Martínez-Sáez, Elia Seguí, Isabel García-Fructuoso, Paula Blasco, Oleguer Castillo, Ángela Aguirre, Valeria Sirenko, Pol Giménez, María Rey, Jordi Canes, Patricia Galván, Tomás Pascual, Maria Vidal, Adela Rodriguez Hernandez, Eva Ciruelos, Meritxell Bellet, Aleix Prat, Montserrat Muñoz, Fara Brasó-Maristany
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P2-05-18.
https://doi.org/10.1158/1557-3265.SABCS24-P2-05-18
Published: 13 June 2025
View articletitled, Abstract P2-05-18: Molecular effects of short pre-operative endocrine therapy in hormone receptor-positive and HER2-negative early breast cancer
Journal Articles

Abstract P2-12-13: Clinico-Pathological Characteristics and Incidence Trends of Breast Cancer in Young Women: A 10-Year Single Institution Retrospective Study

Free
Francisco Javier Muñoz i Carrillo, Benjamin Walbaum, María Rey, Carme Crous, Clara Rodrigo, Esther Sanfeliu, Fara Brasó-Maristany, Isabel Garcia-Fructuoso, Elia Seguí, Raquel Gómez-Bravo, Barbara Adamo, Tomás Pascual, Olga Martínez-Sáez, Francesco Schettini, Núria Chic, Montserrat Muñoz, Aleix Prat, Maria Vidal
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P2-12-13.
https://doi.org/10.1158/1557-3265.SABCS24-P2-12-13
Published: 13 June 2025
View articletitled, Abstract P2-12-13: Clinico-Pathological Characteristics and Incidence Trends of Breast Cancer in Young Women: A 10-Year Single Institution Retrospective Study
Journal Articles

Abstract P3-10-17: Phase I/II study of the novel radioligand therapy [177Lu]Lu-NeoB plus capecitabine in patients w/ ER+/HER2- advanced breast cancer (ABC) w/GRPR expression after progression on prior endocrine therapy (ET) plus a CDK4/6 inhibitor (CDK4/6i) for ABC

Free
Mario Campone, Louise Emmett, Dejan Juric, Debasish Tripathy, Sonia Pernas, Monica Zuradelli, Kevin Perraud, Aleix Prat
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P3-10-17.
https://doi.org/10.1158/1557-3265.SABCS24-P3-10-17
Published: 13 June 2025
View articletitled, Abstract P3-10-17: Phase I/II study of the novel radioligand therapy [177Lu]Lu-NeoB plus capecitabine in patients w/ ER+/HER2- advanced breast cancer (ABC) w/GRPR expression after progression on prior endocrine therapy (ET) plus a CDK4/6 inhibitor (CDK4/6i) for ABC
Journal Articles

Abstract PS2-09: Liquid biopsy DNADX assay in advanced ER+/HER2-negative breast cancer after progression on CDK4/6 and aromatase inhibitors: a correlative analysis from the PACE phase II randomized trial

Free
Guilherme Nader-Marta, Rosario Vega-León, Guillermo Villacampa, Reshma Mahtani, Cynthia Ma, Angele DeMichele, Sandra Cobo, Francisco Pardo, Massimo Cristofanilli, Jane Meisel, Kathy D. Miller, Yara Abdou, Elizabeth C. Riley, Ashka Patel, Melissa E. Hughes, Fara Brasó-Maristany, Oleguer Castillo, Patricia Galván, Rubina Qamar, Priyanka Sharma, Laia Paré, Marina Gómez Rey, Judit Matito, Sonya Reid, Michelle DeMeo, Patricia Villagrasa, Charles M. Perou, Joel S. Parker, Ana Vivancos, Yuan Liu, Eric Gauthier, Harold J. Burstein, Sara M. Tolaney, Rinath Jeselsohn, Aleix Prat, Erica L. Mayer
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): PS2-09.
https://doi.org/10.1158/1557-3265.SABCS24-PS2-09
Published: 13 June 2025
View articletitled, Abstract PS2-09: Liquid biopsy DNADX assay in advanced ER+/HER2-negative breast cancer after progression on CDK4/6 and aromatase inhibitors: a correlative analysis from the PACE phase II randomized trial
Journal Articles

Abstract LB1-06: Primary results of SOLTI VALENTINE: neoadjuvant randomized phase II trial of HER3-DXd alone or in combination with letrozole for high-risk hormone receptor positive (HR+)/HER2-negative (neg) early breast cancer (EBC)

Free
Mafalda Oliveira, Tomás Pascual, Kepa Amillano Parraga, Javier Salvador Bofill, Santiago González-Santiago, Clara Martínz Vila, Josefina Cruz, Xavier González-Farré, Elena Galve, Pilar Sánchez Henarejos, Juan Miguel Cejalvo, Maria-Eva Pérez-Lopez, Montse Muñoz, Serafin Morales, Alba González-Haba, Maria Borrell Puy, Encarnación González, Juan A. Guerra, Sergio Hoyos, Antonia Perelló, Pablo Tolosa Ortega, Juan De la Haba, Yenlik Zheteyava, David W. Sternberg, Fumitaka Suto, Esther Pang, Dalila Sellami, Rodrigo Sánchez-Bayona, Guillermo Villacampa, Samyukta Chillara, Mariana Paes Dias, Juan M. Ferrero-Cafiero, Aleix Prat
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): LB1-06.
https://doi.org/10.1158/1557-3265.SABCS24-LB1-06
Published: 13 June 2025
View articletitled, Abstract LB1-06: Primary results of SOLTI VALENTINE: neoadjuvant randomized phase II trial of HER3-DXd alone or in combination with letrozole for high-risk hormone receptor positive (HR+)/HER2-negative (neg) early breast cancer (EBC)
Journal Articles

Abstract PS2-07: Intrinsic Subtype at Progression to CDK4/6 Inhibitors Plus Endocrine Therapy in Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer (MBC)

Free
Isabel Garcia-Fructuoso, Fara Brasó-Maristany, Olga Martínez-Sáez, Raquel Gómez-Bravo, Sabrina Nucera, Elia Seguí, Oleguer Castillo, Paula Blasco, Valeria Sirenko, Angela Aguirre, Natalia Lorman-Carbó, Patricia Galván, Benjamín Walbaum, Esther Sanfeliu, Blanca Gonzalez-Farre, Tomás Pascual, Barbara Adamo, Maria Vidal, Montserrat Muñoz, Aleix Prat, Francesco Schettini
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): PS2-07.
https://doi.org/10.1158/1557-3265.SABCS24-PS2-07
Published: 13 June 2025
View articletitled, Abstract PS2-07: Intrinsic Subtype at Progression to CDK4/6 Inhibitors Plus Endocrine Therapy in Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer (MBC)
Journal Articles

Abstract PS4-06: HER2DX ERBB2 mRNA Score in First-Line Metastatic HER2-Positive Breast Cancer Treated with Docetaxel, Trastuzumab and Pertuzumab: Correlative Analysis from CLEOPATRA Phase III Trial

Free
Javier Cortés, Fara Brasó-Maristany, Guillermo Villacampa, Eva Ciruelos, Mercedes Marín-Aguilera, Patricia Galván, Sanne de Haas, Eleonora Restuccia, Mahesh Shivhare, Laia Paré, Wesley Buckingham, Joel S. Parker, Ana Vivancos, Charles M. Perou, Patricia Villagrasa, Julia Maués, Aleix Prat, Sandra Swain
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): PS4-06.
https://doi.org/10.1158/1557-3265.SABCS24-PS4-06
Published: 13 June 2025
View articletitled, Abstract PS4-06: HER2DX ERBB2 mRNA Score in First-Line Metastatic HER2-Positive Breast Cancer Treated with Docetaxel, Trastuzumab and Pertuzumab: Correlative Analysis from CLEOPATRA Phase III Trial
Journal Articles

Low Allele Frequency Variants Identified on Germline Multi-Gene Panel Testing for Cancer Predisposition Can Suggest the Presence of Constitutional Mosaicism

Open Access
Adela Rodriguez-Hernandez, Linda M. Polfus, Brittany L. Bychkovsky, Beth Souders, Aleix Prat, Barbara Adamo, Judy E. Garber, Carolyn Horton, Huma Q. Rana
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF10.
https://doi.org/10.1158/1078-0432.CCR-24-4105
Published: 20 May 2025
View articletitled, Low Allele Frequency Variants Identified on Germline Multi-Gene Panel Testing for Cancer Predisposition Can Suggest the Presence of Constitutional Mosaicism
Open the PDF for Low Allele Frequency Variants Identified on Germline Multi-Gene Panel Testing for Cancer Predisposition Can Suggest the Presence of Constitutional Mosaicism in another window
Includes: Supplementary data
Journal Articles

Elacestrant in Women with Estrogen Receptor–Positive and HER2-Negative Early Breast Cancer: Results from the Preoperative Window-of-Opportunity ELIPSE Trial

Open Access
Maria Vidal, Claudette Falato, Tomás Pascual, Rodrigo Sanchez-Bayona, Montserrat Muñoz-Mateu, Isaac Cebrecos, Xavier Gonzalez-Farré, Tomás Cortadellas, Mireia Margelí Vila, Miguel A. Luna, Christian Siso, Kepa Amillano, Patricia Galván, Milana A. Bergamino, Juan M. Ferrero-Cafiero, Fernando Salvador, Alejandra Espinosa Guerrero, Laia Pare, Esther Sanfeliu, Aleix Prat, Meritxell Bellet
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (7): 1223–1232.
https://doi.org/10.1158/1078-0432.CCR-24-2460
Published: 01 April 2025
View articletitled, Elacestrant in Women with Estrogen Receptor–Positive and HER2-Negative Early Breast Cancer: Results from the Preoperative Window-of-Opportunity ELIPSE Trial
Open the PDF for Elacestrant in Women with Estrogen Receptor–Positive and HER2-Negative Early Breast Cancer: Results from the Preoperative Window-of-Opportunity ELIPSE Trial in another window
Includes: Supplementary data
Journal Articles

HER2DX Genomic Assay in HER2-Positive Early Breast Cancer Treated with Trastuzumab and Pertuzumab: A Correlative Analysis from the PHERGain Phase II Trial

Open Access
Antonio Llombart-Cussac, Jose Pérez-García, Fara Brasó-Maristany, Laia Paré, Guillermo Villacampa, Maria Gion, Peter Schmid, Marco Colleoni, Manuel R. Borrego, Patricia Galván, Joel S. Parker, Wesley Buckingham, Charles M. Perou, Patricia Villagrasa, Jose A. Guerrero, Miguel Sampayo-Cordero, Mario Mancino, Aleix Prat, Javier Cortés
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (18): 4123–4130.
https://doi.org/10.1158/1078-0432.CCR-24-0464
Published: 13 September 2024
View articletitled, HER2DX Genomic Assay in HER2-Positive Early Breast Cancer Treated with Trastuzumab and Pertuzumab: A Correlative Analysis from the PHERGain Phase II Trial
Open the PDF for HER2DX Genomic Assay in HER2-Positive Early Breast Cancer Treated with Trastuzumab and Pertuzumab: A Correlative Analysis from the PHERGain Phase II Trial in another window
Includes: Supplementary data
Journal Articles

Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition

Available to Purchase
Leonard Schmiester, Fara Brasó-Maristany, Blanca González-Farré, Tomás Pascual, Joaquín Gavilá, Xavier Tekpli, Jürgen Geisler, Vessela N. Kristensen, Arnoldo Frigessi, Aleix Prat, Alvaro Köhn-Luque
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (17): 3779–3787.
https://doi.org/10.1158/1078-0432.CCR-24-0244
Published: 03 September 2024
View articletitled, Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition
Open the PDF for Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition in another window
Includes: Supplementary data
Journal Articles

Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7

Open Access
Aleix Prat, Nadia Solovieff, Fabrice André, Joyce O'Shaughnessy, David A. Cameron, Wolfgang Janni, Gabe S. Sonke, Yoon-Sim Yap, Denise A. Yardley, Ann H. Partridge, Astrid Thuerigen, Juan Pablo Zarate, Agnes Lteif, Fei Su, Lisa A. Carey
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (4): 793–802.
https://doi.org/10.1158/1078-0432.CCR-23-0561
Published: 16 February 2024
View articletitled, Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7
Open the PDF for Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7 in another window
Includes: Supplementary data
Journal Articles

SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials

Open Access
Benedetta Conte, Luca Boni, Giancarlo Bisagni, Antonio Durando, Giovanni Sanna, Stefania Gori, Ornella Garrone, Stefano Tamberi, Sabino De Placido, Francesco Schettini, Antonio Pazzola, Riccardo Ponzone, Filippo Montemurro, Gianluigi Lunardi, Rosario Notaro, Maria De Angioletti, Anna Turletti, Mauro Mansutti, Fabio Puglisi, Antonio Frassoldati, Mauro Porpiglia, Alessandra Fabi, Daniele Generali, Giovanni Scognamiglio, Maura Rossi, Fara Brasó-Maristany, Aleix Prat, Barbara Cardinali, Patrizia Piccioli, Martina Serra, Sonia Lastraioli, Claudia Bighin, Francesca Poggio, Matteo Lambertini, Lucia Del Mastro
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (24): 5217–5226.
https://doi.org/10.1158/1078-0432.CCR-23-1568
Published: 15 December 2023
View articletitled, SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials
Open the PDF for SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials in another window
Includes: Supplementary data