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Journal Articles

Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer

Giorgio Patelli, Gianluca Mauri, Federica Tosi, Alessio Amatu, Katia Bencardino, Erica Bonazzina, Elio Gregory Pizzutilo, Federica Villa, Gabriele Calvanese, Alberto Giuseppe Agostara, Stefano Stabile, Silvia Ghezzi, Giovanni Crisafulli, Federica Di Nicolantonio, Silvia Marsoni, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF10.
https://doi.org/10.1158/1078-0432.CCR-23-0079
Published: 25 July 2023
View article titled, Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer
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Journal Articles

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

Erika Durinikova, Nicole M. Reilly, Kristi Buzo, Elisa Mariella, Rosaria Chilà, Annalisa Lorenzato, João M. L. Dias, Gaia Grasso, Federica Pisati, Simona Lamba, Giorgio Corti, Andrea Degasperi, Carlotta Cancelliere, Gianluca Mauri, Pietro Andrei, Michael Linnebacher, Silvia Marsoni, Salvatore Siena, Andrea Sartore-Bianchi, Serena Nik-Zainal, Federica Di Nicolantonio, Alberto Bardelli, Sabrina Arena
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3874–3889.
https://doi.org/10.1158/1078-0432.CCR-22-0875
Published: 01 September 2022
View article titled, Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Abstract 16: Landscape and outcome of TRK fusion-positive Cancers

Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_1): 16.
https://doi.org/10.1158/1557-3265.ADVPRECMED20-16
Published: 15 June 2020
View article titled, Abstract 16: Landscape and outcome of TRK fusion-positive Cancers
Journal Articles

Abstract IA13: Tracking and targeting colorectal cancer evolution

Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): IA13.
https://doi.org/10.1158/1557-3265.LiqBiop20-IA13
Published: 01 June 2020
View article titled, Abstract IA13: Tracking and targeting colorectal cancer evolution
Journal Articles

Abstract B11: Whole-exome sequencing analysis of urine transrenal tumor DNA in metastatic colorectal cancer patients

Giovanni Crisafulli, Benedetta Mussolin, Andrea Cassingena, Monica Montone, Alice Bartolini, Ludovic Barault, Antonio Martinetti, Federica Morano, Filippo Pietrantonio, Andrea Sartore-Bianchi, Salvatore Siena, Federica Di Nicolatonio, Silvia Marsoni, Alberto Bardelli, Giulia Siravegna
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): B11.
https://doi.org/10.1158/1557-3265.LiqBiop20-B11
Published: 01 June 2020
View article titled, Abstract B11: Whole-exome sequencing analysis of urine transrenal tumor DNA in metastatic colorectal cancer patients
Journal Articles

TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations

Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (7): 1624–1632.
https://doi.org/10.1158/1078-0432.CCR-19-3165
Published: 01 April 2020
View article titled, TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations
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Includes: Supplementary data
Journal Articles

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Sabrina Arena, Giorgio Corti, Erika Durinikova, Monica Montone, Nicole M. Reilly, Mariangela Russo, Annalisa Lorenzato, Pamela Arcella, Luca Lazzari, Giuseppe Rospo, Massimiliano Pagani, Carlotta Cancelliere, Carola Negrino, Claudio Isella, Alice Bartolini, Andrea Cassingena, Alessio Amatu, Gianluca Mauri, Andrea Sartore-Bianchi, Gloria Mittica, Enzo Medico, Silvia Marsoni, Michael Linnebacher, Sergio Abrignani, Salvatore Siena, Federica Di Nicolantonio, Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1372–1384.
https://doi.org/10.1158/1078-0432.CCR-19-2409
Published: 13 March 2020
View article titled, A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin
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Includes: Supplementary data
Journal Articles

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Luca Lazzari, Giorgio Corti, Gabriele Picco, Claudio Isella, Monica Montone, Pamela Arcella, Erika Durinikova, Eugenia R. Zanella, Luca Novara, Fabiane Barbosa, Andrea Cassingena, Carlotta Cancelliere, Enzo Medico, Andrea Sartore-Bianchi, Salvatore Siena, Mathew J. Garnett, Andrea Bertotti, Livio Trusolino, Federica Di Nicolantonio, Michael Linnebacher, Alberto Bardelli, Sabrina Arena
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (20): 6243–6259.
https://doi.org/10.1158/1078-0432.CCR-18-3440
Published: 15 October 2019
View article titled, Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer

Giulia Siravegna, Andrea Sartore-Bianchi, Rebecca J. Nagy, Kanwal Raghav, Justin I. Odegaard, Richard B. Lanman, Livio Trusolino, Silvia Marsoni, Salvatore Siena, Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 3046–3053.
https://doi.org/10.1158/1078-0432.CCR-18-3389
Published: 15 May 2019
View article titled, Plasma HER2 (<em>ERBB2</em>) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Giuseppe Lo Russo, Massimo Moro, Michele Sommariva, Valeria Cancila, Mattia Boeri, Giovanni Centonze, Simona Ferro, Monica Ganzinelli, Patrizia Gasparini, Veronica Huber, Massimo Milione, Luca Porcu, Claudia Proto, Giancarlo Pruneri, Diego Signorelli, Sabina Sangaletti, Lucia Sfondrini, Chiara Storti, Elena Tassi, Alberto Bardelli, Silvia Marsoni, Valter Torri, Claudio Tripodo, Mario Paolo Colombo, Andrea Anichini, Licia Rivoltini, Andrea Balsari, Gabriella Sozzi, Marina Chiara Garassino
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (3): 989–999.
https://doi.org/10.1158/1078-0432.CCR-18-1390
Published: 01 February 2019
View article titled, Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
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Includes: Supplementary data
Journal Articles

Abstract IA18: Cancer evolution as a therapeutic target

Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (1_Supplement): IA18.
https://doi.org/10.1158/1557-3265.TCM17-IA18
Published: 02 January 2018
View article titled, Abstract IA18: Cancer evolution as a therapeutic target
Journal Articles

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients

Carmine Carbone, Geny Piro, Francesca Simionato, Francesca Ligorio, Chiara Cremolini, Fotios Loupakis, Greta Alì, Daniele Rossini, Valeria Merz, Raffaela Santoro, Camilla Zecchetto, Marco Zanotto, Federica Di Nicolantonio, Alberto Bardelli, Gabriella Fontanini, Giampaolo Tortora, Davide Melisi
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4312–4322.
https://doi.org/10.1158/1078-0432.CCR-16-3153
Published: 01 August 2017
View article titled, Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients
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Includes: Supplementary data
Journal Articles

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers

Takeo Fujii, Afsaneh Barzi, Andrea Sartore-Bianchi, Andrea Cassingena, Giulia Siravegna, Daniel D. Karp, Sarina A. Piha-Paul, Vivek Subbiah, Apostolia M. Tsimberidou, Helen J. Huang, Silvio Veronese, Federica Di Nicolantonio, Sandeep Pingle, Cecile Rose T. Vibat, Saege Hancock, David Berz, Vladislava O. Melnikova, Mark G. Erlander, Rajyalakshmi Luthra, E. Scott Kopetz, Funda Meric-Bernstam, Salvatore Siena, Heinz-Josef Lenz, Alberto Bardelli, Filip Janku
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (14): 3657–3666.
https://doi.org/10.1158/1078-0432.CCR-16-2592
Published: 13 July 2017
View article titled, Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of <em>KRAS</em> Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers
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Includes: Supplementary data
Journal Articles

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer

Filippo Pietrantonio, Claudio Vernieri, Giulia Siravegna, Alessia Mennitto, Rosa Berenato, Federica Perrone, Annunziata Gloghini, Elena Tamborini, Sara Lonardi, Federica Morano, Benedetta Picciani, Adele Busico, Chiara Costanza Volpi, Antonia Martinetti, Francesca Battaglin, Ilaria Bossi, Alessio Pellegrinelli, Massimo Milione, Chiara Cremolini, Maria Di Bartolomeo, Alberto Bardelli, Filippo de Braud
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (10): 2414–2422.
https://doi.org/10.1158/1078-0432.CCR-16-1863
Published: 14 May 2017
View article titled, Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer

Francisco J. Sánchez-Martín, Beatriz Bellosillo, Mariona Gelabert-Baldrich, Alba Dalmases, Israel Cañadas, Joana Vidal, Alejandro Martinez, Guillem Argilés, Giulia Siravegna, Sabrina Arena, Klaus Koefoed, Laura Visa, Oriol Arpí, Ivan David Horak, Mar Iglesias, Christopher Stroh, Michael Kragh, Ana Rovira, Joan Albanell, Josep Tabernero, Alberto Bardelli, Clara Montagut
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (13): 3260–3267.
https://doi.org/10.1158/1078-0432.CCR-15-2400
Published: 30 June 2016
View article titled, The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer

Sabrina Arena, Beatriz Bellosillo, Giulia Siravegna, Alejandro Martínez, Israel Cañadas, Luca Lazzari, Noelia Ferruz, Mariangela Russo, Sandra Misale, Iria González, Mar Iglesias, Elena Gavilan, Giorgio Corti, Sebastijan Hobor, Giovanni Crisafulli, Marta Salido, Juan Sánchez, Alba Dalmases, Joaquim Bellmunt, Gianni De Fabritiis, Ana Rovira, Federica Di Nicolantonio, Joan Albanell, Alberto Bardelli, Clara Montagut
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (9): 2157–2166.
https://doi.org/10.1158/1078-0432.CCR-14-2821
Published: 30 April 2015
View article titled, Emergence of Multiple <em>EGFR</em> Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

TGFα and Amphiregulin Paracrine Network Promotes Resistance to EGFR Blockade in Colorectal Cancer Cells

Sebastijan Hobor, Beth O. Van Emburgh, Emily Crowley, Sandra Misale, Federica Di Nicolantonio, Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (24): 6429–6438.
https://doi.org/10.1158/1078-0432.CCR-14-0774
Published: 14 December 2014
View article titled, TGFα and Amphiregulin Paracrine Network Promotes Resistance to EGFR Blockade in Colorectal Cancer Cells
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Includes: Supplementary data
Journal Articles

Circulating pEGFR Is a Candidate Response Biomarker of Cetuximab Therapy in Colorectal Cancer

Theodora Katsila, Mercè Juliachs, Josep Gregori, Teresa Macarulla, Laura Villarreal, Alberto Bardelli, Chris Torrance, Elena Elez, Josep Tabernero, Josep Villanueva
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (24): 6346–6356.
https://doi.org/10.1158/1078-0432.CCR-14-0361
Published: 14 December 2014
View article titled, Circulating pEGFR Is a Candidate Response Biomarker of Cetuximab Therapy in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Minimal Residual Disease in Breast Cancer: In Blood Veritas

Giulia Siravegna, Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (10): 2505–2507.
https://doi.org/10.1158/1078-0432.CCR-14-0370
Published: 14 May 2014
View article titled, Minimal Residual Disease in Breast Cancer: In Blood Veritas
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Journal Articles

Mouse Models of Kras-Mutant Colorectal Cancer: Valuable GEMMs for Drug Testing?

Federica Di Nicolantonio, Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 2794–2796.
https://doi.org/10.1158/1078-0432.CCR-13-0339
Published: 30 May 2013
View article titled, Mouse Models of <em>Kras</em>-Mutant Colorectal Cancer: Valuable GEMMs for Drug Testing?
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