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Alan Melcher
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Journal Articles

Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers

Patrycja Gazinska, Charlotte Milton, Jacopo Iacovacci, Joseph Ward, Richard Buus, Thanussuyah Alaguthurai, Rosalind Graham, Ayse Akarca, Esther Lips, Kalnisha Naidoo, Jelle Wesseling, Teresa Marafioti, Maggie Cheang, Cheryl Gillett, Yin Wu, Aadil Khan, Alan Melcher, Roberto Salgado, Mitch Dowsett, Andrew Tutt, Ioannis Roxanis, Syed Haider, Sheeba Irshad
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (20): 4494–4508.
https://doi.org/10.1158/1078-0432.CCR-22-0543
Published: 14 October 2022
View article titled, Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers
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Includes: Supplementary data
Journal Articles

APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable

Richard G. Vile, Alan Melcher, Hardev Pandha, Kevin J. Harrington, Jose S. Pulido
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (12): 3280–3290.
https://doi.org/10.1158/1078-0432.CCR-20-1888
Published: 15 June 2021
View article titled, APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable
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Journal Articles

PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma

Henry G. Smith, David Mansfield, Victoria Roulstone, Joan N. Kyula-Currie, Martin McLaughlin, Radhika R. Patel, Katharina F. Bergerhoff, James T. Paget, Magnus T. Dillon, Aadil Khan, Alan Melcher, Khin Thway, Kevin J. Harrington, Andrew J. Hayes
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (11): 3443–3454.
https://doi.org/10.1158/1078-0432.CCR-18-3767
Published: 03 June 2019
View article titled, PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma
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Includes: Supplementary data
Journal Articles

ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment

Magnus T. Dillon, Katharina F. Bergerhoff, Malin Pedersen, Harriet Whittock, Eva Crespo-Rodriguez, Emmanuel C. Patin, Alex Pearson, Henry G. Smith, James T.E. Paget, Radhika R. Patel, Shane Foo, Galabina Bozhanova, Chanthirika Ragulan, Elisa Fontana, Krisha Desai, Anna C. Wilkins, Anguraj Sadanandam, Alan Melcher, Martin McLaughlin, Kevin J. Harrington
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (11): 3392–3403.
https://doi.org/10.1158/1078-0432.CCR-18-1821
Published: 03 June 2019
View article titled, ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment
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Includes: Supplementary data
Journal Articles

REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer

Charles Comins, James Spicer, Andrew Protheroe, Victoria Roulstone, Katie Twigger, Christine M. White, Richard Vile, Alan Melcher, Matt C. Coffey, Karl L. Mettinger, Gerard Nuovo, David E. Cohn, Mitch Phelps, Kevin J. Harrington, Hardev S. Pandha
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (22): 5564–5572.
https://doi.org/10.1158/1078-0432.CCR-10-1233
Published: 14 November 2010
View article titled, REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer
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Journal Articles

Synergistic Effects of Oncolytic Reovirus and Cisplatin Chemotherapy in Murine Malignant Melanoma

Hardev S. Pandha, Lucy Heinemann, Guy R. Simpson, Alan Melcher, Robin Prestwich, Fiona Errington, Matt Coffey, Kevin J. Harrington, Richard Morgan
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (19): 6158–6166.
https://doi.org/10.1158/1078-0432.CCR-09-0796
Published: 30 September 2009
View article titled, Synergistic Effects of Oncolytic Reovirus and Cisplatin Chemotherapy in Murine Malignant Melanoma
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Journal Articles

Improved Systemic Delivery of Oncolytic Reovirus to Established Tumors Using Preconditioning with Cyclophosphamide-Mediated Treg Modulation and Interleukin-2

Timothy Kottke, Jill Thompson, Rosa Maria Diaz, Jose Pulido, Candice Willmon, Matt Coffey, Peter Selby, Alan Melcher, Kevin Harrington, Richard G. Vile
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (2): 561–569.
https://doi.org/10.1158/1078-0432.CCR-08-1688
Published: 15 January 2009
View article titled, Improved Systemic Delivery of Oncolytic Reovirus to Established Tumors Using Preconditioning with Cyclophosphamide-Mediated Treg Modulation and Interleukin-2
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Journal Articles

A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer

Laura Vidal, Hardev S. Pandha, Timothy A. Yap, Christine L. White, Katie Twigger, Richard G. Vile, Alan Melcher, Matt Coffey, Kevin J. Harrington, Johann S. DeBono
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (21): 7127–7137.
https://doi.org/10.1158/1078-0432.CCR-08-0524
Published: 03 November 2008
View article titled, A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer
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Journal Articles

Cyclophosphamide Facilitates Antitumor Efficacy against Subcutaneous Tumors following Intravenous Delivery of Reovirus

Jian Qiao, Hongxun Wang, Timothy Kottke, Christine White, Katie Twigger, Rosa Maria Diaz, Jill Thompson, Peter Selby, Johann de Bono, Alan Melcher, Hardev Pandha, Matt Coffey, Richard Vile, Kevin Harrington
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 259–269.
https://doi.org/10.1158/1078-0432.CCR-07-1510
Published: 02 January 2008
View article titled, Cyclophosphamide Facilitates Antitumor Efficacy against Subcutaneous Tumors following Intravenous Delivery of Reovirus
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Journal Articles

Vaccination of Colorectal Cancer Patients with Modified Vaccinia Ankara Encoding the Tumor Antigen 5T4 (TroVax) Given Alongside Chemotherapy Induces Potent Immune Responses

Richard Harrop, Noel Drury, William Shingler, Priscilla Chikoti, Irina Redchenko, Miles W. Carroll, Susan M. Kingsman, Stuart Naylor, Alan Melcher, Joanna Nicholls, Harpreet Wassan, Nagy Habib, Alan Anthoney
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (15): 4487–4494.
https://doi.org/10.1158/1078-0432.CCR-07-0704
Published: 01 August 2007
View article titled, Vaccination of Colorectal Cancer Patients with Modified Vaccinia Ankara Encoding the Tumor Antigen 5T4 (TroVax) Given Alongside Chemotherapy Induces Potent Immune Responses
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Journal Articles

Allogeneic tumor cells expressing fusogenic membrane glycoproteins as a platform for clinical cancer immunotherapy.

Fiona Errington, Andrew Bateman, Tim Kottke, Jill Thompson, Kevin Harrington, Alison Merrick, Paul Hatfield, Peter Selby, Richard Vile, Alan Melcher
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (4): 1333–1341.
https://doi.org/10.1158/1078-0432.CCR-05-1113
Published: 17 February 2006
View article titled, Allogeneic tumor cells expressing fusogenic membrane glycoproteins as a platform for clinical cancer immunotherapy.
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