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Journal Articles

Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma

James M. Cleary, Brian M. Wolpin, Stephanie K. Dougan, Srivatsan Raghavan, Harshabad Singh, Brandon Huffman, Nilay S. Sethi, Jonathan A. Nowak, Geoffrey I. Shapiro, Andrew J. Aguirre, Alan D. D'Andrea

Clin Cancer Res (2021) 27 (24): 6622–6637.

DOI: https://doi.org/10.1158/1078-0432.CCR-21-1367

Published: 15 December 2021

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Journal Articles

Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors

Khanh T. Do, Bose Kochupurakkal, Sarah Kelland, Adrienne de Jonge, Jennifer Hedglin, Allison Powers, Nicholas Quinn, Courtney Gannon, Loan Vuong, Kalindi Parmar, Jean-Bernard Lazaro, Alan D. D'Andrea, Geoffrey I. Shapiro

Clin Cancer Res (2021) 27 (17): 4710–4716.

DOI: https://doi.org/10.1158/1078-0432.CCR-21-1279

Published: 01 September 2021

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Includes: Supplementary data

Journal Articles

Abstract PR06: Dissecting mechanisms of replication fork stabilization in patient-derived high-grade serous organoid cultures and their impact on therapeutic sensitivity and the immune-tumor interaction

Sarah J. Hill, Patrick Lizotte, Nikolas Kesten, Neil S. Horowitz, Michael G. Muto, Michael J. Worley, Colleen M. Feltmate, Ross S. Berkowitz, Henry Long, Ursula A. Matulonis, Christopher P. Crum, Myles Brown, Alan D. D'Andrea

Clin Cancer Res (2020) 26 (13_Supplement): PR06.

DOI: https://doi.org/10.1158/1557-3265.OVCA19-PR06

Published: 01 July 2020

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Journal Articles

Abstract AP22: DNA DAMAGE RESPONSES AND IMMUNE PROFILING THROUGH HIGHLY MULTIPLEXED TISSUE IMMUNOFLUORESCENCE (T-CYCIF) IN HIGH-GRADE SEROUS OVARIAN CANCER

Anniina Färkkilä, Jia-Ren Lin, Zoltan Maliga, Sameer S. Chopra, Bose Koruchupakkal, Brooke E. Howitt, Kyle C. Strickland, Sandro Santagata, Elizabeth M. Swisher, Ursula A. Matulonis, Jennifer. L. Guerriero, Kevin Elias, Panagiotis Konstantinopoulos, Peter K. Sorger, Alan D. D'Andrea

Clin Cancer Res (2019) 25 (22_Supplement): AP22.

DOI: https://doi.org/10.1158/1557-3265.OVCASYMP18-AP22

Published: 15 November 2019

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Journal Articles

Abstract GMM-027: DYNLL1 INHIBITS DNA END RESECTION IN BRCA1-DEFICIENT CELLS AND REGULATES PARP INHIBITOR SENSITIVITY

Yizhou Joseph He, Khyati Meghani, Marie-Christine Caron, Chunyu Yang, Daryl A. Ronato, Jie Bian, Anchal Sharma, Jessica Miller, Niraj Joshi, Alexandre Detappe, John G. Doench, Gaelle Legube, David E. Root, Alan D. D'Andrea, Pascal Drané, Subhojyoti De, Panagiotis Konstantinopoulos, Jean-Yves Masson, Dipanjan Chowdhury

Clin Cancer Res (2019) 25 (22_Supplement): GMM-027.

DOI: https://doi.org/10.1158/1557-3265.OVCASYMP18-GMM-027

Published: 15 November 2019

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Journal Articles

Abstract AP10: REAL-TIME ASSESSMENT OF HGSC DNA DAMAGE REPAIR DEFECTS AND DEFECT-INDUCED RESPONSE TO THERAPY IN OVARIAN CANCER ORGANOIDS

Clin Cancer Res (2019) 25 (22_Supplement): AP10.

DOI: https://doi.org/10.1158/1557-3265.OVCASYMP18-AP10

Published: 15 November 2019

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Journal Articles

The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition

Kalindi Parmar, Bose S. Kochupurakkal, Jean-Bernard Lazaro, Zhigang C. Wang, Sangeetha Palakurthi, Paul T. Kirschmeier, Chunyu Yang, Larissa A. Sambel, Anniina Färkkilä, Elizaveta Reznichenko, Hunter D. Reavis, Connor E. Dunn, Lee Zou, Khanh T. Do, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Joyce F. Liu, Alan D. D'Andrea, Geoffrey I. Shapiro

Clin Cancer Res (2019) 25 (20): 6127–6140.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-0448

Published: 15 October 2019

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Includes: Supplementary data

Journal Articles

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer

Clin Cancer Res (2019) 25 (3): 977–988.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-1001

Published: 01 February 2019

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Includes: Supplementary data

Journal Articles

Abstract A04: Profiling DNA damage repair and immunophenotypes in BRCA1/2 mutated high-grade serous ovarian cancers

Anniina Farkkila, Bose Kochupurakkal, Brooke E. Howitt, Kyle C. Strickland, Dipanjan Chowdhury, Geoffrey Shapiro, Evisa Gjini, Scott J. Rodig, Ursula A. Matulonis, Panagiotis Konstantinopoulos, Alan D. D’Andrea

Clin Cancer Res (2018) 24 (15_Supplement): A04.

DOI: https://doi.org/10.1158/1557-3265.OVCA17-A04

Published: 01 August 2018

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Journal Articles

Abstract IA20: Targeting DNA repair in cancer therapy

Alan D. D'Andrea

Clin Cancer Res (2018) 24 (1_Supplement): IA20.

DOI: https://doi.org/10.1158/1557-3265.TCM17-IA20

Published: 02 January 2018

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Journal Articles

Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma

Kent W. Mouw, James M. Cleary, Brendan Reardon, Jonathan Pike, Lior Z. Braunstein, Jaegil Kim, Ali Amin-Mansour, Diana Miao, Alexis Damish, Joanna Chin, Patrick A. Ott, Charles S. Fuchs, Neil E. Martin, Gad Getz, Scott Carter, Harvey J. Mamon, Jason L. Hornick, Eliezer M. Van Allen, Alan D. D'Andrea

Clin Cancer Res (2017) 23 (12): 3214–3222.

DOI: https://doi.org/10.1158/1078-0432.CCR-16-2017

Published: 14 June 2017

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Includes: Supplementary data

Journal Articles

Abstract IA12: Targeting DNA repair in cancer therapy

Alan D. D'Andrea

Clin Cancer Res (2017) 23 (1_Supplement): IA12.

DOI: https://doi.org/10.1158/1557-3265.PMCCAVULN16-IA12

Published: 02 January 2017

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Journal Articles

Abstract IA04: Targeting DNA repair in ovarian cancer therapy.

Alan D. D'Andrea.

Clin Cancer Res (2016) 22 (2_Supplement): IA04.

DOI: https://doi.org/10.1158/1557-3265.OVCA15-IA04

Published: 15 January 2016

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Journal Articles

Abstract POSTER-BIOL-1331: Nucleotide excision repair mutations confer sensitivity to platinum but not PARP-inhibitors in epithelial ovarian cancer

Raphael Ceccaldi, Kevin O'Connor, Kent W. Mouw, Adam Y. Li, Ursula A. Matulonis, Alan D. D'Andrea, Panagiotis A. Konstantinopoulos

Clin Cancer Res (2015) 21 (16_Supplement): POSTER-BIOL-1331.

DOI: https://doi.org/10.1158/1557-3265.OVCASYMP14-POSTER-BIOL-1331

Published: 15 August 2015

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Journal Articles

XPF Expression Correlates with Clinical Outcome in Squamous Cell Carcinoma of the Head and Neck

Alec Vaezi, XiaoZhe Wang, Shama Buch, William Gooding, Lin Wang, Raja R. Seethala, David T. Weaver, Alan D. D'Andrea, Athanassios Argiris, Marjorie Romkes, Laura J. Niedernhofer, Jennifer R. Grandis

Clin Cancer Res (2011) 17 (16): 5513–5522.

DOI: https://doi.org/10.1158/1078-0432.CCR-11-0086

Published: 14 August 2011

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Includes: Supplementary data

Journal Articles

DNA Repair Protein Biomarkers Associated with Time to Recurrence in Triple-Negative Breast Cancer

Brian M. Alexander, Kam Sprott, D. Allan Farrow, XiaoZhe Wang, Alan D. D'Andrea, Stuart J. Schnitt, Laura C. Collins, David T. Weaver, Judy E. Garber

Clin Cancer Res (2010) 16 (23): 5796–5804.

DOI: https://doi.org/10.1158/1078-0432.CCR-10-0292

Published: 06 December 2010

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Includes: Supplementary data

NARROW

Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma

Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors

Abstract PR06: Dissecting mechanisms of replication fork stabilization in patient-derived high-grade serous organoid cultures and their impact on therapeutic sensitivity and the immune-tumor interaction

Abstract AP22: DNA DAMAGE RESPONSES AND IMMUNE PROFILING THROUGH HIGHLY MULTIPLEXED TISSUE IMMUNOFLUORESCENCE (T-CYCIF) IN HIGH-GRADE SEROUS OVARIAN CANCER

Abstract GMM-027: DYNLL1 INHIBITS DNA END RESECTION IN BRCA1-DEFICIENT CELLS AND REGULATES PARP INHIBITOR SENSITIVITY

Abstract AP10: REAL-TIME ASSESSMENT OF HGSC DNA DAMAGE REPAIR DEFECTS AND DEFECT-INDUCED RESPONSE TO THERAPY IN OVARIAN CANCER ORGANOIDS

The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition

ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer

Abstract A04: Profiling DNA damage repair and immunophenotypes in BRCA1/2 mutated high-grade serous ovarian cancers

Abstract IA20: Targeting DNA repair in cancer therapy

Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma

Abstract IA12: Targeting DNA repair in cancer therapy

Abstract IA04: Targeting DNA repair in ovarian cancer therapy.

Abstract POSTER-BIOL-1331: Nucleotide excision repair mutations confer sensitivity to platinum but not PARP-inhibitors in epithelial ovarian cancer

XPF Expression Correlates with Clinical Outcome in Squamous Cell Carcinoma of the Head and Neck

DNA Repair Protein Biomarkers Associated with Time to Recurrence in Triple-Negative Breast Cancer

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