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Journal Articles

Validation of Anticorrelated TGFβ Signaling and Alternative End-Joining DNA Repair Signatures that Predict Response to Genotoxic Cancer Therapy

Ines Guix, Qi Liu, Miquel Angel Pujana, Patrick Ha, Josep Piulats, Isabel Linares, Ferran Guedea, Jian-Hua Mao, Ann Lazar, Jocelyn Chapman, Sue S. Yom, Alan Ashworth, Mary Helen Barcellos-Hoff
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (7): 1372–1382.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-2846
Published: 01 April 2022
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ATR Inhibitors and Paclitaxel in Melanoma

Alan Ashworth
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (17): 4667–4668.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-1778
Published: 01 September 2021
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Autoantibody Landscape in Patients with Advanced Prostate Cancer

William S. Chen, Winston A. Haynes, Rebecca Waitz, Kathy Kamath, Agustin Vega-Crespo, Raunak Shrestha, Minlu Zhang, Adam Foye, Ignacio Baselga Carretero, Ivan Perez Garcilazo, Meng Zhang, Shuang G. Zhao, Martin Sjöström, David A. Quigley, Jonathan Chou, Tomasz M. Beer, Matthew Rettig, Martin Gleave, Christopher P. Evans, Primo Lara, Kim N. Chi, Robert E. Reiter, Joshi J. Alumkal, Alan Ashworth, Rahul Aggarwal, Eric J. Small, Patrick S. Daugherty, Antoni Ribas, David Y. Oh, John C. Shon, Felix Y. Feng
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6204–6214.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-1966
Published: 01 December 2020
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DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway

Vishal Kothari, Jonathan F. Goodwin, Shuang G. Zhao, Justin M. Drake, Yi Yin, S. Laura Chang, Joseph R. Evans, Kari Wilder-Romans, Kristina Gabbara, Emanuela Dylgjeri, Jonathan Chou, Grace Sun, Scott A. Tomlins, Rohit Mehra, Kristen Hege, Ellen H. Filvaroff, Edward M. Schaeffer, R. Jeffrey Karnes, David A. Quigley, Dana E. Rathkopf, Housheng H. He, Corey Speers, Daniel E. Spratt, Luke A. Gilbert, Alan Ashworth, Arul M. Chinnaiyan, Ganesh V. Raj, Karen E. Knudsen, Felix Y. Feng
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5608–5622.
DOI: https://doi.org/10.1158/1078-0432.CCR-18-2387
Published: 13 September 2019
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Journal Articles

Synthetic Lethal Approaches to the Treatment of Cancers with DNA Repair Defects

Alan Ashworth
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): ED02-03.
Published: 15 August 2014
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Journal Articles

Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study

Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Greve, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-May Chen, Michael L. Friedlander, Bella Kaufman, Amit M. Oza, Ursula Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James Campbell, Lina Chen, Johann S. de Bono, Martin E. Gore, Christopher J. Lord, Alan Ashworth, Stan B. Kaye
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19): 5485–5493.
DOI: https://doi.org/10.1158/1078-0432.CCR-13-1262
Published: 01 October 2013
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BMN 673, a Novel and Highly Potent PARP1/2 Inhibitor for the Treatment of Human Cancers with DNA Repair Deficiency

Yuqiao Shen, Farah L. Rehman, Ying Feng, Julia Boshuizen, Ilirjana Bajrami, Richard Elliott, Bing Wang, Christopher J. Lord, Leonard E. Post, Alan Ashworth
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2013) 19 (18): 5003–5015.
DOI: https://doi.org/10.1158/1078-0432.CCR-13-1391
Published: 16 September 2013
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Noninvasive Detection of HER2 Amplification with Plasma DNA Digital PCR

Heidrun Gevensleben, Isaac Garcia-Murillas, Monika K. Graeser, Gaia Schiavon, Peter Osin, Marina Parton, Ian E. Smith, Alan Ashworth, Nicholas C. Turner
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (12): 3276–3284.
DOI: https://doi.org/10.1158/1078-0432.CCR-12-3768
Published: 13 June 2013
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FGFR Signaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both In Vitro and In Vivo

Rachel Sharpe, Alex Pearson, Maria T. Herrera-Abreu, Damian Johnson, Alan Mackay, Jonathan C. Welti, Rachael Natrajan, Andrew R. Reynolds, Jorge S. Reis-Filho, Alan Ashworth, Nicholas C. Turner
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (16): 5275–5286.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-2727
Published: 14 August 2011
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Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas

David S.P. Tan, Marjan Iravani, W. Glenn McCluggage, Maryou B.K. Lambros, Fernanda Milanezi, Alan Mackay, Charles Gourley, Felipe C. Geyer, Radost Vatcheva, Joanne Millar, Karen Thomas, Rachael Natrajan, Kay Savage, Kerry Fenwick, Alistair Williams, Charles Jameson, Mona El-Bahrawy, Martin E. Gore, Hani Gabra, Stanley B. Kaye, Alan Ashworth, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (6): 1521–1534.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-1688
Published: 15 March 2011
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Journal Articles

A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer

Monika Graeser, Afshan McCarthy, Christopher J. Lord, Kay Savage, Margaret Hills, Janine Salter, Nicholas Orr, Marina Parton, Ian E. Smith, Jorge S. Reis-Filho, Mitch Dowsett, Alan Ashworth, Nicholas C. Turner
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (24): 6159–6168.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-1027
Published: 16 December 2010
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Therapeutic Targeting of the DNA Mismatch Repair Pathway

Sarah A. Martin, Christopher J. Lord, Alan Ashworth
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (21): 5107–5113.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-0821
Published: 31 October 2010
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A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas

Dorine A. Bax, Alan Mackay, Suzanne E. Little, Diana Carvalho, Marta Viana-Pereira, Narinder Tamber, Anita E. Grigoriadis, Alan Ashworth, Rui M. Reis, David W. Ellison, Safa Al-Sarraj, Darren Hargrave, Chris Jones
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (13): 3368–3377.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-0438
Published: 30 June 2010
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Bringing DNA Repair in Tumors into Focus

Christopher J. Lord, Alan Ashworth
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (10): 3241–3243.
DOI: https://doi.org/10.1158/1078-0432.CCR-09-0434
Published: 18 May 2009
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Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers

Rachael Natrajan, Maryou B. Lambros, Socorro María Rodríguez-Pinilla, Gema Moreno-Bueno, David S.P. Tan, Caterina Marchió, Radost Vatcheva, Sydonia Rayter, Betania Mahler-Araujo, Laura G. Fulford, Daniela Hungermann, Alan Mackay, Anita Grigoriadis, Kerry Fenwick, Narinder Tamber, David Hardisson, Andrew Tutt, Jose Palacios, Christopher J. Lord, Horst Buerger, Alan Ashworth, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (8): 2711–2722.
DOI: https://doi.org/10.1158/1078-0432.CCR-08-1878
Published: 15 April 2009
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PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas

David S.P. Tan, Maryou B.K. Lambros, Sydonia Rayter, Rachael Natrajan, Radost Vatcheva, Qiong Gao, Caterina Marchiò, Felipe C. Geyer, Kay Savage, Suzanne Parry, Kerry Fenwick, Narinder Tamber, Alan Mackay, Tim Dexter, Charles Jameson, W. Glenn McCluggage, Alistair Williams, Ashley Graham, Dana Faratian, Mona El-Bahrawy, Adam J. Paige, Hani Gabra, Martin E. Gore, Marketa Zvelebil, Christopher J. Lord, Stanley B. Kaye, Alan Ashworth, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (7): 2269–2280.
DOI: https://doi.org/10.1158/1078-0432.CCR-08-2403
Published: 01 April 2009
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Perilobar Nephrogenic Rests Are Nonobligate Molecular Genetic Precursor Lesions of Insulin-Like Growth Factor-II-Associated Wilms Tumors

Raisa Vuononvirta, Neil J. Sebire, Anthony R. Dallosso, Jorge S. Reis-Filho, Richard D. Williams, Alan Mackay, Kerry Fenwick, Anita Grigoriadis, Alan Ashworth, Kathy Pritchard-Jones, Keith W. Brown, Gordan M. Vujanic, Chris Jones
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (23): 7635–7644.
DOI: https://doi.org/10.1158/1078-0432.CCR-08-1620
Published: 01 December 2008
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Caveolin 1 Is Overexpressed and Amplified in a Subset of Basal-like and Metaplastic Breast Carcinomas: A Morphologic, Ultrastructural, Immunohistochemical, and In situ Hybridization Analysis

Kay Savage, Maryou B.K. Lambros, David Robertson, Robin L. Jones, Chris Jones, Alan Mackay, Michelle James, Jason L. Hornick, Emilio M. Pereira, Fernanda Milanezi, Christopher D.M. Fletcher, Fernando C. Schmitt, Alan Ashworth, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (1): 90–101.
DOI: https://doi.org/10.1158/1078-0432.CCR-06-1371
Published: 02 January 2007
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FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas

Jorge Sergio Reis-Filho, Pete T. Simpson, Nicholas C. Turner, Maryou Ballo Lambros, Chris Jones, Alan Mackay, Anita Grigoriadis, David Sarrio, Kay Savage, Tim Dexter, Marjan Iravani, Kerry Fenwick, Barbara Weber, David Hardisson, Fernando Carlos Schmitt, Jose Palacios, Sunil R. Lakhani, Alan Ashworth
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (22): 6652–6662.
DOI: https://doi.org/10.1158/1078-0432.CCR-06-1164
Published: 22 November 2006
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Targeting the Double-Strand DNA Break Repair Pathway as a Therapeutic Strategy

Christopher J. Lord, Michelle D. Garrett, Alan Ashworth
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (15): 4463–4468.
DOI: https://doi.org/10.1158/1078-0432.CCR-06-1269
Published: 09 August 2006
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