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Journal Articles

Correction: Effects of Tobacco Smoking On the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma

Janis V. de la Iglesia, Robbert J.C. Slebos, Laura Martin-Gomez, Xuefeng Wang, Jamie K. Teer, Aik Choon Tan, Travis A. Gerke, Garrick Aden-Buie, Tessa van Veen, Jude Masannat, Ritu Chaudhary, Feifei Song, Michelle Fournier, Erin M. Siegel, Matthew B. Schabath, J. Trad Wadsworth, Jimmy Caudell, Louis Harrison, Bruce M. Wenig, Jose Conejo-Garcia, Juan C. Hernandez-Prera, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (17): 4941.
https://doi.org/10.1158/1078-0432.CCR-21-2432
Published: 01 September 2021
View article titled, Correction: Effects of Tobacco Smoking On the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma
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Journal Articles

Abstract PO-082: Automated tumor segmentation, grading, and analysis of tumor heterogeneity in preclinical models of lung adenocarcinoma

John H. Lockhart, Hayley D. Ackerman, Kyubum Lee, Mahmoud Abdalah, Andrew Davis, Nicole Montey, Theresa Boyle, James Saller, Ayensur Keske, Kay Hänggi, Brian Ruffell, Olya Stringfield, Aik Choon Tan, Elsa R. Flores
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5_Supplement): PO-082.
https://doi.org/10.1158/1557-3265.ADI21-PO-082
Published: 01 March 2021
View article titled, Abstract PO-082: Automated tumor segmentation, grading, and analysis of tumor heterogeneity in preclinical models of lung adenocarcinoma
Journal Articles

Exogenous Thyroid Hormone Is Associated with Shortened Survival and Upregulation of High-Risk Gene Expression Profiles in Steroid Receptor–Positive Breast Cancers

Reema S. Wahdan-Alaswad, Susan M. Edgerton, Hiba Salem, Hyun Min Kim, Aik Choon Tan, Jessica Finlay-Schultz, Elizabeth A. Wellberg, Carol A. Sartorius, Britta M. Jacobsen, Bryan R. Haugen, Bolin Liu, Ann D. Thor
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (2): 585–597.
https://doi.org/10.1158/1078-0432.CCR-20-2647
Published: 19 January 2021
View article titled, Exogenous Thyroid Hormone Is Associated with Shortened Survival and Upregulation of High-Risk Gene Expression Profiles in Steroid Receptor–Positive Breast Cancers
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Includes: Supplementary data
Journal Articles

Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors

S. Lindsey Davis, Anastasia A. Ionkina, Stacey M. Bagby, James D. Orth, Brian Gittleman, Joshua M. Marcus, Elaine T. Lam, Bradley R. Corr, Cindy L. O'Bryant, Ashley E. Glode, Aik-Choon Tan, Jihye Kim, John J. Tentler, Anna Capasso, Kyrie L. Lopez, Daniel L. Gustafson, Wells A. Messersmith, Stephen Leong, S. Gail Eckhardt, Todd M. Pitts, Jennifer R. Diamond
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (17): 4633–4642.
https://doi.org/10.1158/1078-0432.CCR-19-3498
Published: 01 September 2020
View article titled, Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors
Open the PDF for Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma

Janis V. de la Iglesia, Robbert J.C. Slebos, Laura Martin-Gomez, Xuefeng Wang, Jamie K. Teer, Aik Choon Tan, Travis A. Gerke, Garrick Aden-Buie, Tessa van Veen, Jude Masannat, Ritu Chaudhary, Feifei Song, Michelle Fournier, Erin M. Siegel, Matthew B. Schabath, J. Trad Wadsworth, Jimmy Caudell, Louis Harrison, Bruce M. Wenig, Jose Conejo-Garcia, Juan C. Hernandez-Prera, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1474–1485.
https://doi.org/10.1158/1078-0432.CCR-19-1769
Published: 13 March 2020
View article titled, Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies

Iñigo Landa, Nikita Pozdeyev, Christopher Korch, Laura A. Marlow, Robert C. Smallridge, John A. Copland, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik Choon Tan, Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James A. Fagin, Rebecca E. Schweppe
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 3141–3151.
https://doi.org/10.1158/1078-0432.CCR-18-2953
Published: 15 May 2019
View article titled, Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies
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Includes: Supplementary data
Journal Articles

Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration

Ayman Oweida, Mohammad K. Hararah, Andy Phan, David Binder, Shilpa Bhatia, Shelby Lennon, Sanjana Bukkapatnam, Benjamin Van Court, Nomin Uyanga, Laurel Darragh, Hyun Min Kim, David Raben, Aik Choon Tan, Lynn Heasley, Eric Clambey, Raphael Nemenoff, Sana D. Karam
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (21): 5368–5380.
https://doi.org/10.1158/1078-0432.CCR-18-1038
Published: 01 November 2018
View article titled, Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration
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Includes: Supplementary data
Journal Articles

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers

Nikita Pozdeyev, Laurie M. Gay, Ethan S. Sokol, Ryan Hartmaier, Kelsi E. Deaver, Stephanie Davis, Jena D. French, Pierre Vanden Borre, Daniel V. LaBarbera, Aik-Choon Tan, Rebecca E. Schweppe, Lauren Fishbein, Jeffrey S. Ross, Bryan R. Haugen, Daniel W. Bowles
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (13): 3059–3068.
https://doi.org/10.1158/1078-0432.CCR-18-0373
Published: 01 July 2018
View article titled, Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers
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Includes: Supplementary data
Journal Articles

Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression

Stephen B. Keysar, Justin R. Eagles, Bettina Miller, Brian C. Jackson, Farshad N. Chowdhury, Julie Reisinger, Tugs-Saikhan Chimed, Phuong N. Le, John J. Morton, Hilary L. Somerset, Marileila Varella-Garcia, Aik-Choon Tan, John I. Song, Daniel W. Bowles, Mary E. Reyland, Antonio Jimeno
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (12): 2935–2943.
https://doi.org/10.1158/1078-0432.CCR-17-3871
Published: 14 June 2018
View article titled, Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression
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Includes: Supplementary data
Journal Articles

Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen

Heather M. Brechbuhl, Jessica Finlay-Schultz, Tomomi M. Yamamoto, Austin E. Gillen, Diana M. Cittelly, Aik-Choon Tan, Sharon B. Sams, Manoj M. Pillai, Anthony D. Elias, William A. Robinson, Carol A. Sartorius, Peter Kabos
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (7): 1710–1721.
https://doi.org/10.1158/1078-0432.CCR-15-2851
Published: 02 April 2017
View article titled, Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
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Includes: Supplementary data
Journal Articles

AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non–Small Cell Lung Cancer Cells Following EGFR Inhibition

Hannah A. Scarborough, Barbara A. Helfrich, Matias Casás-Selves, Alwin G. Schuller, Shaun E. Grosskurth, Jihye Kim, Aik-Choon Tan, Daniel C. Chan, Zhiyong Zhang, Vadym Zaberezhnyy, Paul A. Bunn, James DeGregori
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1531–1541.
https://doi.org/10.1158/1078-0432.CCR-16-1179
Published: 14 March 2017
View article titled, AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non–Small Cell Lung Cancer Cells Following EGFR Inhibition
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Includes: Supplementary data
Journal Articles

Abstract PR03: Characterizing the immune context of responses to immunotherapy in humanized patient derived xenograft models of CRC

Anna Capasso, Julie Lang, Todd M. Pitts, S. Lindsey Davis, Chris H. Lieu, Stacey M. Bagby, Aik Choon Tan, John J. Tentler, Jill E. Slansky, Roberta Pelanda, S. Gail Eckhardt
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): PR03.
https://doi.org/10.1158/1557-3265.PDX16-PR03
Published: 15 August 2016
View article titled, Abstract PR03: Characterizing the immune context of responses to immunotherapy in humanized patient derived xenograft models of CRC
Journal Articles

Abstract IA20: Challenges, opportunities, and lessons learned in the bench-to-bedside translation of xenopatient studies

S. Gail Eckhardt, Todd Pitts, Aik Choon Tan, Stacey Bagby, John Arcaroli, Anna Capasso, Kit Wong, Peter Klauck, Wells Messersmith, S Lindsey Davis, Christopher Lieu, Stephen Leong, Jennifer Diamond, John Tentler
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): IA20.
https://doi.org/10.1158/1557-3265.PDX16-IA20
Published: 15 August 2016
View article titled, Abstract IA20: Challenges, opportunities, and lessons learned in the bench-to-bedside translation of xenopatient studies
Journal Articles

FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers

Friederike Göke, Alina Franzen, Trista K. Hinz, Lindsay A. Marek, Petros Yoon, Rakesh Sharma, Maike Bode, Anne von Maessenhausen, Brigitte Lankat-Buttgereit, Antonia Göke, Carsten Golletz, Robert Kirsten, Diana Boehm, Wenzel Vogel, Emily K. Kleczko, Justin R. Eagles, Fred R. Hirsch, Tobias Van Bremen, Friedrich Bootz, Andreas Schroeck, Jihye Kim, Aik-Choon Tan, Antonio Jimeno, Lynn E. Heasley, Sven Perner
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (19): 4356–4364.
https://doi.org/10.1158/1078-0432.CCR-14-3357
Published: 30 September 2015
View article titled, FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers
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Includes: Supplementary data
Journal Articles

Developing a novel method for predicting tumor responses to drug combination based on pathway expression signatures

Maria Villarroel, Aik Choon Tan, Ignacio Garrido-Laguna, Belen Rubio-Viqueira, N.V RajeshKummar, Antonio Jimeno, Manuel Hidalgo
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (19_Supplement): B51.
Published: 15 August 2014
View article titled, Developing a novel method for predicting tumor responses to drug combination based on pathway expression signatures
Journal Articles

Activity of the T-type calcium channel antagonist Mibefradil in pancreatic cancer xenografts

Ignacio Garrido-Laguna, Aik Choon Tan, Maria Cristina Villarroel, N.V. Rajeshkumar, Belen Rubio-Viqueira, Lloyd Gray, Manuel Hidalgo
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (19_Supplement): B49.
Published: 15 August 2014
View article titled, Activity of the T-type calcium channel antagonist Mibefradil in pancreatic cancer xenografts
Journal Articles

FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies

Murry W. Wynes, Trista K. Hinz, Dexiang Gao, Michael Martini, Lindsay A. Marek, Kathryn E. Ware, Michael G. Edwards, Diana Böhm, Sven Perner, Barbara A. Helfrich, Rafal Dziadziuszko, Jacek Jassem, Szymon Wojtylak, Aleksandra Sejda, Joseph M. Gozgit, Paul A. Bunn, Jr, D. Ross Camidge, Aik-Choon Tan, Fred R. Hirsch, Lynn E. Heasley
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (12): 3299–3309.
https://doi.org/10.1158/1078-0432.CCR-13-3060
Published: 12 June 2014
View article titled, FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
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Includes: Supplementary data
Journal Articles

Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models

Sara A. Flanigan, Todd M. Pitts, Timothy P. Newton, Gillian N. Kulikowski, Aik Choon Tan, Martine C. McManus, Anna Spreafico, Maria I. Kachaeva, Heather M. Selby, John J. Tentler, S. Gail Eckhardt, Stephen Leong
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (22): 6219–6229.
https://doi.org/10.1158/1078-0432.CCR-13-0145
Published: 14 November 2013
View article titled, Overcoming IGF1R/IR Resistance through Inhibition of MEK Signaling in Colorectal Cancer Models
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Includes: Supplementary data
Journal Articles

Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer

Anna Spreafico, John J. Tentler, Todd M. Pitts, Aik Choon Tan, Mark A. Gregory, John J. Arcaroli, Peter J. Klauck, Martine C. McManus, Ryan J. Hansen, Jihye Kim, Lindsey N. Micel, Heather M. Selby, Timothy P. Newton, Kelly L. McPhillips, Daniel L. Gustafson, James V. DeGregori, Wells A. Messersmith, Robert A. Winn, S. Gail Eckhardt
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (15): 4149–4162.
https://doi.org/10.1158/1078-0432.CCR-12-3140
Published: 31 July 2013
View article titled, Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Abstract A46: Tumor P-glycoprotein Correlates with Efficacy of PF-03758309 Against In Vitro and In Vivo models of Colorectal Cancer

Erica L. Bradshaw-Pierce, Todd M. Pitts, Kelly L. McPhillips, Daniel L. Gustafson, Aik-Choon Tan, Leslie Nguyen, Mark West, Timothy Fisher, Brion W. Murray, S. Gail Eckhardt
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10_Supplement): A46.
https://doi.org/10.1158/1078-0432.MECHRES-A46
Published: 04 March 2013
View article titled, Abstract A46: Tumor P-glycoprotein Correlates with Efficacy of PF-03758309 Against In Vitro and In Vivo models of Colorectal Cancer
Open the PDF for Abstract A46: Tumor P-glycoprotein Correlates with Efficacy of PF-03758309 Against In Vitro and In Vivo models of Colorectal Cancer in another window