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Adrian L. Harris
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Journal Articles

Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non–Small Cell Lung Cancer

Michael Skwarski, Daniel R. McGowan, Elizabeth Belcher, Francesco Di Chiara, Dionisios Stavroulias, Mark McCole, Jennifer L. Derham, Kwun-Ye Chu, Eugene Teoh, Jagat Chauhan, Dawn O’Reilly, Benjamin H.L. Harris, Philip S. Macklin, Joshua A. Bull, Marcus Green, Gonzalo Rodriguez-Berriguete, Remko Prevo, Lisa K. Folkes, Leticia Campo, Petra Ferencz, Paula L. Croal, Helen Flight, Cathy Qi, Jane Holmes, James P.B. O’Connor, Fergus V. Gleeson, W. Gillies McKenna, Adrian L. Harris, Daniel Bulte, Francesca M. Buffa, Ruth E. Macpherson, Geoff S. Higgins
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2459–2469.
https://doi.org/10.1158/1078-0432.CCR-20-4128
Published: 01 May 2021
View article titled, Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases

Pavitra Kannan, Warren W. Kretzschmar, Helen Winter, Daniel Warren, Russell Bates, Philip D. Allen, Nigar Syed, Benjamin Irving, Bartlomiej W. Papiez, Jakob Kaeppler, Bosjtan Markelc, Paul Kinchesh, Stuart Gilchrist, Sean Smart, Julia A. Schnabel, Tim Maughan, Adrian L. Harris, Ruth J. Muschel, Mike Partridge, Ricky A. Sharma, Veerle Kersemans
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (19): 4694–4704.
https://doi.org/10.1158/1078-0432.CCR-18-0033
Published: 01 October 2018
View article titled, Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
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Includes: Supplementary data
Journal Articles

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients

Lingjian Yang, Janet Taylor, Amanda Eustace, Joely J. Irlam, Helen Denley, Peter J. Hoskin, Jan Alsner, Francesca M. Buffa, Adrian L. Harris, Ananya Choudhury, Catharine M.L. West
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (16): 4761–4768.
https://doi.org/10.1158/1078-0432.CCR-17-0038
Published: 14 August 2017
View article titled, A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients
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Includes: Supplementary data
Journal Articles

Abstract A11: Phase II trial of letrozole (L), cyclophosphamide (C) and sorafenib (S) as neoadjuvant therapy in breast cancer patients (BC): Pharmacokinetic (PK) and pharmacodinamic (PD) analysis

Letizia Bazzola, Chiara Foroni, Daniele Andreis, Francesco Ferrozzi, Luigi Dogliotti, Alfredo Berruti, Stephen B. Fox, Adrian L. Harris, Daniele Generali, Alberto Bottini
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (7_Supplement): A11.
https://doi.org/10.1158/1078-0432.TCME10-A11
Published: 02 February 2016
View article titled, Abstract A11: Phase II trial of letrozole (L), cyclophosphamide (C) and sorafenib (S) as neoadjuvant therapy in breast cancer patients (BC): Pharmacokinetic (PK) and pharmacodinamic (PD) analysis
Journal Articles

Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer

Rebecca A. Previs, Robert L. Coleman, Adrian L. Harris, Anil K. Sood
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (5): 955–961.
https://doi.org/10.1158/1078-0432.CCR-14-0809
Published: 01 March 2015
View article titled, Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer
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Journal Articles

The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis

Leonid L. Nikitenko, Russell Leek, Stephen Henderson, Nischalan Pillay, Helen Turley, Daniele Generali, Sarah Gunningham, Helen R. Morrin, Andrea Pellagatti, Margaret C.P. Rees, Adrian L. Harris, Stephen B. Fox
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5740–5748.
https://doi.org/10.1158/1078-0432.CCR-13-1712
Published: 14 October 2013
View article titled, The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis
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Includes: Supplementary data
Journal Articles

A 26-Gene Hypoxia Signature Predicts Benefit from Hypoxia-Modifying Therapy in Laryngeal Cancer but Not Bladder Cancer

Amanda Eustace, Navin Mani, Paul N. Span, Joely J. Irlam, Janet Taylor, Guy N.J. Betts, Helen Denley, Crispin J. Miller, Jarrod J. Homer, Ana M. Rojas, Peter J. Hoskin, Francesca M. Buffa, Adrian L. Harris, Johannes H.A.M. Kaanders, Catharine M.L. West
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (17): 4879–4888.
https://doi.org/10.1158/1078-0432.CCR-13-0542
Published: 02 September 2013
View article titled, A 26-Gene Hypoxia Signature Predicts Benefit from Hypoxia-Modifying Therapy in Laryngeal Cancer but Not Bladder Cancer
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Includes: Supplementary data
Journal Articles

Microenvironmental Induced Essentiality of Autophagy

Dean C. Singleton, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 2791–2793.
https://doi.org/10.1158/1078-0432.CCR-13-0634
Published: 30 May 2013
View article titled, Microenvironmental Induced Essentiality of Autophagy
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Journal Articles

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

Alan McIntyre, Shalini Patiar, Simon Wigfield, Ji-liang Li, Ioanna Ledaki, Helen Turley, Russell Leek, Cameron Snell, Kevin Gatter, William S. Sly, Richard D. Vaughan-Jones, Pawel Swietach, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (11): 3100–3111.
https://doi.org/10.1158/1078-0432.CCR-11-1877
Published: 31 May 2012
View article titled, Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis <em>In Vivo</em> and Inhibition Enhances Anti-VEGF Therapy
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Includes: Supplementary data
Journal Articles

Abstract B8: Targeting p21-activated kinases in human lung cancer

Christy C. Ong, Adrian M. Jubb, Peter M. Haverty, Wei Zhou, Adrian L. Harris, Marcia Belvin, Lori S. Friedman, Hartmut Koeppen, Klaus P. Hoeflich
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3_Supplement): B8.
https://doi.org/10.1158/1078-0432.12AACRIASLC-B8
Published: 01 February 2012
View article titled, Abstract B8: Targeting p21-activated kinases in human lung cancer
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Journal Articles

Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy

Michael I. Koukourakis, Alexandra Giatromanolaki, Efthimios Sivridis, Kevin C. Gatter, Tanja Trarbach, Gunnar Folprecht, Michael M. Shi, David Lebwohl, Tarja Jalava, Dirk Laurent, Gerold Meinhardt, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (14): 4892–4900.
https://doi.org/10.1158/1078-0432.CCR-10-2918
Published: 17 July 2011
View article titled, Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy
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Journal Articles

Close and Stable Relationship between Proliferation and a Hypoxia Metagene in Aromatase Inhibitor–Treated ER-Positive Breast Cancer

Zara Ghazoui, Francesca M. Buffa, Anita K. Dunbier, Helen Anderson, Tim Dexter, Simone Detre, Janine Salter, Ian E. Smith, Adrian L. Harris, Mitchell Dowsett
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (9): 3005–3012.
https://doi.org/10.1158/1078-0432.CCR-10-1704
Published: 01 May 2011
View article titled, Close and Stable Relationship between Proliferation and a Hypoxia Metagene in Aromatase Inhibitor–Treated ER-Positive Breast Cancer
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Includes: Supplementary data
Journal Articles

Impact of Exploratory Biomarkers on the Treatment Effect of Bevacizumab in Metastatic Breast Cancer

Adrian M. Jubb, Kathy D. Miller, Hope S. Rugo, Adrian L. Harris, Dafeng Chen, James D. Reimann, Melody A. Cobleigh, Maike Schmidt, Virginia K. Langmuir, Kenneth J. Hillan, Daniel S. Chen, Hartmut Koeppen
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (2): 372–381.
https://doi.org/10.1158/1078-0432.CCR-10-1791
Published: 16 January 2011
View article titled, Impact of Exploratory Biomarkers on the Treatment Effect of Bevacizumab in Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Phase I/II Trial of Bevacizumab and Radiotherapy for Locally Advanced Inoperable Colorectal Cancer: Vasculature-Independent Radiosensitizing Effect of Bevacizumab

Michael I. Koukourakis, Alexandra Giatromanolaki, Helen Sheldon, Francesca M. Buffa, George Kouklakis, Ioannis Ragoussis, Efthimios Sivridis, Adrian L. Harris, for the Tumour and Angiogenesis Research Group
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 7069–7076.
https://doi.org/10.1158/1078-0432.CCR-09-0688
Published: 11 November 2009
View article titled, Phase I/II Trial of Bevacizumab and Radiotherapy for Locally Advanced Inoperable Colorectal Cancer: Vasculature-Independent Radiosensitizing Effect of Bevacizumab
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Includes: Supplementary data
Journal Articles

Immunomodulation of FOXP3+ Regulatory T Cells by the Aromatase Inhibitor Letrozole in Breast Cancer Patients

Daniele Generali, Gaynor Bates, Alfredo Berruti, Maria P. Brizzi, Leticia Campo, Simone Bonardi, Alessandra Bersiga, Giovanni Allevi, Manuela Milani, Sergio Aguggini, Luigi Dogliotti, Alison H. Banham, Adrian L. Harris, Alberto Bottini, Stephen B. Fox
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (3): 1046–1051.
https://doi.org/10.1158/1078-0432.CCR-08-1507
Published: 02 February 2009
View article titled, Immunomodulation of FOXP3<sup>+</sup> Regulatory T Cells by the Aromatase Inhibitor Letrozole in Breast Cancer Patients
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Includes: Supplementary data
Journal Articles

Phase I Study of Copper-Binding Agent ATN-224 in Patients with Advanced Solid Tumors

Sarah A. Lowndes, Avril Adams, Anthony Timms, Nita Fisher, Jon Smythe, Suzanne M. Watt, Simon Joel, Fernando Donate, Carolyn Hayward, Steven Reich, Mark Middleton, Andrew Mazar, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (22): 7526–7534.
https://doi.org/10.1158/1078-0432.CCR-08-0315
Published: 14 November 2008
View article titled, Phase I Study of Copper-Binding Agent ATN-224 in Patients with Advanced Solid Tumors
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Journal Articles

Down-Regulation of Phosphatidylinositol 3′-Kinase/AKT/Molecular Target of Rapamycin Metabolic Pathway by Primary Letrozole-Based Therapy in Human Breast Cancer

Daniele Generali, Stephen B. Fox, Maria Pia Brizzi, Giovanni Allevi, Simone Bonardi, Sergio Aguggini, Manuela Milani, Alessandra Bersiga, Leticia Campo, Rossana Dionisio, Federica Vergoni, Roberto Giardini, Luigi Dogliotti, Alberto Bottini, Adrian L. Harris, Alfredo Berruti
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (9): 2673–2680.
https://doi.org/10.1158/1078-0432.CCR-07-1046
Published: 01 May 2008
View article titled, Down-Regulation of Phosphatidylinositol 3′-Kinase/AKT/Molecular Target of Rapamycin Metabolic Pathway by Primary Letrozole-Based Therapy in Human Breast Cancer
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Journal Articles

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

Carme Camps, Francesca M. Buffa, Stefano Colella, John Moore, Christos Sotiriou, Helen Sheldon, Adrian L. Harris, Jonathan M. Gleadle, Jiannis Ragoussis
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (5): 1340–1348.
https://doi.org/10.1158/1078-0432.CCR-07-1755
Published: 03 March 2008
View article titled, hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
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Includes: Supplementary data
Journal Articles

Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series

Christine Desmedt, Fanny Piette, Sherene Loi, Yixin Wang, Françoise Lallemand, Benjamin Haibe-Kains, Giuseppe Viale, Mauro Delorenzi, Yi Zhang, Mahasti Saghatchian d'Assignies, Jonas Bergh, Rosette Lidereau, Paul Ellis, Adrian L. Harris, Jan G.M. Klijn, John A. Foekens, Fatima Cardoso, Martine J. Piccart, Marc Buyse, Christos Sotiriou, on behalf of the TRANSBIG Consortium
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (11): 3207–3214.
https://doi.org/10.1158/1078-0432.CCR-06-2765
Published: 01 June 2007
View article titled, Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series
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Journal Articles

The Unfolded Protein Response and Integrated Stress Response to Anoxia

Tomasz Rzymski, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (9): 2537–2540.
https://doi.org/10.1158/1078-0432.CCR-06-2126
Published: 01 May 2007
View article titled, The Unfolded Protein Response and Integrated Stress Response to Anoxia
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