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Abdullah A. Osman
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Journal Articles

FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner

Phillip M. Pifer, Liangpeng Yang, Manish Kumar, Tongxin Xie, Mitchell Frederick, Andrew Hefner, Beth Beadle, David Molkentine, Jessica Molkentine, Annika Dhawan, Mohamed Abdelhakiem, Abdullah A. Osman, Brian J. Leibowitz, Jeffrey N. Myers, Curtis R. Pickering, Vlad C. Sandulache, John Heymach, Heath D. Skinner
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (1): 187–197.
https://doi.org/10.1158/1078-0432.CCR-23-0964
Published: 05 January 2024
View article titled, FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
Open the PDF for FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner in another window
Includes: Supplementary data
Journal Articles

Abstract PO-085: Inhibition of ATR as a therapeutic strategy to enhance immunotherapy in head and neck cancer

Abdullah A. Osman, Fabio H. B. da Costa, Adewale A. Adebayo, Mason D. Bartels, Tongxin Xie, Moran Amit, Mutsuki Kawabe, Roberto Rangel, Mitchell J. Frederick, Vlad Sandulache, Andrew G. Sikora, Jeffrey N. Myers
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18_Supplement): PO-085.
https://doi.org/10.1158/1557-3265.AACRAHNS23-PO-085
Published: 15 September 2023
View article titled, Abstract PO-085: Inhibition of ATR as a therapeutic strategy to enhance immunotherapy in head and neck cancer
Journal Articles

Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma

Abdullah A. Osman, Emre Arslan, Mason Bartels, Chieko Michikawa, Antje Lindemann, Katarzyna Tomczak, Wangjie Yu, Vlad Sandulache, Wencai Ma, Li Shen, Jing Wang, Anand K. Singh, Mitchell J. Frederick, Nakia D. Spencer, Jeffery Kovacs, Timothy Heffernan, William F. Symmans, Kunal Rai, Jeffrey N. Myers
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (7): 1344–1359.
https://doi.org/10.1158/1078-0432.CCR-22-2747
Published: 03 April 2023
View article titled, Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma
Open the PDF for Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract PR08: Inhibition of ATR as a therapeutic strategy to overcome cisplatin resistance in HNSCC

Antje Lindemann, Hideaki Takahashi, Ameeta A. Patel, Walter N. Hittelman, Abdullah A. Osman, Jeffrey N. Myers
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_2): PR08.
https://doi.org/10.1158/1557-3265.AACRAHNS19-PR08
Published: 15 June 2020
View article titled, Abstract PR08: Inhibition of ATR as a therapeutic strategy to overcome cisplatin resistance in HNSCC
Journal Articles

COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms

Antje Lindemann, Ameeta A. Patel, Natalie L. Silver, Lin Tang, Zhiyi Liu, Li Wang, Noriaki Tanaka, Xiayu Rao, Hideaki Takahashi, Nakachi K. Maduka, Mei Zhao, Tseng-Cheng Chen, WeiWei Liu, Meng Gao, Jing Wang, Steven J. Frank, Walter N. Hittelman, Gordon B. Mills, Jeffrey N. Myers, Abdullah A. Osman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (18): 5650–5662.
https://doi.org/10.1158/1078-0432.CCR-19-0096
Published: 13 September 2019
View article titled, COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 44: Synergistic antitumor activity of olaparib combined with AZD1775 in head and neck squamous cell carcinoma

Hideaki Takahashi, Antje Lindemann, Ameeta A. Patel, Weiwei Liu, Noriaki Tanaka, Lin Tang, Mei Zhao, Walter N. Hittelman, Jeffrey N. Myers, Abdullah A. Osman
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23_Supplement): 44.
https://doi.org/10.1158/1557-3265.AACRAHNS17-44
Published: 30 November 2017
View article titled, Abstract 44: Synergistic antitumor activity of olaparib combined with AZD1775 in head and neck squamous cell carcinoma
Journal Articles

Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation

Noriaki Tanaka, Ameeta A. Patel, Lin Tang, Natalie L. Silver, Antje Lindemann, Hideaki Takahashi, Roman Jaksik, Xiayu Rao, Nene N. Kalu, Tseng-Cheng Chen, Jiping Wang, Mitchell J. Frederick, Faye Johnson, Frederico O. Gleber-Netto, Siqing Fu, Marek Kimmel, Jing Wang, Walter N. Hittelman, Curtis R. Pickering, Jeffrey N. Myers, Abdullah A. Osman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (21): 6541–6554.
https://doi.org/10.1158/1078-0432.CCR-17-0947
Published: 31 October 2017
View article titled, Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk <em>TP53</em> Mutation
Open the PDF for Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk <em>TP53</em> Mutation in another window
Includes: Multimedia, Supplementary data
Journal Articles

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Noriaki Tanaka, Ameeta A. Patel, Jiping Wang, Mitchell J. Frederick, Nene N. Kalu, Mei Zhao, Alison L. Fitzgerald, Tong-xin Xie, Natalie L. Silver, Carlos Caulin, Ge Zhou, Heath D. Skinner, Faye M. Johnson, Jeffrey N. Myers, Abdullah A. Osman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (21): 4831–4844.
https://doi.org/10.1158/1078-0432.CCR-15-0279
Published: 01 November 2015
View article titled, Wee-1 Kinase Inhibition Sensitizes High-Risk HPV<sup>+</sup> HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins
Open the PDF for Wee-1 Kinase Inhibition Sensitizes High-Risk HPV<sup>+</sup> HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins in another window
Includes: Supplementary data