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A. Hilary Calvert
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Journal Articles

The Development of Phase I Cancer Trial Methodologies: the Use of Pharmacokinetic and Pharmacodynamic End Points Sets the Scene for Phase 0 Cancer Clinical Trials

A. Hilary Calvert, Ruth Plummer
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3664–3669.
https://doi.org/10.1158/1078-0432.CCR-07-4559
Published: 16 June 2008
View article titled, The Development of Phase I Cancer Trial Methodologies: the Use of Pharmacokinetic and Pharmacodynamic End Points Sets the Scene for Phase 0 Cancer Clinical Trials
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Journal Articles

A Phase I and Pharmacokinetic Study of Paclitaxel Poliglumex (XYOTAX), Investigating Both 3-Weekly and 2-Weekly Schedules

Alan V. Boddy, E. Ruth Plummer, Radha Todd, Julieann Sludden, Melanie Griffin, Lesley Robson, James Cassidy, Donald Bissett, Alberto Bernareggi, Mark W. Verrill, A. Hilary Calvert
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (21): 7834–7840.
https://doi.org/10.1158/1078-0432.CCR-05-0803
Published: 08 November 2005
View article titled, A Phase I and Pharmacokinetic Study of Paclitaxel Poliglumex (XYOTAX), Investigating Both 3-Weekly and 2-Weekly Schedules
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Journal Articles

Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1

E. Ruth Plummer, Mark R. Middleton, Christopher Jones, Anna Olsen, Ian Hickson, Peter McHugh, Geoffrey P. Margison, Gail McGown, Mary Thorncroft, Amanda J. Watson, Alan V. Boddy, A. Hilary Calvert, Adrian L. Harris, David R. Newell, Nicola J. Curtin
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (9): 3402–3409.
https://doi.org/10.1158/1078-0432.CCR-04-2353
Published: 02 May 2005
View article titled, Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes <em>O</em><sup>6</sup>-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1
Open the PDF for Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes <em>O</em><sup>6</sup>-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1 in another window
Journal Articles

Patterns of Elevation of Plasma 2′-Deoxyuridine, a Surrogate Marker of Thymidylate Synthase (TS) Inhibition, after Administration of Two Different Schedules of 5-Fluorouracil and the Specific TS Inhibitors Raltitrexed (Tomudex) and ZD9331

Hugo E. R. Ford, Fraser Mitchell, David Cunningham, David C. Farrugia, Mark E. Hill, Charlotte Rees, A. Hilary Calvert, Ian R. Judson, Ann L. Jackman
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (1): 103–109.
Published: 01 January 2002
View article titled, Patterns of Elevation of Plasma 2′-Deoxyuridine, a Surrogate Marker of Thymidylate Synthase (TS) Inhibition, after Administration of Two Different Schedules of 5-Fluorouracil and the Specific TS Inhibitors Raltitrexed (Tomudex) and ZD9331
Open the PDF for Patterns of Elevation of Plasma 2′-Deoxyuridine, a Surrogate Marker of Thymidylate Synthase (TS) Inhibition, after Administration of Two Different Schedules of 5-Fluorouracil and the Specific TS Inhibitors Raltitrexed (Tomudex) and ZD9331 in another window
Journal Articles

In Vitro and in Vivo Properties of Novel Nucleoside Transport Inhibitors with Improved Pharmacological Properties That Potentiate Antifolate Activity

Peter G. Smith, Huw D. Thomas, Hannah C. Barlow, Roger J. Griffin, Bernard T. Golding, A. Hilary Calvert, David R. Newell, Nicola J. Curtin
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (7): 2105–2113.
Published: 01 July 2001
View article titled, <em>In Vitro</em> and <em>in Vivo</em> Properties of Novel Nucleoside Transport Inhibitors with Improved Pharmacological Properties That Potentiate Antifolate Activity
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Journal Articles

Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines

Carol A. Delaney, Lan-Z Wang, Suzanne Kyle, Alex W. White, A. Hilary Calvert, Nicola J. Curtin, Barbara W. Durkacz, Zdenek Hostomsky, David R. Newell
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (7): 2860–2867.
Published: 01 July 2000
View article titled, Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines
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Journal Articles

Phase I Studies with the Nonclassical Antifolate Nolatrexed Dihydrochloride (AG337, THYMITAQ) Administered Orally for 5 Days

Andy N. Hughes, Imran Rafi, Melanie J. Griffin, A. Hilary Calvert, David R. Newell, Joanne A. Calvete, Amanda Johnston, Neil Clendeninn, Alan V. Boddy
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (1): 111–118.
Published: 01 January 1999
View article titled, Phase I Studies with the Nonclassical Antifolate Nolatrexed Dihydrochloride (AG337, THYMITAQ) Administered Orally for 5 Days
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