Skip to Main Content

Advertisement

Skip Nav Destination

CCR Focus Archive 2010


CCR Focus Archive Home


2017  |  2016  |  2015  |  2014  |  2013  |  2012  |  2011  |  2010  |  2009  |  2008  |  2007  |  2006


Outcomes of New Cancer Therapies: Enhancing the Process and Creating Meaningful Value (December 15, 2010)
Re-energizing DNA Damage and Repair as a Therapeutic Target (September 15, 2010)
Targeting the Journey: From Embryogenesis to Cancer Stem Cell (June 15, 2010)
Phase I Trials: Critical Steps on the Critical Path (March 15, 2010)

2010 CCR Focus Sections


CCR Focus Cover

Outcomes of New Cancer Therapies: Enhancing the Process and Creating Meaningful Value
December 15, 2010
Guest Editors: Patricia M. LoRusso, Walter Wolf, Steven D. Averbuch, and Lowell E. Schnipper, 16 (24) : 5950–6008

Striving to Improve Outcomes in Oncology: Unmet Expectations in a Complex Disease
Susan E. Bates

Translating Clinical Trials into Meaningful Outcomes
Patricia M. LoRusso, Lowell E. Schnipper, David J. Stewart, Scott A. Boerner, Steven D. Averbuch, and Walter Wolf

Making the Investigational Oncology Pipeline More Efficient and Effective: Are We Headed in the Right Direction?
Patricia M. LoRusso, Aparna B. Anderson, Scott A. Boerner, and Steven D. Averbuch

Evaluating Patient-Centered Outcomes in the Randomized Controlled Trial and Beyond: Informing the Future with Lessons from the Past
Christopher M. Booth

Biologically Targeted Cancer Therapy and Marginal Benefits: Are We Making Too Much of Too Little or Are We Achieving Too Little by Giving Too Much?
Tito Fojo and David R. Parkinson

Explaining Marginal Benefits to Patients, When "Marginal" Means Additional but Not Necessarily Small
Thomas J. Smith and Bruce E. Hillner

The 2010 Health Care Reform Act: A Potential Opportunity to Advance Cancer Research by Taking Cancer Personally
William S. Dalton, Daniel M. Sullivan, Timothy J. Yeatman, and David A. Fenstermacher

The Impact of Insurance on Access to Cancer Clinical Trials at a Comprehensive Cancer Center
Justin F. Klamerus, Suanna S. Bruinooge, Xiaobu Ye, Mandi L. Klamerus, Dorothy Damron, Dina Lansey, John C. Lowery, Luis A. Diaz, Jr., Jean G. Ford, Norma Kanarek, and Charles M. Rudin

Value and Cancer Care: Toward an Equitable Future
Lowell E. Schnipper, Neal J. Meropol, and Dan W. Brock

Back to top


 

Re-energizing DNA Damage and Repair as a Therapeutic Target
September 15, 2010
Guest Editor: Eddie Reed, 16 (18) : 4510–4560

From the Editor—DNA Repair: A Reinvigorated Therapeutic Target
Susan E. Bates

DNA Damage and Repair in Translational Oncology: An Overview
Eddie Reed

Poly (ADP-Ribose) Polymerase as a Novel Therapeutic Target in Cancer
Christina M. Annunziata and Joyce O'Shaughnessy

Perspective on the Pipeline of Drugs Being Developed with Modulation of DNA Damage as a Target
Ruth Plummer

Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers
Christophe E. Redon, Asako J. Nakamura, Yong-Wei Zhang, Jiuping (Jay) Ji, William M. Bonner, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, and Yves Pommier

Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair
Dorine Rossetto, Andrew W. Truman, Stephen J. Kron, and Jacques Côté

"Contextual" Synthetic Lethality and/or Loss of Heterozygosity: Tumor Hypoxia and Modification of DNA Repair
Norman Chan and Robert G. Bristow

Back to top


 

Targeting the Journey: From Embryogenesis to Cancer Stem Cell
June 15, 2010
Guest Editor: S. Percy Ivy, 16 (12) : 3089–3295

From the Editor—Drugs That Target the Stemness Pathways
Susan E. Bates

Controversies in Cancer Stem Cells: Targeting Embryonic Signaling Pathways
Naoko Takebe and S. Percy Ivy

Cancer Stem Cells and Self-renewal
Catherine Adell O'Brien, Antonija Kreso, and Catriona H.M. Jamieson

The Difficulty of Targeting Cancer Stem Cell Niches
Mark A. LaBarge

Targeting Hedgehog — a Cancer Stem Cell Pathway
Akil A. Merchant and William Matsui

Targeting Notch to Target Cancer Stem Cells
Antonio Pannuti, Kimberly Foreman, Paola Rizzo, Clodia Osipo, Todd Golde, Barbara Osborne, and Lucio Miele

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
Fumi Takahashi-Yanaga and Michael Kahn

Back to top


CCR Focus Cover

Phase I Trials: Critical Steps on the Critical Path
March 15, 2010
Guest Editors: Patricia LoRusso and Lesley Seymour, 16 (6) : 1693–1969

From the Editor—Phase I Clinical Trials: Overcoming Barriers
Susan E. Bates

An Overview of the Optimal Planning, Design, and Conduct of Phase I Studies of New Therapeutics
Patricia M. LoRusso, Scott A. Boerner, and Lesley Seymour

Information Needed to Conduct First-in-Human Oncology Trials in the United States: A View from a Former FDA Medical Reviewer
Adrian M. Senderowicz

Approaches to Phase 1 Clinical Trial Design Focused on Safety, Efficiency, and Selected Patient Populations: A Report from the Clinical Trial Design Task Force of the National Cancer Institute Investigational Drug Steering Committee
S. Percy Ivy, Lillian L. Siu, Elizabeth Garrett-Mayer, and Larry Rubinstein

Performing Phase I Clinical Trials of Anticancer Agents: Perspectives from within the European Union and Japan
Martin D. Forster, Nagahiro Saijo, Lesley Seymour, and Hilary Calvert

Guidelines for the Development and Incorporation of Biomarker Studies in Early Clinical Trials of Novel Agents
Janet E. Dancey, Kevin K. Dobbin, Susan Groshen, J. Milburn Jessup, Andrew H. Hruszkewycz, Maria Koehler, Ralph Parchment, Mark J. Ratain, Lalitha K. Shankar, Walter M. Stadler, Lawrence D. True, Amy Gravell, Michael R. Grever, and On behalf of the Biomarkers Task Force of the NCI Investigational Drug Steering Committee

GCP Data Quality for Early Clinical Development
Edwin P. Rock, Vernette J. Molloy, and Jeffrey S. Humphrey

The Design of Phase II Clinical Trials Testing Cancer Therapeutics: Consensus Recommendations from the Clinical Trial Design Task Force of the National Cancer Institute Investigational Drug Steering Committee
Lesley Seymour, S. Percy Ivy, Daniel Sargent, David Spriggs, Laurence Baker, Larry Rubinstein, Mark J. Ratain, Michael Le Blanc, David Stewart, John Crowley, Susan Groshen, Jeffrey S. Humphrey, Pamela West, and Donald Berry

Close Modal

or Create an Account

Close Modal
Close Modal