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CCR Focus Archive 2006

CCR Focus Archive Home

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EGF Receptor: Mutations, Misregulation and More (December 15, 2006)
Mouse Models Get Another Chance (September 15, 2006)

2006 CCR Focus Sections


EGF Receptor: Mutations, Misregulation and More
December 15, 2006
Guest Editor: Rafael Rosell, 12 (24) : 7203–7497

From the Editor
Susan E. Bates

Epidermal Growth Factor Receptor Activation: How Exon 19 and 21 Mutations Changed Our Understanding of the Pathway
Rafael Rosell, Miquel Taron, Noemi Reguart, Dolores Isla, and Teresa Moran

Update on Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer
Gregory J. Riely, Katerina A. Politi, Vincent A. Miller, and William Pao

Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs
Mayumi Ono and Michihiko Kuwano

Mechanisms of egfr Gene Transcription Modulation: Relationship to Cancer Risk and Therapy Response
Burkhard Brandt, Sönke Meyer-Staeckling, Hartmut Schmidt, Konstantin Agelopoulos, and Horst Buerger

Epidermal Growth Factor Receptor-Mediated Signal Transduction in the Development and Therapy of Gliomas
M. Kelly Nicholas, Rimas V. Lukas, Nazia F. Jafri, Leonardo Faoro, and Ravi Salgia

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Mouse Models Get Another Chance
September 15, 2006
Guest Editor: Cory Abate-Shen, 12 (18) : 5225–5603

From the Editor — Introducing CCR Focus
Susan E. Bates

A New Generation of Mouse Models of Cancer for Translational Research
Cory Abate-Shen

The Use of Targeted Mouse Models for Preclinical Testing of Novel Cancer Therapeutics
Kenneth P. Olive and David A. Tuveson

Mouse Models of Brain Tumors and Their Applications in Preclinical Trials
Elena I. Fomchenko and Eric C. Holland

A Mouse Model System to Genetically Dissect the Molecular Mechanisms Regulating Tumorigenesis
Kurt Degenhardt and Eileen White

Mouse Modeling in Oncologic Preclinical and Translational Research
Brett S. Carver and Pier P. Pandolfi

Using Genetically Engineered Mouse Models of Cancer to Aid Drug Development: An Industry Perspective
Mallika Singh and Leisa Johnson

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