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Review July 25 2023
Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer
Giorgio Patelli; Gianluca Mauri; Federica Tosi; Alessio Amatu; Katia Bencardino; Erica Bonazzina; Elio Gregory Pizzutilo; Federica Villa; Gabriele Calvanese; Alberto Giuseppe Agostara; Stefano Stabile; Silvia Ghezzi; Giovanni Crisafulli; Federica Di Nicolantonio; Silvia Marsoni; Alberto Bardelli; Salvatore Siena; Andrea Sartore-Bianchi
Clin Cancer Res (2023)
Research Article July 24 2023
The Clinical Implications of Reversions in Patients with Advanced Pancreatic Cancer and Pathogenic Variants in BRCA1, BRCA2, or PALB2 After Progression on Rucaparib
Timothy J. Brown; Arielle Yablonovitch; Jacob E. Till; Jennifer Yen; Lesli A. Kiedrowski; Ryan Hood; Mark H. O'Hara; Ursina Teitelbaum; Thomas B. Karasic; Charles Schneider; Erica L. Carpenter; Katherine Nathanson; Susan M. Domchek; Kim A. Reiss
Clin Cancer Res CCR-23-1467.
Research Article July 20 2023
Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Emma D. Wrenn; April A. Apfelbaum; Erin R. Rudzinski; Xuemei Deng; Wei Jiang; Sudha Sud; Raelene A. Van Noord; Erika A. Newman; Nicolas M. Garcia; Aya Miyaki; Virginia J. Hoglund; Shruti S. Bhise; Sami B. Kanaan; Olivia G. Waltner; Scott N. Furlan; Elizabeth R. Lawlor
Clin Cancer Res CCR-23-1111.
Translational Cancer Mechanisms and Therapy July 19 2023
Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors
Naoual Menssouri; Loïc Poiraudeau; Carole Helissey; Ludovic Bigot; Jonathan Sabio; Tony Ibrahim; Cédric Pobel; Claudio Nicotra; Maud Ngo-Camus; Ludovic Lacroix; Etienne Rouleau; Lambros Tselikas; Anne Chauchereau; Félix Blanc-Durand; Alice Bernard-Tessier; Anna Patrikidou; Natacha Naoun; Ronan Flippot; Emeline Colomba; Alina Fuerea; Laurence Albiges; Pernelle Lavaud; Paul van de Wiel; Eveline den Biezen; Yvonne Wesseling-Rozendaal; Santiago Ponce; Stefan Michiels; Christophe Massard; Daniel Gautheret; Fabrice Barlesi; Fabrice André; Benjamin Besse; Jean-Yves Scoazec; Luc Friboulet; Karim Fizazi; Yohann Loriot
Clin Cancer Res (2023)
Translational Cancer Mechanisms and Therapy July 19 2023
Impact of Frontline Ivosidenib on Volumetric Growth Patterns in Isocitrate Dehydrogenase–mutant Astrocytic and Oligodendroglial Tumors
David Olayinka Kamson; Sushant Puri; Yingying Sang; Meihui Jessica Shi; Lindsay Blair; Jaishri O. Blakeley; John Laterra
Clin Cancer Res (2023)
Translational Cancer Mechanisms and Therapy July 18 2023
Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Gabrielle Leclercq-Cohen; Nathalie Steinhoff; Llucia Albertí Servera; Sina Nassiri; Sabrina Danilin; Emily Piccione; Emilio Yángüez; Tamara Hüsser; Sylvia Herter; Stephan Schmeing; Petra Gerber; Petra Schwalie; Johannes Sam; Stefanie Briner; Sylvia Jenni; Roberta Bianchi; Marlene Biehl; Floriana Cremasco; Katerina Apostolopoulou; Hélène Haegel; Christian Klein; Pablo Umaña; Marina Bacac
Clin Cancer Res (2023)
Clinical Trials: Targeted Therapy July 14 2023
Safety and Efficacy of Tucatinib, Letrozole, and Palbociclib in Patients with Previously Treated HR+/HER2+ Breast Cancer
Elena Shagisultanova; William Gradishar; Ursa Brown-Glaberman; Pavani Chalasani; Andrew J. Brenner; Alison Stopeck; Hannah Parris; Dexiang Gao; Tessa McSpadden; Jose Mayordomo; Jennifer R. Diamond; Peter Kabos; Virginia F. Borges
Clin Cancer Res (2023)
Clinical Trials: Immunotherapy July 14 2023
Safety, Efficacy, and Biomarker Analyses of Dostarlimab in Patients with Endometrial Cancer: Interim Results of the Phase I GARNET Study
Ana Oaknin; Bhavana Pothuri; Lucy Gilbert; Renaud Sabatier; Jubilee Brown; Sharad Ghamande; Cara Mathews; David M. O'Malley; Rebecca Kristeleit; Valentina Boni; Adriano Gravina; Susana Banerjee; Rowan Miller; Joanna Pikiel; Mansoor R. Mirza; Ninad Dewal; Grace Antony; Yuping Dong; Eleftherios Zografos; Jennifer Veneris; Anna V. Tinker
Clin Cancer Res (2023)
Precision Medicine and Imaging July 13 2023
Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer
Christopher J.M. Williams; Faye Elliott; Nancy Sapanara; Faranak Aghaei; Liping Zhang; Andrea Muranyi; Dongyao Yan; Isaac Bai; Zuo Zhao; Michael Shires; Henry M. Wood; Susan D. Richman; Gemma Hemmings; Michael Hale; Daniel Bottomley; Leanne Galvin; Caroline Cartlidge; Sarah Dance; Chris M. Bacon; Laura Mansfield; Kathe Young-Zvandasara; Ajay Sudan; Katy Lambert; Irena Bibby; Sarah E. Coupland; Amir Montazeri; Natalie Kipling; Kathryn Hughes; Simon S. Cross; Alice Dewdney; Leanne Pheasey; Cathryn Leng; Tatenda Gochera; D. Chas Mangham; Mark Saunders; Martin Pritchard; Helen Stott; Abhik Mukherjee; Mohammad Ilyas; Rafael Silverman; Georgina Hyland; Declan Sculthorpe; Kirsty Thornton; Imogen Gould; Ann O'Callaghan; Nicholas Brown; Samantha Turnbull; Lisa Shaw; Matthew T. Seymour; Nicholas P. West; Jenny F. Seligmann; Shalini Singh; Kandavel Shanmugam; Philip Quirke
Clin Cancer Res (2023)
Research Article July 11 2023
Clinical and molecular features of long-term response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer
Rohit Thummalapalli; Biagio Ricciuti; Chaitanya Bandlamudi; Daniel Muldoon; Hira Rizvi; Arielle Elkrief; Jia Luo; Joao V. Alessi; Federica Pecci; Giuseppe Lamberti; Alessandro Di Federico; Lingzhi Hong; Jianjun Zhang; John V. Heymach; Don L. Gibbons; Andrew J. Plodkowski; Vignesh Ravichandran; Mark T.A. Donoghue; Chad Vanderbilt; Marc Ladanyi; Charles M. Rudin; Mark G. Kris; Gregory J. Riely; Jamie E. Chaft; Matthew D. Hellmann; Natalie I. Vokes; Mark M. Awad; Adam J. Schoenfeld
Clin Cancer Res CCR-23-1207.
CCR Drug Updates June 29 2023
FDA Approval Summary: Tucatinib with Trastuzumab for Advanced Unresectable or Metastatic, Chemotherapy Refractory, HER2-Positive RAS Wild-Type Colorectal Cancer
Sandra J. Casak; M. Naomi Horiba; Mengdie Yuan; Joyce Cheng; Steven J. Lemery; Yuan Li Shen; Wentao Fu; Jason N. Moore; Yangbing Li; Youwei Bi; Doris Auth; Nataliya Fesenko; Paul G. Kluetz; Richard Pazdur; Lola A. Fashoyin-Aje
Clin Cancer Res (2023)
CCR Drug Updates June 27 2023
FDA Approval Summary: Futibatinib for Unresectable Advanced or Metastatic, Chemotherapy Refractory Intrahepatic Cholangiocarcinoma with FGFR2 Fusions or Other Rearrangements
Shruti U. Gandhy; Sandra J. Casak; Sirisha L. Mushti; Joyce Cheng; Sriram Subramaniam; Hong Zhao; Miao Zhao; Youwei Bi; Guansheng Liu; Jianghong Fan; Oluseyi Adeniyi; Rosane Charlab; Dubravka Kufrin; Matthew D. Thompson; Kristin Jarrell; Doris Auth; Steven J. Lemery; Richard Pazdur; Paul G. Kluetz; Lola A. Fashoyin-Aje
Clin Cancer Res (2023)
Translational Cancer Mechanisms and Therapy June 22 2023
Autocrine 17-β-Estradiol/Estrogen Receptor-α Loop Determines the Response to Immune Checkpoint Inhibitors in Non–Small Cell Lung Cancer
Dario P. Anobile; Iris C. Salaroglio; Fabrizio Tabbò; Sofia La Vecchia; Muhlis Akman; Francesca Napoli; Maristella Bungaro; Federica Benso; Elisabetta Aldieri; Paolo Bironzo; Joanna Kopecka; Francesco Passiglia; Luisella Righi; Silvia Novello; Giorgio V. Scagliotti; Chiara Riganti
Clin Cancer Res (2023)
Precision Medicine and Imaging June 16 2023
Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
Timothy P. DiPeri; Kurt W. Evans; Maria Gabriela Raso; Ming Zhao; Yasmeen Q. Rizvi; Xiaofeng Zheng; Bailiang Wang; Bryce P. Kirby; Kathleen Kong; Michael Kahle; Timothy A. Yap; Ecaterina E. Dumbrava; Jaffer A. Ajani; Siqing Fu; Khandan Keyomarsi; Funda Meric-Bernstam
Clin Cancer Res (2023)
Translational Cancer Mechanisms and Therapy June 7 2023
Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases
Olivia M. Lucero; Ji-Ann Lee; Jenna Bowman; Kara Johnson; Gopal Sapparapu; John K. Thomas; Guang Fan; Bill H. Chang; Karina Thiel-Klare; Christopher A. Eide; Craig Okada; Mike Palazzolo; Evan Lind; Yoko Kosaka; Brian J. Druker; Nicholas Lydon; Peter M. Bowers
Clin Cancer Res (2023)
CCR Drug Updates June 7 2023
FDA Approval Summary: Mirvetuximab Soravtansine-Gynx for FRα-Positive, Platinum-Resistant Ovarian Cancer
Asma Dilawari; Mirat Shah; Gwynn Ison; Haley Gittleman; Mallorie H. Fiero; Ankit Shah; Salaheldin S. Hamed; Junshan Qiu; Jingyu Yu; Wimolnut Manheng; Tiffany K. Ricks; Rajan Pragani; Arulvathani Arudchandran; Paresma Patel; Shadia Zaman; Arpita Roy; Shyam Kalavar; Soma Ghosh; William F. Pierce; Nam Atiqur Rahman; Shenghui Tang; Bronwyn D. Mixter; Paul G. Kluetz; Richard Pazdur; Laleh Amiri-Kordestani
Clin Cancer Res (2023)
Clinical Trials: Immunotherapy June 2 2023
Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency
Anirban Das; Uri Tabori; Lauren C. Sambira Nahum; Natalie B. Collins; Rebecca Deyell; Rina Dvir; Cecile Faure-Conter; Timothy E. Hassall; Jane E. Minturn; Melissa Edwards; Elissa Brookes; Vanessa Bianchi; Adrian Levine; Simone C. Stone; Sumedha Sudhaman; Santiago Sanchez Ramirez; Ayse B. Ercan; Lucie Stengs; Jill Chung; Logine Negm; Gad Getz; Yosef E. Maruvka; Birgit Ertl-Wagner; Pamela S. Ohashi; Trevor Pugh; Cynthia Hawkins; Eric Bouffet; Daniel A. Morgenstern
Clin Cancer Res (2023)
Translational Cancer Mechanisms and Therapy May 12 2023
Uncoupling CD4+ TIL-Mediated Tumor Killing from JAK-Signaling in Melanoma
Arianna Draghi; Mario Presti; Agnete W.P. Jensen; Christopher A. Chamberlain; Benedetta Albieri; Anne-Christine K. Rasmussen; Mads H. Andersen; Michael D. Crowther; Inge Marie Svane; Marco Donia
Clin Cancer Res (2023)
Biology of Human Tumors July 25 2016
GRM1 is An Androgen-Regulated Gene and its Expression Correlates with Prostate Cancer Progression in Pre-Clinical Models
Mojgan Shourideh; Gissou Azabdaftari; Kristopher Attwood; Adam DePriest; Kristine M Wadosky; Bryan M Gillard; Ellen Karasik; Hannelore Heemers; Natasha Kyprianou; Irwin H. Gelman; Eva Corey; Robert L Vessella; James L. Mohler; Shahriar Koochekpour
Clin Cancer Res clincanres.0137.2016.
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