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Research Article March 14 2025
Protein profiles predict treatment responses to the PI3K inhibitor umbralisib in patients with chronic lymphocytic leukemia
Yanping Yin; Haifeng Xu; Liye He; Jennifer R. Brown; Anthony R. Mato; Tero Aittokallio; Sigrid S. Skånland
Clin Cancer Res (2025)
CCR Translations March 14 2025
Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy
Clin Cancer Res (2025)
Clinical Trials: Targeted Therapy March 14 2025
177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study
Hao Fu; Jingxiong Huang; Liang Zhao; Yuhang Chen; Weizhi Xu; Jiayu Cai; Lingyu Yu; Yizhen Pang; Wei Guo; Bishan Su; Long Sun; Hua Wu; Jingjing Zhang; Xiaoyuan Chen; Haojun Chen
Clin Cancer Res (2025)
Research Article March 13 2025
Mutational Landscape of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Association with Immune Checkpoint Inhibitor Outcome
Patricia McCoon; Ying Wang; Zhongwu Lai; Qu Zhang; Weimin Li; Sophie Wildsmith; Nassim Morsli; Rajiv Raja; Nicholas Holoweckyj; Jill Walker; Melissa de los Reyes; Ricard Mesía; Lisa Licitra; Robert L. Ferris; Jérôme Fayette; Dan P. Zandberg; Lillian L. Siu; Robert Haddad
Clin Cancer Res (2025)
Research Article March 12 2025
Validation of Diagnostic Utility of Washout CYFRA 21-1 in Lymph Node Metastasis of Thyroid Cancer
Jeongmin Lee; Yuri Shin; Jeongun Kwak; Hye Lim Park; Sohee Lee; Mee Kyung Kim; Ja Seong Bae; Chan Kwon Jung; So Lyung Jung; Jung-Min Lee; Sang-Ah Chang; Dong-Jun Lim
Clin Cancer Res (2025)
Perspective March 12 2025
Update on Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome
Maria Isabel Achatz; Anita Villani; Alison A. Bertuch; Gaëlle Bougeard; Vivian Y. Chang; Andrea S. Doria; Bailey Gallinger; Lucy A. Godley; Mary-Louise C. Greer; Junne Kamihara; Payal P. Khincha; Wendy K. Kohlmann; Christian P. Kratz; Suzanne P. MacFarland; Luke D. Maese; Kara N. Maxwell; Sarah G. Mitchell; Yoshiko Nakano; Stefan M. Pfister; Jonathan D. Wasserman; Emma R. Woodward; Judy E. Garber; David Malkin
Clin Cancer Res (2025)
Research Article March 11 2025
Adjuvant Aspirin Treatment in PIK3CA Mutated Colon Cancer Patients: The SAKK 41/13 - Prospective Randomized Placebo-Controlled Double-Blind Trial
Ulrich Güller; Stefanie Hayoz; Daniel Horber; Wolfram Jochum; Sara De Dosso; Dieter Koeberle; Sabina Schacher; Roman Inauen; Michael Stahl; Thierry Delaunoit; Thomas Ettrich; György Bodoky; Pierre Michel; Thibaud Koessler; Karin Rothgiesser; Sandra Calmonte; Markus Joerger
Clin Cancer Res (2025)
Research Article March 11 2025
A phase II trial of Naxitamab plus stepped-up dosing of GM-CSF for patients with high-risk neuroblastoma in first complete remission
Brian H. Kushner; Shakeel Modak; Audrey Mauguen; Ellen M. Basu; Kim Kramer; Stephen S. Roberts; Irene Y. Cheung; Nai-Kong V. Cheung
Clin Cancer Res (2025)
Precision Medicine and Imaging March 11 2025
Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy
Anil P. Bidkar; Robin Peter; Anju Wadhwa; Kondapa Naidu Bobba; Scott Bidlingmaier; Niranjan Meher; Jonathan Chou; Nancy Greenland; Chandrashekhar Dasari; Shubhankar Naik; Athira Raveendran; Megha Basak; Juan Antonio Camara Serrano; Veronica Steri; Scott Kogan; Adam Oskowitz; Jiang He; David M. Wilson; Rahul Aggarwal; Renuka Sriram; Henry F. VanBrocklin; Youngho Seo; Bin Liu; Robert R. Flavell
Clin Cancer Res (2025)
Clinical Trials: Targeted Therapy March 11 2025
Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer
Kristen K. Ciombor; Seong-Woo Bae; Jennifer G. Whisenant; Gregory D. Ayers; Quanhu Sheng; Todd E. Peterson; Gary T. Smith; Kangyu Lin; Saikat Chowdhury; Preeti Kanikarla Marie; Alexey Sorokin; Allison S. Cohen; Laura W. Goff; Dana B. Cardin; John Paul Shen; Scott Kopetz; Cathy Eng; Yu Shyr; Jordan Berlin; H. Charles Manning
Clin Cancer Res (2025)
Clinical Trials: Immunotherapy March 11 2025
AZD8701, an Antisense Oligonucleotide Targeting FOXP3 mRNA, as Monotherapy and in Combination with Durvalumab: A Phase I Trial in Patients with Advanced Solid Tumors
Lillian L. Siu; Sophie Postel-Vinay; Rafael Villanueva-Vázquez; Guillermo de Velasco; Eduardo Castanon Alvarez; Christos E. Kyriakopoulos; Melissa Johnson; Kaïssa Ouali; Stephen McMorn; Helen K. Angell; Felicia Ng; Shashank Saran; Mahdiye Bayat; Teresa Collins; Archana Roy; Arthur W. Lambert; Song Cho; Neil Miller; Michele Petruzzelli; John Stone; Christophe Massard
Clin Cancer Res (2025)
Research Article March 10 2025
Emerin Dysregulation Drives the Very-Small-Nuclear Phenotype and Lineage Plasticity that Associates with a Clinically Aggressive Subtype of Prostate Cancer
Le Zhang; Pai-Chi Teng; Karen A. Cavassani; Jasmine Wang; Catherine Grasso; Joshua Watson; Zijing Chen; Kai-Han Tu; Brenda Salumbides; Krizia Rohena-Rivera; Lilit Gevorkian; Minhyung Kim; Sungyong You; Dolores Di Vizio; Howard M. Sandler; Timothy Daskivich; Neil A. Bhowmick; Michael R. Freeman; Hsian-Rong Tseng; Jie-Fu Chen; Edwin M. Posadas
Clin Cancer Res (2025)
Research Article March 10 2025
DLK1 distinguishes subsets of NF1-associated malignant peripheral nerve sheath tumors with divergent molecular signatures
Dana K. Mitchell; Kylee Brewster; Stavriani C. Makri; Jaffar Khan; Eric A. Albright; Andrew Horvai; Henry Mang; Qingbo Lu; Shelley A. H. Dixon; Emily White; M. Reza Saadatzadeh; Khadijeh Bijangi-Vishehsaraei; Silpa Gampala; Brooke E. Hickey; Hannah Leffew; Xiaohong Li; Li Jiang; Marisa D. Ciesielski; Waylan K. Bessler; Christopher D. Collier; Aaron Cohen-Gadol; Melissa L. Fishel; Christine A. Pratilas; Karen E. Pollok; Steven P. Angus; Steven Rhodes; D. Wade. Clapp
Clin Cancer Res (2025)
Research Article March 10 2025
The spectrum of IDH- and H3-wildtype high-grade glioma subgroups occurring across teenage and young adult patient populations
Rita Pereira; Alan Mackay; Yura Grabovska; Amelia Bradley; Tabitha Bloom; James Nicoll; Delphine Boche; John Procter; Mellissa Maybury; Johanna Schagen; Liam Walker; Federico Roncaroli; Konstantina Karabatsou; Olumide Ogunbiyi; Thijs van Dalen; Jai Sidpra; Sabrina Rossi; Evelina Miele; David S. Ziegler; Zhifeng Shi; Thomas S. Jacques; Darren Hargrave; Bassel Zebian; Cristina Bleil; Joseph Yates; Emma Norton; Henry Mandeville; Antonia Creak; Liam Welsh; Lynley Marshall; Fernando Carceller; Sucheta J. Vaidya; Zita Reisz; Safa Al-Sarraj; Angela Mastronuzzi; Andrea Carai; Maria Vinci; Kathreena M. Kurian; Ho-keung Ng; Sebastian Brandner; Chris Jones; Matthew Clarke
Clin Cancer Res (2025)
Research Article March 7 2025
Radiation Dose-Volume Effects on Negative Tumor-Draining Lymph Nodes Impacted T-Cell Activation and Prognosis in Esophageal Cancer with Chemoradiotherapy
Ihsuan Tseng; Yun Chen; Dashan Ai; Zhengfei Zhu; Weixin Zhao; Min Fan; Ling Li; Hongcheng Zhu; Fangfang Li; Yang Xu; Lu Yu; Zezhou Wang; Junqi Wang; Qi Liu; Jiaying Deng; Shengnan Hao; Qingsong Fan; Jinjun Ye; Jialiang Zhou; Chaoyang Wu; Huarong Tang; Qin Lin; Jiancheng Li; Yunhai Li; Shihong Wei; Hui Luo; Jianzhong Cao; Xiangpeng Zheng; Guang Huang; Yuwei Zheng; Bo Ping; Kuaile Zhao
Clin Cancer Res (2025)
Research Article March 7 2025
Zanubrutinib plus Ixazomib and Dexamethasone in newly diagnosed symptomatic Waldenström macroglobulinemia:a phase II study
Wenjie Xiong; Yuting Yan; Tingyu Wang; Weiwei Sui; Ying Yu; Tengteng Yu; Rui Lyu; Yi Wang; Wei Liu; Huimin Liu; Gang An; Yan Xu; Wenyang Huang; Dehui Zou; Lugui Qiu; Shuhua Yi
Clin Cancer Res (2025)
Research Article March 7 2025
Targeting Acetyl-CoA Carboxylase Suppresses De Novo Lipogenesis and Tumor Cell Growth in Multiple Myeloma
Eugenio Morelli; Caroline Fidalgo. Ribeiro; Silvia D. Rodrigues; Claire Gao; Fabio Socciarelli; Domenico Maisano; Vanessa Favasuli; Na Liu; Katia Todoerti; Chandraditya Chakraborty; Yao Yao; Mariateresa Fulciniti; Mehmet Samur; Anil Aktas-Samur; Nicola Amodio; Marcello Turi; Francesca Barello; Johany Penailillo; Cesarina Giallongo; Alessandra Romano; Annamaria Gulla; Kenneth C. Anderson; Giorgio Inghirami; Nikhil C. Munshi; Massimo Loda
Clin Cancer Res (2025)
Research Article March 7 2025
Pembrolizumab in combination with binimetinib in patients with unresectable locally advanced or metastatic triple-negative breast cancer
Saranya Chumsri; Joseph J. Larson; Emily Liu; Kathleen S. Tenner; Daniel Adams; Morgan T. Weidner; Amanda N. Arnold; Dana L. Haley; Pooja Advani; Kostandinos Sideras; Alvaro Moreno-Aspitia; E. Aubrey Thompson; Edith A. Perez; Keith L. Knutson
Clin Cancer Res (2025)
Research Article March 6 2025
Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-Type Non-Small Cell Lung Cancer
Ioannis P. Trontzas; Mengni He; Anna Wurtz; Charles J. Robbins; Nathaniel Robinson; Katherine Bates; Matthew Liu; Thazin N. Aung; Liam Scott; Nay Chan; Sneha Burela; Jacob Schillo; Daniel C. Liebler; Salisha Hill; Ryan D. Morrison; Ioannis Vathiotis; Konstantinos N. Syrigos; Sarah B. Goldberg; Katerina Politi; David L. Rimm
Clin Cancer Res (2025)
Clinical Trials: Targeted Therapy March 6 2025
A Phase II Study of Abemaciclib for Patients with Retinoblastoma-Positive, Metastatic Triple-Negative Breast Cancer
Shom Goel; Bojana Jovanović; Xiangying Chu; Melissa Hughes; Timothy K. Erick; Douglas Russo; Molly DiLullo; Eileen Wrabel; Rinath Jeselsohn; Nancy U. Lin; Nabihah Tayob; Elizabeth Mittendorf; Stuart Schnitt; Sara M. Tolaney
Clin Cancer Res (2025)
Clinical Trials: Targeted Therapy March 6 2025
Olaparib, Temozolomide, and Concomitant Radiotherapy for Partially Resected or Biopsy-Only Glioblastoma First-Line Treatment: Results from the OLA-TMZ-RTE-01 Phase I Study
Dinu Stefan; Paul Lesueur; Justine Lequesne; Loic Feuvret; Charlotte Bronnimann; Marie Castéra; Pierre-Emmanuel Brachet; Ioana Hrab; Mathilde Ducloie; Joëlle Lacroix; Marie Lecornu; Grégoire Braux; François Christy; Marie-Pierre Sunyach; Elisabeth Cohen-Jonathan Moyal; William Kao; Maxime Faisant; Evelyne Emery; Jean-Michel Grellard; Francois Sichel; Carine Laurent; Maxime Fontanilles; Bénédicte Clarisse
Clin Cancer Res (2025)
Translational Cancer Mechanisms and Therapy March 6 2025
Endothelial Cell pY397-FAK Expression Predicts the Risk of Breast Cancer Recurrences after Radiotherapy in the SweBCG91-RT Cohort
Rebecca J.G. Drake; Amalia H. Landén; Erik Holmberg; Axel Stenmark Tullberg; Fredrika Killander; Emma Niméus; Alexander Jordan; Jennifer McGuinness; Per Karlsson; Kairbaan Hodivala-Dilke
Clin Cancer Res (2025)
Research Article March 5 2025
Neoadjuvant Chemotherapy with Dual Immune Checkpoint Inhibitors for Advanced-Stage Ovarian Cancer: Final Analysis of TRU-D Phase II Nonrandomized Clinical Trial
Junsik Park; Je-Gun Joung; Myong Cheol Lim; Jungbok Lee; Byoung-Gie Kim; Jae-Weon Kim; So Jin Shin; Sunghoon Kim; Eunhyang Park; Chel Hun Choi; Hee Seung Kim; Sang Yoon Park; Jung-Yun Lee
Clin Cancer Res (2025)
Research Article March 5 2025
A phase I dose escalation study of the HIF-2 alpha inhibitor DFF332 in patients with advanced clear cell renal cell carcinoma
Sumanta K. Pal; Alice Bernard-Tessier; Peter Grell; Xin Gao; Ritesh R. Kotecha; Joel Picus; Filippo de Braud; Shunji Takahashi; Alvin Wong; Cristina Suárez; Javier A. Otero; Nicole Kundamal; Xin Yang; Sherif Sharaby; Mike Roy; Patrizia Barzaghi-Rinaudo; Nizar M. Tannir
Clin Cancer Res (2025)
Clinical Trials: Targeted Therapy March 5 2025
Phase I Clinical Trial of High Doses of Seleno-L-methionine in Combination with Axitinib in Patients with Previously Treated Metastatic Clear-cell Renal Cell Carcinoma
Yousef Zakharia; Ryan J. Reis; Matthew R. Kroll; Aseel O. Rataan; Srija Manchkanti; Bilal Rahim; Rohan Garje; Umang Swami; Sarah L. Mott; K.D. Zamba; Jessica C. Sieren; Aliasger K. Salem; Youcef Rustum
Clin Cancer Res (2025)
Clinical Trials: Targeted Therapy March 5 2025
Anlotinib versus Placebo as Adjuvant Therapy for Localized High-Grade Soft-Tissue Sarcomas: A Phase II, Double-Blinded, Randomized Controlled Trial
Chunmeng Wang; Xianglin Hu; Lingge Yang; Yu Xu; Biqiang Zheng; Jilong Yang; Zhichao Liao; Zhengwang Sun; Shengjian Zhang; Lin Yu; Yan Yan; Yong Chen; Tomohiro Fujiwara; Jianrong Zhang; Ilia N. Buhtoiarov; Yangbai Sun; Wangjun Yan
Clin Cancer Res (2025)
Research Article March 4 2025
PERK+ macrophages drive immunotherapy resistance in lymph node metastases of oral squamous cell carcinoma
Wei Zhang; Jin-Bang Li; Hai-Ming Liu; Kui-Ming Wang; Bo-Lin Xiao; Yi-Man Wang; Jia-Jie Liang; Jun Zeng; Lin-Zhou Zhang; Yang-Ying-Fan Feng; Qiu-Yun Fu; Xin-Xin Wang; Yu-Tong Liu; Xiao-Xia Cheng; Jing Li; Yu-Ying Zhang; Gao Zhang; Jia-Li Zhang; Zi-Li Yu; Zhe Shao; Xue-Peng Xiong; Jun Jia; Bing Liu; Gang Chen
Clin Cancer Res (2025)
CCR Perspectives in Regulatory Science and Policy March 4 2025
Adoption of Decentralized Trial Elements in Cancer Clinical Trials Supporting FDA Approvals During COVID-19
Timil H. Patel; Amy Corneli; Pamela Balcazar; Craig Lipset; Sara B. Calvert; Sabrena Mervin-Blake; Vinit Nalawade; Paul G. Kluetz
Clin Cancer Res (2025)
Precision Medicine and Imaging March 4 2025
Impact of Race/Ethnicity on Clinical and Genomic Characteristics, Trial Participation, and Genotype-Matched Therapy among Patients with Metastatic Breast Cancer
Rupali Sood; Andrzej Niemierko; Lianne Ryan; Laura Spring; Beverly Moy; Aditya Bardia; Neelima Vidula
Clin Cancer Res (2025)
Translational Cancer Mechanisms and Therapy March 4 2025
BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
Prashanta Kumar Panda; Ana Carolina Paschoalini Mafra; Alliny C.S. Bastos; Li Cao; Maria Serra Bonet; Caitlyn B. Brashears; Ethan Yang Chen; Heather M. Benedict-Hamilton; William Ehrhardt; John Bomalaski; Carina Dehner; Leonard C. Rogers; Toshinao Oyama; Brian A. Van Tine
Clin Cancer Res (2025)
Research Article March 3 2025
XMT-2056, a HER2-Directed STING Agonist Antibody-Drug Conjugate, Induces Innate Anti-Tumor Immune Responses by Acting on Cancer Cells and Tumor-Resident Immune Cells
Raghida A. Bukhalid; Jeremy R. Duvall; Kelly Lancaster; Kalli C. Catcott; Naniye Malli Cetinbas; Travis Monnell; Caitlin Routhier; Joshua D. Thomas; Keith W. Bentley; Scott D. Collins; Elizabeth Ditty; Timothy K. Eitas; Eugene W. Kelleher; Pamela Shaw; Jahna Soomer-James; Elena Ter-Ovanesyan; Ling Xu; Jeffrey Zurita; Dorin Toader; Marc Damelin; Timothy B. Lowinger
Clin Cancer Res (2025)
Research Article March 3 2025
Single cell RNA-sequencing of Ewing sarcoma tumors demonstrates transcriptional heterogeneity and clonal evolution
Andrew Goodspeed; Avery Bodlak; Alexis B. Duffy; Sarah Nelson-Taylor; Naoki Oike; Timothy Porfilio; Ryota Shirai; Deandra Walker; Amy Treece; Jennifer Black; Nathan Donaldson; Carrye Cost; Tim Garrington; Brian Greffe; Sandra Luna-Fineman; Jenna Demedis; Jessica Lake; Etienne P. Danis; Michael Verneris; Daniel L. Adams; Masanori Hayashi
Clin Cancer Res (2025)
Precision Medicine and Imaging March 3 2025
Predicting c-KIT Inhibitor Efficacy in Patient-Derived Models of Sinonasal Mucosal Melanomas through Integrated Histogram Analysis of Whole-Tumor DKI, IVIM, and DCE-MRI
Cong Wang; Xuewei Niu; Tianyi Xia; Peng Wang; Yuzhe Wang; Zhongshuai Zhang; Jianyuan Zhang; Shenghong Ju; Zebin Xiao
Clin Cancer Res (2025)
Perspective March 3 2025
Update on Cancer and Central Nervous System Tumor Surveillance in Pediatric NF2-, SMARCB1-, and LZTR1-Related Schwannomatosis
Melissa R. Perrino; Marjolijn C.J. Jongmans; Gail E. Tomlinson; Mary-Louise C. Greer; Sarah R. Scollon; Sarah G. Mitchell; Jordan R. Hansford; Kris Ann P. Schultz; Wendy K. Kohlmann; Jennifer M. Kalish; Suzanne P. MacFarland; Anirban Das; Kara N. Maxwell; Stefan M. Pfister; Rosanna Weksberg; Orli Michaeli; Uri Tabori; Gina M. Ney; Philip J. Lupo; Jack J. Brzezinski; Douglas R. Stewart; Emma R. Woodward; Christian P. Kratz
Clin Cancer Res (2025)
Translational Cancer Mechanisms and Therapy March 3 2025
Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone
Chun-Lung Chiu; Dalin Zhang; Hongjuan Zhao; Yi Wei; Alexandra Lapat Polasko; Mikkel Thy Thomsen; Vanessa Yang; Kasie Kexin Yang; Spencer Hauck; Eric E. Peterson; Ru M. Wen; Zhengyuan Qiu; Eva Corey; Yu Rebecca Miao; Erinn B. Rankin; Donna M. Peehl; Jiaoti Huang; Amato J. Giaccia; James D. Brooks
Clin Cancer Res (2025)
Research Article February 28 2025
Germline-Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking ATM to TP53 Synthetic Essentiality
Ali T. Arafa; Siddhartha Yadav; Catherine H. Marshall; Elizabeth Mauer; Minxuan Huang; Binyam Yilma; Ymke van der Pol; Stamatina Fragkogianni; Emily A. Teslow; Samuel Kellen; Ella Boytim; Christine Luo; Megan Ludwig; Weijie Zhang; Arockia Jayaraj; Deborah K. Armstrong; William B. Isaacs; Justin M. Drake; Hai Dang Nguyen; R. Stephanie Huang; Calvin Y. Chao; Emil Lou; Scott M. Dehm; Fergus J. Couch; Justin H. Hwang; Emmanuel S. Antonarakis
Clin Cancer Res (2025)
Research Article February 28 2025
Health-related quality of life in patients with HR+/HER2− early breast cancer treated with ribociclib plus a nonsteroidal aromatase inhibitor: results from the NATALEE trial
Peter A. Fasching; Dennis Slamon; Zbigniew Nowecki; Bozena Kukielka-Budny; Daniil Stroyakovskiy; Denise A. Yardley; Chiun-Sheng Huang; Arlene Chan; Stephen Chia; Miguel Martín; Hope S. Rugo; Sherene Loi; Sara Hurvitz; Michael Untch; Karen Afenjar; Rodrigo Fresco; Andriy Danyliv; Ilia Ferrusi; Zheng Li; Gabriel Hortobagyi
Clin Cancer Res (2025)
Research Article February 28 2025
Phase II trial of atezolizumab and bevacizumab for treatment of HPV-positive unresectable or metastatic squamous cell carcinoma of the anal canal
Van K. Morris; Suyu Liu; Kangyu Lin; Haifeng Zhu; Seema Prasad; Armeen Mahvash; Priya Bhosale; Baohua Sun; Edwin R. Parra; Ignacio Wistuba; Arjun Peddireddy; James Yao; Julia Mendoza-Perez; Mark Knafl; Scott E. Woodman; Cathy Eng; Daniel Halperin
Clin Cancer Res (2025)
CCR Perspectives in Regulatory Science and Policy February 28 2025
Integrating Botanicals into Oncology Care: Consideration of FDA Regulation of Botanical Products and Botanical Clinical Trials
Clin Cancer Res (2025)
Research Article February 28 2025
Personalized tumor-specific amplified DNA junctions in peripheral blood of patients with glioblastoma
Mohamed F. Ali; Cecile Riviere-Cazaux; Sarah H. Johnson; Rebecca Salvatori; Alan R. Penheiter; James B. Smadbeck; Stephen J. Murphy; Faye R. Harris; Lex F. McCune; Lucas P. Carlstrom; Michael T. Barrett; Farhad Kosari; Leila A. Jones; Cristiane Ida; Mitesh J. Borad; Bernard R. Bendok; Alfredo Quiñones-Hinojosa; Alyx B. Porter; Maciej M. Mrugala; Kurt A. Jaeckle; Panos Z. Anastasiadis; Sani H. Kizilbash; John C. Cheville; David M. Routman; Terry C. Burns; George Vasmatzis
Clin Cancer Res (2025)
CCR Translations February 28 2025
Biomarkers of Radioresistance in Head and Neck Cancer: A New Beginning
Clin Cancer Res (2025)
Precision Medicine and Imaging February 28 2025
Corticosteroid-Dependent Association between Prognostic Peripheral Blood Cell-Free DNA Levels and Neutrophil-Mediated NETosis in Patients with Glioblastoma
Jacob E. Till; Nicholas J. Seewald; Zachariya Yazdani; Zhuoyang Wang; Dominique Ballinger; Heather Samberg; Siri Dandu; Camilla Macia; Melinda Yin; Aseel Abdalla; Timothy Prior; Shivani S. Shah; Thara Patel; Emily McCoy; Maikel Mansour; Carson A. Wills; Veronica Bochenek; Jonathan Serrano; Matija Snuderl; Richard E. Phillips; Donald M. O’Rourke; Nduka M. Amankulor; Ali Nabavizadeh; Arati S. Desai; Kandace Gollomp; Zev A. Binder; Wanding Zhou; Stephen J. Bagley; Erica L. Carpenter
Clin Cancer Res (2025)
Clinical Trials: Immunotherapy February 28 2025
Intratumoral or Subcutaneous MK-2118, a Noncyclic Dinucleotide STING Agonist, with or without Pembrolizumab, for Advanced or Metastatic Solid Tumors or Lymphomas
Jason J. Luke; Randy F. Sweis; J. Randolph Hecht; Reva Schneider; Mark N. Stein; Talia Golan; Timothy A. Yap; Anuradha Khilnani; Mo Huang; Runchen Zhao; Thomas Jemielita; Sandip Pravin Patel
Clin Cancer Res (2025)
Translational Cancer Mechanisms and Therapy February 28 2025
Patient-Derived Organoids and Xenografts Uncover Therapeutic Vulnerabilities in Colorectal Signet Ring Cell Carcinomas
Nazia Chaudhary; Alessandro La Ferlita; Bhagya Shree Choudhary; Eeshrita Jog; Mufaddal Kazi; Showket Yahya; Afiya Dalwai; Vikas Ostwal; Satishkumar Singh; Siddhi Redkar; Nileema Khapare; Vaishali Kailaje; Akshaya B; Poonam Gera; Munita Bal; Nandini Verma; Rahul Thorat; Avanish Saklani; Lalit Sehgal; Sorab N. Dalal
Clin Cancer Res (2025)
Perspective February 27 2025
Revolutionizing Patient Reported Outcomes Analysis for Oncology Drug Development Using Population Models
Clin Cancer Res (2025)
Clinical Trials: Immunotherapy February 27 2025
First-in-Human Phase I Study of a CD16A Bispecific Innate Cell Engager, AFM24, Targeting EGFR-Expressing Solid Tumors
Anthony El-Khoueiry; Omar Saavedra; Jacob Thomas; Claire Livings; Elena Garralda; Gabriele Hintzen; Laura Kohlhas; Dessislava Vanosmael; Joachim Koch; Erich Rajkovic; Paulien Ravenstijn; Paolo Nuciforo; Todd A. Fehniger; Mark Foster; Melissa M. Berrien-Elliott; Susanne Wingert; Sina Stäble; Daniela Morales-Espinosa; Delcia Rivas; Michael Emig; Juanita Lopez
Clin Cancer Res (2025)
Research Briefs: Precision Medicine and Therapeutics February 27 2025
Human Epidermal Growth Factor Receptor 2 Loss following Treatment with Trastuzumab Deruxtecan in Patients with Metastatic Breast Cancer
Mohamed A. Gouda; Amrit Gonugunta; Ecaterina E. Dumbrava; Timothy A. Yap; Jordi Rodon; Sarina A. Piha-Paul; Paula R. Pohlmann; Senthil Damodaran; Rashmi Murthy; Vicente Valero; Jason A. Mouabbi; Debasish Tripathy; Aysegul A. Sahin; Hui Chen; Funda Meric-Bernstam
Clin Cancer Res (2025)
Precision Medicine and Imaging February 26 2025
Characterization of Plasma Cell-Free DNA Variants as of Tumor or Clonal Hematopoiesis Origin in 16,812 Advanced Cancer Patients
Daniel Magee; Valeriy Domenyuk; Jim Abraham; Nieves Perdigones Borderias; Jeff Swensen; Praveena Solipuram; Adanma Ayanambakkam; Raja Mehdi; Jagathi Challagalla; Elisabeth Heath; Megan Landsverk; Magdalena Jurkiewicz; Brian Shimkus; Ian Pinto; Daniel Patterson; David Hsiehchen; Supriya Koya; Bradley Somer; Michel Velez; Anthony F. Shields; Jennifer Cultrera; Jennifer R. Ribeiro; Robert Hahn-Lowry; George W. Sledge; Matthew Oberley; Milan Radovich; David Spetzler
Clin Cancer Res (2025)
Clinical Trials: Targeted Therapy February 26 2025
Cladribine Added to Idarubicin and Cytarabine as an Induction Regimen for Patients with De Novo Acute Myeloid Leukemia: A Multicenter, Randomized Phase III Trial
Xiang Zhang; Yue Han; Huiying Qiu; Miaoxinqi Han; Aining Sun; Shengli Xue; Zhengming Jin; Miao Miao; Ying Wang; Chengcheng Fu; Xiaowen Tang; Suning Chen; Caixia Li; Lian Bai; Zhihong Lin; Jun Chen; Haohao Han; Jia Chen; Depei Wu
Clin Cancer Res (2025)
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