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Research Article May 24 2022
Selinexor combined with ibrutinib demonstrates tolerability and safety in advanced B-cell malignancies: A phase I study
Deborah M. Stephens; Ying Huang; Amy S. Ruppert; Janek S. Walker; Daniel Canfield; Casey B. Cempre; Qiang Fu; Sharyn Baker; Boyu Hu; Harsh Shah; Renee Vadeboncoeur; Kerry A. Rogers; Seema Bhat; Samantha M. Jaglowski; Hank Lockman; Rosa Lapalombella; John C. Byrd; Jennifer A. Woyach
Clin Cancer Res clincanres.3867.2021.
Article Commentary May 24 2022
Trials, tribunals, and opportunities for lung cancer KRASG12C brain metastases
Clin Cancer Res clincanres.1137.2022.
Research Article May 24 2022
Replication of Overall Survival, Progression-Free Survival, and Overall Response in Chemotherapy Arms of Non–Small Cell Lung Cancer Trials Using Real-World Data
Thanh G.N. Ton; Navdeep Pal; Huong Trinh; Sami Mahrus; Michael T. Bretscher; Robson J.M. Machado; Natalia Sadetsky; Nayan Chaudhary; Michael W. Lu; Gregory J. Riely
Clin Cancer Res (2022)
Research Article May 23 2022
CUB domain containing protein 1 (CDCP1) is a target for radioligand therapy in castration resistant prostate cancer including PSMA null disease
Ning Zhao; Shalini Chopra; Kai Trepka; Yung-hua Wang; Sasank Sakhamuri; Nima Hooshdaran; Hyunjung Kim; Jie Zhou; Kevin K. Leung; Emily A. Egusa; Jun Zhu; Li Zhang; Adam Foye; Renuka Sriram; Emily Chan; Youngho Seo; Felix Y. Feng; Eric J. Small; Jonathan Chou; James A. Wells; Rahul Aggarwal; Michael J. Evans
Clin Cancer Res clincanres.3858.2021-11-1 14:03:07.837.
Research Article May 23 2022
All About That Ras: Novel Fusion Drives Ras Pathway Activation in Lung Cancer
Clin Cancer Res (2022)
Review Article May 23 2022
Data-Rich Spatial Profiling of Cancer Tissue: Astronomy Informs Pathology
Clin Cancer Res (2022)
Research Article May 20 2022
Enhancing Radioiodine Incorporation Into Radio Iodine Refractory Thyroid Cancer With MAPK Inhibition (ERRITI): A Single-Center Prospective Two-Arm Study
Manuel Weber; David Kersting; Burkhard Riemann; Tim Brandenburg; Dagmar Führer-Sakel; Frank Grünwald; Michael C. Kreissl; Henning Dralle; Frank Weber; Kurt Werner. Schmid; Ken Herrmann; Walter Jentzen; Hong Grafe; Christoph Rischpler; Sarah Theurer; Andreas Bockisch; James Nagarajah; Wolfgang P. Fendler
Clin Cancer Res clincanres.0437.2022-2-9 05:28:38.980.
Research Article May 20 2022
Circulating tumor DNA-based MRD assessment in patients with CLL treated with obinutuzumab, acalabrutinib and venetoclax
Moritz Fürstenau; Jonathan Weiss; Adam Giza; Fabian Franzen; Sandra Robrecht; Anna-Maria Fink; Kirsten Fischer; Christof Schneider; Eugen Tausch; Stephan Stilgenbauer; Matthias Ritgen; Anke Schilhabel; Monika Brüggemann; Barbara Eichhorst; Michael Hallek; Paula Cramer
Clin Cancer Res clincanres.0433.2022-2-8 15:40:23.327.
Review Article May 20 2022
Cancer Immunoediting in the Era of Immuno-oncology
Clin Cancer Res clincanres.1804.2022.
Research Article May 20 2022
Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma
Virginia Aragon-Sanabria; Anusha Aditya; Li Zhang; Feng Chen; Barney Yoo; Tianye Cao; Brian Madajewski; Rachel Lee; Melik Z. Turker; Kai Ma; Sebastien Monette; Peiming Chen; Jing Wu; Shutian Ruan; Michael Overholtzer; Pat Zanzonico; Charles M. Rudin; Cameron Brennan; Ulrich Wiesner; Michelle S. Bradbury
Clin Cancer Res (2022)
Research Article May 20 2022
Safety and Activity of PolyPEPI1018 Combined with Maintenance Therapy in Metastatic Colorectal Cancer: an Open-Label, Multicenter, Phase Ib Study
Joleen M. Hubbard; Enikő R. Tőke; Roberto Moretto; Rondell P. Graham; Hagop Youssoufian; Orsolya Lőrincz; Levente Molnár; Zsolt Csiszovszki; Jessica L. Mitchell; Jaclynn Wessling; József Tóth; Chiara Cremolini
Clin Cancer Res (2022)
Research Article May 20 2022
Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Patients with Relapsed Ewing Sarcoma: Results of a Basket Phase II Study
Vivek Subbiah; Irene Braña; Alessandra Longhi; Valentina Boni; Jean-Pierre Delord; Ahmad Awada; Pascaline Boudou-Rouquette; John Sarantopoulos; Geoffrey I. Shapiro; Anthony Elias; Ravin Ratan; Cristian Fernandez; Carmen Kahatt; Martin Cullell-Young; Mariano Siguero; Ali Zeaiter; Sant P. Chawla
Clin Cancer Res (2022)
Article Commentary May 19 2022
War Against NRAS-mutant Melanoma Using Targeted Therapies Remains Challenging
Clin Cancer Res clincanres.1256.2022.
Article Commentary May 19 2022
Hostile Takeover: Tregs expand in IFN-γ-rich AML microenvironment
Clin Cancer Res clincanres.1030.2022.
Research Article May 18 2022
Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition
John D. Martin; Ryan M. Lanning; Vikash P. Chauhan; Margaret R. Martin; Ahmed S. Mousa; Walid S. Kamoun; Hee-Sun Han; Hang Lee; Triantafyllos Stylianopoulos; Moungi G. Bawendi; Dan G. Duda; Edward B. Brown; Timothy P. Padera; Dai Fukumura; Rakesh K. Jain
Clin Cancer Res clincanres.0486.2022.
Research Article May 18 2022
VERONICA: Randomized Phase 2 Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors - Efficacy, Safety, Biomarker Results
Geoffrey J. Lindeman; Tharu M. Fernando; Rebecca Bowen; Katarzyna J. Jerzak; Xinni Song; Thomas Decker; Frances Boyle; Steven McCune; Anne Armstrong; Catherine Shannon; Gianfilippo Bertelli; Ching-Wei Chang; Rupal Desai; Kushagra Gupta; Timothy R. Wilson; Aulde Flechais; Aditya Bardia
Clin Cancer Res clincanres.3811.2021.
Research Article May 18 2022
Phase II clinical trial of Eribulin-gemcitabine combination therapy in previously treated patients with advanced liposarcoma or leiomyosarcoma
Chang Gon Kim; Nam Suk Sim; Jeong Eun Kim; Kum-Hee Yun; Young Han Lee; Seung Hyun Kim; Wooyeol Baek; Yoon Dae Han; Sang Kyum Kim; Jee Hung Kim; Yoon Woo Koh; Inkyung Jung; Su-Jin Shin; Sun Young Rha; Jin-Hee Ahn; Hyo Song Kim
Clin Cancer Res clincanres.CCR-22-0518-E.2022.
Research Article May 18 2022
Phenotypic composition of commercial anti-CD19 CAR-T cells affects in vivo expansion and disease response in large B-cell lymphoma patients
Chiara Monfrini; Federico Stella; Vanessa Aragona; Martina Magni; Silva Ljevar; Cristina Vella; Eugenio Fardella; Annalisa Chiappella; Francesca Nanetti; Martina Pennisi; Anna Dodero; Anna Guidetti; Paolo Corradini; Cristiana Carniti
Clin Cancer Res clincanres.0164.2022.
Research Article May 18 2022
Overcoming Taxane Resistance: Preclinical and Phase 1 Studies of Relacorilant, a Selective Glucocorticoid Receptor Antagonist, with Nab-Paclitaxel in Solid Tumors
Pamela N. Munster; Andrew E. Greenstein; Gini F. Fleming; Erkut Borazanci; Manish R. Sharma; Joseph M. Custodio; Iulia Cristina Tudor; Hristina I. Pashova; Stacie Peacock Shepherd; Andreas Grauer; Jasgit C. Sachdev
Clin Cancer Res clincanres.4363.2021.
Research Article May 18 2022
Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL
Patrick R. Hagner; Hsiling Chiu; Vivek S. Chopra; Martino Colombo; Nisha Patel; Maria Ortiz Estevez; Michelle F. Waldman; Remco Loos; Fadi Towfic; Anita K. Gandhi
Clin Cancer Res clincanres.3347.2021.
Review Article May 18 2022
RNA in cancer immunotherapy: unlocking the potential of the immune system
Clin Cancer Res clincanres.3304.2022.
Review Article May 17 2022
Molecular Pathways and Mechanisms of LAG-3 in Cancer Therapy
Lawrence P. Andrews; Anthony R. Cillo; Lilit Karapetyan; John M. Kirkwood; Creg J. Workman; Dario A.A. Vignali
Clin Cancer Res clincanres.2390.2022.
Research Article May 17 2022
Autologous Nanobody-Derived Fratricide-Resistant CD7-CAR T-cell Therapy for Patients with Relapsed and Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma
Mingzhi Zhang; Dan Chen; Xiaorui Fu; Huimin Meng; Feifei Nan; Zhenchang Sun; Hui Yu; Lei Zhang; Ling Li; Xin Li; Xinhua Wang; Min Wang; Fengtao You; Zhaoming Li; Yu Chang; Zhiyuan Zhou; Jiaqin Yan; Jiwei Li; Xiaolong Wu; Yu Wang; Yinyan Wang; Shufen Xiang; YuSheng Chen; Guifang Pan; Hanying Xu; Bozhen Zhang; Lin Yang
Clin Cancer Res (2022)
Research Article May 17 2022
Phase IB Study of GITR Agonist Antibody TRX518 Singly and in Combination with Gemcitabine, Pembrolizumab, or Nivolumab in Patients with Advanced Solid Tumors
Diwakar Davar; Roberta Zappasodi; Hong Wang; Girish S. Naik; Takami Sato; Todd Bauer; David Bajor; Olivier Rixe; Walter Newman; Jingjing Qi; Aliya Holland; Phillip Wong; Lianna Sifferlen; Diane Piper; Cynthia A. Sirard; Taha Merghoub; Jedd D. Wolchok; Jason J. Luke
Clin Cancer Res (2022)
Research Article May 17 2022
A Phase Ib/II Study of Sabizabulin, a Novel Oral Cytoskeleton Disruptor, in Men with Metastatic Castration-resistant Prostate Cancer with Progression on an Androgen Receptor–targeting Agent
Mark C. Markowski; Ronald Tutrone; Christopher Pieczonka; K. Gary Barnette; Robert H. Getzenberg; Domingo Rodriguez; Mitchell S. Steiner; Daniel R. Saltzstein; Mario A. Eisenberger; Emmanuel S. Antonarakis
Clin Cancer Res (2022)
Research Article May 17 2022
The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma
Shuang Ma; Ryan Kanai; Ajaybabu V. Pobbati; Shuo Li; Kepeng Che; Caleb N. Seavey; Andrea Hallett; Ashley Burtscher; John M. Lamar; Brian P. Rubin
Clin Cancer Res (2022)
Research Article May 17 2022
Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer
Clin Cancer Res (2022)
Research Article May 16 2022
Detection of Occult Recurrence Using Circulating Tumor Tissue Modified Viral HPV DNA among patients treated for HPV-driven Oropharyngeal Carcinoma
Barry M. Berger; Glenn J. Hanna; Marshall R. Posner; Eric M. Genden; Julio Lautersztain; Stephen P. Naber; Catherine Del Vecchio Fitz; Charlotte Kuperwasser
Clin Cancer Res clincanres.0562.2022.
Research Article May 16 2022
Telaglenastat Plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 ENTRATA Trial
Chung-Han Lee; Robert Motzer; Hamid Emamekhoo; Marc Matrana; Ivor Percent; James J. Hsieh; Arif Hussain; Ulka Vaishampayan; Sandy Liu; Steven McCune; Vijay Patel; Montaser Shaheen; Johanna Bendell; Alice C. Fan; Benjamin A. Gartrell; Oscar B. Goodman; Petros G. Nikolinakos; Arash Rezazadeh. Kalebasty; Yousef Zakharia; Zhentao Zhang; Hema Parmar; Lalith Akella; Keith Orford; Nizar M. Tannir
Clin Cancer Res clincanres.0061.2022.
Article Commentary May 16 2022
PD-1 inhibition - trouble for subsequent TIL therapy in patients with melanoma?
Clin Cancer Res clincanres.0832.2022.
Research Article May 12 2022
Overall Survival With Palbociclib And Fulvestrant in Women With HR+/HER2- ABC: Updated Exploratory Analyses of PALOMA-3, a Double-Blind, Phase 3 Randomized Study
Massimo Cristofanilli; Hope S. Rugo; Seock-Ah Im; Dennis J. Slamon; Nadia Harbeck; Igor Bondarenko; Norikazu Masuda; Marco Colleoni; Angela DeMichele; Sherene Loi; Hiroji Iwata; Ben O'Leary; Fabrice André; Sibylle Loibl; Eustratios Bananis; Yuan Liu; Xin Huang; Sindy Kim; Maria Jose. Lechuga Frean; Nicholas C. Turner
Clin Cancer Res clincanres.0305.2022.
Research Article May 12 2022
Safety and efficacy of irradiation boost based on 18F-FET-PET in patients with newly diagnosed glioblastoma
Maciej Harat; Maciej Blok; Izabela Miechowicz; Izabela Wiatrowska; Karolina Makarewicz; Bogdan Małkowski
Clin Cancer Res clincanres.0171.2022.
Research Article May 12 2022
Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration Resistant Prostate Cancer
Ilsa M. Coleman; Navonil DeSarkar; Colm Morrissey; Li Xin; Martine P. Roudier; Erolcan Sayar; Dapei Li; Eva Corey; Michael C. Haffner; Peter S. Nelson
Clin Cancer Res clincanres.4289.2021.
Research Article May 12 2022
Initial phase I safety study of gedatolisib plus cofetuzumab pelidotin for patients with metastatic triple-negative breast cancer
Milan Radovich; Jeffrey P. Solzak; Chao Jack. Wang; Bradley A. Hancock; Sunil S. Badve; Sandra K. Althouse; Steven M. Bray; Anna Maria. Storniolo; Tarah J. Ballinger; Bryan P. Schneider; Kathy D. Miller
Clin Cancer Res clincanres.3078.2021.
Research Article May 12 2022
Translocon-associated protein subunit SSR3 determines and predicts susceptibility to paclitaxel in breast cancer and glioblastoma
Crismita Dmello; Aarón Sonabend; Victor A. Arrieta; Daniel Y. Zhang; Deepak Kanojia; Li Chen; Andrew Gould; Jiangshan Zhang; Seong Jae Kang; Jan Winter; Craig Horbinski; Christina Amidei; Balázs Győrffy; Alex Cordero; Catalina Lee-Chang; Brandyn Castro; Patrick Hsu; Atique U. Ahmed; Maciej S. Lesniak; Roger Stupp; Adam M. Sonabend
Clin Cancer Res clincanres.2563.2021.
Research Article May 12 2022
Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction
Mojun Zhu; Chunhua Chen; Nathan R. Foster; Christopher Hartley; Taofic Mounajjed; Marcela A. Salomao; Briant F. Fruth; Staci E. Beamer; Yohan Kim; Susan M. Harrington; Henry C. Pitot; Cristobal T. Sanhueza; Yening Feng; Joerg Hermann; Robert R. McWilliams; Fabrice Lucien; Bing Q. Huang; Wen Wee Ma; Tanios S. Bekaii-Saab; Haidong Dong; Dennis Wigle; Daniel H. Ahn; Chris L. Hallemeier; Shanda Blackmon; Harry H. Yoon
Clin Cancer Res clincanres.0413.2022.
Research Article May 12 2022
Prostate Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer
Beshara Sheehan; Antje Neeb; Lorenzo Buroni; Alec Paschalis; Ruth Riisnaes; Bora Gurel; Veronica Gil; Susana Miranda; Mateus Crespo; Christina Guo; Juan Jiménez Vacas; Ines Figueiredo; Ana Ferreira; Jon Welti; Wei Yuan; Suzanne Carreira; Adam Sharp; Johann de Bono
Clin Cancer Res clincanres.4531.2021.
Review Article May 12 2022
A road map for designing phase I clinical trials of radiotherapy-novel agent combinations
Sarah R. Brown; Samantha Hinsley; Emma Hall; Chris Hurt; Richard D. Baird; Martin Forster; Andrew F. Scarsbrook; Richard A. Adams
Clin Cancer Res clincanres.4087.2021.
Research Article May 12 2022
Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer
Min Liu; Nabihah Tayob; Livius Penter; MacLean Sellars; Anna Tarren; Vipheaviny Chea; Isabel Carulli; Teddy Huang; Shuqiang Li; Su-Chun Cheng; Phuong Le; Laura Frackiewicz; Julia Fasse; Courtney Qi; Joyce F. Liu; Elizabeth H. Stover; Jennifer Curtis; Kenneth J. Livak; Donna Neuberg; Guanglan Zhang; Ursula A. Matulonis; Catherine J. Wu; Derin B. Keskin; Panagiotis A. Konstantinopoulos
Clin Cancer Res (2022)
Research Article May 12 2022
Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection
Xiuning Le; Frederico O. Gleber-Netto; M. Laura Rubin; Yun Qing; Robyn Du; Merrill Kies; George Blumenschein, Jr; Charles Lu; Faye M. Johnson; Diana Bell; Jeff Lewis; Jiexin Zhang; Lei Feng; Kaye Wilson; Kathrina Marcelo-Lewis; Jing Wang; Lawrence Ginsberg; Maura Gillison; J. Jack Lee; Funda Meric-Berstam; Gordon B. Mills; William N. William, Jr; Jeffrey N. Myers; Curtis R. Pickering
Clin Cancer Res (2022)
Review Article May 12 2022
Molecular Pathways and Mechanisms of BRAF in Cancer Therapy
Clin Cancer Res (2022)
Research Article May 12 2022
Long-term Safety of Treatment with Autologous Mesenchymal Stem Cells in Patients with Radiation-Induced Xerostomia: Primary Results of the MESRIX Phase I/II Randomized Trial
Charlotte Duch Lynggaard; Christian Grønhøj; Siri B. Jensen; Robin Christensen; Lena Specht; Elo Andersen; Tobias T. Andersen; Urszula M. Ciochon; Gulla S. Rathje; Adam E. Hansen; Helene Stampe; Anne Fischer-Nielsen; Christian von Buchwald
Clin Cancer Res (2022)
Research Article May 10 2022
An autologous dendritic cell vaccine promotes anticancer immunity in ovarian cancer patients with low mutational burden and cold tumors
Jitka Fucikova; Michal Hensler; Lenka Kasikova; Tereza Lanickova; Josef Pasulka; Jana Rakova; Jana Drozenova; Tessa Fredriksen; Marek Hraska; Tereza Hrnciarova; Klara Sochorova; Daniela Rozkova; Ludek Sojka; Pavel Dundr; Jan Laco; Tomas Brtnicky; Ivan Praznovec; Michael J. Halaska; Lukas Rob; Ales Ryska; An Coosemans; Ignace Vergote; David Cibula; Jirina Bartunkova; Jerome Galon; Lorenzo Galluzzi; Radek Spisek
Clin Cancer Res clincanres.4413.2021.
Research Article May 9 2022
Phase Ib/II Study of Enzalutamide with Samotolisib (LY3023414) or Placebo in Patients with Metastatic Castration-Resistant Prostate Cancer
Christopher J. Sweeney; Ivor J. Percent; Sunil Babu; Jennifer L. Cultrera; Bryan A. Mehlhaff; Oscar B. Goodman; David S. Morris; Ian D. Schnadig; Costantine Albany; Neal D. Shore; Paul R. Sieber; Susan C. Guba; Wei Zhang; Volker Wacheck; Gregory P. Donoho; Anna M. Szpurka; Sophie Callies; Boris Kin Lin; Johanna C. Bendell
Clin Cancer Res (2022)
Review Article May 9 2022
Combining Targeted Radionuclide Therapy and Immune Checkpoint Inhibition for Cancer Treatment
Simone C. Kleinendorst; Egbert Oosterwijk; Johan Bussink; Harm Westdorp; Mark W. Konijnenberg; Sandra Heskamp
Clin Cancer Res (2022)
Research Article May 6 2022
MGP Panel is a comprehensive targeted genomics panel for molecular profiling of multiple myeloma patients
Parvathi Sudha; Aarif Ahsan; Cody Ashby; Tasneem Kausar; Akhil Khera; Mohammad Kazeroun; Chih-Chao Hsu; Lin Wang; Evelyn Fitzsimons; Outi Salminen; Patrick Blaney; Magdalena Czader; Jonathan Williams; Mohammad I. Abu Zaid; Naser Ansari-Pour; Kwee L. Yong; Frits van Rhee; William E. Pierceall; Gareth J. Morgan; Erin Flynt; Sarah Gooding; Rafat Abonour; Karthik Ramasamy; Anjan Thakurta; Brian A. Walker
Clin Cancer Res clincanres.3695.2021.
Research Article May 6 2022
MAPK Pathway Genetic Alterations Are Associated with Prolonged Overall Survival in Low-Grade Serous Ovarian Carcinoma
Beryl Manning-Geist; Sushmita Gordhandas; Ying L. Liu; Qin Zhou; Alexia Iasonos; Arnaud Da Cruz Paula; Diana Mandelker; Kara Long Roche; Oliver Zivanovic; Anna Maio; Yelena Kemel; Dennis S. Chi; Roisin E. O'Cearbhaill; Carol Aghajanian; Britta Weigelt; M. Herman Chui; Rachel N. Grisham
Clin Cancer Res (2022)
Review Article May 6 2022
The Need for New Treatments Targeting MPNST: The Potential of Strategies Combining MEK Inhibitors with Antiangiogenic Agents
Clin Cancer Res (2022)
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