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Volume 9, Issue 6

1 June 2003

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ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Reviews
Report from the FDA
Special Article
The Biology Behind
Advances in Brief
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology
Letters to the Editor

Reviews

Soft Tissue Sarcomas of Adults: State of the Translational Science 1

Ernest C. Borden; Laurence H. Baker; Robert S. Bell; Vivien Bramwell; George D. Demetri; Burton L. Eisenberg; Christopher D. M. Fletcher; Jonathan A. Fletcher; Marc Ladanyi; Paul Meltzer; Brian O’Sullivan; David R. Parkinson; Peter W. T. Pisters; Scott Saxman; Samuel Singer; Murali Sundaram; Allan T. van Oosterom; Jaap Verweij; Jill Waalen; Sharon W. Weiss; Murray F. Brennan

Tumor Response to Ionizing Radiation Combined with Antiangiogenesis or Vascular Targeting Agents: Exploring Mechanisms of Interaction 1

Phyllis Wachsberger; Randy Burd; Adam P. Dicker

Report from the FDA

Approval Summary: Imatinib Mesylate Capsules for Treatment of Adult Patients with Newly Diagnosed Philadelphia Chromosome-positive Chronic Myelogenous Leukemia in Chronic Phase

John R. Johnson; Peter Bross; Martin Cohen; Mark Rothmann; Gang Chen; Anne Zajicek; Joga Gobburu; Atiqur Rahman; Ann Staten; Richard Pazdur

Special Article

The Estrogen Receptor: A Model for Molecular Medicine 1

Elwood V. Jensen; V. Craig Jordan

The Biology Behind

Is There a Role for the Assessment of Health-related Quality of Life in the Clinical Evaluation of Novel Cytostatic Agents? : Commentary re: P. M. LoRusso, Improvements in Quality of Life and Disease-related Symptoms in Phase I Trials of the Selective Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Non-Small Cell Lung Cancer and Other Solid Tumors. Clin. Cancer Res., 9: 2040–2048, 2003.

Linda J. Patrick-Miller

Advances in Brief

Molecular Oncology, Markers, Clinical Correlates

Association of 17q21-q24 Gain in Ovarian Clear Cell Adenocarcinomas with Poor Prognosis and Identification of PPM1D and APPBP2 as Likely Amplification Targets 1

Akira Hirasawa; Fumiko Saito-Ohara; Jun Inoue; Daisuke Aoki; Nobuyuki Susumu; Tetsuji Yokoyama; Shiro Nozawa; Johji Inazawa; Issei Imoto

Two Molecular Subgroups of Wilms’ Tumors with or without WT1 Mutations 1

Valérie Schumacher; Stefanie Schuhen; Sandra Sonner; Angela Weirich; Ivo Leuschner; Dieter Harms; Jonathan Licht; Stefan Roberts; Brigitte Royer-Pokora

Experimental Therapeutics, Preclinical Pharmacology

Helicobacter pylori VacA Toxin Up-Regulates Vascular Endothelial Growth Factor Expression in MKN 28 Gastric Cells through an Epidermal Growth Factor Receptor-, Cyclooxygenase-2-dependent Mechanism 1

Rosa Caputo; Concetta Tuccillo; Barbara A. Manzo; Raffaele Zarrilli; Giampaolo Tortora; Camillo Del Vecchio Blanco; Vittorio Ricci; Fortunato Ciardiello; Marco Romano

Gene Expression Profiling and Functional Activity of Human Dendritic Cells Induced with IFN-α-2b: Implications for Cancer Immunotherapy 1

Federica Moschella; Brygida Bisikirska; Antonella Maffei; Kyriakos P. Papadopoulos; Donna Skerrett; Zhuoru Liu; Charles S. Hesdorffer; Paul E. Harris

Regular Articles

Clinical Trials

Phase I Trial and Pharmacokinetics of Fenretinide in Children with Neuroblastoma 1

Alberto Garaventa; Roberto Luksch; Maria Serena Lo Piccolo; Elena Cavadini; Paolo G. Montaldo; Maria Rosa Pizzitola; Luca Boni; Mirco Ponzoni; Andrea Decensi; Bruno De Bernardi; Franca Fossati Bellani; Franca Formelli

Improvements in Quality of Life and Disease-related Symptoms in Phase I Trials of the Selective Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Non-Small Cell Lung Cancer and Other Solid Tumors 1

Patricia M. LoRusso; Roy S. Herbst; Danny Rischin; Malcolm Ranson; Hilary Calvert; Eric Raymond; Dirk Kieback; Stan Kaye; Luca Gianni; Adrian Harris; Thomas Bjork; Anne-Marie Maddox; Mace L. Rothenberg; Eric J. Small; Eric H. Rubin; Andrea Feyereislova; Anne Heyes; Steven D. Averbuch; Judith Ochs; José Baselga

Phase I Trial of ZD9331, a Nonpolyglutamatable Thymidylate Synthase Inhibitor, Given as a 5-Day Continuous Infusion to Patients with Refractory Solid Malignancies

Charlotte Rees; P. Beale; Jose Manuel Trigo; Fraser Mitchell; Anne Jackman; Robert Smith; Edwin Douglass; Ian Judson

A Phase I Study of Recombinant Human Leukemia Inhibitory Factor in Patients with Advanced Cancer 1

Dishan H. Gunawardana; Russell L. Basser; Ian D. Davis; Jonathan Cebon; Paul Mitchell; Craig Underhill; Trevor J. Kilpatrick; Katrina Reardon; Michael D. Green; Peter Bardy; Pene Amor; David Crump; Siobhan Ng; Roger L. Nation; C. Glenn Begley

Phase I and Pharmacological Study of Oral 9-Aminocamptothecin Colloidal Dispersion (NSC 603071) in Patients with Advanced Solid Tumors 1

Henry Q. Xiong; Hai T. Tran; Timothy L. Madden; Robert A. Newman; James L. Abbruzzese

10-Propargyl-10-deazaaminopterin: An Antifolate with Activity in Patients with Previously Treated Non-Small Cell Lung Cancer 1

Lee M. Krug; Christopher G. Azzoli; Mark G. Kris; Vincent A. Miller; Nushmia Z. Khokhar; William Tong; Michelle S. Ginsberg; Ennapadam Venkatraman; Leslie Tyson; Barbara Pizzo; Valerie Baez; Kenneth K. Ng; F. M. Sirotnak

Effects of Whole Body Hyperthermia (41.8°C) on the Frequency of Tumor Cells in the Peripheral Blood of Patients with Advanced Malignancies 1

Susanna Hegewisch-Becker; Katharina Braun; Markus Otte; Aneta Corovic; Djordje Atanackovic; Axel Nierhaus; Dieter K. Hossfeld; Klaus Pantel

A Phase I Study of Topotecan/Paclitaxel Alternating with Etoposide/Cisplatin and Thoracic Irradiation in Patients with Limited Small Cell Lung Cancer 1

Charles Lu; Ritsuko Komaki; Jin Soo Lee; Dong M. Shin; J. Lynn Palmer; Brenda J. Coldman; Katherine M. Pisters; Jonathan M. Kurie; Frank V. Fossella; Bonnie S. Glisson

The Effect of Dose Increase of Imatinib Mesylate in Patients with Chronic or Accelerated Phase Chronic Myelogenous Leukemia with Inadequate Hematologic or Cytogenetic Response to Initial Treatment

Jeffrey A. Zonder; Pamela Pemberton; Helen Brandt; Anwar N. Mohamed; Charles A. Schiffer

Dose Escalation Study of Intravenous Estramustine Phosphate in Combination with Paclitaxel and Carboplatin in Patients with Advanced Prostate Cancer 1

William Kevin Kelly; Andrew X. Zhu; Howard Scher; Tracey Curley; Mary Fallon; Susan Slovin; Lawrence Schwartz; Steve Larson; William Tong; Beryl Hartley-Asp; Cinzia Pellizzoni; Maurizio Rocchetti

In Vivo Activation of Signal Transducer and Activator of Transcription 1 after CD154 Gene Therapy for Chronic Lymphocytic Leukemia Is Associated with Clinical and Immunologic Response 1

Traci E. Battle; William G. Wierda; Laura Z. Rassenti; David Zahrieh; Donna Neuberg; Thomas J. Kipps; David A. Frank

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Homozygous Deletion of CDKN2A and Codeletion of the Methylthioadenosine Phosphorylase Gene in the Majority of Pleural Mesotheliomas

Peter B. Illei; Valerie W. Rusch; Maureen F. Zakowski; Marc Ladanyi

Expression of Epstein-Barr Virus Latent Membrane Protein-1 in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin’s Lymphoma: Associations with Presenting Features, Serum Interleukin 10 Levels, and Clinical Outcome 1

Marco Herling; George Z. Rassidakis; L. Jeffrey Medeiros; Theodoros P. Vassilakopoulos; Kay-Oliver Kliche; Gianpaolo Nadali; Simonetta Viviani; Valeria Bonfante; Roberto Giardini; Marco Chilosi; Christos Kittas; Alessandro M. Gianni; Gianni Bonadonna; Giovanni Pizzolo; Gerassimos A. Pangalis; Fernando Cabanillas; Andreas H. Sarris

The Human T-Cell Factor-4 Gene Splicing Isoforms, Wnt Signal Pathway, and Apoptosis in Renal Cell Carcinoma 1

Hiroaki Shiina; Mikio Igawa; Julia Breault; Leopoldo Ribeiro-Filho; Deepa Pookot; Shinji Urakami; Masaharu Terashima; Masao Deguchi; Masaki Yamanaka; Masato Shirai; Masanori Kaneuchi; Christopher J. Kane; Rajvir Dahiya

The t(14;18) Is Associated with Germinal Center-derived Diffuse Large B-Cell Lymphoma and Is a Strong Predictor of Outcome 1

Sharon L. Barrans; Paul A. S. Evans; Sheila J. M. O’Connor; S. Jane Kendall; Roger G. Owen; Andrew P. Haynes; Gareth J. Morgan; Andrew S. Jack

Overexpression and Constitutive Activation of FLT3 Induces STAT5 Activation in Primary Acute Myeloid Leukemia Blast Cells 1

Karsten Spiekermann; Ksenia Bagrintseva; Ruth Schwab; Karin Schmieja; Wolfgang Hiddemann

Age-associated Increase of Codon 72 Arginine p53 Frequency in Gastric Cardia and Non-Cardia Adenocarcinoma

Zun-Wu Zhang; Paul Newcomb; Andrew Hollowood; Roger Feakins; Moganaden Moorghen; Alan Storey; Michael J. G. Farthing; Derek Alderson; Jeff Holly

Focal Adhesion Kinase Is Expressed in the Angiogenic Blood Vessels of Malignant Astrocytic Tumors in Vivo and Promotes Capillary Tube Formation of Brain Microvascular Endothelial Cells 1

Henry Haskell; Meera Natarajan; Timothy P. Hecker; Qiang Ding; Jerry Stewart, Jr.; J. Robert Grammer; Candece L. Gladson

−174 G>C Polymorphism of Interleukin 6 Gene Promoter Affects Interleukin 6 Serum Level in Patients with Colorectal Cancer

Claudio Belluco; Fabiola Olivieri; Massimiliano Bonafè; Simona Giovagnetti; Enzo Mammano; Romano Scalerta; Alessandro Ambrosi; Claudio Franceschi; Donato Nitti; Mario Lise

Loss of p16 Expression Has Prognostic Significance in Human Nasopharyngeal Carcinoma 1

Antti A. Mäkitie; Christina MacMillan; James Ho; Wei Shi; Andrew Lee; Brian O’Sullivan; David Payne; Melania Pintilie; Bernard Cummings; John Waldron; Padraig Warde; Jonathan Irish; Dale Brown; Ralph Gilbert; Patrick Gullane; Fei-Fei Liu; Suzanne Kamel-Reid

The Relative mRNA Expression Levels of Matrix Metalloproteinase to E-Cadherin in Prostate Biopsy Specimens Distinguishes Organ-confined from Advanced Prostate Cancer at Radical Prostatectomy 1

Hiroki Kuniyasu; Rinzo Ukai; Dennis Johnston; Patricia Troncoso; Isaiah J. Fidler; Curtis A. Pettaway

Value of Immunohistochemical Markers in Preinvasive Bronchial Lesions in Risk Assessment of Lung Cancer 1

Michel Jeanmart; Sylvie Lantuejoul; Frédéric Fievet; Denis Moro; Nathalie Sturm; Christian Brambilla; Elisabeth Brambilla

Expression of Fatty Acid Synthase as a Prognostic Indicator in Soft Tissue Sarcomas 1

Tajino Takahiro; Kikuchi Shinichi; Suzuki Toshimitsu

Prognostic Significance of MUC-1 Expression in Systemic Anaplastic Large Cell Lymphoma 1

George Z. Rassidakis; Andre Goy; L. Jeffrey Medeiros; Yunfang Jiang; Athanasios Thomaides; Yvonne Remache; Fernando Cabanillas; Andreas H. Sarris; Frederic Gilles

PC Cell-derived Growth Factor (Granulin Precursor) Expression and Action in Human Multiple Myeloma 1

Wengang Wang; Jun Hayashi; Wes E. Kim; Ginette Serrero

Association of Serum Estrone Levels with Estrogen Receptor-positive Breast Cancer Risk in Postmenopausal Japanese Women 1

Yasuo Miyoshi; Yoshio Tanji; Tetsuya Taguchi; Yasuhiro Tamaki; Shinzaburo Noguchi

Overexpression of Hypoxia-inducible Factor 1α Indicates Diminished Response to Radiotherapy and Unfavorable Prognosis in Patients Receiving Radical Radiotherapy for Cervical Cancer 1

Barbara Bachtiary; Monika Schindl; Richard Pötter; Bettina Dreier; Thomas Hendrik Knocke; Johannes A. Hainfellner; Reinhard Horvat; Peter Birner

Expression and Prognostic Significance of Kit, Protein Kinase B, and Mitogen-activated Protein Kinase in Patients with Small Cell Lung Cancer 1

Fiona H. Blackhall; Melania Pintilie; Michael Michael; Natasha Leighl; Ronald Feld; Ming-Sound Tsao; Frances A. Shepherd

Expression and Activation of the Nerve Growth Factor Receptor TrkA in Serous Ovarian Carcinoma

Ben Davidson; Reuven Reich; Philip Lazarovici; Jahn M. Nesland; Martina Skrede; Björn Risberg; Claes G. Tropé; Vivi Ann Flørenes

Elevated Expression of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 Promotes Progression of Non-Small Cell Lung Cancer 1

Wulf Sienel; Sebastian Dango; Ute Woelfle; Alicia Morresi-Hauf; Christoph Wagener; Jens Brümmer; Wolf Mutschler; Bernward Passlick; Klaus Pantel

Tumor-specific Transcription Factor Binding to an Activator Protein-2/Sp1 Element of the Urokinase-type Plasminogen Activator Receptor Promoter in a First Large Series of Resected Gastrointestinal Cancers 1

Denis Martin Schewe; Joerg H. Leupold; Douglas D. Boyd; Ernst R. Lengyel; Heng Wang; Klaus Uwe Gruetzner; Friedrich W. Schildberg; Karl W. Jauch; Heike Allgayer

Frequent HOXA11 and THBS2 Promoter Methylation, and a Methylator Phenotype in Endometrial Adenocarcinoma 1

Bradford P. Whitcomb; David G. Mutch; Thomas J. Herzog; Janet S. Rader; Randall K. Gibb; Paul J. Goodfellow

High Expression of Steroid Sulfatase mRNA Predicts Poor Prognosis in Patients with Estrogen Receptor-positive Breast Cancer 1

Yasuo Miyoshi; Akiko Ando; Seiichi Hasegawa; Makoto Ishitobi; Tetsuya Taguchi; Yasuhiro Tamaki; Shinzaburo Noguchi

Chromosomal Instability Detected by Fluorescence in Situ Hybridization in Surgical Specimens of Non-Small Cell Lung Cancer Is Associated with Poor Survival 1

Haruhiko Nakamura; Hisashi Saji; Aute Idiris; Norihito Kawasaki; Makoto Hosaka; Akihiko Ogata; Takamoto Saijo; Harubumi Kato

The Role of Novel Oncogenes Squamous Cell Carcinoma-related Oncogene and Phosphatidylinositol 3-Kinase p110α in Squamous Cell Carcinoma of the Oral Tongue 1

Cherry L. Estilo; Pornchai O-charoenrat; Ivan Ngai; Snehal G. Patel; Pabbathi G. Reddy; Su Dao; Ashok R. Shaha; Dennis H. Kraus; Jay O. Boyle; Richard J. Wong; David G. Pfister; Joseph M. Huryn; Ian M. Zlotolow; Jatin P. Shah; Bhuvanesh Singh

Chromosomal Instability Rather Than p53 Mutation Is Associated with Response to Neoadjuvant Cisplatin-based Chemotherapy in Gastric Carcinoma 1

Katja Ott; Holger Vogelsang; James Mueller; Karen Becker; Martina Müller; Ulrich Fink; Jörg Rüdiger Siewert; Heinz Höfler; Gisela Keller

Experimental Therapeutics, Preclinical Pharmacology

Response to Epidermal Growth Factor Receptor Inhibitors in Non-Small Cell Lung Cancer Cells: Limited Antiproliferative Effects and Absence of Apoptosis Associated with Persistent Activity of Extracellular Signal-regulated Kinase or Akt Kinase Pathways

Maarten L. Janmaat; Frank A. E. Kruyt; José A. Rodriguez; Giuseppe Giaccone

DNA Mismatch Repair (MMR) Mediates 6-Thioguanine Genotoxicity by Introducing Single-strand Breaks to Signal a G₂-M Arrest in MMR-proficient RKO Cells 1

Tao Yan; Suzanne E. Berry; Anand B. Desai; Timothy J. Kinsella

Neovascular Targeting Therapy: Paclitaxel Encapsulated in Cationic Liposomes Improves Antitumoral Efficacy 1

Marcus Schmitt-Sody; Sebastian Strieth; Senat Krasnici; Birgitta Sauer; Brita Schulze; Michael Teifel; Uwe Michaelis; Kurt Naujoks; Marc Dellian

Glial Cell-induced Endothelial Morphogenesis Is Inhibited by Interfering with Extracellular Signal-regulated Kinase Signaling 1

Nirmala Chandrasekar; Sanjeeva Mohanam; S. Sajani Lakka; Dzung H. Dinh; William C. Olivero; Meena Gujrati; Jasti. S. Rao

The Combination of a Potent Vitamin D₃ Analog, EB 1089, with Ionizing Radiation Reduces Tumor Growth and Induces Apoptosis of MCF-7 Breast Tumor Xenografts in Nude Mice 1

Sujatha Sundaram; Andrea Sea; Stephanie Feldman; Rendall Strawbridge; P. Jack Hoopes; Eugene Demidenko; Lise Binderup; David A. Gewirtz

Intensification of Antitumor Effect by T Helper 1-dominant Adoptive Immunogene Therapy for Advanced Orthotopic Colon Cancer 1

Mikihito Nakamori; Makoto Iwahashi; Masaki Nakamura; Kentaro Ueda; Xiaoliu Zhang; Hiroki Yamaue

Paclitaxel Induces Apoptosis via Protein Kinase A- and p38 Mitogen-activated Protein-dependent Inhibition of the Na⁺/H⁺ Exchanger (NHE) NHE Isoform 1 in Human Breast Cancer Cells 1

Stephan J. Reshkin; Antonia Bellizzi; Rosa Angela Cardone; Massimo Tommasino; Valeria Casavola; Angelo Paradiso

Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer 1

Constance M. John; Hakon Leffler; Barbro Kahl-Knutsson; Inga Svensson; Gary A. Jarvis

Letters to the Editor

Correspondence re: A. Lipton et al., Serum Osteoprotegerin Levels in Healthy Controls and Cancer Patients. Clin. Cancer Res., 8: 2306–2310, 2002.

Andrea Dovio; Maria Luisa Sartori; Alberto Angeli

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