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Editorial

Prognostic Factors in Multiple Myeloma: It’s in the Genes

P. Leif Bergsagel

View articletitled, Prognostic Factors in Multiple Myeloma: It’s in the Genes

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Minireview

Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies

Farhad Ravandi; Moshe Talpaz; Zeev Estrov

Abstract

View articletitled, Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies

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The Biology Behind

Matrix Metalloproteinases, Angiogenesis, and Cancer: Commentary re: A. C. Lockhart et al., Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix Metalloproteinase Inhibitor. Clin. Cancer Res., 9: 00–00, 2003.

Joyce E. Rundhaug

Extract

View articletitled, Matrix Metalloproteinases, Angiogenesis, and Cancer: Commentary re: A. C. Lockhart et al., Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix Metalloproteinase Inhibitor. Clin. Cancer Res., 9: 00–00, 2003.

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Advances in Brief

Clinical Trials

A Phase I/II Trial of Intratumoral Endoscopic Ultrasound Injection of ONYX-015 with Intravenous Gemcitabine in Unresectable Pancreatic Carcinoma 1

J. Randolph Hecht; Rudolph Bedford; James L. Abbruzzese; Sandeep Lahoti; Tony R. Reid; Roy M. Soetikno; David H. Kirn; Scott M. Freeman

Abstract

View articletitled, A Phase I/II Trial of Intratumoral Endoscopic Ultrasound Injection of ONYX-015 with Intravenous Gemcitabine in Unresectable Pancreatic Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Flavopiridol-related Proinflammatory Syndrome Is Associated with Induction of Interleukin-6

Richard A. Messmann; Claudio Dansky Ullmann; Tyler Lahusen; Audrey Kalehua; Jason Wasfy; Giovanni Melillo; Ivan Ding; Donna Headlee; William D. Figg; Edward A. Sausville; Adrian M. Senderowicz

Abstract

View articletitled, Flavopiridol-related Proinflammatory Syndrome Is Associated with Induction of Interleukin-6

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Capecitabine Induces Rapid, Sustained Response in Two Patients with Extensive Oral Verrucous Carcinoma 1

Anastasios Salesiotis; Richie Soong; Robert B. Diasio; Andra Frost; Kevin J. Cullen

Abstract

View articletitled, Capecitabine Induces Rapid, Sustained Response in Two Patients with Extensive Oral Verrucous Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix Metalloproteinase Inhibitor 1

A. Craig Lockhart; Rod D. Braun; Daohai Yu; Joel R. Ross; Mark W. Dewhirst; Jeffrey S. Humphrey; Seth Thompson; Kathleen M. Williams; Bruce Klitzman; Fan Yuan; James M. Grichnik; Alan D. Proia; Delina A. Conway; Herbert I. Hurwitz

Abstract

View articletitled, Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix Metalloproteinase Inhibitor<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trial

Immunoscintigraphic Detection of the ED-B Domain of Fibronectin, a Marker of Angiogenesis, in Patients with Cancer 1

Monica Santimaria; Giovanni Moscatelli; Giuseppe L. Viale; Leonardo Giovannoni; Giovanni Neri; Francesca Viti; Alessandra Leprini; Laura Borsi; Patrizia Castellani; Luciano Zardi; Dario Neri; Pietro Riva

Abstract

View articletitled, Immunoscintigraphic Detection of the ED-B Domain of Fibronectin, a Marker of Angiogenesis, in Patients with Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Tissue Microarray Analysis of Signal Transducers and Activators of Transcription 3 (Stat3) and Phospho-Stat3 (Tyr705) in Node-negative Breast Cancer Shows Nuclear Localization Is Associated with a Better Prognosis 1

Marisa Dolled-Filhart; Robert L. Camp; Diane P. Kowalski; Bradley L. Smith; David L. Rimm

Abstract

View articletitled, Tissue Microarray Analysis of Signal Transducers and Activators of Transcription 3 (Stat3) and Phospho-Stat3 (Tyr705) in Node-negative Breast Cancer Shows Nuclear Localization Is Associated with a Better Prognosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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High and Differential Expression of HER-2/neu Extracellular Domain in Bilateral Ductal Fluids from Women with Unilateral Invasive Breast Cancer 1

Henry M. Kuerer; Patricia A. Thompson; Savitri Krishnamurthy; Herbert A. Fritsche; Sylvie M. Marcy; Gildy V. Babiera; S. Eva Singletary; Massimo Cristofanilli; Nour Sneige; Kelly K. Hunt

Abstract

View articletitled, High and Differential Expression of HER-2/neu Extracellular Domain in Bilateral Ductal Fluids from Women with Unilateral Invasive Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increase of Regulatory T Cells in the Peripheral Blood of Cancer Patients 1

Anna Maria Wolf; Dominik Wolf; Michael Steurer; Guenther Gastl; Eberhard Gunsilius; Beatrix Grubeck-Loebenstein

Abstract

View articletitled, Increase of Regulatory T Cells in the Peripheral Blood of Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Predictive Value of the EphA2 Receptor Tyrosine Kinase in Lung Cancer Recurrence and Survival

Michael S. Kinch; Mary-Beth Moore; David H. Harpole, Jr.

Abstract

View articletitled, Predictive Value of the EphA2 Receptor Tyrosine Kinase in Lung Cancer Recurrence and Survival

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Experimental Therapeutics, Preclinical Pharmacology

CD40 Is Expressed on Ovarian Cancer Cells and Can Be Utilized for Targeting Adenoviruses 1

Tanja Hakkarainen; Akseli Hemminki; Alexander V. Pereboev; Shannon D. Barker; Clement K. Asiedu; Theresa V. Strong; Anna Kanerva; Jarmo Wahlfors; David T. Curiel

Abstract

View articletitled, CD40 Is Expressed on Ovarian Cancer Cells and Can Be Utilized for Targeting Adenoviruses<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regular Articles

Clinical Trials

α1 Acid Glycoprotein Binds to Imatinib (STI571) and Substantially Alters Its Pharmacokinetics in Chronic Myeloid Leukemia Patients 1

Carlo Gambacorti-Passerini; Massimo Zucchetti; Domenico Russo; Roberta Frapolli; Magda Verga; Silvia Bungaro; Lucia Tornaghi; Fabio Rossi; Pietro Pioltelli; Enrico Pogliani; Daniele Alberti; Gianmarco Corneo; Maurizio D’Incalci

Abstract

View articletitled, α1 Acid Glycoprotein Binds to Imatinib (STI571) and Substantially Alters Its Pharmacokinetics in Chronic Myeloid Leukemia Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Pilot Study of Protracted Topotecan Dosing Using a Pharmacokinetically Guided Dosing Approach in Children with Solid Tumors 1

Victor M. Santana; William C. Zamboni; Mark N. Kirstein; Ming Tan; Tiebin Liu; Amar Gajjar; Peter J. Houghton; Clinton F. Stewart

Abstract

View articletitled, A Pilot Study of Protracted Topotecan Dosing Using a Pharmacokinetically Guided Dosing Approach in Children with Solid Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enzyme-linked Immunospot, Cytokine Flow Cytometry, and Tetramers in the Detection of T-Cell Responses to a Dendritic Cell-based Multipeptide Vaccine in Patients with Melanoma 1

Theresa L. Whiteside; Yongxiang Zhao; Takashi Tsukishiro; Elaine M. Elder; William Gooding; Joseph Baar

Abstract

View articletitled, Enzyme-linked Immunospot, Cytokine Flow Cytometry, and Tetramers in the Detection of T-Cell Responses to a Dendritic Cell-based Multipeptide Vaccine in Patients with Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increased ^99mTc-Sestamibi Accumulation in Normal Liver and Drug-resistant Tumors after the Administration of the Glycoprotein Inhibitor, XR9576

Manish Agrawal; Jame Abraham; Frank M. Balis; Maureen Edgerly; Wilfred D. Stein; Susan Bates; Tito Fojo; Clara C. Chen

Abstract

View articletitled, Increased 99mTc-Sestamibi Accumulation in Normal Liver and Drug-resistant Tumors after the Administration of the Glycoprotein Inhibitor, XR9576

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Vaccine-induced CD8+ T-cell Responses to MAGE-3 Correlate with Clinical Outcome in Patients with Melanoma 1

Sandra R. Reynolds; Anne Zeleniuch-Jacquotte; Richard L. Shapiro; Daniel F. Roses; Matthew N. Harris; Dean Johnston; Jean-Claude Bystryn

Abstract

View articletitled, Vaccine-induced CD8+ T-cell Responses to MAGE-3 Correlate with Clinical Outcome in Patients with Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Evaluation of Prolonged-infusion Gemcitabine with Fludarabine for Relapsed or Refractory Acute Myelogenous Leukemia 1

David A. Rizzieri; Valerie K. Ibom; Joseph O. Moore; Carlos M. DeCastro; Gary L. Rosner; David J. Adams; Traci Foster; Nancy Payne; Maria Thompson; James J. Vredenburgh; Christina Gasparetto; Gwynn D. Long; Nelson J. Chao; Jon P. Gockerman

Abstract

View articletitled, Phase I Evaluation of Prolonged-infusion Gemcitabine with Fludarabine for Relapsed or Refractory Acute Myelogenous Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Activation of Human Melanoma Reactive CD8+ T Cells by Vaccination with an Immunogenic Peptide Analog Derived from Melan-A/Melanoma Antigen Recognized by T Cells-1 1

Maha Ayyoub; Alfred Zippelius; Mikaël J. Pittet; Donata Rimoldi; Danila Valmori; Jean-Charles Cerottini; Pedro Romero; Ferdy Lejeune; Danielle Liénard; Daniel E. Speiser

Abstract

View articletitled, Activation of Human Melanoma Reactive CD8+ T Cells by Vaccination with an Immunogenic Peptide Analog Derived from Melan-A/Melanoma Antigen Recognized by T Cells-1<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Mechanisms of Peritoneal Metastasis after Operation for Non-Serosa-invasive Gastric Carcinoma: An Ultrarapid Detection System for Intraperitoneal Free Cancer Cells and a Prophylactic Strategy for Peritoneal Metastasis

Takashi Marutsuka; Shinya Shimada; Kenji Shiomori; Naoko Hayashi; Yasushi Yagi; Takaaki Yamane; Michio Ogawa

Abstract

View articletitled, Mechanisms of Peritoneal Metastasis after Operation for Non-Serosa-invasive Gastric Carcinoma: An Ultrarapid Detection System for Intraperitoneal Free Cancer Cells and a Prophylactic Strategy for Peritoneal Metastasis

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Weekly Docetaxel as Neoadjuvant Chemotherapy for Stage II and III Breast Cancer: Efficacy and Correlation with Biological Markers in a Phase II, Multicenter Study 1

Laura G. Estévez; José Miguel Cuevas; Antonio Antón; Jesús Florián; José Manuel López-Vega; Amalia Velasco; Francisco Lobo; Ana Herrero; José Fortes

Abstract

View articletitled, Weekly Docetaxel as Neoadjuvant Chemotherapy for Stage II and III Breast Cancer: Efficacy and Correlation with Biological Markers in a Phase II, Multicenter Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase II Clinical Trial of Intralesional Administration of the Oncolytic Adenovirus ONYX-015 in Patients with Hepatobiliary Tumors with Correlative p53 Studies 1

Della Makower; Alla Rozenblit; Howard Kaufman; Morris Edelman; Maureen E. Lane; James Zwiebel; Hilda Haynes; Scott Wadler

Abstract

View articletitled, Phase II Clinical Trial of Intralesional Administration of the Oncolytic Adenovirus ONYX-015 in Patients with Hepatobiliary Tumors with Correlative p53 Studies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Clinical and Pharmacologic Study of Weekly Cisplatin and Irinotecan Combined with Amifostine for Refractory Solid Tumors 1

Abdul-Kader Souid; Ronald L. Dubowy; Susan M. Blaney; Linda Hershon; Jim Sullivan; Wendy D. McLeod; Mark L. Bernstein

Abstract

View articletitled, Phase I Clinical and Pharmacologic Study of Weekly Cisplatin and Irinotecan Combined with Amifostine for Refractory Solid Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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High-Dose Methotrexate for Intraocular Lymphoma 1

Tracy T. Batchelor; Gina Kolak; Roberto Ciordia; C. Stephen Foster; John W. Henson

Abstract

View articletitled, High-Dose Methotrexate for Intraocular Lymphoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Prognostic Significance of Vascular Endothelial Growth Factor D in Breast Carcinoma with Long-Term Follow-Up

Yasushi Nakamura; Hironao Yasuoka; Masahiko Tsujimoto; Qifeng Yang; Shigeru Imabun; Masaaki Nakahara; Kazuyasu Nakao; Misa Nakamura; Ichiro Mori; Kennichi Kakudo

Abstract

View articletitled, Prognostic Significance of Vascular Endothelial Growth Factor D in Breast Carcinoma with Long-Term Follow-Up

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Immunohistochemical Expression of CD23 and CD40 May Identify Prognostically Favorable Subgroups of Diffuse Large B-cell Lymphoma: A Nordic Lymphoma Group Study 1

Johan Linderoth; Mats Jerkeman; Eva Cavallin-Ståhl; Stein Kvaløy; Emina Torlakovic

Abstract

View articletitled, Immunohistochemical Expression of CD23 and CD40 May Identify Prognostically Favorable Subgroups of Diffuse Large B-cell Lymphoma: A Nordic Lymphoma Group Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Up-Regulation of Tumor Interleukin-8 Expression by Infiltrating Macrophages: Its Correlation with Tumor Angiogenesis and Patient Survival in Non-Small Cell Lung Cancer 1

Jeremy J.W. Chen; Pei-Li Yao; Ang Yuan; Tse-Ming Hong; Chia-Tung Shun; Min-Liang Kuo; Yung-Chie Lee; Pan-Chyr Yang

Abstract

View articletitled, Up-Regulation of Tumor Interleukin-8 Expression by Infiltrating Macrophages: Its Correlation with Tumor Angiogenesis and Patient Survival in Non-Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Caspase 3 in Breast Cancer

Norma O’Donovan; John Crown; Helen Stunell; Arnold D. K. Hill; Enda McDermott; Niall O’Higgins; Michael J. Duffy

Abstract

View articletitled, Caspase 3 in Breast Cancer

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Methylenetetrahydrofolate Reductase 677 C→T Polymorphism and Risk of Proximal Colon Cancer in North Italy 1

Giuseppe Toffoli; Roberta Gafà; Antonio Russo; Giovanni Lanza; Riccardo Dolcetti; Franca Sartor; Massimo Libra; Alessandra Viel; Mauro Boiocchi

Abstract

View articletitled, Methylenetetrahydrofolate Reductase 677 C→T Polymorphism and Risk of Proximal Colon Cancer in North Italy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Serum Antibodies to Lipophilin B Detected in Late Stage Breast Cancer Patients 1

Darrick Carter; Davin C. Dillon; Lisa D. Reynolds; Marc W. Retter; Gary Fanger; David A. Molesh; Paul R. Sleath; Patricia D. McNeill; Thomas S. Vedvick; Steven G. Reed; David H. Persing; Raymond L. Houghton

Abstract

View articletitled, Serum Antibodies to Lipophilin B Detected in Late Stage Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Quantitative Molecular Detection of Minimal Residual Head and Neck Cancer in Lymph Node Aspirates 1

Eline J. C. Nieuwenhuis; Lies H. Jaspars; Jonas A. Castelijns; Branco Bakker; Richard G. A. Wishaupt; Fedor Denkers; C. René Leemans; Gordon B. Snow; Ruud H. Brakenhoff

Abstract

View articletitled, Quantitative Molecular Detection of Minimal Residual Head and Neck Cancer in Lymph Node Aspirates<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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High Expression of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Is Associated with Favorable Ovarian Cancer Survival 1

Johnathan M. Lancaster; Robyn Sayer; Carrie Blanchette; Brian Calingaert; Regina Whitaker; Joellen Schildkraut; Jeffrey Marks; Andrew Berchuck

Abstract

View articletitled, High Expression of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Is Associated with Favorable Ovarian Cancer Survival<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Determinants of Treatment Response in Human Germ Cell Tumors 1

Frank Mayer; Hans Stoop; George L. Scheffer; Rik Scheper; J. Wolter Oosterhuis; Leendert H. J. Looijenga; Carsten Bokemeyer

Abstract

View articletitled, Molecular Determinants of Treatment Response in Human Germ Cell Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increased Plasma Ghrelin Level in Lung Cancer Cachexia 1

Yoshito Shimizu; Noritoshi Nagaya; Takeshi Isobe; Michinori Imazu; Hiroyuki Okumura; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Nobuoki Kohno

Abstract

View articletitled, Increased Plasma Ghrelin Level in Lung Cancer Cachexia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Level of Id-1 Protein Expression Correlates with Poor Differentiation, Enhanced Malignant Potential, and More Aggressive Clinical Behavior of Epithelial Ovarian Tumors

Monika Schindl; Sebastian F. Schoppmann; Thomas Ströbel; Harald Heinzl; Christina Leisser; Reinhard Horvat; Peter Birner

Abstract

View articletitled, Level of Id-1 Protein Expression Correlates with Poor Differentiation, Enhanced Malignant Potential, and More Aggressive Clinical Behavior of Epithelial Ovarian Tumors

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Combination of Dihydropyrimidine Dehydrogenase and Thymidylate Synthase Gene Expressions in Primary Tumors as Predictive Parameters for the Efficacy of Fluoropyrimidine-based Chemotherapy for Metastatic Colorectal Cancer

Wataru Ichikawa; Hiroyuki Uetake; Yoshinori Shirota; Hiroyuki Yamada; Naoto Nishi; Zenro Nihei; Kenichi Sugihara; Renzo Hirayama

Abstract

View articletitled, Combination of Dihydropyrimidine Dehydrogenase and Thymidylate Synthase Gene Expressions in Primary Tumors as Predictive Parameters for the Efficacy of Fluoropyrimidine-based Chemotherapy for Metastatic Colorectal Cancer

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Thymidylate Synthase Expression in Advanced Colorectal Cancer Predicts for Response to Raltitrexed 1

David C. Farrugia; Hugo E. R. Ford; David Cunningham; Kathleen D. Danenberg; Peter V. Danenberg; Jan Brabender; A. David McVicar; G. Wynne Aherne; Anthea Hardcastle; Keith McCarthy; Ann L. Jackman

Abstract

View articletitled, Thymidylate Synthase Expression in Advanced Colorectal Cancer Predicts for Response to Raltitrexed<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Carbonic Anhydrase IX Is an Independent Predictor of Survival in Advanced Renal Clear Cell Carcinoma: Implications for Prognosis and Therapy

Matthew H. T. Bui; David Seligson; Ken-ryu Han; Allan J. Pantuck; Frederick J. Dorey; Yunda Huang; Steve Horvath; Bradley C. Leibovich; Shefali Chopra; Shu-Yuan Liao; Eric Stanbridge; Michael I. Lerman; Aarno Palotie; Robert A. Figlin; Arie S. Belldegrun

Abstract

View articletitled, Carbonic Anhydrase IX Is an Independent Predictor of Survival in Advanced Renal Clear Cell Carcinoma: Implications for Prognosis and Therapy

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Real-Time Analysis of Tyrosine Hydroxylase Gene Expression: A Sensitive and Semiquantitative Marker for Minimal Residual Disease Detection of Neuroblastoma 1

Lambert H. J. Lambooy; Corrie E. M. Gidding; Lambert P. van den Heuvel; Christina A. Hulsbergen-van de Kaa; Marjolijn Ligtenberg; Jos P. M. Bökkerink; Ronney A. De Abreu

Abstract

View articletitled, Real-Time Analysis of Tyrosine Hydroxylase Gene Expression: A Sensitive and Semiquantitative Marker for Minimal Residual Disease Detection of Neuroblastoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Low p27^Kip1 Expression Is an Independent Adverse Prognostic Factor in Patients with Multiple Myeloma 1

Martin Filipits; Gudrun Pohl; Thomas Stranzl; Hannes Kaufmann; Jutta Ackermann; Heinz Gisslinger; Hildegard Greinix; Andreas Chott; Johannes Drach

Abstract

View articletitled, Low p27Kip1 Expression Is an Independent Adverse Prognostic Factor in Patients with Multiple Myeloma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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RNA Expression of Breast Cancer Resistance Protein, Lung Resistance-related Protein, Multidrug Resistance-associated Proteins 1 and 2, and Multidrug Resistance Gene 1 in Breast Cancer: Correlation with Chemotherapeutic Response

Herman Burger; John A. Foekens; Maxime P. Look; Marion E. Meijer-van Gelder; Jan G. M. Klijn; Erik A. C. Wiemer; Gerrit Stoter; Kees Nooter

Abstract

View articletitled, RNA Expression of Breast Cancer Resistance Protein, Lung Resistance-related Protein, Multidrug Resistance-associated Proteins 1 and 2, and Multidrug Resistance Gene 1 in Breast Cancer: Correlation with Chemotherapeutic Response

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Sequence Alterations in the Reduced Folate Carrier Are Observed in Osteosarcoma Tumor Samples 1

Rui Yang; Rebecca Sowers; BethAnne Mazza; John H. Healey; Andrew Huvos; Holcombe Grier; Mark Bernstein; G. Peter Beardsley; Mark D. Krailo; Meenakshi Devidas; Joseph R. Bertino; Paul A. Meyers; Richard Gorlick

Abstract

View articletitled, Sequence Alterations in the Reduced Folate Carrier Are Observed in Osteosarcoma Tumor Samples<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Establishment and Characterization of Cancer Cell Cultures and Xenografts Derived from Primary or Metastatic Mullerian Cancers 1

Claire F. Verschraegen; Wei Hu; Yu Du; John Mendoza; Janet Early; Michael Deavers; Ralph S. Freedman; Robert C. Bast, Jr.; Andrzej P. Kudelka; John J. Kavanagh; Beppino C. Giovanella

Abstract

View articletitled, Establishment and Characterization of Cancer Cell Cultures and Xenografts Derived from Primary or Metastatic Mullerian Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Macrophage Migration Inhibitory Factor and CXC Chemokine Expression in Non-Small Cell Lung Cancer: Role in Angiogenesis and Prognosis 1

Eric S. White; Kevin R. Flaherty; Shannon Carskadon; Ashley Brant; Mark D. Iannettoni; John Yee; Mark B. Orringer; Douglas A. Arenberg

Abstract

View articletitled, Macrophage Migration Inhibitory Factor and CXC Chemokine Expression in Non-Small Cell Lung Cancer: Role in Angiogenesis and Prognosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Apoptosis by Leukemia Cell-targeted Diphtheria Toxin Occurs via Receptor-independent Activation of Fas-associated Death Domain Protein 1

Jacqueline Thorburn; Arthur E. Frankel; Andrew Thorburn

Abstract

View articletitled, Apoptosis by Leukemia Cell-targeted Diphtheria Toxin Occurs via Receptor-independent Activation of Fas-associated Death Domain Protein<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Combined Targeted Inhibition of bcl-2, bcl-XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity

Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Roberta Caputo; Teresa Troiani; Bianca Maria Veneziani; Sabino De Placido; Angelo Raffaele Bianco; Uwe Zangemeister-Wittke; Fortunato Ciardiello

Abstract

View articletitled, Combined Targeted Inhibition of bcl-2, bcl-XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity

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Microglia Cyclooxygenase-2 Activity in Experimental Gliomas: Possible Role in Cerebral Edema Formation 1

Behnam Badie; Jill M. Schartner; Aaron R. Hagar; Sakthivel Prabakaran; Todd R. Peebles; Becky Bartley; Samir Lapsiwala; Daniel K. Resnick; Jessica Vorpahl

Abstract

View articletitled, Microglia Cyclooxygenase-2 Activity in Experimental Gliomas: Possible Role in Cerebral Edema Formation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phytosphingosine Induces Apoptotic Cell Death via Caspase 8 Activation and Bax Translocation in Human Cancer Cells 1

Moon-Taek Park; Jung A Kang; Jung-A Choi; Chang-Mo Kang; Tae-Hwan Kim; Sangwoo Bae; Seongman Kang; Sujong Kim; Weon-Ik Choi; Chul-Koo Cho; Hee-Yong Chung; Yun-Sil Lee; Su-Jae Lee

Abstract

View articletitled, Phytosphingosine Induces Apoptotic Cell Death via Caspase 8 Activation and Bax Translocation in Human Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Docetaxel Enhances the Therapeutic Effect of the Angiogenesis Inhibitor TNP-470 (AGM-1470) in Metastatic Human Transitional Cell Carcinoma

Keiji Inoue; Masakazu Chikazawa; Satoshi Fukata; Chiaki Yoshikawa; Taro Shuin

Abstract

View articletitled, Docetaxel Enhances the Therapeutic Effect of the Angiogenesis Inhibitor TNP-470 (AGM-1470) in Metastatic Human Transitional Cell Carcinoma

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In Vitro Schedule-dependent Interaction between Docetaxel and Gemcitabine in Human Gastric Cancer Cell Lines 1

Luca Ricotti; Anna Tesei; Franca De Paola; Paola Ulivi; Giovanni Luca Frassineti; Carlo Milandri; Dino Amadori; Wainer Zoli

Abstract

View articletitled, In Vitro Schedule-dependent Interaction between Docetaxel and Gemcitabine in Human Gastric Cancer Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Evaluation of Mitoxantrone and Piroxicam in a Canine Model of Human Invasive Urinary Bladder Carcinoma 1

Carolyn J. Henry; Dudley L. McCaw; Susan E. Turnquist; Jeff W. Tyler; Lina Bravo; Sarah Sheafor; Rodney C. Straw; William S. Dernell; Bruce R. Madewell; Linda Jorgensen; Michael A. Scott; Mary Lynn Higginbotham; Ruthanne Chun

Abstract

View articletitled, Clinical Evaluation of Mitoxantrone and Piroxicam in a Canine Model of Human Invasive Urinary Bladder Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Letters to the Editor

Correspondence re: C. G. Ferreira et al., Apoptosis: Target of Cancer Therapy. Clin. Cancer Res., 8: 2024–2034, 2002.

Elisabeth G. E. de Vries; Marjolein N. de Hooge; Jourik A. Gietema; Steven de Jong

Extract

View articletitled, Correspondence re: C. G. Ferreira et al., Apoptosis: Target of Cancer Therapy. Clin. Cancer Res., 8: 2024–2034, 2002.

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Reply

Carlos G. Ferreira; Mirjam Epping; Frank A. E. Kruyt; Giuseppe Giaccone

Extract

View articletitled, Reply

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Correction

Correction for vol. 8, p. 3796

Extract

View articletitled, Correction for vol. 8, p. 3796

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