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Volume 9, Issue 17

15 December 2003

Cover Image

Cover Image

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorial
The Biology Behind
Review
Perspectives
Featured Articles
- Clinical Trials
- Molecular Oncology, Markers, Clinical Correlates
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
Regular Articles
- Molecular Oncology, Markers, and Clinical Correlates

Editorial

Of Peptides and Peptidases: The Role of Cell Surface Peptidases in Cancer

David M. Nanus

The Biology Behind

Cancer Immunotherapy Targeting Survivin: Commentary re: V. Pisarev et al., Full-Length Dominant-Negative Survivin for Cancer Immunotherapy. Clin. Cancer Res., 9:6523–6533, 2003.

John C. Reed; Darcy B. Wilson

Review

The Proteasome as a Target for Cancer Therapy

Peter M. Voorhees; E. Claire Dees; Bert O’Neil; Robert Z. Orlowski

Perspectives

Detection and Clinical Implications of Early Systemic Tumor Cell Dissemination in Breast Cancer

Klaus Pantel; Volkmar Müller; Margherita Auer; Nathalie Nusser; Nadia Harbeck; Stephan Braun

Featured Articles

Clinical Trials

Pharmacokinetics and Pharmacodynamics of Plasma Clofarabine and Cellular Clofarabine Triphosphate in Patients with Acute Leukemias

Varsha Gandhi; Hagop Kantarjian; Stefan Faderl; Peter Bonate; Min Du; Mary Ayres; Mary Beth Rios; Michael J. Keating; William Plunkett

Hyperthermic Isolated Hepatic Perfusion Using Melphalan for Patients with Ocular Melanoma Metastatic to Liver

H. Richard Alexander, Jr.; Steven K. Libutti; James F. Pingpank; Seth M. Steinberg; David L. Bartlett; Cynthia Helsabeck; Tatiana Beresneva

Assessment of Inter- and Intrapatient Variability in C¹⁵O₂ Positron Emission Tomography Measurements of Blood Flow in Patients with Intra-abdominal Cancers

Paula Wells; Terry Jones; Pat Price

Molecular Oncology, Markers, Clinical Correlates

Correlation of Primary Tumor Prostate-Specific Membrane Antigen Expression with Disease Recurrence in Prostate Cancer

Jeffrey S. Ross; Christine E. Sheehan; Hugh A. G. Fisher; Ronald P. Kaufman, Jr.; Prabhjot Kaur; Karen Gray; Iain Webb; Gary S. Gray; Rebecca Mosher; Bhaskar V. S. Kallakury

Vascular Endothelial Growth Factor Independently Predicts the Efficacy of Postoperative Radiotherapy in Node-Negative Breast Cancer Patients

Peggy Manders; Fred C. G. J. Sweep; Vivianne C. G. Tjan-Heijnen; Anneke Geurts-Moespot; Doorléne T. H. van Tienoven; John A. Foekens; Paul N. Span; Jan Bussink; Louk V. A. M. Beex

Transcription Factor Sp1 Expression Is a Significant Predictor of Survival in Human Gastric Cancer

Liwei Wang; Daoyan Wei; Suyun Huang; Zhihai Peng; Xiangdong Le; Tsung Teh Wu; James Yao; Jaffer Ajani; Keping Xie

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Interleukin-13 Receptor α2 Chain in Human Head and Neck Cancer Serves as a Unique Diagnostic Marker

Mariko Kawakami; Koji Kawakami; Jan L. Kasperbauer; Lucinda L. Hinkley; Mamoru Tsukuda; Scott E. Strome; Raj K. Puri

Aberrant Promoter Methylation and Silencing of Laminin-5-Encoding Genes in Breast Carcinoma

Ubaradka G. Sathyanarayana; Asha Padar; Chun Xian Huang; Makoto Suzuki; Hisayuki Shigematsu; B. Nebiyou Bekele; Adi F. Gazdar

Identification of HRK as a Target of Epigenetic Inactivation in Colorectal and Gastric Cancer

Toshiro Obata; Minoru Toyota; Ayumi Satoh; Yasushi Sasaki; Kazuhiro Ogi; Kimishige Akino; Hiromu Suzuki; Masafumi Murai; Takefumi Kikuchi; Hiroaki Mita; Fumio Itoh; Jean-Pierre J. Issa; Takashi Tokino; Kohzoh Imai

Detection of Mutations in the Mitogen-Activated Protein Kinase Pathway in Human Melanoma

Janivette Alsina; David H. Gorsk; F. Joseph Germino; Weichung Shih; Shou-En Lu; Zhi-Gang Zhang; Jin-Ming Yang; William N. Hait; James S. Goydos

Progression of Cervical Carcinomas Is Associated with Down-Regulation of CD9 But Strong Local Re-expression at Sites of Transendothelial Invasion

Georg Sauer; Jasmin Windisch; Christian Kurzeder; Volker Heilmann; Rolf Kreienberg; Helmut Deissler

Prognostic Value of Rho GTPases and Rho Guanine Nucleotide Dissociation Inhibitors in Human Breast Cancers

Wen G. Jiang; Gareth Watkins; Jane Lane; Giles H. Cunnick; Anthony Douglas-Jones; Kefah Mokbel; Robert E. Mansel

Rapid and Sensitive Detection of Messenger RNA Expression for Molecular Differential Diagnosis of Renal Cell Carcinoma

Guorong Li; Muriel Cuilleron; Anne Gentil-Perret; Michèle Cottier; Karine Passebosc-Faure; Claude Lambert; Christian Genin; Jacques Tostain

The Role of an 80 kDa Fragment of E-cadherin in the Metastatic Progression of Prostate Cancer

Rainer Kuefer; Matthias D. Hofer; Juergen E. Gschwend; Kenneth J. Pienta; Martin G. Sanda; Arul M. Chinnaiyan; Mark A. Rubin; Mark L. Day

Expression of the MAGE-A4 and NY-ESO-1 Cancer-Testis Antigens in Serous Ovarian Neoplasms

Evgeny Yakirevich; Edmond Sabo; Ofer Lavie; Salam Mazareb; Giulio C. Spagnoli; Murray B. Resnick

Detection of Human Papillomavirus in Cervical Lymph Nodes: A Highly Effective Strategy for Localizing Site of Tumor Origin

Shahnaz Begum; Maura L. Gillison; M. Ali Ansari-Lari; Keerti Shah; William H. Westra

Frequent Loss of Heterozygosity Targeting the Inactive X Chromosome in Melanoma

James O. Indsto; Najah T. Nassif; Richard F. Kefford; Graham J. Mann

NRAS and BRAF Mutations Arise Early during Melanoma Pathogenesis and Are Preserved throughout Tumor Progression

Katarina Omholt; Anton Platz; Lena Kanter; Ulrik Ringborg; Johan Hansson

Experimental Therapeutics, Preclinical Pharmacology

Adipocyte-Derived Leucine Aminopeptidase Suppresses Angiogenesis in Human Endometrial Carcinoma via Renin-Angiotensin System

Yoshiteru Watanabe; Kiyosumi Shibata; Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani

Interferon-γ–Induced Sensitization of Colon Carcinomas to ZD9331 Targets Caspases, Downstream of Fas, Independent of Mitochondrial Signaling and the Inhibitor of Apoptosis Survivin

James Geller; Istvan Petak; Kinga Szekely Szucs; Katalin Nagy; David M. Tillman; Janet A. Houghton

Antitumor Therapy with Bacterial DNA and Toxin: Complete Regression of Established Tumor Induced by Liposomal CpG Oligodeoxynucleotides plus Interleukin-13 Cytotoxin

Ken J. Ishii; Koji Kawakami; Ihsan Gursel; Jacqueline Conover; Bharat H. Joshi; Dennis M. Klinman; Raj K. Puri

Full-Length Dominant-Negative Survivin for Cancer Immunotherapy

Vladimir Pisarev; Bin Yu; Raoul Salup; Simon Sherman; Dario C. Altieri; Dmitry I. Gabrilovich

Inhibition of Platelet-Derived Growth Factor Receptor Phosphorylation by STI571 (Gleevec) Reduces Growth and Metastasis of Human Pancreatic Carcinoma in an Orthotopic Nude Mouse Model

Rosa F. Hwang; Kenji Yokoi; Corazon D. Bucana; Rachel Tsan; Jerald J. Killion; Douglas B. Evans; Isaiah J. Fidler

Improvement of the Antitumor Activity of Intraperitoneally and Orally Administered 5,6-Dimethylxanthenone-4-Acetic Acid by Optimal Scheduling

Liangli Zhao; Lai-Ming Ching; Philip Kestell; Bruce C. Baguley

In Vivo Fate of Folate-Targeted Polyethylene-Glycol Liposomes in Tumor-Bearing Mice

Alberto Gabizon; Aviva T. Horowitz; Dorit Goren; Dina Tzemach; Hilary Shmeeda; Samuel Zalipsky

A Fully Human Antimelanoma Cellular Adhesion Molecule/MUC18 Antibody Inhibits Spontaneous Pulmonary Metastasis of Osteosarcoma Cells In Vivo

Eric C. McGary; Amy Heimberger; Lisa Mills; Kristy Weber; Gary W. Thomas; Mikhail Shtivelband; Dina Chelouche Lev; Menashe Bar-Eli

Cure of SCID Mice Bearing Human B-Lymphoma Xenografts by an Anti-CD74 Antibody-Anthracycline Drug Conjugate

Gary L. Griffiths; M. Jules Mattes; Rhona Stein; Serengulam V. Govindan; Ivan D. Horak; Hans J. Hansen; David M. Goldenberg

Regular Articles

Molecular Oncology, Markers, and Clinical Correlates

Aberrant Promoter Methylation of Laminin-5–Encoding Genes in Prostate Cancers and Its Relationship to Clinicopathological Features

Ubaradka G. Sathyanarayana; Asha Padar; Makoto Suzuki; Riichiroh Maruyama; Hisayuki Shigematsu; Jer-Tsong Hsieh; Eugene P. Frenkel; Adi F. Gazdar

Loss of Caspase-8 Protein Expression Correlates with Unfavorable Survival Outcome in Childhood Medulloblastoma

Carmen Pingoud-Meier; Doris Lang; Anna J. Janss; Lucy B. Rorke; Peter C. Phillips; Tarek Shalaby; Michael A. Grotzer

Epidermal Growth Factor Receptor, p53 Mutation, and Pathological Response Predict Survival in Patients with Locally Advanced Esophageal Cancer Treated with Preoperative Chemoradiotherapy

Michael K. Gibson; Susan C. Abraham; Tsung-Teh Wu; Barbara Burtness; Richard F. Heitmiller; Elisabeth Heath; Arlene Forastiere

Prognostic Value of Apoptosis-Regulating Protein Expression in Anal Squamous Cell Carcinoma

Abdelkarim S. Allal; Laurent Waelchli; Marie-Anne Bründler

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Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification

Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor–Positive Breast Cancer

Facts and Hopes in Immunotherapy of Pancreatic Cancer

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-X_L Anti-apoptotic Protein in Kidney Cancer

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