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Issues

Volume 9, Issue 17
15 December 2003
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All Issues
ISSN 1078-0432
EISSN 1557-3265

Editorial

Of Peptides and Peptidases: The Role of Cell Surface Peptidases in Cancer
David M. Nanus
View articletitled, Of Peptides and Peptidases<span class="subtitle-colon">: </span><span class="subtitle">The Role of Cell Surface Peptidases in Cancer</span>
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The Biology Behind

Cancer Immunotherapy Targeting Survivin: Commentary re: V. Pisarev et al., Full-Length Dominant-Negative Survivin for Cancer Immunotherapy. Clin. Cancer Res., 9:6523–6533, 2003.
John C. Reed; Darcy B. Wilson
View articletitled, Cancer Immunotherapy Targeting Survivin<span class="subtitle-colon">: </span><span class="subtitle">Commentary re: V. Pisarev <strong><em>et al.</em></strong>, Full-Length Dominant-Negative Survivin for Cancer Immunotherapy. Clin. Cancer Res., <strong><em>9:</em></strong>6523–6533, 2003.</span>
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Review

The Proteasome as a Target for Cancer Therapy
Peter M. Voorhees; E. Claire Dees; Bert O’Neil; Robert Z. Orlowski
View articletitled, The Proteasome as a Target for Cancer Therapy
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Perspectives

Detection and Clinical Implications of Early Systemic Tumor Cell Dissemination in Breast Cancer
Klaus Pantel; Volkmar Müller; Margherita Auer; Nathalie Nusser; Nadia Harbeck; Stephan Braun
View articletitled, Detection and Clinical Implications of Early Systemic Tumor Cell Dissemination in Breast Cancer
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Featured Articles

Clinical Trials
Pharmacokinetics and Pharmacodynamics of Plasma Clofarabine and Cellular Clofarabine Triphosphate in Patients with Acute Leukemias
Varsha Gandhi; Hagop Kantarjian; Stefan Faderl; Peter Bonate; Min Du; Mary Ayres; Mary Beth Rios; Michael J. Keating; William Plunkett
View articletitled, Pharmacokinetics and Pharmacodynamics of Plasma Clofarabine and Cellular Clofarabine Triphosphate in Patients with Acute Leukemias
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Hyperthermic Isolated Hepatic Perfusion Using Melphalan for Patients with Ocular Melanoma Metastatic to Liver
H. Richard Alexander, Jr.; Steven K. Libutti; James F. Pingpank; Seth M. Steinberg; David L. Bartlett; Cynthia Helsabeck; Tatiana Beresneva
View articletitled, Hyperthermic Isolated Hepatic Perfusion Using Melphalan for Patients with Ocular Melanoma Metastatic to Liver
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Assessment of Inter- and Intrapatient Variability in C15O2 Positron Emission Tomography Measurements of Blood Flow in Patients with Intra-abdominal Cancers
Paula Wells; Terry Jones; Pat Price
View articletitled, Assessment of Inter- and Intrapatient Variability in C<sup>15</sup>O<sub>2</sub> Positron Emission Tomography Measurements of Blood Flow in Patients with Intra-abdominal Cancers
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Molecular Oncology, Markers, Clinical Correlates
Correlation of Primary Tumor Prostate-Specific Membrane Antigen Expression with Disease Recurrence in Prostate Cancer
Jeffrey S. Ross; Christine E. Sheehan; Hugh A. G. Fisher; Ronald P. Kaufman, Jr.; Prabhjot Kaur; Karen Gray; Iain Webb; Gary S. Gray; Rebecca Mosher; Bhaskar V. S. Kallakury
View articletitled, Correlation of Primary Tumor Prostate-Specific Membrane Antigen Expression with Disease Recurrence in Prostate Cancer
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Vascular Endothelial Growth Factor Independently Predicts the Efficacy of Postoperative Radiotherapy in Node-Negative Breast Cancer Patients
Peggy Manders; Fred C. G. J. Sweep; Vivianne C. G. Tjan-Heijnen; Anneke Geurts-Moespot; Doorléne T. H. van Tienoven; John A. Foekens; Paul N. Span; Jan Bussink; Louk V. A. M. Beex
View articletitled, Vascular Endothelial Growth Factor Independently Predicts the Efficacy of Postoperative Radiotherapy in Node-Negative Breast Cancer Patients
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Transcription Factor Sp1 Expression Is a Significant Predictor of Survival in Human Gastric Cancer
Liwei Wang; Daoyan Wei; Suyun Huang; Zhihai Peng; Xiangdong Le; Tsung Teh Wu; James Yao; Jaffer Ajani; Keping Xie
View articletitled, Transcription Factor Sp1 Expression Is a Significant Predictor of Survival in Human Gastric Cancer
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Research Articles

Molecular Oncology, Markers, Clinical Correlates
Interleukin-13 Receptor α2 Chain in Human Head and Neck Cancer Serves as a Unique Diagnostic Marker
Mariko Kawakami; Koji Kawakami; Jan L. Kasperbauer; Lucinda L. Hinkley; Mamoru Tsukuda; Scott E. Strome; Raj K. Puri
View articletitled, Interleukin-13 Receptor α2 Chain in Human Head and Neck Cancer Serves as a Unique Diagnostic Marker
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Aberrant Promoter Methylation and Silencing of Laminin-5-Encoding Genes in Breast Carcinoma
Ubaradka G. Sathyanarayana; Asha Padar; Chun Xian Huang; Makoto Suzuki; Hisayuki Shigematsu; B. Nebiyou Bekele; Adi F. Gazdar
View articletitled, Aberrant Promoter Methylation and Silencing of Laminin-5-Encoding Genes in Breast Carcinoma
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Identification of HRK as a Target of Epigenetic Inactivation in Colorectal and Gastric Cancer
Toshiro Obata; Minoru Toyota; Ayumi Satoh; Yasushi Sasaki; Kazuhiro Ogi; Kimishige Akino; Hiromu Suzuki; Masafumi Murai; Takefumi Kikuchi; Hiroaki Mita; Fumio Itoh; Jean-Pierre J. Issa; Takashi Tokino; Kohzoh Imai
View articletitled, Identification of <strong><em>HRK</em></strong> as a Target of Epigenetic Inactivation in Colorectal and Gastric Cancer
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Detection of Mutations in the Mitogen-Activated Protein Kinase Pathway in Human Melanoma
Janivette Alsina; David H. Gorsk; F. Joseph Germino; Weichung Shih; Shou-En Lu; Zhi-Gang Zhang; Jin-Ming Yang; William N. Hait; James S. Goydos
View articletitled, Detection of Mutations in the Mitogen-Activated Protein Kinase Pathway in Human Melanoma
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Progression of Cervical Carcinomas Is Associated with Down-Regulation of CD9 But Strong Local Re-expression at Sites of Transendothelial Invasion
Georg Sauer; Jasmin Windisch; Christian Kurzeder; Volker Heilmann; Rolf Kreienberg; Helmut Deissler
View articletitled, Progression of Cervical Carcinomas Is Associated with Down-Regulation of CD9 But Strong Local Re-expression at Sites of Transendothelial Invasion
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Prognostic Value of Rho GTPases and Rho Guanine Nucleotide Dissociation Inhibitors in Human Breast Cancers
Wen G. Jiang; Gareth Watkins; Jane Lane; Giles H. Cunnick; Anthony Douglas-Jones; Kefah Mokbel; Robert E. Mansel
View articletitled, Prognostic Value of Rho GTPases and Rho Guanine Nucleotide Dissociation Inhibitors in Human Breast Cancers
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Rapid and Sensitive Detection of Messenger RNA Expression for Molecular Differential Diagnosis of Renal Cell Carcinoma
Guorong Li; Muriel Cuilleron; Anne Gentil-Perret; Michèle Cottier; Karine Passebosc-Faure; Claude Lambert; Christian Genin; Jacques Tostain
View articletitled, Rapid and Sensitive Detection of Messenger RNA Expression for Molecular Differential Diagnosis of Renal Cell Carcinoma
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The Role of an 80 kDa Fragment of E-cadherin in the Metastatic Progression of Prostate Cancer
Rainer Kuefer; Matthias D. Hofer; Juergen E. Gschwend; Kenneth J. Pienta; Martin G. Sanda; Arul M. Chinnaiyan; Mark A. Rubin; Mark L. Day
View articletitled, The Role of an 80 kDa Fragment of E-cadherin in the Metastatic Progression of Prostate Cancer
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Expression of the MAGE-A4 and NY-ESO-1 Cancer-Testis Antigens in Serous Ovarian Neoplasms
Evgeny Yakirevich; Edmond Sabo; Ofer Lavie; Salam Mazareb; Giulio C. Spagnoli; Murray B. Resnick
View articletitled, Expression of the MAGE-A4 and NY-ESO-1 Cancer-Testis Antigens in Serous Ovarian Neoplasms
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Detection of Human Papillomavirus in Cervical Lymph Nodes: A Highly Effective Strategy for Localizing Site of Tumor Origin
Shahnaz Begum; Maura L. Gillison; M. Ali Ansari-Lari; Keerti Shah; William H. Westra
View articletitled, Detection of Human Papillomavirus in Cervical Lymph Nodes<span class="subtitle-colon">: </span><span class="subtitle">A Highly Effective Strategy for Localizing Site of Tumor Origin</span>
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Frequent Loss of Heterozygosity Targeting the Inactive X Chromosome in Melanoma
James O. Indsto; Najah T. Nassif; Richard F. Kefford; Graham J. Mann
View articletitled, Frequent Loss of Heterozygosity Targeting the Inactive X Chromosome in Melanoma
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NRAS and BRAF Mutations Arise Early during Melanoma Pathogenesis and Are Preserved throughout Tumor Progression
Katarina Omholt; Anton Platz; Lena Kanter; Ulrik Ringborg; Johan Hansson
View articletitled, <strong><em>NRAS</em></strong> and <strong><em>BRAF</em></strong> Mutations Arise Early during Melanoma Pathogenesis and Are Preserved throughout Tumor Progression
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Experimental Therapeutics, Preclinical Pharmacology
Adipocyte-Derived Leucine Aminopeptidase Suppresses Angiogenesis in Human Endometrial Carcinoma via Renin-Angiotensin System
Yoshiteru Watanabe; Kiyosumi Shibata; Fumitaka Kikkawa; Hiroaki Kajiyama; Kazuhiko Ino; Akira Hattori; Masafumi Tsujimoto; Shigehiko Mizutani
View articletitled, Adipocyte-Derived Leucine Aminopeptidase Suppresses Angiogenesis in Human Endometrial Carcinoma via Renin-Angiotensin System
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Interferon-γ–Induced Sensitization of Colon Carcinomas to ZD9331 Targets Caspases, Downstream of Fas, Independent of Mitochondrial Signaling and the Inhibitor of Apoptosis Survivin
James Geller; Istvan Petak; Kinga Szekely Szucs; Katalin Nagy; David M. Tillman; Janet A. Houghton
View articletitled, Interferon-γ–Induced Sensitization of Colon Carcinomas to ZD9331 Targets Caspases, Downstream of Fas, Independent of Mitochondrial Signaling and the Inhibitor of Apoptosis Survivin
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Antitumor Therapy with Bacterial DNA and Toxin: Complete Regression of Established Tumor Induced by Liposomal CpG Oligodeoxynucleotides plus Interleukin-13 Cytotoxin
Ken J. Ishii; Koji Kawakami; Ihsan Gursel; Jacqueline Conover; Bharat H. Joshi; Dennis M. Klinman; Raj K. Puri
View articletitled, Antitumor Therapy with Bacterial DNA and Toxin<span class="subtitle-colon">: </span><span class="subtitle">Complete Regression of Established Tumor Induced by Liposomal CpG Oligodeoxynucleotides plus Interleukin-13 Cytotoxin</span>
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Full-Length Dominant-Negative Survivin for Cancer Immunotherapy
Vladimir Pisarev; Bin Yu; Raoul Salup; Simon Sherman; Dario C. Altieri; Dmitry I. Gabrilovich
View articletitled, Full-Length Dominant-Negative Survivin for Cancer Immunotherapy
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Inhibition of Platelet-Derived Growth Factor Receptor Phosphorylation by STI571 (Gleevec) Reduces Growth and Metastasis of Human Pancreatic Carcinoma in an Orthotopic Nude Mouse Model
Rosa F. Hwang; Kenji Yokoi; Corazon D. Bucana; Rachel Tsan; Jerald J. Killion; Douglas B. Evans; Isaiah J. Fidler
View articletitled, Inhibition of Platelet-Derived Growth Factor Receptor Phosphorylation by STI571 (Gleevec) Reduces Growth and Metastasis of Human Pancreatic Carcinoma in an Orthotopic Nude Mouse Model
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Improvement of the Antitumor Activity of Intraperitoneally and Orally Administered 5,6-Dimethylxanthenone-4-Acetic Acid by Optimal Scheduling
Liangli Zhao; Lai-Ming Ching; Philip Kestell; Bruce C. Baguley
View articletitled, Improvement of the Antitumor Activity of Intraperitoneally and Orally Administered 5,6-Dimethylxanthenone-4-Acetic Acid by Optimal Scheduling
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In Vivo Fate of Folate-Targeted Polyethylene-Glycol Liposomes in Tumor-Bearing Mice
Alberto Gabizon; Aviva T. Horowitz; Dorit Goren; Dina Tzemach; Hilary Shmeeda; Samuel Zalipsky
View articletitled, <strong><em>In Vivo</em></strong> Fate of Folate-Targeted Polyethylene-Glycol Liposomes in Tumor-Bearing Mice
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A Fully Human Antimelanoma Cellular Adhesion Molecule/MUC18 Antibody Inhibits Spontaneous Pulmonary Metastasis of Osteosarcoma Cells In Vivo
Eric C. McGary; Amy Heimberger; Lisa Mills; Kristy Weber; Gary W. Thomas; Mikhail Shtivelband; Dina Chelouche Lev; Menashe Bar-Eli
View articletitled, A Fully Human Antimelanoma Cellular Adhesion Molecule/MUC18 Antibody Inhibits Spontaneous Pulmonary Metastasis of Osteosarcoma Cells <strong><em>In Vivo</em></strong>
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Cure of SCID Mice Bearing Human B-Lymphoma Xenografts by an Anti-CD74 Antibody-Anthracycline Drug Conjugate
Gary L. Griffiths; M. Jules Mattes; Rhona Stein; Serengulam V. Govindan; Ivan D. Horak; Hans J. Hansen; David M. Goldenberg
View articletitled, Cure of SCID Mice Bearing Human B-Lymphoma Xenografts by an Anti-CD74 Antibody-Anthracycline Drug Conjugate
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Regular Articles

Molecular Oncology, Markers, and Clinical Correlates
Aberrant Promoter Methylation of Laminin-5–Encoding Genes in Prostate Cancers and Its Relationship to Clinicopathological Features
Ubaradka G. Sathyanarayana; Asha Padar; Makoto Suzuki; Riichiroh Maruyama; Hisayuki Shigematsu; Jer-Tsong Hsieh; Eugene P. Frenkel; Adi F. Gazdar
View articletitled, Aberrant Promoter Methylation of Laminin-5–Encoding Genes in Prostate Cancers and Its Relationship to Clinicopathological Features
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Loss of Caspase-8 Protein Expression Correlates with Unfavorable Survival Outcome in Childhood Medulloblastoma
Carmen Pingoud-Meier; Doris Lang; Anna J. Janss; Lucy B. Rorke; Peter C. Phillips; Tarek Shalaby; Michael A. Grotzer
View articletitled, Loss of Caspase-8 Protein Expression Correlates with Unfavorable Survival Outcome in Childhood Medulloblastoma
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Epidermal Growth Factor Receptor, p53 Mutation, and Pathological Response Predict Survival in Patients with Locally Advanced Esophageal Cancer Treated with Preoperative Chemoradiotherapy
Michael K. Gibson; Susan C. Abraham; Tsung-Teh Wu; Barbara Burtness; Richard F. Heitmiller; Elisabeth Heath; Arlene Forastiere
View articletitled, Epidermal Growth Factor Receptor, p53 Mutation, and Pathological Response Predict Survival in Patients with Locally Advanced Esophageal Cancer Treated with Preoperative Chemoradiotherapy
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Prognostic Value of Apoptosis-Regulating Protein Expression in Anal Squamous Cell Carcinoma
Abdelkarim S. Allal; Laurent Waelchli; Marie-Anne Bründler
View articletitled, Prognostic Value of Apoptosis-Regulating Protein Expression in Anal Squamous Cell Carcinoma
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