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Volume 9, Issue 12

1 October 2003

Cover Image

Cover Image

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Review
Perspectives
The Biology Behind
Report from the FDA
Featured Articles
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology
Letters to the Editor
Correction

Review

Therapeutic Exploitation of the Physiological and Molecular Genetic Alterations in Head and Neck Cancer

Quynh-Thu Le; Amato J. Giaccia

Perspectives

Natural T Cell Immunity against Cancer

Dirk Nagorsen; Carmen Scheibenbogen; Francesco M. Marincola; Anne Letsch; Ulrich Keilholz

The Biology Behind

Ribonucleotide Reductase Subunit One as Gene Therapy Target : Commentary re: M-Y. Cao et al., Adenovirus-mediated Ribonucleotide Reductase R1 Gene Therapy of Human Colon Adenocarcinoma. Clin. Cancer Res., 9: 4304-4308, 2003.

Yun Yen

Report from the FDA

Fulvestrant in Postmenopausal Women with Advanced Breast Cancer

Peter F. Bross; Amy Baird; Gang Chen; Josephine M. Jee; Richard T. Lostritto; David E. Morse; Liliam A. Rosario; Gene M. Williams; Peiling Yang; Atiqur Rahman; Grant Williams; Richard Pazdur

Featured Articles

Clinical Trials

Variability in Response Assessment in Solid Tumors: Effect of Number of Lesions Chosen for Measurement

Lawrence H. Schwartz; Madhu Mazumdar; Wendy Brown; Alex Smith; David M. Panicek

Celecoxib Modulates the Expression of Cyclooxygenase-2, Ki67, Apoptosis-Related Marker, and Microvessel Density in Human Cervical Cancer: A Pilot Study

Gabriella Ferrandina; Franco O. Ranelletti; Francesco Legge; Libero Lauriola; Vanda Salutari; Marco Gessi; Antonia C. Testa; Ulrike Werner; Pierluigi Navarra; Giuseppe Tringali; Alessandra Battaglia; Giovanni Scambia

Molecular Oncology, Markers, Clinical Correlates

The Relationship of Human Wound Vascular Endothelial Growth Factor (VEGF) After Breast Cancer Surgery to Circulating VEGF and Angiogenesis

Emma Hormbrey; Cheng Han; Anthony Roberts; Duncan Angus McGrouther; Adrian L. Harris

Experimental Therapeutics, Preclinical Pharmacology

Resistance to Gefitinib in PTEN-Null HER-Overexpressing Tumor Cells Can Be Overcome through Restoration of PTEN Function or Pharmacologic Modulation of Constitutive Phosphatidylinositol 3′-Kinase/Akt Pathway Signaling

Qing-Bai She; David Solit; Andrea Basso; Mark M. Moasser

Regular Articles

Clinical Trials

Amplification of Virus-Induced Antimelanoma T-Cell Reactivity by High-Dose Interferon-α2b: Implications for Cancer Vaccines

Igor Astsaturov; Teresa Petrella; E. Umit Bagriacik; Mark de Benedette; Robert Uger; Gail Lumber; Neil Berinstein; Ileana Elias; Neill Iscoe; Caitlin Hammond; Paul Hamilton; David E. Spaner

Tirapazamine Plus Carboplatin and Paclitaxel in Advanced Malignant Solid Tumors: A California Cancer Consortium Phase I and Molecular Correlative Study

Primo N. Lara, Jr.; Paul Frankel; Philip C. Mack; Paul H. Gumerlock; Irina Galvin; Cynthia L. Martel; Jeff Longmate; James H. Doroshow; Heinz Josef Lenz; Derick H. M. Lau; David R. Gandara

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Dihydropyrimidinase Deficiency and Severe 5-Fluorouracil Toxicity

André B. P. van Kuilenburg; Rutger Meinsma; Bernard A. Zonnenberg; Lida Zoetekouw; Frank Baas; Koichi Matsuda; Nanaya Tamaki; Albert H. van Gennip

Reduced MLH1 Expression after Chemotherapy Is an Indicator for Poor Prognosis in Esophageal Cancers

Kentaro Kishi; Yuichiro Doki; Masahiko Yano; Takushi Yasuda; Yoshiyuki Fujiwara; Syuji Takiguchi; Sontae Kim; Ichiro Higuchi; Morito Monden

Evaluation of Pre-existent Immunity in Patients with Primary Breast Cancer: Molecular and Cellular Assays to Quantify Antigen-Specific T Lymphocytes in Peripheral Blood Mononuclear Cells

Christine Rentzsch; Simone Kayser; Susanne Stumm; Iris Watermann; Steffen Walter; Stefan Stevanoviç; Diethelm Wallwiener; Brigitte Gückel

Pretreatment Proliferation Parameters Do Not Add Predictive Power to Clinical Factors in Cervical Cancer Treated with Definitive Radiation Therapy

Richard W. Tsang; Stephen Juvet; Melania Pintilie; Richard P. Hill; C. Shun Wong; Michael Milosevic; William Chapman; Anthony W. Fyles

Polymorphisms in BRCA1 and BRCA2 and Risk of Epithelial Ovarian Cancer

Robert M. Wenham; Joellen M. Schildkraut; Kia McLean; Brian Calingaert; Rex C. Bentley; Jeffrey Marks; Andrew Berchuck

Increased Populations of Regulatory T Cells in Peripheral Blood and Tumor-Infiltrating Lymphocytes in Patients with Gastric and Esophageal Cancers

Fumiko Ichihara; Koji Kono; Akihiro Takahashi; Hiromichi Kawaida; Hidemitsu Sugai; Hideki Fujii

Increased Expression of Integrin-Linked Kinase Is Correlated with Melanoma Progression and Poor Patient Survival

Derek L. Dai; Nikita Makretsov; Eric I. Campos; Changzheng Huang; Youwen Zhou; David Huntsman; Madgalena Martinka; Gang Li

Expression Analysis of DNA Methyltransferases 1, 3A, and 3B in Sporadic Breast Carcinomas

Igor Girault; Sengül Tozlu; Rosette Lidereau; Ivan Bièche

High Levels of Serum HER-2/neu and YKL-40 Independently Reflect Aggressiveness of Metastatic Breast Cancer

Benny Vittrup Jensen; Julia S. Johansen; Paul A. Price

Meningiomas: Analysis of Loss of Heterozygosity on Chromosome 10 in Tumor Progression and the Delineation of Four Regions of Chromosomal Deletion in Common with Other Cancers

Dana Mihaila; Jorge A. Gutiérrez; Mark L. Rosenblum; Irene F. Newsham; Oliver Bögler; Sandra A. Rempel; on behalf of NABTT CNS Consortium

Meningiomas: Loss of Heterozygosity on Chromosome 10 and Marker-Specific Correlations with Grade, Recurrence, and Survival

Dana Mihaila; Michelle Jankowski; Jorge A. Gutiérrez; Mark L. Rosenblum; Irene F. Newsham; Oliver Bögler; Sandra A. Rempel; on behalf of the NABTT CNS Consortium

BRCA2 Mutations and Androgen Receptor Expression as Independent Predictors of Outcome of Male Breast Cancer Patients

Eliza Kwiatkowska; Marek Teresiak; Violetta Filas; Aldona Karczewska; Danuta Breborowicz; Andrzej Mackiewicz

HLA-G Is a Potential Tumor Marker in Malignant Ascites

Gad Singer; Vera Rebmann; Yu-Chi Chen; Hsu-Tai Liu; Syed Z. Ali; Jochen Reinsberg; Michael T. McMaster; Kerstin Pfeiffer; Daniel W. Chan; Eva Wardelmann; Hans Grosse-Wilde; Chih-Chien Cheng; Robert J. Kurman; Ie-Ming Shih

Gene-specific Formation and Repair of DNA Monoadducts and Interstrand Cross-links after Therapeutic Exposure to Nitrogen Mustards

Vassilis L. Souliotis; Meletios A. Dimopoulos; Petros P. Sfikakis

Estrogen Receptor-β Expression in Human Testicular Germ Cell Tumors

Vernon Pais; Irwin Leav; Kin-Mang Lau; Zhong Jiang; Shuk-Mei Ho

Experimental Therapeutics, Preclinical Pharmacology

FLT3 Expressing Leukemias Are Selectively Sensitive to Inhibitors of the Molecular Chaperone Heat Shock Protein 90 through Destabilization of Signal Transduction-Associated Kinases

Qing Yao; Ritsuo Nishiuchi; Quanzhi Li; Ashish R. Kumar; Wendy A. Hudson; John H. Kersey

Anti-Leukemia Effect of Perillyl Alcohol in Bcr/Abl-Transformed Cells Indirectly Inhibits Signaling through Mek in a Ras- and Raf-Independent Fashion

Steven S. Clark; Li Zhong; Daniele Filiault; Sarah Perman; Zhibin Ren; Michael Gould; Xinhai Yang

Preclinical Evaluation of Targeted Cytotoxic Luteinizing Hormone-Releasing Hormone Analogue AN-152 in Androgen-Sensitive and Insensitive Prostate Cancers

Markus Letsch; Andrew V. Schally; Karoly Szepeshazi; Gabor Halmos; Attila Nagy

Stress-Related Mediators Stimulate Vascular Endothelial Growth Factor Secretion by Two Ovarian Cancer Cell Lines

Susan K. Lutgendorf; Steven Cole; Erin Costanzo; Sarah Bradley; Jeremy Coffin; Sarvenaz Jabbari; Kaitlin Rainwater; Justine M. Ritchie; Maria Yang; Anil K. Sood

Nonviral Cytokine Gene Therapy on an Orthotopic Bladder Cancer Model

Qinghui Wu; Ratha Mahendran; Kesavan Esuvaranathan

Metabolic Response of the CWR22 Prostate Tumor Xenograft after 20 Gy of Radiation Studied by ¹H Spectroscopic Imaging

Jonathan P. Dyke; Kristen L. Zakian; William M. Spees; Cornelia Matei; Yuchen Chen; Xiangling Mao; Dikoma C. Shungu; Jason A. Koutcher

Drug Interactions between the Proteasome Inhibitor Bortezomib and Cytotoxic Chemotherapy, Tumor Necrosis Factor (TNF) α, and TNF-Related Apoptosis-Inducing Ligand in Prostate Cancer

Jiabin An; Yi-Ping Sun; Julian Adams; Myrna Fisher; Arie Belldegrun; Matthew B. Rettig

Changes in Tumor Vascularization after Irradiation, Anthracyclin, or Antiangiogenic Treatment in Nitrosomethyl Ureas-Induced Rat Mammary Tumors

Fabrice Denis; Séverine Colas; Linda Chami; Pascal Louisot; Olivier le Floch; François Tranquart; Philippe Bougnoux

Adenovirus-Mediated Ribonucleotide Reductase R1 Gene Therapy of Human Colon Adenocarcinoma

Ming-Yu Cao; Yoon Lee; Ning-Ping Feng; Keyong Xiong; Hongnan Jin; Ming Wang; Aikaterini Vassilakos; Stéphane Viau; Jim A. Wright; Aiping H. Young

Is Interferon γ One Key of Metastatic Potential Increase in Human Bladder Carcinoma?

Pierre Champelovier; Annick Simon; Catherine Garrel; Geraldine Levacher; Vincent Praloran; Daniel Seigneurin

Effects of the Proteasome Inhibitor, Bortezomib, on Apoptosis in Isolated Lymphocytes Obtained from Patients with Chronic Lymphocytic Leukemia

Jessica C. Pahler; Stacey Ruiz; Irina Niemer; Leslie R. Calvert; Michael Andreeff; Michael Keating; Stefan Faderl; David J. McConkey

Inhibition of Intracerebral Glioblastoma Growth by Local Treatment with the Scatter Factor/Hepatocyte Growth Factor-Antagonist NK4

Marc A. Brockmann; Apollon Papadimitriou; Michael Brandt; Regina Fillbrandt; Manfred Westphal; Katrin Lamszus

Flavopiridol Potently Induces Small Cell Lung Cancer Apoptosis during S Phase in a Manner That Involves Early Mitochondrial Dysfunction

Julie Litz; Patricia Carlson; G. Sakuntala Warshamana-Greene; Steven Grant; Geoffrey W. Krystal

Targeted Liposomal c-myc Antisense Oligodeoxynucleotides Induce Apoptosis and Inhibit Tumor Growth and Metastases in Human Melanoma Models

Fabio Pastorino; Chiara Brignole; Danilo Marimpietri; Gabriella Pagnan; Adriana Morando; Domenico Ribatti; Sean C. Semple; Claudio Gambini; Theresa M. Allen; Mirco Ponzoni

Retinoid Receptor-Dependent and Independent Biological Activities of Novel Fenretinide Analogues and Metabolites

Anita L. Sabichi; Hui Xu; Susan Fischer; Changchan Zou; Xiulan Yang; Vernon E. Steele; Gary J. Kelloff; Reuben Lotan; John L. Clifford

Selective Estrogen Receptor Modulators as Inhibitors of Repopulation of Human Breast Cancer Cell Lines after Chemotherapy

Wu Licun; Ian F. Tannock

Synergistic Activity of Recombinant Human Endostatin in Combination with Adriamycin: Analysis of in Vitro Activity on Endothelial Cells and in Vivo Tumor Progression in an Orthotopic Murine Mammary Carcinoma Model

Stacy M. Plum; Arthur D. Hanson; Kirk M. Volker; Hong A. Vu; B. Kim Lee Sim; William E. Fogler; Anne H. Fortier

Control of COX-2 Gene Expression through Peroxisome Proliferator-Activated Receptor γ in Human Cervical Cancer Cells

Shouwei Han; Hiroyasu Inoue; Lisa C. Flowers; Neil Sidell

Letters to the Editor

Treatment of Ifosfamide Encephalopathy with Intravenous Thiamin

José M. Buesa; Paula García-Teijido; Raquel Losa; Joaquín Fra

Correction

Correction for vol. 9, p. 3021

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