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Volume 9, Issue 11

15 September 2003

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Cover Image

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Featured Articles
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology

Featured Articles

Clinical Trials

Recombinant Human Angiostatin by Twice-Daily Subcutaneous Injection in Advanced Cancer: A Pharmacokinetic and Long-Term Safety Study 1

Laurens V. Beerepoot; Els O. Witteveen; Gerard Groenewegen; William E. Fogler; B. Kim Leel Sim; Carolyn Sidor; Bernard A. Zonnenberg; Franz Schramel; Martijn F. B. G. Gebbink; Emile E. Voest

Abstract

View articletitled, Recombinant Human Angiostatin by Twice-Daily Subcutaneous Injection in Advanced Cancer: A Pharmacokinetic and Long-Term Safety Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

The Androgen Receptor Gene is Preferentially Hypermethylated in Follicular Non-Hodgkin’s Lymphomas

Hongyu Yang; Chuan-Mu Chen; Pearlly Yan; Tim H-M. Huang; Huidong Shi; Mattias Burger; Inko Nimmrich; Sabine Maier; Kurt Berlin; Charles W. Caldwell

Abstract

View articletitled, The Androgen Receptor Gene is Preferentially Hypermethylated in Follicular Non-Hodgkin’s Lymphomas

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Association of Tapasin and HLA Class I Antigen Down-Regulation in Primary Maxillary Sinus Squamous Cell Carcinoma Lesions with Reduced Survival of Patients 1

Takeshi Ogino; Nobuyuki Bandoh; Tatsuya Hayashi; Naoyuki Miyokawa; Yasuaki Harabuchi; Soldano Ferrone

Abstract

View articletitled, Association of Tapasin and HLA Class I Antigen Down-Regulation in Primary Maxillary Sinus Squamous Cell Carcinoma Lesions with Reduced Survival of Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

All-trans-Retinoic Acid-induced Apoptosis in Human Medulloblastoma: Activation of Caspase-3/Poly(ADP-ribose) Polymerase 1 Pathway 1

Kiranmai Gumireddy; Leslie N. Sutton; Peter C. Phillips; C. Damodar Reddy

Abstract

View articletitled, All-trans-Retinoic Acid-induced Apoptosis in Human Medulloblastoma: Activation of Caspase-3/Poly(ADP-ribose) Polymerase 1 Pathway<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Bcl-2 Transgene Protects T Cells from Renal Cell Carcinoma-mediated Apoptosis 1

Luis Molto; Pat Rayman; Ewa Paszkiewicz-Kozik; Mark Thornton; Lisa Reese; John C. Thomas; Tanya Das; Daisuke Kudo; Ronald Bukowski; James Finke; Charles Tannenbaum

Abstract

View articletitled, The Bcl-2 Transgene Protects T Cells from Renal Cell Carcinoma-mediated Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regular Articles

Clinical Trials

A Safety Study of a Mixed-backbone Oligonucleotide (GEM231) Targeting the Type I Regulatory Subunit α of Protein Kinase A Using a Continuous Infusion Schedule in Patients with Refractory Solid Tumors 1

Sanjay Goel; Kavita Desai; Anca Bulgaru; Abbie Fields; Gary Goldberg; Sudhir Agrawal; Russell Martin; Michael Grindel; Sridhar Mani

Abstract

View articletitled, A Safety Study of a Mixed-backbone Oligonucleotide (GEM231) Targeting the Type I Regulatory Subunit α of Protein Kinase A Using a Continuous Infusion Schedule in Patients with Refractory Solid Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase II Study of 1α-Hydroxyvitamin D₂ in the Treatment of Advanced Androgen-independent Prostate Cancer 1

Glenn Liu; George Wilding; Mary Jane Staab; Dorthea Horvath; Kelly Miller; Amy Dresen; Dona Alberti; Rhoda Arzoomanian; Rick Chappell; Howard H. Bailey

Abstract

View articletitled, Phase II Study of 1α-Hydroxyvitamin D2 in the Treatment of Advanced Androgen-independent Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Study of Oral Topotecan in Hematological Malignancies 1

Miloslav Beran; Susan O’Brien; Deborah A. Thomas; Hai T. Tran; Jorge E. Cortes-Franco; Francis Giles; Elihu Estey; Hagop M. Kantarjian

Abstract

View articletitled, Phase I Study of Oral Topotecan in Hematological Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I and Pharmacokinetic Study of Triapine, a Potent Ribonucleotide Reductase Inhibitor, Administered Daily for Five Days in Patients with Advanced Solid Tumors 1

John Murren; Manuel Modiano; Caroline Clairmont; Paula Lambert; Niramol Savaraj; Terry Doyle; Mario Sznol

Abstract

View articletitled, Phase I and Pharmacokinetic Study of Triapine, a Potent Ribonucleotide Reductase Inhibitor, Administered Daily for Five Days in Patients with Advanced Solid Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Pharmacological and Bioavailability Study of Oral Diflomotecan (BN80915), a Novel E-Ring-modified Camptothecin Analogue in Adults with Solid Tumors

Hans Gelderblom; Ramon Salazar; Jaap Verweij; George Pentheroudakis; Maja J. A. de Jonge; Martin Devlin; Christel van Hooije; Francis Seguy; Rosendo Obach; Joan Pruñonosa; Paola Principe; Chris Twelves

Abstract

View articletitled, Phase I Pharmacological and Bioavailability Study of Oral Diflomotecan (BN80915), a Novel E-Ring-modified Camptothecin Analogue in Adults with Solid Tumors

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A Phase I/IIA Trial of Continuous Five-Day Infusion of Squalamine Lactate (MSI-1256F) Plus Carboplatin and Paclitaxel in Patients with Advanced Non-Small Cell Lung Cancer 1

Roy S. Herbst; Lisa A. Hammond; David P. Carbone; Hai T. Tran; Kenneth J. Holroyd; Avinash Desai; Jon I. Williams; B. Nebiyou Bekele; Howard Hait; Victoria Allgood; Stephen Solomon; Joan H. Schiller

Abstract

View articletitled, A Phase I/IIA Trial of Continuous Five-Day Infusion of Squalamine Lactate (MSI-1256F) Plus Carboplatin and Paclitaxel in Patients with Advanced Non-Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Thymidylate Synthase and Dihydropyrimidine Dehydrogenase mRNA Expression Levels: Predictors for Survival in Colorectal Cancer Patients Receiving Adjuvant 5-Fluorouracil 1

Marko Kornmann; Wolfgang Schwabe; Silvia Sander; Martina Kron; Jörn Sträter; Sucan Polat; Erika Kettner; Hans F. Weiser; Wolfram Baumann; Harald Schramm; Peter Häusler; Kati Ott; Detlev Behnke; Ludger Staib; Hans G. Beger; Karl H. Link

Abstract

View articletitled, Thymidylate Synthase and Dihydropyrimidine Dehydrogenase mRNA Expression Levels: Predictors for Survival in Colorectal Cancer Patients Receiving Adjuvant 5-Fluorouracil<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology Cytokines

Identification of S100A2 as a Target of the ΔNp63 Oncogenic Pathway

Kenji Hibi; Shin-ichi Fujitake; Tsunenobu Takase; Yasuhiro Kodera; Katsuki Ito; Seiji Akiyama; Masatoshi Shirane; Akimasa Nakao

Abstract

View articletitled, Identification of S100A2 as a Target of the ΔNp63 Oncogenic Pathway

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Expression of Endothelin-1, Endothelin-A, and Endothelin-B Receptor in Human Breast Cancer and Correlation with Long-Term Follow-Up 1

Pia Wülfing; Raihanatou Diallo; Christian Kersting; Christian Wülfing; Christopher Poremba; Achim Rody; Robert R. Greb; Werner Böcker; Ludwig Kiesel

Abstract

View articletitled, Expression of Endothelin-1, Endothelin-A, and Endothelin-B Receptor in Human Breast Cancer and Correlation with Long-Term Follow-Up<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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p15^INK4b, p14^ARF, and p16^INK4a Inactivation in Sporadic and Neurofibromatosis Type 1-related Malignant Peripheral Nerve Sheath Tumors 1

Federica Perrone; Silvia Tabano; Federica Colombo; Gianpaolo Dagrada; Sarah Birindelli; Alessandro Gronchi; Maurizio Colecchia; Marco A. Pierotti; Silvana Pilotti

Abstract

View articletitled, p15INK4b, p14ARF, and p16INK4a Inactivation in Sporadic and Neurofibromatosis Type 1-related Malignant Peripheral Nerve Sheath Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Impact of p53 Protein Core Domain Structural Alteration on Ovarian Cancer Survival 1

Stephen L. Rose; Andrew D. Robertson; Michael J. Goodheart; Brian J. Smith; Barry R. DeYoung; Richard E. Buller

Abstract

View articletitled, The Impact of p53 Protein Core Domain Structural Alteration on Ovarian Cancer Survival<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Early Stage Cervical Cancers Containing Human Papillomavirus Type 18 DNA Have More Nodal Metastasis and Deeper Stromal Invasion 1

Samuel S. Im; Sharon P. Wilczynski; Robert A. Burger; Bradley J. Monk

Abstract

View articletitled, Early Stage Cervical Cancers Containing Human Papillomavirus Type 18 DNA Have More Nodal Metastasis and Deeper Stromal Invasion<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Short Postoperative Survival for Glioblastoma Patients with a Dysfunctional Rb1 Pathway in Combination with No Wild-type PTEN1

L. Magnus Bäcklund; Bo R. Nilsson; Helena M. Goike; Esther E. Schmidt; Lu Liu; Koichi Ichimura; V. Peter Collins

Abstract

View articletitled, Short Postoperative Survival for Glioblastoma Patients with a Dysfunctional Rb1 Pathway in Combination with No Wild-type PTEN<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Major Histocompatibility Antigens and Antigen-processing Molecules in Uveal Melanoma 1

Subramanian Krishnakumar; Dhiraj Abhyankar; Amirtha Lakshmi Sundaram; Vaijayanthi Pushparaj; Mahesh Palanivelu Shanmugam; Jyotirmay Biswas

Abstract

View articletitled, Major Histocompatibility Antigens and Antigen-processing Molecules in Uveal Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Thymidylate Synthase Expression Predicts the Response to 5-Fluorouracil-based Adjuvant Therapy in Pancreatic Cancer

Ying Chuan Hu; Richard A. Komorowski; Shannon Graewin; Galen Hostetter; Olli-P. Kallioniemi; Henry A. Pitt; Steven A. Ahrendt

Abstract

View articletitled, Thymidylate Synthase Expression Predicts the Response to 5-Fluorouracil-based Adjuvant Therapy in Pancreatic Cancer

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Artificial Intelligence in Predicting Bladder Cancer Outcome: A Comparison of Neuro-Fuzzy Modeling and Artificial Neural Networks 1

James W. F. Catto; Derek A. Linkens; Maysam F. Abbod; Minyou Chen; Julian L. Burton; Kenneth M. Feeley; Freddie C. Hamdy

Abstract

View articletitled, Artificial Intelligence in Predicting Bladder Cancer Outcome: A Comparison of Neuro-Fuzzy Modeling and Artificial Neural Networks<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Squamous Cell Carcinoma of the Esophagus Can Be Detected by Microsatellite Analysis in Tumor and Serum 1

Claus F. Eisenberger; Wolfram T. Knoefel; Matthias Peiper; Petra Merkert; Emre F. Yekebas; Peter Scheunemann; Katharina Steffani; Nikolas H. Stoecklein; Stefan B. Hosch; Jakob R. Izbicki

Abstract

View articletitled, Squamous Cell Carcinoma of the Esophagus Can Be Detected by Microsatellite Analysis in Tumor and Serum<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Two Prognostic Groups of Inflammatory Breast Cancer Have Distinct Genotypes 1

Florence Lerebours; Philippe Bertheau; Ivan Bieche; Louis-François Plassa; Marie-Helene Champeme; Kamel Hacene; Christine Toulas; Marc Espie; Michel Marty; Rosette Lidereau

Abstract

View articletitled, Two Prognostic Groups of Inflammatory Breast Cancer Have Distinct Genotypes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Consequences of Loss of Progesterone Receptor Expression in Development of Invasive Endometrial Cancer 1

Eline E. Hanekamp; Susanne C. J. P. Gielen; Ellen Smid-Koopman; Liesbeth C. M. Kühne; Petra E. de Ruiter; Savi Chadha-Ajwani; Albert O. Brinkmann; J. Anton Grootegoed; Curt W. Burger; Frans J. Huikeshoven; Leen J. Blok

Abstract

View articletitled, Consequences of Loss of Progesterone Receptor Expression in Development of Invasive Endometrial Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Correlation between Aberrant Connexin 43 mRNA Expression Induced by Promoter Methylation and Nodal Micrometastasis in Non-Small Cell Lung Cancer 1

Jung-Ta Chen; Ya-Wen Cheng; Ming-Chih Chou; Tong Sen-Lin; Wu-Wei Lai; William L. Ho; Huei Lee

Abstract

View articletitled, The Correlation between Aberrant Connexin 43 mRNA Expression Induced by Promoter Methylation and Nodal Micrometastasis in Non-Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Responsiveness to the Retinoic Acid Receptor-selective Retinoid LGD1550 Correlates with Abrogation of Transforming Growth Factor α/Epidermal Growth Factor Receptor Autocrine Signaling in Head and Neck Squamous Carcinoma Cells 1

Miriam Lango; Abbey L. Wentzel; John I. Song; Sichuan Xi; Daniel E. Johnson; William W. Lamph; Lori Miller; Jennifer Rubin Grandis

Abstract

View articletitled, Responsiveness to the Retinoic Acid Receptor-selective Retinoid LGD1550 Correlates with Abrogation of Transforming Growth Factor α/Epidermal Growth Factor Receptor Autocrine Signaling in Head and Neck Squamous Carcinoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Platelet-activating Factor Inactivation by Local Expression of Platelet-activating Factor Acetyl-Hydrolase Modifies Tumor Vascularization and Growth 1

Luigi Biancone; Vincenzo Cantaluppi; Lorenzo Del Sorbo; Simona Russo; Larry W. Tjoelker; Giovanni Camussi

Abstract

View articletitled, Platelet-activating Factor Inactivation by Local Expression of Platelet-activating Factor Acetyl-Hydrolase Modifies Tumor Vascularization and Growth<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Differential Vascular and Transcriptional Responses to Anti-Vascular Endothelial Growth Factor Antibody in Orthotopic Human Pancreatic Cancer Xenografts 1

Maximilian Bockhorn; Yoshikazu Tsuzuki; Lei Xu; Andreja Frilling; Christoph E. Broelsch; Dai Fukumura

Abstract

View articletitled, Differential Vascular and Transcriptional Responses to Anti-Vascular Endothelial Growth Factor Antibody in Orthotopic Human Pancreatic Cancer Xenografts<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Predictive Value of the in Vitro Cell Line, Human Xenograft, and Mouse Allograft Preclinical Cancer Models 1

Theodora Voskoglou-Nomikos; Joseph L. Pater; Lesley Seymour

Abstract

View articletitled, Clinical Predictive Value of the in Vitro Cell Line, Human Xenograft, and Mouse Allograft Preclinical Cancer Models<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Vaccination against B-cell Chronic Lymphocytic Leukemia with Trioma Cells: Preclinical Evaluation 1

Ulrich Wahl; Elfriede Nöβner; Konrad Kronenberger; Rainer Gangnus; Heike Pohla; Martin S. Staege; Hans-Jochem Kolb; Michael Hallek; Ralph Mocikat

Abstract

View articletitled, Vaccination against B-cell Chronic Lymphocytic Leukemia with Trioma Cells: Preclinical Evaluation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors 1

Amy B. Heimberger; Laura E. Crotty; Gary E. Archer; Kenneth R. Hess; Carol J. Wikstrand; Allan H. Friedman; Henry S. Friedman; Darell D. Bigner; John H. Sampson

Abstract

View articletitled, Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cisplatin Down-Regulation of Cellular Fas-associated Death Domain-like Interleukin-1β-converting Enzyme-like Inhibitory Proteins to Restore Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Melanoma Cells 1

Jin H. Song; Doyoun K. Song; Meenhard Herlyn; Kenneth C. Petruk; Chunhai Hao

Abstract

View articletitled, Cisplatin Down-Regulation of Cellular Fas-associated Death Domain-like Interleukin-1β-converting Enzyme-like Inhibitory Proteins to Restore Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Melanoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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BCL-2 Antisense Oligonucleotide Genasense Is Active against Imatinib-resistant BCR-ABL-positive Cells 1

Tetsuzo Tauchi; Masahiko Sumi; Akihiro Nakajima; Goro Sashida; Takashi Shimamoto; Kazuma Ohyashiki

Abstract

View articletitled, BCL-2 Antisense Oligonucleotide Genasense Is Active against Imatinib-resistant BCR-ABL-positive Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Reduction of Stromal Fibroblast-induced Mammary Tumor Growth, by Retroviral Ribozyme Transgenes to Hepatocyte Growth Factor/Scatter Factor and its Receptor, c-MET 1

Wen G. Jiang; David Grimshaw; Tracey A. Martin; Gaynor Davies; Christian Parr; Gareth Watkins; Jane Lane; Roger Abounader; John Laterra; Robert E. Mansel

Abstract

View articletitled, Reduction of Stromal Fibroblast-induced Mammary Tumor Growth, by Retroviral Ribozyme Transgenes to Hepatocyte Growth Factor/Scatter Factor and its Receptor, c-MET<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cover Image

Featured Articles

Clinical Trials

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Regular Articles

Clinical Trials

Cancer Biology, Immunology Cytokines

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

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