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A Message from the Editor-in-Chief

John Mendelsohn

Extract

View articletitled, A Message from the Editor-in-Chief

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Molecular Targets for Radiation Therapy: Bringing Preclinical Data into Clinical Trials 1

Philip J. Tofilon; Scott Saxman; C. Norman Coleman

Extract

View articletitled, Molecular Targets for Radiation Therapy: Bringing Preclinical Data into Clinical Trials<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Biology Behind

Telomerase Therapeutics: Telomeres Recognized as a DNA Damage Signal 1: Commentary re: K. Kraemer et al., Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells. Clin. Cancer Res., 9: 3794–3800, 2003.

Jerry W. Shay

Extract

View articletitled, Telomerase Therapeutics: Telomeres Recognized as a DNA Damage Signal<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>: Commentary re: K. Kraemer et al., Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells. Clin. Cancer Res., 9: 3794–3800, 2003.

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Featured Articles

Clinical Trials

Randomized Phase I Clinical and Pharmacologic Study of Weekly versus Twice-Weekly Dose-intensive Cisplatin and Gemcitabine in Patients with Advanced Non-Small Cell Lung Cancer 1

Mirjam Crul; Nadja E. Schoemaker; Dick Pluim; Marc Maliepaard; René W. M. Underberg; Margaret Schot; Rolf W. Sparidans; Paul Baas; Jos H. Beijnen; Nico van Zandwijk; Jan H. M. Schellens

Abstract

View articletitled, Randomized Phase I Clinical and Pharmacologic Study of Weekly versus Twice-Weekly Dose-intensive Cisplatin and Gemcitabine in Patients with Advanced Non-Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Role of Decreased Levels of Lipid Phosphate Phosphatase-1 in Accumulation of Lysophosphatidic Acid in Ovarian Cancer 1

Abstract

View articletitled, Role of Decreased Levels of Lipid Phosphate Phosphatase-1 in Accumulation of Lysophosphatidic Acid in Ovarian Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Anti-ICAM-2 Monoclonal Antibody Synergizes with Intratumor Gene Transfer of Interleukin-12 Inhibiting Activation-induced T-Cell Death 1

Ignacio Melero; Izaskun Gabari; Iñigo Tirapu; Ainhoa Arina; Guillermo Mazzolini; Elena Baixeras; Esperanza Feijoo; Carlos Alfaro; Cheng Qian; Jesús Prieto

Abstract

View articletitled, Anti-ICAM-2 Monoclonal Antibody Synergizes with Intratumor Gene Transfer of Interleukin-12 Inhibiting Activation-induced T-Cell Death<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regular Articles

Clinical Trials

A Phase II Study of DT Fusion Protein Denileukin Diftitox in Patients with Fludarabine-refractory Chronic Lymphocytic Leukemia 1

Arthur E. Frankel; Donald R. Fleming; Philip D. Hall; Bayard L. Powell; Jennifer H. Black; Carole Leftwich; Ronald Gartenhaus

Abstract

View articletitled, A Phase II Study of DT Fusion Protein Denileukin Diftitox in Patients with Fludarabine-refractory Chronic Lymphocytic Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Trial of CD3/CD28-activated T Cells (Xcellerated T Cells) and Interleukin-2 in Patients with Metastatic Renal Cell Carcinoma 1

John A. Thompson; Robert A. Figlin; Christi Sifri-Steele; Ronald J. Berenson; Mark W. Frohlich

Abstract

View articletitled, A Phase I Trial of CD3/CD28-activated T Cells (Xcellerated T Cells) and Interleukin-2 in Patients with Metastatic Renal Cell Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Proton Beam Therapy with High-Dose Irradiation for Superficial and Advanced Esophageal Carcinomas 1

Shohei Koyama; Hirohiko Tsujii

Abstract

View articletitled, Proton Beam Therapy with High-Dose Irradiation for Superficial and Advanced Esophageal Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Clinical Trial of Histone Deacetylase Inhibitor: Suberoylanilide Hydroxamic Acid Administered Intravenously 1

Wm. Kevin Kelly; Victoria M. Richon; Owen O’Connor; Tracy Curley; Barbara MacGregor-Curtelli; William Tong; Mark Klang; Lawrence Schwartz; Stacie Richardson; Eddie Rosa; Marija Drobnjak; Carlos Cordon-Cordo; Judy H. Chiao; Richard Rifkind; Paul A. Marks; Howard Scher

Abstract

View articletitled, Phase I Clinical Trial of Histone Deacetylase Inhibitor: Suberoylanilide Hydroxamic Acid Administered Intravenously<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Study of Docosahexaenoic Acid-Paclitaxel: a Taxane-Fatty Acid Conjugate with a Unique Pharmacology and Toxicity Profile 1

Antonio C. Wolff; Ross C. Donehower; M. Katherine Carducci; Michael A. Carducci; Julie R. Brahmer; Yelena Zabelina; Matthews O. Bradley; Forrest H. Anthony; Charles S. Swindell; Philip A. Witman; Nigel L. Webb; Sharyn D. Baker

Abstract

View articletitled, Phase I Study of Docosahexaenoic Acid-Paclitaxel: a Taxane-Fatty Acid Conjugate with a Unique Pharmacology and Toxicity Profile<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, and Clinical Correlates

Differential Expression and Clinical Significance of Tyrosine-phosphorylated STAT3 in ALK⁺ and ALK⁻ Anaplastic Large Cell Lymphoma

Joseph D. Khoury; L. Jeffrey Medeiros; George Z. Rassidakis; Marwan A. Yared; Panagiota Tsioli; Vasiliki Leventaki; Annette Schmitt-Graeff; Marco Herling; Hesham M. Amin; Raymond Lai

Abstract

View articletitled, Differential Expression and Clinical Significance of Tyrosine-phosphorylated STAT3 in ALK+ and ALK− Anaplastic Large Cell Lymphoma

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Experimental Therapeutics,Preclinical Pharmacology

Radiolabeling of Avidin with Very High Specific Activity for Internal Radiation Therapy of Intraperitoneally Disseminated Tumors 1

Marcelo Mamede; Tsuneo Saga; Hisataka Kobayashi; Takayoshi Ishimori; Tatsuya Higashi; Noriko Sato; Martin W. Brechbiel; Junji Konishi

Abstract

View articletitled, Radiolabeling of Avidin with Very High Specific Activity for Internal Radiation Therapy of Intraperitoneally Disseminated Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Biology

Prolonged Dormancy and Site-specific Growth Potential of Cancer Cells Spontaneously Disseminated from Nonmetastatic Breast Tumors as Revealed by Labeling with Green Fluorescent Protein

Steve Goodison; Kanji Kawai; Jun Hihara; Ping Jiang; Meng Yang; Virginia Urquidi; Robert M. Hoffman; David Tarin

Abstract

View articletitled, Prolonged Dormancy and Site-specific Growth Potential of Cancer Cells Spontaneously Disseminated from Nonmetastatic Breast Tumors as Revealed by Labeling with Green Fluorescent Protein

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Pancreatic Carcinoma in Carriers of a Specific 19 Base Pair Deletion of CDKN2A/p16 (p16-Leiden)1

Wouter H. de Vos tot Nederveen Cappel; G. Johan A. Offerhaus; Marjo van Puijenbroek; Eric Caspers; Nelleke A. Gruis; Femke A. de Snoo; Cornelis B. H. W. Lamers; Gerrit Griffioen; Wilma Bergman; Hans F. A. Vasen; Hans Morreau

Abstract

View articletitled, Pancreatic Carcinoma in Carriers of a Specific 19 Base Pair Deletion of CDKN2A/p16 (p16-Leiden)<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunohistochemical Characteristics Defined by Tissue Microarray of Hereditary Breast Cancer Not Attributable to BRCA1 or BRCA2 Mutations: Differences from Breast Carcinomas Arising in BRCA1 and BRCA2 Mutation Carriers 1

José Palacios; Emiliano Honrado; Ana Osorio; Alicia Cazorla; David Sarrió; Alicia Barroso; Sandra Rodríguez; Juan C. Cigudosa; Orland Diez; Carmen Alonso; Enrique Lerma; Lydia Sánchez; Carmen Rivas; Javier Benítez

Abstract

View articletitled, Immunohistochemical Characteristics Defined by Tissue Microarray of Hereditary Breast Cancer Not Attributable to BRCA1 or BRCA2 Mutations: Differences from Breast Carcinomas Arising in BRCA1 and BRCA2 Mutation Carriers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Distinct K-ras Mutation Pattern Characterizes Signet Ring Cell Colorectal Carcinoma 1

Ignacio I. Wistuba; Carmen Behrens; Jorge Albores-Saavedra; Ruby Delgado; Francisco Lopez; Adi F. Gazdar

Abstract

View articletitled, Distinct K-ras Mutation Pattern Characterizes Signet Ring Cell Colorectal Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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ERBB1 Is Amplified and Overexpressed in High-grade Diffusely Infiltrative Pediatric Brain Stem Glioma 1

Richard J. Gilbertson; D. Ashley Hill; Roberto Hernan; Mehmet Kocak; Russell Geyer; Jim Olson; Amar Gajjar; Lisa Rush; Ronald L. Hamilton; Sydney D. Finkelstein; Ian F. Pollack

Abstract

View articletitled, ERBB1 Is Amplified and Overexpressed in High-grade Diffusely Infiltrative Pediatric Brain Stem Glioma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Significance of CCR4 Expression in Adult T-Cell Leukemia/Lymphoma: Its Close Association with Skin Involvement and Unfavorable Outcome 1

Takashi Ishida; Atae Utsunomiya; Shinsuke Iida; Hiroshi Inagaki; Yoshifusa Takatsuka; Shigeru Kusumoto; Genji Takeuchi; Shigeki Shimizu; Masato Ito; Hirokazu Komatsu; Atsushi Wakita; Tadaaki Eimoto; Kouji Matsushima; Ryuzo Ueda

Abstract

View articletitled, Clinical Significance of CCR4 Expression in Adult T-Cell Leukemia/Lymphoma: Its Close Association with Skin Involvement and Unfavorable Outcome<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Epigenetic Inactivation of RASSF1A in Head and Neck Cancer 1

Seung Myung Dong; Dong-Il Sun; Nicole E. Benoit; Igor Kuzmin; Michael I. Lerman; David Sidransky

Abstract

View articletitled, Epigenetic Inactivation of RASSF1A in Head and Neck Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enolase-α Is Frequently Down-Regulated in Non-Small Cell Lung Cancer and Predicts Aggressive Biological Behavior 1

Yoon Soo Chang; Weiguo Wu; Garrett Walsh; Waun Ki Hong; Li Mao

Abstract

View articletitled, Enolase-α Is Frequently Down-Regulated in Non-Small Cell Lung Cancer and Predicts Aggressive Biological Behavior<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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HER-2/Neu Alterations in Non-Small Cell Lung Cancer: A Comprehensive Evaluation by Real Time Reverse Transcription-PCR, Fluorescence in Situ Hybridization, and Immunohistochemistry 1

Caterina Pellegrini; Monica Falleni; Antonio Marchetti; Barbara Cassani; Monica Miozzo; Fiamma Buttitta; Massimo Roncalli; Guido Coggi; Silvano Bosari

Abstract

View articletitled, HER-2/Neu Alterations in Non-Small Cell Lung Cancer: A Comprehensive Evaluation by Real Time Reverse Transcription-PCR, Fluorescence in Situ Hybridization, and Immunohistochemistry<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Development of an Immunoassay for Serum Caveolin-1: A Novel Biomarker for Prostate Cancer 1

Salahaldin A. Tahir; Chengzhen Ren; Terry L. Timme; Yehoshua Gdor; Ron Hoogeveen; Joel D. Morrisett; Anna Frolov; Gustavo Ayala; Thomas M. Wheeler; Timothy C. Thompson

Abstract

View articletitled, Development of an Immunoassay for Serum Caveolin-1: A Novel Biomarker for Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Loss of the Expression of the Tumor Suppressor Gene ARHI Is Associated with Progression of Breast Cancer 1

Lin Wang; Ashraful Hoque; Robert Z. Luo; Jiuhong Yuan; Zhen Lu; Arata Nishimoto; Jinsong Liu; Aysegul A. Sahin; Scott M. Lippman; Robert C. Bast, Jr.; Yinhua Yu

Abstract

View articletitled, Loss of the Expression of the Tumor Suppressor Gene ARHI Is Associated with Progression of Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Short Androgen Receptor Allele Length Is a Poor Prognostic Factor in Epithelial Ovarian Carcinoma 1

Andrew J. Li; Rae Lynn Baldwin; Beth Y. Karlan

Abstract

View articletitled, Short Androgen Receptor Allele Length Is a Poor Prognostic Factor in Epithelial Ovarian Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Aberrant Methylation of the HIC1 Promoter Is a Frequent Event in Specific Pediatric Neoplasms 1

Asha Rathi; Arvind K. Virmani; Kenichi Harada; Charles F. Timmons; Kuniharu Miyajima; Robert J. Hay; Domenico Mastrangelo; Anirban Maitra; Gail E. Tomlinson; Adi F. Gazdar

Abstract

View articletitled, Aberrant Methylation of the HIC1 Promoter Is a Frequent Event in Specific Pediatric Neoplasms<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of Retinoic Acid Receptor α in Hepatocellular Carcinoma 1

Keiji Sano; Tadatoshi Takayama; Koji Murakami; Ikuo Saiki; Masatoshi Makuuchi

Abstract

View articletitled, Overexpression of Retinoic Acid Receptor α in Hepatocellular Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Laminin-5 Chains Are Expressed Differentially in Metastatic and Nonmetastatic Hepatocellular Carcinoma 1

Gianluigi Giannelli; Emilia Fransvea; Carlo Bergamini; Felice Marinosci; Salvatore Antonaci

Abstract

View articletitled, Laminin-5 Chains Are Expressed Differentially in Metastatic and Nonmetastatic Hepatocellular Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Polymorphism in the Thymidylate Synthase Promoter Enhancer Region Is Not an Efficacious Marker for Tumor Sensitivity to 5-Fluorouracil-based Oral Adjuvant Chemotherapy in Colorectal Cancer

Takashi Tsuji; Shigekazu Hidaka; Terumitsu Sawai; Tohru Nakagoe; Hiroshi Yano; Masatoshi Haseba; Hideaki Komatsu; Hisakazu Shindou; Hidetoshi Fukuoka; Megumi Yoshinaga; Shinichi Shibasaki; Atsushi Nanashima; Hiroyuki Yamaguchi; Tohru Yasutake; Yutaka Tagawa

Abstract

View articletitled, Polymorphism in the Thymidylate Synthase Promoter Enhancer Region Is Not an Efficacious Marker for Tumor Sensitivity to 5-Fluorouracil-based Oral Adjuvant Chemotherapy in Colorectal Cancer

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Overexpression of E2F-1 Is Associated with Increased Disease-free Survival in Squamous Cell Carcinoma of the Anterior Tongue 1

Rhonda A. Kwong; Tuan V. Nguyen; Ronaldo J. Bova; James G. Kench; Ian E. Cole; Elizabeth A. Musgrove; Susan M. Henshall; Robert L. Sutherland

Abstract

View articletitled, Overexpression of E2F-1 Is Associated with Increased Disease-free Survival in Squamous Cell Carcinoma of the Anterior Tongue<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Combination Therapy with Pretarget CC49 Radioimmunotherapy and Gemcitabine Prolongs Tumor Doubling Time in a Murine Xenograft Model of Colon Cancer More Effectively Than Either Monotherapy 1

Scott S. Graves; Erica Dearstyne; Yukang Lin; Yuting Zuo; James Sanderson; Jody Schultz; Anastasia Pantalias; David Gray; Don Axworthy; H. Mark Jones; Karen Auditore-Hargreaves

Abstract

View articletitled, Combination Therapy with Pretarget CC49 Radioimmunotherapy and Gemcitabine Prolongs Tumor Doubling Time in a Murine Xenograft Model of Colon Cancer More Effectively Than Either Monotherapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Impact of p210^Bcr-Abl on Ultraviolet C Wavelength-induced DNA Damage and Repair

Eunice Laurent; David L. Mitchell; Zeev Estrov; Megan Lowery; Susan L. Tucker; Moshe Talpaz; Razelle Kurzrock

Abstract

View articletitled, Impact of p210Bcr-Abl on Ultraviolet C Wavelength-induced DNA Damage and Repair

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Antitumor Efficacy of TRA-8 Anti-DR5 Monoclonal Antibody Alone or in Combination with Chemotherapy and/or Radiation Therapy in a Human Breast Cancer Model 1

Donald J. Buchsbaum; Tong Zhou; William E. Grizzle; Patsy G. Oliver; Charlotte J. Hammond; Sijian Zhang; Mark Carpenter; Albert F. LoBuglio

Abstract

View articletitled, Antitumor Efficacy of TRA-8 Anti-DR5 Monoclonal Antibody Alone or in Combination with Chemotherapy and/or Radiation Therapy in a Human Breast Cancer Model<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Targeted Doxorubicin-containing Luteinizing Hormone-releasing Hormone Analogue AN-152 Inhibits the Growth of Doxorubicin-resistant MX-1 Human Breast Cancers 1

Ana M. Bajo; Andrew V. Schally; Gabor Halmos; Attila Nagy

Abstract

View articletitled, Targeted Doxorubicin-containing Luteinizing Hormone-releasing Hormone Analogue AN-152 Inhibits the Growth of Doxorubicin-resistant MX-1 Human Breast Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enhanced Cell Killing Induced by the Combination of Radiation and the Heat Shock Protein 90 Inhibitor 17-Allylamino-17- Demethoxygeldanamycin: A Multitarget Approach to Radiosensitization

Jeffery S. Russell; William Burgan; Kelli A. Oswald; Kevin Camphausen; Philip J. Tofilon

Abstract

View articletitled, Enhanced Cell Killing Induced by the Combination of Radiation and the Heat Shock Protein 90 Inhibitor 17-Allylamino-17- Demethoxygeldanamycin: A Multitarget Approach to Radiosensitization

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Dexamethasone and Medroxyprogesterone Acetate Elevate Nm23-H1 Metastasis Suppressor Gene Expression in Metastatic Human Breast Carcinoma Cells: New Uses for Old Compounds

Taoufik Ouatas; Douglas Halverson; Patricia S. Steeg

Abstract

View articletitled, Dexamethasone and Medroxyprogesterone Acetate Elevate Nm23-H1 Metastasis Suppressor Gene Expression in Metastatic Human Breast Carcinoma Cells: New Uses for Old Compounds

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The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 Selectively Potentiates Radiation Response of Human Tumors in Nude Mice, with a Marked Improvement in Therapeutic Index 1

Yuhong She; Fei Lee; Jing Chen; Adriana Haimovitz-Friedman; Vincent A. Miller; Valerie R. Rusch; Mark G. Kris; F. M. Sirotnak

Abstract

View articletitled, The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 Selectively Potentiates Radiation Response of Human Tumors in Nude Mice, with a Marked Improvement in Therapeutic Index<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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STI571 Enhances the Therapeutic Index of Epothilone B by a Tumor-selective Increase of Drug Uptake

Kristian Pietras; Michael Stumm; Martine Hubert; Elisabeth Buchdunger; Kristofer Rubin; Carl-Henrik Heldin; Paul McSheehy; Markus Wartmann; Arne Östman

Abstract

View articletitled, STI571 Enhances the Therapeutic Index of Epothilone B by a Tumor-selective Increase of Drug Uptake

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Treatment with Halofuginone Results in Marked Growth Inhibition of a von Hippel-Lindau Pheochromocytoma in Vivo

David J. Gross; Israel Reibstein; Lola Weiss; Shimon Slavin; Hagit Dafni; Michal Neeman; Mark Pines; Arnon Nagler

Abstract

View articletitled, Treatment with Halofuginone Results in Marked Growth Inhibition of a von Hippel-Lindau Pheochromocytoma in Vivo

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Antisense-mediated hTERT Inhibition Specifically Reduces the Growth of Human Bladder Cancer Cells 1

Kai Kraemer; Susanne Fuessel; Uta Schmidt; Matthias Kotzsch; Bernd Schwenzer; Manfred P. Wirth; Axel Meye

Abstract

View articletitled, Antisense-mediated hTERT Inhibition Specifically Reduces the Growth of Human Bladder Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Sensitization of Pancreatic Tumor Xenografts to Carmustine and Temozolomide by Inactivation of Their O⁶-Methylguanine-DNA Methyltransferase with O⁶-Benzylguanine or O⁶-Benzyl-2′-Deoxyguanosine 1

Demetrius M. Kokkinakis; Mansoor M. Ahmed; Damodaran Chendil; Robert C. Moschel; Anthony E. Pegg

Abstract

View articletitled, Sensitization of Pancreatic Tumor Xenografts to Carmustine and Temozolomide by Inactivation of Their O6-Methylguanine-DNA Methyltransferase with O6-Benzylguanine or O6-Benzyl-2′-Deoxyguanosine<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Letter to the Editor

Commentary re: N. J. McCarthy et al., Microvessel density, expression of estrogen receptor α, MIB-1, p53 and c-erbB-2 in inflammatory breast cancer. Clin. Cancer Res., 8: 3857–3862, 2002.

Cecile G. Colpaert; Peter B. Vermeulen; Luc Y. Dirix; Eric A. Van Marck

Extract

View articletitled, Commentary re: N. J. McCarthy et al., Microvessel density, expression of estrogen receptor α, MIB-1, p53 and c-erbB-2 in inflammatory breast cancer. Clin. Cancer Res., 8: 3857–3862, 2002.

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Supplement Articles

Introduction to the Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates 1

David M. Goldenberg

Extract

View articletitled, Introduction to the Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Session I: ANTIBODIES AND NON-ISOTOPIC IMMUNOCONJUGATES

Targeting Endothelial Growth with Monoclonal Antibodies against Tie-1 Kinase in Mouse Models 1

Päivi Karnani; Kalevi Kairemo

Abstract

View articletitled, Targeting Endothelial Growth with Monoclonal Antibodies against Tie-1 Kinase in Mouse Models<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The New Tie-1 Monoclonal Antibodies Detect Angiogenesis in Metastatic Malignancies 1

Päivi Karnani; Kalevi Kairemo

Abstract

View articletitled, The New Tie-1 Monoclonal Antibodies Detect Angiogenesis in Metastatic Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Therapeutic Potential of Chimeric Amyloid-reactive Monoclonal Antibody 11-1F4 1

Alan Solomon; Deborah T. Weiss; Jonathan S. Wall

Abstract

View articletitled, Therapeutic Potential of Chimeric Amyloid-reactive Monoclonal Antibody 11-1F4<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Session II: ISOTOPIC CONJUGATES, PRECLINICAL AND PRETARGETING

Radioimmunoscintigraphy of Human Met-Expressing Tumor Xenografts Using Met3, a New Monoclonal Antibody 1

Rick V. Hay; Brian Cao; R. Scot Skinner; Ling-Mei Wang; Yanli Su; James H. Resau; Beatrice S. Knudsen; Margaret F. Gustafson; Han-Mo Koo; George F. Vande Woude; Milton D. Gross

Abstract

View articletitled, Radioimmunoscintigraphy of Human Met-Expressing Tumor Xenografts Using Met3, a New Monoclonal Antibody<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Selection and Characterization of Anti-MUC-1 scFvs Intended for Targeted Therapy 1

Michelle D. Winthrop; Sally J. DeNardo; Huguette Albrecht; Gary R. Mirick; Linda A. Kroger; Kathleen R. Lamborn; Česlovas Venclovas; Michael E. Colvin; Patricia A. Burke; Gerald L. DeNardo

Abstract

View articletitled, Selection and Characterization of Anti-MUC-1 scFvs Intended for Targeted Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effect of Molecular Size of Pegylated Peptide on the Pharmacokinetics and Tumor Targeting in Lymphoma-Bearing Mice 1

Sally J. DeNardo; Zhengsheng Yao; Kit S. Lam; Aimin Song; Patricia A. Burke; Gary R. Mirick; Kathleen R. Lamborn; Robert T. O’Donnell; Gerald L. DeNardo

Abstract

View articletitled, Effect of Molecular Size of Pegylated Peptide on the Pharmacokinetics and Tumor Targeting in Lymphoma-Bearing Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Preclinical Evaluation of Cathepsin-degradable Peptide Linkers for Radioimmunoconjugates 1

Gerald L. DeNardo; Sally J. DeNardo; James J. Peterson; Laird A. Miers; Kit S. Lam; Christine Hartmann-Siantar; Kathleen R. Lamborn

Abstract

View articletitled, Preclinical Evaluation of Cathepsin-degradable Peptide Linkers for Radioimmunoconjugates<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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²¹¹At-labeled and Biotinylated Effector Molecules for Pretargeted Radioimmunotherapy Using Poly-l- and Poly-d-Lysine as Multicarriers 1

Sture Lindegren; Börje Karlsson; Lars Jacobsson; Håkan Andersson; Ragnar Hultborn; Gunnar Skarnemark

Abstract

View articletitled, 211At-labeled and Biotinylated Effector Molecules for Pretargeted Radioimmunotherapy Using Poly-l- and Poly-d-Lysine as Multicarriers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pretargeting with Labeled Bivalent Peptides Allowing the Use of Four Radionuclides: ¹¹¹In, ¹³¹I, ^99mTc, and ¹⁸⁸Re 1

Frank G. van Schaijk; Egbert Oosterwijk; Annemiele C. Soede; Wim J. G. Oyen; William J. McBride; Gary L. Griffiths; David M. Goldenberg; Frans H. M. Corstens; Otto C. Boerman

Abstract

View articletitled, Pretargeting with Labeled Bivalent Peptides Allowing the Use of Four Radionuclides: 111In, 131I, 99mTc, and 188Re<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Development of New Multivalent-bispecific Agents for Pretargeting Tumor Localization and Therapy 1

Edmund A. Rossi; Robert M. Sharkey; William McBride; Habibe Karacay; Li Zeng; Hans J. Hansen; David M. Goldenberg; Chien-Hsing Chang

Abstract

View articletitled, Development of New Multivalent-bispecific Agents for Pretargeting Tumor Localization and Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Optimizing Bispecific Antibody Pretargeting for Use in Radioimmunotherapy 1

Robert M. Sharkey; Habibe Karacay; Heidi Richel; William J. McBride; Edmund A. Rossi; Ken Chang; Dion Yeldell; Gary L. Griffiths; Hans J. Hansen; David M. Goldenberg

Abstract

View articletitled, Optimizing Bispecific Antibody Pretargeting for Use in Radioimmunotherapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Session III: EXPERIMENTAL RADIOIMMUNOTHERAPY

Astatine-211-labeled Antibodies for Treatment of Disseminated Ovarian Cancer: An Overview of Results in an Ovarian Tumor Model 1

Håkan Andersson; Jörgen Elgqvist; György Horvath; Ragnar Hultborn; Lars Jacobsson; Holger Jensen; Börje Karlsson; Sture Lindegren; Stig Palm

Abstract

View articletitled, Astatine-211-labeled Antibodies for Treatment of Disseminated Ovarian Cancer: An Overview of Results in an Ovarian Tumor Model<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Locoregional α-Radioimmunotherapy of Intraperitoneal Tumor Cell Dissemination Using a Tumor-specific Monoclonal Antibody 1

Roswitha Huber; Christof Seidl; Ernst Schmid; Sabine Seidenschwang; Karl-Friedrich Becker; Christoph Schuhmacher; Christos Apostolidis; Tuomo Nikula; Elisabeth Kremmer; Markus Schwaiger; Reingard Senekowitsch-Schmidtke

Abstract

View articletitled, Locoregional α-Radioimmunotherapy of Intraperitoneal Tumor Cell Dissemination Using a Tumor-specific Monoclonal Antibody<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Low-Dose Radioimmunotherapy (⁹⁰Y-PAM4) Combined with Gemcitabine for the Treatment of Experimental Pancreatic Cancer 1

David V. Gold; Keith Schutsky; David Modrak; Thomas M. Cardillo

Abstract

View articletitled, Low-Dose Radioimmunotherapy (90Y-PAM4) Combined with Gemcitabine for the Treatment of Experimental Pancreatic Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Session IV: CLINICAL STUDIES: SOLID TUMORS

Enhanced Therapeutic Index of Radioimmunotherapy (RIT) in Prostate Cancer Patients: Comparison of Radiation Dosimetry for 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid (DOTA)-Peptide versus 2IT-DOTA Monoclonal Antibody Linkage for RIT 1

Sally J. DeNardo; Gerald L. DeNardo; A. Yuan; Carol M. Richman; Robert T. O’Donnell; Primo N. Lara; David L. Kukis; Arutselvan Natarajan; Kathleen R. Lamborn; Frederik Jacobs; Christine L. Hartmann Siantar

Abstract

View articletitled, Enhanced Therapeutic Index of Radioimmunotherapy (RIT) in Prostate Cancer Patients: Comparison of Radiation Dosimetry for 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid (DOTA)-Peptide versus 2IT-DOTA Monoclonal Antibody Linkage for RIT<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Pilot Study of Chemoimmunotherapy (Cyclophosphamide, Prednisone, and Rituximab) in Patients with Post-Transplant Lymphoproliferative Disorder following Solid Organ Transplantation 1

Manuela Orjuela; Thomas G. Gross; Ying-Kuen Cheung; Bachir Alobeid; Erin Morris; Mitchell S. Cairo

Abstract

View articletitled, A Pilot Study of Chemoimmunotherapy (Cyclophosphamide, Prednisone, and Rituximab) in Patients with Post-Transplant Lymphoproliferative Disorder following Solid Organ Transplantation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Targeting of Metastatic Renal Cell Carcinoma with the Chimeric Monoclonal Antibody G250 Labeled with ¹³¹I or ¹¹¹In: An Intrapatient Comparison 1

Adrienne H. Brouwers; Wilhelmina C. A. M. Buijs; Egbert Oosterwijk; Otto C. Boerman; Carola Mala; Pieter H. M. De Mulder; Frans H. M. Corstens; Peter F. A. Mulders; Wim J. G. Oyen

Abstract

View articletitled, Targeting of Metastatic Renal Cell Carcinoma with the Chimeric Monoclonal Antibody G250 Labeled with 131I or 111In: An Intrapatient Comparison<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Therapy Study with ¹⁸⁶Re-labeled Humanized Monoclonal Antibody BIWA 4 (Bivatuzumab) in Patients with Head and Neck Squamous Cell Carcinoma 1

Pontus K. E. Börjesson; Ernst J. Postema; Jan C. Roos; David R. Colnot; Henri A. M. Marres; Mathijs H. van Schie; Gerd Stehle; Remco de Bree; Gordon B. Snow; Wim J. G. Oyen; Guus A. M. S. van Dongen

Abstract

View articletitled, Phase I Therapy Study with 186Re-labeled Humanized Monoclonal Antibody BIWA 4 (Bivatuzumab) in Patients with Head and Neck Squamous Cell Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pharmacokinetics and Dosimetry Studies for Optimization of Anti-Carcinoembryonic Antigen × Anti-Hapten Bispecific Antibody-mediated Pretargeting of Iodine-131-labeled Hapten in a Phase I Radioimmunotherapy Trial 1

Françoise Kraeber-Bodéré; Alain Faivre-Chauvet; Ludovic Ferrer; Jean-Philippe Vuillez; Pierre-Yves Brard; Caroline Rousseau; Isabelle Resche; Anne Devillers; Sophie Laffont; Manuel Bardiès; Ken Chang; Robert M. Sharkey; David M. Goldenberg; Jean-François Chatal; Jacques Barbet

Abstract

View articletitled, Pharmacokinetics and Dosimetry Studies for Optimization of Anti-Carcinoembryonic Antigen × Anti-Hapten Bispecific Antibody-mediated Pretargeting of Iodine-131-labeled Hapten in a Phase I Radioimmunotherapy Trial<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Session V: CLINICAL STUDIES: HEMATOLOGICAL TUMORS

Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22: Characterization of in Vitro Properties 1

Josette Carnahan; Paul Wang; Richard Kendall; Ching Chen; Sylvia Hu; Tom Boone; Todd Juan; Jane Talvenheimo; Silvia Montestruque; Jilin Sun; Gary Elliott; John Thomas; John Ferbas; Brent Kern; Robert Briddell; John P. Leonard; Alessandra Cesano

Abstract

View articletitled, Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22: Characterization of in Vitro Properties<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Epratuzumab: Targeting B-Cell Malignancies through CD22 1

Morton Coleman; David M. Goldenberg; Abby B. Siegel; Jamie C. Ketas; Michelle Ashe; Jennifer M. Fiore; John P. Leonard

Abstract

View articletitled, Epratuzumab: Targeting B-Cell Malignancies through CD22<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Final Results of a Phase I Radioimmunotherapy Trial Using ¹⁸⁶Re-Epratuzumab for the Treatment of Patients with Non-Hodgkin’s Lymphoma 1

Ernst J. Postema; John M. M. Raemaekers; Wim J. G. Oyen; Otto C. Boerman; Caroline M. P. W. Mandigers; David M. Goldenberg; Guus A. M. S. van Dongen; Frans H. M. Corstens

Abstract

View articletitled, Final Results of a Phase I Radioimmunotherapy Trial Using 186Re-Epratuzumab for the Treatment of Patients with Non-Hodgkin’s Lymphoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Change in Tumor-absorbed Dose due to Decrease in Mass during Fractionated Radioimmunotherapy in Lymphoma Patients 1

Cecilia Hindorf; Ola Lindén; Lars Stenberg; Jan Tennvall; Sven-Erik Strand

Abstract

View articletitled, Change in Tumor-absorbed Dose due to Decrease in Mass during Fractionated Radioimmunotherapy in Lymphoma Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Documentation of Idiotypic Cascade after Lym-1 Radioimmunotherapy in a Patient with Non-Hodgkin’s Lymphoma: Basis for Extended Survival?1

Bonnie M. Bradt; Sally J. DeNardo; Gary R. Mirick; Gerald L. DeNardo

Abstract

View articletitled, Documentation of Idiotypic Cascade after Lym-1 Radioimmunotherapy in a Patient with Non-Hodgkin’s Lymphoma: Basis for Extended Survival?<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Characterization of Human IgG Antimouse Antibody in Patients with B-Cell Malignancies 1

Gerald L. DeNardo; Gary R. Mirick; Linda A. Kroger; Bonnie M. Bradt; Kathleen R. Lamborn; Sally J. DeNardo

Abstract

View articletitled, Characterization of Human IgG Antimouse Antibody in Patients with B-Cell Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Concluding Remarks: Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates

Edward A. Sausville

Extract

View articletitled, Concluding Remarks: Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates

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Issues

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Editorials

The Biology Behind

Telomerase Therapeutics: Telomeres Recognized as a DNA Damage Signal1: Commentary re: K. Kraemer et al., Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells. Clin. Cancer Res., 9: 3794–3800, 2003.

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Session I: ANTIBODIES AND NON-ISOTOPIC IMMUNOCONJUGATES

Session II: ISOTOPIC CONJUGATES, PRECLINICAL AND PRETARGETING

Session III: EXPERIMENTAL RADIOIMMUNOTHERAPY

Session IV: CLINICAL STUDIES: SOLID TUMORS

Session V: CLINICAL STUDIES: HEMATOLOGICAL TUMORS

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Telomerase Therapeutics: Telomeres Recognized as a DNA Damage Signal 1: Commentary re: K. Kraemer et al., Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells. Clin. Cancer Res., 9: 3794–3800, 2003.