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Peroxisome Proliferator-activated Receptor γ and Cancers 1

H. Phillip Koeffler

View articletitled, Peroxisome Proliferator-activated Receptor γ and Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prevention of Ovarian Cancer: Intraepithelial Neoplasia

Molly A. Brewer; Karen Johnson; Michele Follen; David Gershenson; Robert Bast, Jr.

Abstract

View articletitled, Prevention of Ovarian Cancer: Intraepithelial Neoplasia

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Minireview

The Statins as Anticancer Agents

Kelvin K. W. Chan; Amit M. Oza; Lillian L. Siu

Abstract

View articletitled, The Statins as Anticancer Agents

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The Biology Behind

Commentary re: Q-T. Le et al., Identification of Osteopontin as a Prognostic Marker for Head and Neck Squamous Cell Carcinomas. Clin. Cancer Res., 9: 31–32, 2003.

David T. Denhardt

Extract

View articletitled, Commentary re: Q-T. Le et al., Identification of Osteopontin as a Prognostic Marker for Head and Neck Squamous Cell Carcinomas. Clin. Cancer Res., 9: 31–32, 2003.

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Advances in Brief

Molecular Oncology, Markers, Clinical Correlates

Persistent Replication of the Modified Chimeric Adenovirus ONYX-015 in both Tumor and Stromal Cells from a Patient with Gall Bladder Carcinoma Implants 1

Scott Wadler; Bo Yu; Jian-You Tan; Ron Kaleya; Alla Rozenblit; Della Makower; Morris Edelman; Maureen Lane; Elizabath Hyjek; Marshall Horwitz

Abstract

View articletitled, Persistent Replication of the Modified Chimeric Adenovirus ONYX-015 in both Tumor and Stromal Cells from a Patient with Gall Bladder Carcinoma Implants<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Granulin-Epithelin Precursor/PC-Cell-derived Growth Factor Is a Growth Factor for Epithelial Ovarian Cancer

Monica Brown Jones; Chad M. Michener; James O. Blanchette; Vladimir A. Kuznetsov; Mark Raffeld; Ginette Serrero; Michael R. Emmert-Buck; Emanuel F. Petricoin; David B. Krizman; Lance A. Liotta; Elise C. Kohn

Abstract

View articletitled, The Granulin-Epithelin Precursor/PC-Cell-derived Growth Factor Is a Growth Factor for Epithelial Ovarian Cancer

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Deletions in Chromosome Arms 3p and 11q Are New Prognostic Markers in Localized and 4s Neuroblastoma 1

Ruediger Spitz; Barbara Hero; Karen Ernestus; Frank Berthold

Abstract

View articletitled, Deletions in Chromosome Arms 3p and 11q Are New Prognostic Markers in Localized and 4s Neuroblastoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Identification of Osteopontin as a Prognostic Plasma Marker for Head and Neck Squamous Cell Carcinomas 1

Quynh-Thu Le; Patrick D. Sutphin; Soumya Raychaudhuri; Sheue Ching T. Yu; David J. Terris; Ho Sheng Lin; Bert Lum; Harlan A Pinto; Albert C. Koong; Amato J. Giaccia

Abstract

View articletitled, Identification of Osteopontin as a Prognostic Plasma Marker for Head and Neck Squamous Cell Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Hepatocyte Growth Factor Receptor, Matrix Metalloproteinase-11, Tissue Inhibitor of Metalloproteinase-1, and Fibronectin Are Up-Regulated in Papillary Thyroid Carcinoma: A cDNA and Tissue Microarray Study

Veli-Matti Wasenius; Samuli Hemmer; Eeva Kettunen; Sakari Knuutila; Kaarle Franssila; Heikki Joensuu

Abstract

View articletitled, Hepatocyte Growth Factor Receptor, Matrix Metalloproteinase-11, Tissue Inhibitor of Metalloproteinase-1, and Fibronectin Are Up-Regulated in Papillary Thyroid Carcinoma: A cDNA and Tissue Microarray Study

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Regular Articles

Clinical Trials

Repeated Administrations of Interleukin (IL)-12 Are Associated with Persistently Elevated Plasma Levels of IL-10 and Declining IFN-γ, Tumor Necrosis Factor-α, IL-6, and IL-8 Responses

Johanna E. A. Portielje; Cor H. J. Lamers; Wim H. J. Kruit; Alex Sparreboom; Reinder L. H. Bolhuis; Gerrit Stoter; Christoph Huber; Jan W. Gratama

Abstract

View articletitled, Repeated Administrations of Interleukin (IL)-12 Are Associated with Persistently Elevated Plasma Levels of IL-10 and Declining IFN-γ, Tumor Necrosis Factor-α, IL-6, and IL-8 Responses

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Low-Dose IFN-γ Induces Tumor MHC Expression in Metastatic Malignant Melanoma

David J. Propper; David Chao; Jeremy P. Braybrooke; Pru Bahl; Parames Thavasu; Frances Balkwill; Helen Turley; Nicola Dobbs; Kevin Gatter; Denis C. Talbot; Adrian L. Harris; Trivadi S. Ganesan

Abstract

View articletitled, Low-Dose IFN-γ Induces Tumor MHC Expression in Metastatic Malignant Melanoma

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Induction of p53-regulated Genes and Tumor Regression in Lung Cancer Patients after Intratumoral Delivery of Adenoviral p53 (INGN 201) and Radiation Therapy 1

Abstract

View articletitled, Induction of p53-regulated Genes and Tumor Regression in Lung Cancer Patients after Intratumoral Delivery of Adenoviral p53 (INGN 201) and Radiation Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I and Pharmacokinetic Study of Escalating Dose of Docetaxel Administered with Granulocyte Colony-stimulating Factor Support in Adult Advanced Solid Tumors

Anthony Gonçalves; Frederic Viret; Joseph Ciccolini; Dominique Genre; Gwenaelle Gravis; Marc Giovanini; Jacques Camerlo; Jacques Catalin; Dominique Maraninchi; Patrice Viens

Abstract

View articletitled, Phase I and Pharmacokinetic Study of Escalating Dose of Docetaxel Administered with Granulocyte Colony-stimulating Factor Support in Adult Advanced Solid Tumors

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Weekly Bryostatin-1 in Metastatic Renal Cell Carcinoma: A Phase II Study 1

Naomi B. Haas; Mitchell Smith; Nancy Lewis; Lynn Littman; Gwen Yeslow; Indira D. Joshi; Anthony Murgo; Joyce Bradley; Robert Gordon; Hao Wang; Andre Rogatko; Gary R. Hudes

Abstract

View articletitled, Weekly Bryostatin-1 in Metastatic Renal Cell Carcinoma: A Phase II Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Trial of ISIS 2503, an Antisense Inhibitor of H-ras, in Combination with Gemcitabine in Patients with Advanced Cancer 1

Alex A. Adjei; Grace K. Dy; Charles Erlichman; Joel M. Reid; Jeff A. Sloan; Henry C. Pitot; Steven R. Alberts; Richard M. Goldberg; Lorelei J. Hanson; Pamela J. Atherton; Tanya Watanabe; Richard S. Geary; Jon Holmlund; F. Andrew Dorr

Abstract

View articletitled, A Phase I Trial of ISIS 2503, an Antisense Inhibitor of H-ras, in Combination with Gemcitabine in Patients with Advanced Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Prospective Randomized Pilot Study to Evaluate Predictors of Response in Serial Core Biopsies to Single Agent Neoadjuvant Doxorubicin or Paclitaxel for Patients with Locally Advanced Breast Cancer 1

Vered Stearns; Baljit Singh; Theodore Tsangaris; Jeanette G. Crawford; Antonella Novielli; Mathew J. Ellis; Claudine Isaacs; Marie Pennanen; Cecilia Tibery; Ahmad Farhad; Rebecca Slack; Daniel F. Hayes

Abstract

View articletitled, A Prospective Randomized Pilot Study to Evaluate Predictors of Response in Serial Core Biopsies to Single Agent Neoadjuvant Doxorubicin or Paclitaxel for Patients with Locally Advanced Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Study with Pharmacokinetics of S-1 on an Oral Daily Schedule for 28 Days in Patients with Solid Tumors 1

Paulo M. Hoff; Everardo D. Saad; Jaffer A. Ajani; Yvonne Lassere; Cynthia Wenske; Diana Medgyesy; Sunita Dwivedy; Mark Russo; Richard Pazdur

Abstract

View articletitled, Phase I Study with Pharmacokinetics of S-1 on an Oral Daily Schedule for 28 Days in Patients with Solid Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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European Organization for Research and Treatment of Cancer (EORTC) 08957 Phase II Study of Topotecan in Combination with Cisplatin as Second-Line Treatment of Refractory and Sensitive Small Cell Lung Cancer 1

Andrea Ardizzoni; Christian Manegold; Channa Debruyne; Rabab Gaafar; Erika Buchholz; Egbert F. Smit; Pilar Lianes; Guul ten Velde; Lionel Bosquee; Catherine Legrand; Carlo Neumaier; Kathrine King; Giuseppe Giaccone for the EORTC Lung Cancer Group

Abstract

View articletitled, European Organization for Research and Treatment of Cancer (EORTC) 08957 Phase II Study of Topotecan in Combination with Cisplatin as Second-Line Treatment of Refractory and Sensitive Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Disposition of Docosahexaenoic Acid-Paclitaxel, a Novel Taxane, in Blood: In Vitro and Clinical Pharmacokinetic Studies 1

Alex Sparreboom; Antonio C. Wolff; Jaap Verweij; Yelena Zabelina; Desiree M. van Zomeren; Gregory L. McIntire; Charles S. Swindell; Ross C. Donehower; Sharyn D. Baker

Abstract

View articletitled, Disposition of Docosahexaenoic Acid-Paclitaxel, a Novel Taxane, in Blood: In Vitro and Clinical Pharmacokinetic Studies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

Elevated Sod2 Activity Augments Matrix Metalloproteinase Expression: Evidence for the Involvement of Endogenous Hydrogen Peroxide in Regulating Metastasis 1

Kristin K. Nelson; Aparna C. Ranganathan; Jelriza Mansouri; Ana M. Rodriguez; Kirwin M. Providence; Joni L. Rutter; Kevin Pumiglia; James A. Bennett; J. Andres Melendez

Abstract

View articletitled, Elevated Sod2 Activity Augments Matrix Metalloproteinase Expression: Evidence for the Involvement of Endogenous Hydrogen Peroxide in Regulating Metastasis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Gastric Epithelial Reactive Oxygen Species Prevent Normoxic Degradation of Hypoxia-inducible Factor-1α in Gastric Cancer Cells 1

Jung-Hyun Park; Tae-You Kim; Hyun-Soon Jong; Tai Young Kim; Yang-Sook Chun; Jong-Wan Park; Choon-Taek Lee; Hyun Chae Jung; Noe Kyeong Kim; Yung-Jue Bang

Abstract

View articletitled, Gastric Epithelial Reactive Oxygen Species Prevent Normoxic Degradation of Hypoxia-inducible Factor-1α in Gastric Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Quantitative Polymerase Chain Reaction Monitoring of BCR-ABL during Therapy with Imatinib Mesylate (STI571; Gleevec) in Chronic-Phase Chronic Myelogenous Leukemia

Hagop M. Kantarjian; Moshe Talpaz; Jorge Cortes; Susan O’Brien; Stefan Faderl; Deborah Thomas; Francis Giles; Mary Beth Rios; Jianqin Shan; Ralph Arlinghaus

Abstract

View articletitled, Quantitative Polymerase Chain Reaction Monitoring of BCR-ABL during Therapy with Imatinib Mesylate (STI571; Gleevec) in Chronic-Phase Chronic Myelogenous Leukemia

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Differential Expression of Cancer Testis Genes in Histological Subtypes of Non-Hodgkin’s Lymphomas 1

Xiaoxun Xie; Hans-Heinrich Wacker; Shaoming Huang; Evi Regitz; Klaus-Dieter Preuss; Bernd Romeike; Reza Parwaresch; Markus Tiemann; Michael Pfreundschuh

Abstract

View articletitled, Differential Expression of Cancer Testis Genes in Histological Subtypes of Non-Hodgkin’s Lymphomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Influence of Adjuvant Hormone Therapy and Chemotherapy on the Immune System Analysed in the Bone Marrow of Patients with Breast Cancer 1

Erich-Franz Solomayer; Markus Feuerer; Lianhua Bai; Victor Umansky; Philipp Beckhove; Gabriele C. Meyberg; Gunther Bastert; Volker Schirrmacher; Ingo Jakob Diel

Abstract

View articletitled, Influence of Adjuvant Hormone Therapy and Chemotherapy on the Immune System Analysed in the Bone Marrow of Patients with Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of the c-Met Proto-Oncogene and Its Possible Involvement in Liver Invasion in Adult T-cell Leukemia 1

Yoshitaka Imaizumi; Hiroyuki Murota; Shigeru Kanda; Yoshitaka Hishikawa; Takehiko Koji; Takashi Taguchi; Yuetsu Tanaka; Yasuaki Yamada; Shuichi Ikeda; Tomoko Kohno; Kazuo Yamamoto; Naoki Mori; Masao Tomonaga; Toshifumi Matsuyama

Abstract

View articletitled, Expression of the c-Met Proto-Oncogene and Its Possible Involvement in Liver Invasion in Adult T-cell Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Characterization of c-kit Expression in Small Cell Lung Cancer: Prognostic and Therapeutic Implications

Patrick Micke; Maryam Basrai; Andreas Faldum; Fernando Bittinger; Lars Rönnstrand; Andree Blaukat; Kai Michael Beeh; Franz Oesch; Berthold Fischer; Roland Buhl; Jan Georg Hengstler

Abstract

View articletitled, Characterization of c-kit Expression in Small Cell Lung Cancer: Prognostic and Therapeutic Implications

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Lymphocyte Recovery in Advanced Ovarian Cancer Patients after High-Dose Chemotherapy and Peripheral Blood Stem Cell Plus Growth Factor Support: Clinical Implications 1

Gabriella Ferrandina; Luca Pierelli; Alessandro Perillo; Sergio Rutella; Manuela Ludovisi; Giuseppe Leone; Salvatore Mancuso; Giovanni Scambia

Abstract

View articletitled, Lymphocyte Recovery in Advanced Ovarian Cancer Patients after High-Dose Chemotherapy and Peripheral Blood Stem Cell Plus Growth Factor Support: Clinical Implications<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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P7 Antigen Expression in Human Breast Cancer 1

Xiaowei Yang; Susan Groshen; Silvia C. Formenti; Nancy E. Davidson; Michael F. Press

Abstract

View articletitled, P7 Antigen Expression in Human Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Reduced Expression of the Small Leucine-rich Proteoglycans, Lumican, and Decorin Is Associated with Poor Outcome in Node-negative Invasive Breast Cancer 1

Sandra Troup; Catherine Njue; Erich V. Kliewer; Michelle Parisien; Cal Roskelley; Shukti Chakravarti; Peter J. Roughley; Leigh C. Murphy; Peter H. Watson

Abstract

View articletitled, Reduced Expression of the Small Leucine-rich Proteoglycans, Lumican, and Decorin Is Associated with Poor Outcome in Node-negative Invasive Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of Focal Adhesion Kinase in Primary Colorectal Carcinomas and Colorectal Liver Metastases: Immunohistochemistry and Real-Time PCR Analyses 1

Amy L. Lark; Chad A. Livasy; Benjamin Calvo; Laura Caskey; Dominic T. Moore; XiHui Yang; William G. Cance

Abstract

View articletitled, Overexpression of Focal Adhesion Kinase in Primary Colorectal Carcinomas and Colorectal Liver Metastases: Immunohistochemistry and Real-Time PCR Analyses<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Quantitative O⁶-Methylguanine DNA Methyltransferase Methylation Analysis in Curatively Resected Non-Small Cell Lung Cancer: Associations with Clinical Outcome

Jan Brabender; Henning Usadel; Ralf Metzger; Paul M. Schneider; JiMin Park; Dennis Salonga; Denise D. Tsao-Wei; Susan Groshen; Reginald V. Lord; Naoko Takebe; Sylke Schneider; Arnulf H. Hölscher; Kathleen D. Danenberg; Peter V. Danenberg

Abstract

View articletitled, Quantitative O6-Methylguanine DNA Methyltransferase Methylation Analysis in Curatively Resected Non-Small Cell Lung Cancer: Associations with Clinical Outcome

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p53 Mutations in Human Aggressive and Nonaggressive Basal and Squamous Cell Carcinomas 1

Svetlana Bolshakov; Christopher M. Walker; Sara S. Strom; Mano S. Selvan; Gary L. Clayman; Adel El-Naggar; Scott M. Lippman; Margaret L. Kripke; Honnavara N. Ananthaswamy

Abstract

View articletitled, p53 Mutations in Human Aggressive and Nonaggressive Basal and Squamous Cell Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Detecting Homozygous Deletions in the CDKN2A(p16^INK4a)/ARF(p14^ARF) Gene in Urinary Bladder Cancer Using Real-Time Quantitative PCR

Petra Berggren; Rajiv Kumar; Shigeru Sakano; Liina Hemminki; Takashi Wada; Gunnar Steineck; Jan Adolfsson; Per Larsson; Ulf Norming; Hans Wijkström; Kari Hemminki

Abstract

View articletitled, Detecting Homozygous Deletions in the CDKN2A(p16INK4a)/ARF(p14ARF) Gene in Urinary Bladder Cancer Using Real-Time Quantitative PCR

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Cell Culture in Esophageal Squamous Cell Carcinoma and the Association with Molecular Markers 1

Yutaka Shimada; Masato Maeda; Go Watanabe; Seiji Yamasaki; Izumi Komoto; Junichi Kaganoi; Takatsugu Kan; Yosuke Hashimoto; Issei Imoto; Johji Inazawa; Masayuki Imamura

Abstract

View articletitled, Cell Culture in Esophageal Squamous Cell Carcinoma and the Association with Molecular Markers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Independent Prognostic Impact of Lymphatic Vessel Density and Presence of Low-Grade Lymphangiogenesis in Cutaneous Melanoma 1

Oddbjørn Straume; David G. Jackson; Lars A. Akslen

Abstract

View articletitled, Independent Prognostic Impact of Lymphatic Vessel Density and Presence of Low-Grade Lymphangiogenesis in Cutaneous Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Combined Microsatellite and FGFR3 Mutation Analysis Enables a Highly Sensitive Detection of Urothelial Cell Carcinoma in Voided Urine 1

Bas W. G. van Rhijn; Irene Lurkin; Dominique K. Chopin; Wim J. Kirkels; Jean-Paul Thiery; Theo H. van der Kwast; François Radvanyi; Ellen C. Zwarthoff

Abstract

View articletitled, Combined Microsatellite and FGFR3 Mutation Analysis Enables a Highly Sensitive Detection of Urothelial Cell Carcinoma in Voided Urine<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of Endocrine Gland-derived Vascular Endothelial Growth Factor in Ovarian Carcinoma 1

Lin Zhang; Nuo Yang; Jose-Ramon Conejo-Garcia; Dionyssios Katsaros; Alisha Mohamed-Hadley; Stefano Fracchioli; Katia Schlienger; Alanna Toll; Bruce Levine; Stephen C. Rubin; George Coukos

Abstract

View articletitled, Expression of Endocrine Gland-derived Vascular Endothelial Growth Factor in Ovarian Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Hepatocyte Growth Factor and c-Met in Cervical Intraepithelial Neoplasia: Overexpression of Proteins Associated with Oncogenic Human Papillomavirus and Human Immunodeficiency Virus 1

Francine Walker; Stéphanie Kermorgant; Emile Daraï; Patrick Madelenat; Anne Claude Cremieux; Dominique Hénin; Thérèse Lehy

Abstract

View articletitled, Hepatocyte Growth Factor and c-Met in Cervical Intraepithelial Neoplasia: Overexpression of Proteins Associated with Oncogenic Human Papillomavirus and Human Immunodeficiency Virus<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Effective Combination of Chemotherapy and Dendritic Cell Administration for the Treatment of Advanced-Stage Experimental Breast Cancer

Bin Yu; Sergei Kusmartsev; Fengdong Cheng; Maria Paolini; Yulia Nefedova; Eduardo Sotomayor; Dmitry Gabrilovich

Abstract

View articletitled, Effective Combination of Chemotherapy and Dendritic Cell Administration for the Treatment of Advanced-Stage Experimental Breast Cancer

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Zoledronic Acid Exhibits Inhibitory Effects on Osteoblastic and Osteolytic Metastases of Prostate Cancer 1

Eva Corey; Lisha G. Brown; Janna E. Quinn; Martin Poot; Martine P. Roudier; Celestia S. Higano; Robert L. Vessella

Abstract

View articletitled, Zoledronic Acid Exhibits Inhibitory Effects on Osteoblastic and Osteolytic Metastases of Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Timed Sequential Therapy of Acute Leukemia with Flavopiridol: In Vitro Model for a Phase I Clinical Trial 1

Judith E. Karp; Douglas D. Ross; Weidong Yang; Michael L. Tidwell; Yuetong Wei; Jacqueline Greer; Dean L. Mann; Takeo Nakanishi; John J. Wright; A. Dmitri Colevas

Abstract

View articletitled, Timed Sequential Therapy of Acute Leukemia with Flavopiridol: In Vitro Model for a Phase I Clinical Trial<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Inhibition of Constitutive STAT3 Activity Sensitizes Resistant Non-Hodgkin’s Lymphoma and Multiple Myeloma to Chemotherapeutic Drug-mediated Apoptosis 1

Steve Alas; Benjamin Bonavida

Abstract

View articletitled, Inhibition of Constitutive STAT3 Activity Sensitizes Resistant Non-Hodgkin’s Lymphoma and Multiple Myeloma to Chemotherapeutic Drug-mediated Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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In Vivo Antitumor Activity of SU11248, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Receptors: Determination of a Pharmacokinetic/Pharmacodynamic Relationship

Abstract

View articletitled, In Vivo Antitumor Activity of SU11248, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Receptors: Determination of a Pharmacokinetic/Pharmacodynamic Relationship

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Hepatitis B Virus X Protein Sensitizes Hepatocellular Carcinoma Cells to Cytolysis Induced by E1B-deleted Adenovirus through the Disruption of p53 Function 1

Jeng-Long Hsieh; Chao-Liang Wu; Che-Hsin Lee; Ai-Li Shiau

Abstract

View articletitled, Hepatitis B Virus X Protein Sensitizes Hepatocellular Carcinoma Cells to Cytolysis Induced by E1B-deleted Adenovirus through the Disruption of p53 Function<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Function of Nuclear Factor κB in Pancreatic Cancer Metastasis 1

Shuichi Fujioka; Guido M. Sclabas; Christian Schmidt; Wayne A. Frederick; Qiang G. Dong; James L. Abbruzzese; Douglas B. Evans; Cheryl Baker; Paul J. Chiao

Abstract

View articletitled, Function of Nuclear Factor κB in Pancreatic Cancer Metastasis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Reduction of Vascular and Permeable Regions in Solid Tumors Detected by Macromolecular Contrast Magnetic Resonance Imaging after Treatment with Antiangiogenic Agent TNP-470 1

Zaver M. Bhujwalla; Dmitri Artemov; Kshama Natarajan; Meiyappan Solaiyappan; Peggy Kollars; Paul E. G. Kristjansen

Abstract

View articletitled, Reduction of Vascular and Permeable Regions in Solid Tumors Detected by Macromolecular Contrast Magnetic Resonance Imaging after Treatment with Antiangiogenic Agent TNP-470<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effect of Dimethyl Sulfoxide on Bladder Tissue Penetration of Intravesical Paclitaxel 1

Danny Chen; Di Song; M. Guillaume Wientjes; Jessie L-S. Au

Abstract

View articletitled, Effect of Dimethyl Sulfoxide on Bladder Tissue Penetration of Intravesical Paclitaxel<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Interleukin-6 Promotes Androgen-independent Growth in LNCaP Human Prostate Cancer Cells 1

Soo Ok Lee; Wei Lou; Min Hou; Fernando de Miguel; Lizabeth Gerber; Allen C. Gao

Abstract

View articletitled, Interleukin-6 Promotes Androgen-independent Growth in LNCaP Human Prostate Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Continuous Infusion of Endostatin Inhibits Differentiation, Mobilization, and Clonogenic Potential of Endothelial Cell Progenitors 1

Manuela Capillo; Patrizia Mancuso; Alberto Gobbi; Silvia Monestiroli; Giancarlo Pruneri; Chiara Dell’Agnola; Giovanni Martinelli; Leonard Shultz; Francesco Bertolini

Abstract

View articletitled, Continuous Infusion of Endostatin Inhibits Differentiation, Mobilization, and Clonogenic Potential of Endothelial Cell Progenitors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Novel Mechanism for Aspirin-mediated Growth Inhibition of Human Colon Cancer Cells 1

Ajay Goel; Dong Kyung Chang; Luigi Ricciardiello; Christoph Gasche; C. Richard Boland

Abstract

View articletitled, A Novel Mechanism for Aspirin-mediated Growth Inhibition of Human Colon Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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C-Jun NH₂-terminal Kinase Mediates Proliferation and Tumor Growth of Human Prostate Carcinoma 1

Yong-Min Yang; Frédéric Bost; Wilfried Charbono; Nicholas Dean; Robert McKay; Johng S. Rhim; Chantal Depatie; Dan Mercola

Abstract

View articletitled, C-Jun NH2-terminal Kinase Mediates Proliferation and Tumor Growth of Human Prostate Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Examination of the Antiproliferative Activity of Iron Chelators: Multiple Cellular Targets and the Different Mechanism of Action of Triapine Compared with Desferrioxamine and the Potent Pyridoxal Isonicotinoyl Hydrazone Analogue 311 1

Timothy B. Chaston; David B. Lovejoy; Ralph N. Watts; Des R. Richardson

Abstract

View articletitled, Examination of the Antiproliferative Activity of Iron Chelators: Multiple Cellular Targets and the Different Mechanism of Action of Triapine Compared with Desferrioxamine and the Potent Pyridoxal Isonicotinoyl Hydrazone Analogue 311<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Possible Role of Ceramide as an Indicator of Chemoresistance: Decrease of the Ceramide Content via Activation of Glucosylceramide Synthase and Sphingomyelin Synthase in Chemoresistant Leukemia 1

Mitsuru Itoh; Toshiyuki Kitano; Mitsumasa Watanabe; Tadakazu Kondo; Takeshi Yabu; Yoshimitu Taguchi; Kazuya Iwai; Masaro Tashima; Takashi Uchiyama; Toshiro Okazaki

Abstract

View articletitled, Possible Role of Ceramide as an Indicator of Chemoresistance: Decrease of the Ceramide Content via Activation of Glucosylceramide Synthase and Sphingomyelin Synthase in Chemoresistant Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Correction

Correction for vol. 8, p. 1787

Extract

View articletitled, Correction for vol. 8, p. 1787

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Supplement

Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Summary Consensus Statement 1

Steven E. Come; Aman U. Buzdar; Carlos L. Arteaga; Angela M. Brodie; Nancy E. Davidson; Mitch Dowsett; James N. Ingle; Stephen R. D. Johnston; Adrian V. Lee; C. Kent Osborne; Kathleen I. Pritchard; Victor G. Vogel; Eric P. Winer; Carol S. Hart

Extract

View articletitled, Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Summary Consensus Statement<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Breast Cancer Endocrine Resistance: How Growth Factor Signaling and Estrogen Receptor Coregulators Modulate Response 1

Rachel Schiff; Suleiman Massarweh; Jiang Shou; C. Kent Osborne

Abstract

View articletitled, Breast Cancer Endocrine Resistance: How Growth Factor Signaling and Estrogen Receptor Coregulators Modulate Response<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Predictions from a Preclinical Model: Studies of Aromatase Inhibitors and Antiestrogens 1

Angela Brodie; Danijela Jelovac; Brian J. Long

Abstract

View articletitled, Predictions from a Preclinical Model: Studies of Aromatase Inhibitors and Antiestrogens<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Endocrine Therapy of Advanced Disease: Analysis and Implications of the Existing Data 1

Kathleen I. Pritchard

Abstract

View articletitled, Endocrine Therapy of Advanced Disease: Analysis and Implications of the Existing Data<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pharmacology and Pharmacokinetics of the Newer Generation Aromatase Inhibitors 1

Aman U. Buzdar

Abstract

View articletitled, Pharmacology and Pharmacokinetics of the Newer Generation Aromatase Inhibitors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Differences among the Aromatase Inhibitors 1

Jennifer A. Ligibel; Eric P. Winer

Abstract

View articletitled, Clinical Differences among the Aromatase Inhibitors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Adjuvant Endocrine Therapy in Postmenopausal Breast Cancer 1

James N. Ingle

Abstract

View articletitled, Adjuvant Endocrine Therapy in Postmenopausal Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Adjuvant Hormonal Therapy for Premenopausal Women with Breast Cancer 1

Leisha A. Emens; Nancy E. Davidson

Abstract

View articletitled, Adjuvant Hormonal Therapy for Premenopausal Women with Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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National Surgical Adjuvant Breast and Bowel Project Update: Prevention Trials and Endocrine Therapy of Ductal Carcinoma in Situ1

Victor G. Vogel; Joseph P. Costantino; D. Lawrence Wickerham; Walter M. Cronin

Abstract

View articletitled, National Surgical Adjuvant Breast and Bowel Project Update: Prevention Trials and Endocrine Therapy of Ductal Carcinoma in Situ<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Preoperative Models to Evaluate Endocrine Strategies for Breast Cancer 1

Mitch Dowsett

Abstract

View articletitled, Preoperative Models to Evaluate Endocrine Strategies for Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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ErbB (HER) Receptors Can Abrogate Antiestrogen Action in Human Breast Cancer by Multiple Signaling Mechanisms 1

Hirokazu Kurokawa; Carlos L. Arteaga

Abstract

View articletitled, ErbB (HER) Receptors Can Abrogate Antiestrogen Action in Human Breast Cancer by Multiple Signaling Mechanisms<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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New Mechanisms of Signal Transduction Inhibitor Action: Receptor Tyrosine Kinase Down-Regulation and Blockade of Signal Transactivation 1

Adrian V. Lee; Rachel Schiff; Xiaojiang Cui; Deepali Sachdev; Douglas Yee; Andrew P. Gilmore; Charles H. Streuli; Steffi Oesterreich; Darryl L. Hadsell

Abstract

View articletitled, New Mechanisms of Signal Transduction Inhibitor Action: Receptor Tyrosine Kinase Down-Regulation and Blockade of Signal Transactivation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Integration of Signal Transduction Inhibitors with Endocrine Therapy: An Approach to Overcoming Hormone Resistance in Breast Cancer 1

Stephen R. D. Johnston; Julia Head; Sunil Pancholi; Simone Detre; Lesley-Ann Martin; Ian E. Smith; Mitch Dowsett

Abstract

View articletitled, Integration of Signal Transduction Inhibitors with Endocrine Therapy: An Approach to Overcoming Hormone Resistance in Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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