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Editorial

A New Marker Determining Clonal Outgrowth

Li Mao

Extract

View articletitled, A New Marker Determining Clonal Outgrowth

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Minireview

Apoptosis: Target of Cancer Therapy

Carlos G. Ferreira; Mirjam Epping; Frank A. E. Kruyt; Giuseppe Giaccone

Abstract

View articletitled, Apoptosis: Target of Cancer Therapy

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Advances in Brief

Clinical Trials

Validation of the Pharmacodynamics of BMS-247550, an Analogue of Epothilone B, during a Phase I Clinical Study 1

Hayley M. McDaid; Sridhar Mani; Heng-Jia Shen; Franco Muggia; Daryl Sonnichsen; Susan Band Horwitz

Abstract

View articletitled, Validation of the Pharmacodynamics of BMS-247550, an Analogue of Epothilone B, during a Phase I Clinical Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Active Specific Immunotherapy with a β-Human Chorionic Gonadotropin Peptide Vaccine in Patients with Metastatic Colorectal Cancer: Antibody Response Is Associated with Improved Survival 1

Hong M. Moulton; Paul H. Yoshihara; David H. Mason; Patrick L. Iversen; Pierre L. Triozzi

Abstract

View articletitled, Active Specific Immunotherapy with a β-Human Chorionic Gonadotropin Peptide Vaccine in Patients with Metastatic Colorectal Cancer: Antibody Response Is Associated with Improved Survival<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Infusion of CD4+ Donor Lymphocytes Induces the Expansion of CD8+ Donor T Cells with Cytolytic Activity Directed against Recipient Hematopoietic Cells 1

Emmanuel Zorn; Kathy S. Wang; Ephraim P. Hochberg; Christine Canning; Edwin P. Alyea; Robert J. Soiffer; Jerome Ritz

Abstract

View articletitled, Infusion of CD4+ Donor Lymphocytes Induces the Expansion of CD8+ Donor T Cells with Cytolytic Activity Directed against Recipient Hematopoietic Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Frequent Germ-Line Succinate Dehydrogenase Subunit D Gene Mutations in Patients with Apparently Sporadic Parasympathetic Paraganglioma

Hilde Dannenberg; Winand N. M. Dinjens; Mustaffa Abbou; Hero van Urk; Bernard K. H. Pauw; Diane Mouwen; Wolter J. Mooi; Ronald R. de Krijger

Abstract

View articletitled, Frequent Germ-Line Succinate Dehydrogenase Subunit D Gene Mutations in Patients with Apparently Sporadic Parasympathetic Paraganglioma

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Suppression of Type I Interferon Signaling Proteins Is an Early Event in Squamous Skin Carcinogenesis 1

John L. Clifford; Eugene Walch; Xiulan Yang; Xiaochun Xu; David S. Alberts; Gary L. Clayman; Adel K. El-Naggar; Reuben Lotan; Scott M. Lippman

Abstract

View articletitled, Suppression of Type I Interferon Signaling Proteins Is an Early Event in Squamous Skin Carcinogenesis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cytogenetic Evidence That Circulating Epithelial Cells in Patients with Carcinoma Are Malignant 1

Tanja Fehm; Arthur Sagalowsky; Edward Clifford; Peter Beitsch; Hossein Saboorian; David Euhus; Songdong Meng; Larry Morrison; Thomas Tucker; Nancy Lane; B. Michael Ghadimi; Kerstin Heselmeyer-Haddad; Thomas Ried; Chandra Rao; Jonathan Uhr

Abstract

View articletitled, Cytogenetic Evidence That Circulating Epithelial Cells in Patients with Carcinoma Are Malignant<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Tumor Suppressor Gene LKB1 Is Associated with Prognosis in Human Breast Carcinoma 1

Zan Shen; Xian-Feng Wen; Fei Lan; Zhen-Zhou Shen; Zhi-Ming Shao

Abstract

View articletitled, The Tumor Suppressor Gene LKB1 Is Associated with Prognosis in Human Breast Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Inactivation of the Antiapoptotic Phosphatidylinositol 3-Kinase-Akt Pathway by the Combined Treatment of Taxol and Mitogen-activated Protein Kinase Kinase Inhibition 1

Jeffrey P. MacKeigan; Debra J. Taxman; Deborah Hunter; H. Shelton Earp, III; Lee M. Graves; Jenny P-Y. Ting

Abstract

View articletitled, Inactivation of the Antiapoptotic Phosphatidylinositol 3-Kinase-Akt Pathway by the Combined Treatment of Taxol and Mitogen-activated Protein Kinase Kinase Inhibition<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Coordinate Expression of Apoptosis-associated Proteins in Human Breast Cancer before and during Chemotherapy 1

Marina Parton; Stanislaw Krajewski; Ian Smith; Maryla Krajewska; Caroline Archer; Mihikito Naito; Roger Ahern; John Reed; Mitchell Dowsett

Abstract

View articletitled, Coordinate Expression of Apoptosis-associated Proteins in Human Breast Cancer before and during Chemotherapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regular Articles

Clinical Trials

Measurement of Perfusion in Stage IIIA-N2 Non-Small Cell Lung Cancer Using H₂¹⁵O and Positron Emission Tomography

Corneline J. Hoekstra; Sigrid G. Stroobants; Otto S. Hoekstra; Egbert F. Smit; Johan F. Vansteenkiste; Adriaan A. Lammertsma

Abstract

View articletitled, Measurement of Perfusion in Stage IIIA-N2 Non-Small Cell Lung Cancer Using H215O and Positron Emission Tomography

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Phase I and Pharmacokinetic Study of Once Daily Oral Administration of S-1 in Patients with Advanced Cancer 1

Steven J. Cohen; Cynthia G. Leichman; Gwen Yeslow; Mary Beard; April Proefrock; Brian Roedig; Bharat Damle; Stephen P. Letrent; Arthur P. DeCillis; Neal J. Meropol

Abstract

View articletitled, Phase I and Pharmacokinetic Study of Once Daily Oral Administration of S-1 in Patients with Advanced Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Trial and Correlative Laboratory Studies of Bryostatin 1 (NSC 339555) and High-Dose 1-B-d-Arabinofuranosylcytosine in Patients with Refractory Acute Leukemia 1

Louise H. Cragg; Michael Andreeff; Eric Feldman; John Roberts; Anthony Murgo; Mary Winning; Mary Beth Tombes; Gail Roboz; Lora Kramer; Steven Grant

Abstract

View articletitled, Phase I Trial and Correlative Laboratory Studies of Bryostatin 1 (NSC 339555) and High-Dose 1-B-d-Arabinofuranosylcytosine in Patients with Refractory Acute Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I and Pharmacokinetic Study of DX-8951f (Exatecan Mesylate), a Hexacyclic Camptothecin, on a Daily-Times-Five Schedule in Patients with Advanced Leukemia 1

Francis J. Giles; Jorge E. Cortes; Deborah A. Thomas; Guillermo Garcia-Manero; Stephan Faderl; Sima Jeha; Robert L. De Jager; Hagop M. Kantarjian

Abstract

View articletitled, Phase I and Pharmacokinetic Study of DX-8951f (Exatecan Mesylate), a Hexacyclic Camptothecin, on a Daily-Times-Five Schedule in Patients with Advanced Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Study of Pivaloyloxymethyl Butyrate, a Prodrug of the Differentiating Agent Butyric Acid, in Patients with Advanced Solid Malignancies 1

Amita Patnaik; Eric K. Rowinsky; Miguel A. Villalona; Lisa A. Hammond; Carolyn D. Britten; Lillian L. Siu; Andrew Goetz; Sally A. Felton; Susan Burton; Frank H. Valone; S. Gail Eckhardt

Abstract

View articletitled, A Phase I Study of Pivaloyloxymethyl Butyrate, a Prodrug of the Differentiating Agent Butyric Acid, in Patients with Advanced Solid Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Pharmacologic and Pharmacodynamic Study of Pyrazoloacridine Given as a Weekly 24-Hour Continuous Intravenous Infusion in Adult Cancer Patients

Jean L. Grem; Nancy Harold; Bruce Keith; Alice P. Chen; Viven Kao; Chris H. Takimoto; J. Michael Hamilton; Janet Pang; Marie Pace; Gada B. Jasser; Mary G. Quinn; Brian P. Monahan

Abstract

View articletitled, A Phase I Pharmacologic and Pharmacodynamic Study of Pyrazoloacridine Given as a Weekly 24-Hour Continuous Intravenous Infusion in Adult Cancer Patients

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A Phase I and Pharmacokinetic Study of SAM486A, a Novel Polyamine Biosynthesis Inhibitor, Administered on a Daily-times-five every-three-week Schedule in Patients with Advanced Solid Malignancies 1

Lillian L. Siu; Eric K. Rowinsky; Lisa A. Hammond; Geoffrey R. Weiss; Manuel Hidalgo; Gary M. Clark; Judy Moczygemba; Les Choi; Ron Linnartz; Nicholas C. Barbet; Ivo T. Sklenar; Renaud Capdeville; Gregory Gan; Carl W. Porter; Daniel D. Von Hoff; S. Gail Eckhardt

Abstract

View articletitled, A Phase I and Pharmacokinetic Study of SAM486A, a Novel Polyamine Biosynthesis Inhibitor, Administered on a Daily-times-five every-three-week Schedule in Patients with Advanced Solid Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Treatment of Philadelphia Chromosome-positive, Accelerated-phase Chronic Myelogenous Leukemia with Imatinib Mesylate 1

Hagop M. Kantarjian; Susan O’Brien; Jorge E. Cortes; Terry L. Smith; Mary Beth Rios; Jianqin Shan; Ying Yang; Francis J. Giles; Deborah A. Thomas; Stefan Faderl; Guillermo Garcia-Manero; Sima Jeha; William Wierda; Jean-Pierre J. Issa; Steven M. Kornblau; Michael Keating; Debra Resta; Renaud Capdeville; Moshe Talpaz

Abstract

View articletitled, Treatment of Philadelphia Chromosome-positive, Accelerated-phase Chronic Myelogenous Leukemia with Imatinib Mesylate<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Imatinib Mesylate for Philadelphia Chromosome-positive, Chronic-Phase Myeloid Leukemia after Failure of Interferon-α: Follow-Up Results 1

Abstract

View articletitled, Imatinib Mesylate for Philadelphia Chromosome-positive, Chronic-Phase Myeloid Leukemia after Failure of Interferon-α: Follow-Up Results<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase II Randomized Study of ISIS 3521 and ISIS 5132 in Patients with Locally Advanced or Metastatic Colorectal Cancer: A National Cancer Institute of Canada Clinical Trials Group Study 1

M. Christine Cripps; Alvaro T. Figueredo; Amit M. Oza; Marianne J. Taylor; Anthony L. Fields; John T. Holmlund; Lynn W. McIntosh; Richard S. Geary; Elizabeth A. Eisenhauer

Abstract

View articletitled, Phase II Randomized Study of ISIS 3521 and ISIS 5132 in Patients with Locally Advanced or Metastatic Colorectal Cancer: A National Cancer Institute of Canada Clinical Trials Group Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Clinical and Pharmacokinetic Study of NSC 655649, a Rebeccamycin Analogue, Given in Both Single-Dose and Multiple-Dose Formats 1

Joseph Merchant; Kendra Tutsch; Amy Dresen; Rhoda Arzoomanian; Dona Alberti; Chris Feierabend; Kim Binger; Rebecca Marnoccha; James Thomas; Jim Cleary; George Wilding

Abstract

View articletitled, Phase I Clinical and Pharmacokinetic Study of NSC 655649, a Rebeccamycin Analogue, Given in Both Single-Dose and Multiple-Dose Formats<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Altered Irinotecan Pharmacokinetics in Pediatric High-Grade Glioma Patients Receiving Enzyme-inducing Anticonvulsant Therapy 1

Kristine R. Crews; Clinton F. Stewart; Dana Jones-Wallace; Stephen J. Thompson; Peter J. Houghton; Richard L. Heideman; Maryam Fouladi; Daniel C. Bowers; Murali M. Chintagumpala; Amar Gajjar

Abstract

View articletitled, Altered Irinotecan Pharmacokinetics in Pediatric High-Grade Glioma Patients Receiving Enzyme-inducing Anticonvulsant Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Bone Marrow Angiogenesis in 400 Patients with Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, and Primary Amyloidosis 1

S. Vincent Rajkumar; Ruben A. Mesa; Rafael Fonseca; Georgene Schroeder; Matthew F. Plevak; Angela Dispenzieri; Martha Q. Lacy; John A. Lust; Thomas E. Witzig; Morie A. Gertz; Robert A. Kyle; Stephen J. Russell; Philip R. Greipp

Abstract

View articletitled, Bone Marrow Angiogenesis in 400 Patients with Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, and Primary Amyloidosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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DNA Methylation of Multiple Promoter-associated CpG Islands in Adult Acute Lymphocytic Leukemia 1

Guillermo Garcia-Manero; Jerry Daniel; Terry L. Smith; Steven M. Kornblau; Ming-Sheng Lee; Hagop M. Kantarjian; Jean-Pierre J. Issa

Abstract

View articletitled, DNA Methylation of Multiple Promoter-associated CpG Islands in Adult Acute Lymphocytic Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Suppression of Rho B Expression in Invasive Carcinoma from Head and Neck Cancer Patients 1

Jalila Adnane; Carlos Muro-Cacho; Linda Mathews; Said M. Sebti; Teresita Muñoz-Antonia

Abstract

View articletitled, Suppression of Rho B Expression in Invasive Carcinoma from Head and Neck Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CA125 Response Is Associated with Estrogen Receptor Expression in a Phase II Trial of Letrozole in Ovarian Cancer: Identification of an Endocrine-sensitive Subgroup

Angela Bowman; Hani Gabra; Simon P. Langdon; Alastair Lessells; Moira Stewart; Ann Young; John F. Smyth

Abstract

View articletitled, CA125 Response Is Associated with Estrogen Receptor Expression in a Phase II Trial of Letrozole in Ovarian Cancer: Identification of an Endocrine-sensitive Subgroup

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The Expression of Carbonic Anhydrase II in Hematological Malignancies 1

Mari Leppilampi; Pirjo Koistinen; Eeva-Riitta Savolainen; Jokke Hannuksela; Anna-Kaisa Parkkila; Onni Niemelä; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S. Sly; Seppo Parkkila; Hannu Rajaniemi

Abstract

View articletitled, The Expression of Carbonic Anhydrase II in Hematological Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Methylation Microarray Analysis of Late-Stage Ovarian Carcinomas Distinguishes Progression-free Survival in Patients and Identifies Candidate Epigenetic Markers 1

Susan H. Wei; Chuan-Mu Chen; Gordon Strathdee; Jaturon Harnsomburana; Chi-Ren Shyu; Farahnaz Rahmatpanah; Huidong Shi; Shu-Wing Ng; Pearlly S. Yan; Kenneth P. Nephew; Robert Brown; Tim Hui-Ming Huang

Abstract

View articletitled, Methylation Microarray Analysis of Late-Stage Ovarian Carcinomas Distinguishes Progression-free Survival in Patients and Identifies Candidate Epigenetic Markers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Vascular Endothelial Growth Factor Splice Variants and Their Prognostic Value in Breast and Ovarian Cancer

Margit Stimpfl; Dan Tong; Barbara Fasching; Eva Schuster; Andreas Obermair; Sepp Leodolter; Robert Zeillinger

Abstract

View articletitled, Vascular Endothelial Growth Factor Splice Variants and Their Prognostic Value in Breast and Ovarian Cancer

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Mitochondrial C-tract Alteration in Premalignant Lesions of the Head and Neck: A Marker for Progression and Clonal Proliferation

Patrick K. Ha; Betty C. Tong; William H. Westra; Montserrat Sanchez-Cespedes; Paola Parrella; Marianna Zahurak; David Sidransky; Joseph A Califano

Abstract

View articletitled, Mitochondrial C-tract Alteration in Premalignant Lesions of the Head and Neck: A Marker for Progression and Clonal Proliferation

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Clinicopathological Significance of Loss of Heterozygosity on Chromosome 13q in Hepatocellular Carcinoma 1

Chun Ming Wong; Joyce Man Fong Lee; Tracy Ching Man Lau; Sheung Tat Fan; Irene O. L. Ng

Abstract

View articletitled, Clinicopathological Significance of Loss of Heterozygosity on Chromosome 13q in Hepatocellular Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of Epidermal Growth Factor and Hepatocyte Growth Factor Receptors in a Proportion of Gastrinomas Correlates with Aggressive Growth and Lower Curability

Paolo L. Peghini; Michiko Iwamoto; Mark Raffeld; Yuan-Jia Chen; Stephan U. Goebel; Jose Serrano; Robert T. Jensen

Abstract

View articletitled, Overexpression of Epidermal Growth Factor and Hepatocyte Growth Factor Receptors in a Proportion of Gastrinomas Correlates with Aggressive Growth and Lower Curability

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Low ERCC1 Expression Correlates with Prolonged Survival after Cisplatin plus Gemcitabine Chemotherapy in Non-Small Cell Lung Cancer 1

Reginald V. N. Lord; Jan Brabender; David Gandara; Vicente Alberola; Carlos Camps; Manuel Domine; Felip Cardenal; José M. Sánchez; Paul H. Gumerlock; Miquel Tarón; José J. Sánchez; Kathleen D. Danenberg; Peter V. Danenberg; Rafael Rosell

Abstract

View articletitled, Low ERCC1 Expression Correlates with Prolonged Survival after Cisplatin plus Gemcitabine Chemotherapy in Non-Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Differential Expression of FEZ1/LZTS1 Gene in Lung Cancers and Their Cell Cultures 1

Shinichi Toyooka; Yasuro Fukuyama; Ignacio I. Wistuba; Melvyn S. Tockman; John D. Minna; Adi F. Gazdar

Abstract

View articletitled, Differential Expression of FEZ1/LZTS1 Gene in Lung Cancers and Their Cell Cultures<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Proteomic Analysis of Lung Adenocarcinoma: Identification of a Highly Expressed Set of Proteins in Tumors 1

Guoan Chen; Tarek G. Gharib; Chiang-Ching Huang; Dafydd G. Thomas; Kerby A. Shedden; Jeremy M. G. Taylor; Sharon L. R. Kardia; David E. Misek; Thomas J. Giordano; Mark D. Iannettoni; Mark B. Orringer; Samir M. Hanash; David G. Beer

Abstract

View articletitled, Proteomic Analysis of Lung Adenocarcinoma: Identification of a Highly Expressed Set of Proteins in Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Serum Osteoprotegerin Levels in Healthy Controls and Cancer Patients

Allan Lipton; Suhail M. Ali; Kim Leitzel; Vernon Chinchilli; Lois Witters; Linda Engle; Donna Holloway; Pirow Bekker; Colin R. Dunstan

Abstract

View articletitled, Serum Osteoprotegerin Levels in Healthy Controls and Cancer Patients

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Genetic Classification of Colorectal Cancer Based on Chromosomal Loss and Microsatellite Instability Predicts Survival 1

Sang-Wook Choi; Kyung Jun Lee; Young-An Bae; Ki-Ouk Min; Mi-Seon Kwon; Kyoung-Mee Kim; Mun-Gan Rhyu

Abstract

View articletitled, Genetic Classification of Colorectal Cancer Based on Chromosomal Loss and Microsatellite Instability Predicts Survival<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Validation of the Fluorinated 2-Nitroimidazole SR-4554 as a Noninvasive Hypoxia Marker Detected by Magnetic Resonance Spectroscopy 1

Beatrice M. Seddon; Ross J. Maxwell; Davina J. Honess; Rachel Grimshaw; Florence Raynaud; Gillian M. Tozer; Paul Workman

Abstract

View articletitled, Validation of the Fluorinated 2-Nitroimidazole SR-4554 as a Noninvasive Hypoxia Marker Detected by Magnetic Resonance Spectroscopy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enhancing Immunogenicity of a CTL Epitope from Carcinoembryonic Antigen by Selective Amino Acid Replacements 1

Eduardo Huarte; Pablo Sarobe; Jun Lu; Noelia Casares; Juan José Lasarte; Javier Dotor; Marta Ruiz; Jesús Prieto; Esteban Celis; Francisco Borrás-Cuesta

Abstract

View articletitled, Enhancing Immunogenicity of a CTL Epitope from Carcinoembryonic Antigen by Selective Amino Acid Replacements<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Novel Anti-CD30 Recombinant Immunotoxins Containing Disulfide-stabilized Fv Fragments

Satoshi Nagata; Masanori Onda; Yoshito Numata; Kenneth Santora; Richard Beers; Robert J. Kreitman; Ira Pastan

Abstract

View articletitled, Novel Anti-CD30 Recombinant Immunotoxins Containing Disulfide-stabilized Fv Fragments

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Acquisition of Agonistic Properties of Nonsteroidal Antiandrogens after Treatment with Oncostatin M in Prostate Cancer Cells 1

Sonia Godoy-Tundidor; Alfred Hobisch; Karina Pfeil; Georg Bartsch; Zoran Culig

Abstract

View articletitled, Acquisition of Agonistic Properties of Nonsteroidal Antiandrogens after Treatment with Oncostatin M in Prostate Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinicopathological Significance of Epigenetic Inactivation of RASSF1A at 3p21.3 in Stage I Lung Adenocarcinoma 1

Yoshio Tomizawa; Takashi Kohno; Haruhiko Kondo; Ayaka Otsuka; Michiho Nishioka; Toshiro Niki; Tesshi Yamada; Arafumi Maeshima; Kimio Yoshimura; Ryusei Saito; John D. Minna; Jun Yokota

Abstract

View articletitled, Clinicopathological Significance of Epigenetic Inactivation of RASSF1A at 3p21.3 in Stage I Lung Adenocarcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Inhibition of Nuclear Factor κB Activation in PC3 Cells by Genistein Is Mediated via Akt Signaling Pathway 1

Yiwei Li; Fazlul H. Sarkar

Abstract

View articletitled, Inhibition of Nuclear Factor κB Activation in PC3 Cells by Genistein Is Mediated via Akt Signaling Pathway<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Effect of Second-Line Antiestrogen Therapy on Breast Tumor Growth after First-Line Treatment with the Aromatase Inhibitor Letrozole: Long-Term Studies Using the Intratumoral Aromatase Postmenopausal Breast Cancer Model 1

Brian J. Long; Danijela Jelovac; Apinya Thiantanawat; Angela M. Brodie

Abstract

View articletitled, The Effect of Second-Line Antiestrogen Therapy on Breast Tumor Growth after First-Line Treatment with the Aromatase Inhibitor Letrozole: Long-Term Studies Using the Intratumoral Aromatase Postmenopausal Breast Cancer Model<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Frequent Administration of Angiogenesis Inhibitor TNP-470 (AGM-1470) at an Optimal Biological Dose Inhibits Tumor Growth and Metastasis of Metastatic Human Transitional Cell Carcinoma in the Urinary Bladder

Keiji Inoue; Masakazu Chikazawa; Satoshi Fukata; Chiaki Yoshikawa; Taro Shuin

Abstract

View articletitled, Frequent Administration of Angiogenesis Inhibitor TNP-470 (AGM-1470) at an Optimal Biological Dose Inhibits Tumor Growth and Metastasis of Metastatic Human Transitional Cell Carcinoma in the Urinary Bladder

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Synergistic Activation of the Androgen Receptor by Bombesin and Low-Dose Androgen 1

Jie Dai; Ruoqian Shen; Makoto Sumitomo; Rosalyn Stahl; Daniel Navarro; Marvin C. Gershengorn; David M. Nanus

Abstract

View articletitled, Synergistic Activation of the Androgen Receptor by Bombesin and Low-Dose Androgen<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Randomized Controlled Trial of Octreotide Pamoate Long-acting Release and Carboplatin versus Carboplatin Alone in Dogs with Naturally Occurring Osteosarcoma: Evaluation of Insulin-like Growth Factor Suppression and Chemotherapy

Chand Khanna; Jennifer Prehn; David Hayden; Ryan D. Cassaday; Jana Caylor; Shevin Jacob; Seuli M. Bose; Sung-Hyeok Hong; Stephen M. Hewitt; Lee J. Helman

Abstract

View articletitled, A Randomized Controlled Trial of Octreotide Pamoate Long-acting Release and Carboplatin versus Carboplatin Alone in Dogs with Naturally Occurring Osteosarcoma: Evaluation of Insulin-like Growth Factor Suppression and Chemotherapy

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Synergistic Therapy of Human Ovarian Carcinoma Implanted Orthotopically in Nude Mice by Optimal Biological Dose of Pegylated Interferon α Combined with Paclitaxel 1

Sean Tedjarati; Cheryl H. Baker; Sachin Apte; Suyun Huang; Judith K. Wolf; Jerald J. Killion; Isaiah J. Fidler

Abstract

View articletitled, Synergistic Therapy of Human Ovarian Carcinoma Implanted Orthotopically in Nude Mice by Optimal Biological Dose of Pegylated Interferon α Combined with Paclitaxel<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Methotrexate Intracellular Disposition in Acute Lymphoblastic Leukemia: A Mathematical Model of γ-Glutamyl Hydrolase Activity 1

John Carl Panetta; Amelia Wall; Ching-Hon Pui; Mary V. Relling; William E. Evans

Abstract

View articletitled, Methotrexate Intracellular Disposition in Acute Lymphoblastic Leukemia: A Mathematical Model of γ-Glutamyl Hydrolase Activity<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Src Family Kinase Inhibitor PP2 Restores the E-Cadherin/Catenin Cell Adhesion System in Human Cancer Cells and Reduces Cancer Metastasis 1

Jeong-Seok Nam; Yoshinori Ino; Michiie Sakamoto; Setsuo Hirohashi

Abstract

View articletitled, Src Family Kinase Inhibitor PP2 Restores the E-Cadherin/Catenin Cell Adhesion System in Human Cancer Cells and Reduces Cancer Metastasis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pharmacokinetics of Intrathecal Gemcitabine in Nonhuman Primates

Merrill J. Egorin; Eleanor G. Zuhowski; Cynthia M. McCully; Susan M. Blaney; Jody Z. Kerr; Stacey L. Berg; Frank M. Balis

Abstract

View articletitled, Pharmacokinetics of Intrathecal Gemcitabine in Nonhuman Primates

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Significant Growth Inhibition of Human Lung Cancer Cells Both in Vitro and in Vivo by the Combined Use of a Selective Cyclooxygenase 2 Inhibitor, JTE-522, and Conventional Anticancer Agents 1

Toyoaki Hida; Ken-ichi Kozaki; Hidemi Ito; Osamu Miyaishi; Yoshio Tatematsu; Takeshi Suzuki; Keitaro Matsuo; Takahiko Sugiura; Makoto Ogawa; Toshitada Takahashi; Takashi Takahashi

Abstract

View articletitled, Significant Growth Inhibition of Human Lung Cancer Cells Both in Vitro and in Vivo by the Combined Use of a Selective Cyclooxygenase 2 Inhibitor, JTE-522, and Conventional Anticancer Agents<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Selective Inhibition of the Epidermal Growth Factor Receptor by ZD1839 Decreases the Growth and Invasion of Ovarian Clear Cell Adenocarcinoma Cells 1

Masaki Fujimura; Takao Hidaka; Shigeru Saito

Abstract

View articletitled, Selective Inhibition of the Epidermal Growth Factor Receptor by ZD1839 Decreases the Growth and Invasion of Ovarian Clear Cell Adenocarcinoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A New Type of Antimetastatic Peptide Derived from Fibronectin 1

Rina Kato; Tetsuya Ishikawa; Sadahiro Kamiya; Fumiko Oguma; Masaaki Ueki; Sumio Goto; Hiroshi Nakamura; Takashi Katayama; Fumio Fukai

Abstract

View articletitled, A New Type of Antimetastatic Peptide Derived from Fibronectin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Chemoembolization of the Lung Improves Tumor Control in a Rat Model

Paul Schneider; Stefanie Kampfer; Christoph Loddenkemper; Thomas Foitzik; Heinz J. Buhr

Abstract

View articletitled, Chemoembolization of the Lung Improves Tumor Control in a Rat Model

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