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Review

Mechanisms of Glucocorticoid-mediated Apoptosis in Hematological Malignancies

Stephanie Greenstein; Kulsoom Ghias; Nancy L. Krett; Steven T. Rosen

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The Biology Behind

The Expanding Role of PTEN in Neoplasia: A Molecule for All Seasons?1: Commentary re: M. A. Davies, et al., Adenoviral-mediated Expression of MMAC/PTEN Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells. Clin. Cancer Res., 8: 1904–1914, 2002.

Magali Fernandez; Charis Eng

Abstract

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New HER2-directed Therapies for Breast Cancer.: Commentary re: C. I. Spiridon et al., Targeting Multiple Her-2 Epitopes with Monoclonal Antibodies Results in Improved Antigrowth Activity. Clin. Cancer Res., 8: 1720–1730, 2002.

Arthur E. Frankel

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The Cooperative Group Bulletin Board

Targeted Delivery in Primary and Metastatic Brain Tumors: Summary Report of the Seventh Annual Meeting of the Blood-Brain Barrier Disruption Consortium 1

Nancy D. Doolittle; Lauren E. Abrey; Nicolay Ferrari; Walter A. Hall; Edward R. Laws; Roger E. McLendon; Leslie L. Muldoon; David Peereboom; Darryl R. Peterson; C. Patrick Reynolds; Peter Senter; Edward A. Neuwelt

Abstract

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Advances in Brief

Experimental Therapeutics, Preclinical Pharmacology

A New Human Antitumor Immunoreagent Specific for ErbB2 1

Claudia De Lorenzo; Donald B. Palmer; Renata Piccoli; Mary A. Ritter; Giuseppe D’Alessio

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Targeting Multiple Her-2 Epitopes with Monoclonal Antibodies Results in Improved Antigrowth Activity of a Human Breast Cancer Cell Line in Vitro and in Vivo1

Camelia I. Spiridon; Maria-Ana Ghetie; Jonathan Uhr; Radu Marches; Jia-Ling Li; Guo-Liang Shen; Ellen S. Vitetta

Abstract

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An HLA-A24-restricted Cytotoxic T Lymphocyte Epitope of a Tumor-associated Protein, Survivin

Yoshihiko Hirohashi; Toshihiko Torigoe; Akiko Maeda; Yuki Nabeta; Kenjiro Kamiguchi; Takashi Sato; Junichi Yoda; Hideyuki Ikeda; Kouichi Hirata; Noboru Yamanaka; Noriyuki Sato

Abstract

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Inhibition of Furin-mediated Processing Results in Suppression of Astrocytoma Cell Growth and Invasiveness 1

Javier Mercapide; Ricardo Lopez De Cicco; Daniel E. Bassi; Javier S. Castresana; Gary Thomas; Andres J. P. Klein-Szanto

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Molecular Oncology, Markers, Clinical Correlates

Activated Mitogen-activated Protein Kinase Expression during Human Breast Tumorigenesis and Breast Cancer Progression 1

Adewale Adeyinka; Yulian Nui; Tracy Cherlet; Linda Snell; Peter H. Watson; Leigh C. Murphy

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The Expression of Decorin in Human Ovarian Tumors

Michael A. Nash; Michael T. Deavers; Ralph S. Freedman

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Detection of Gene Promoter Hypermethylation in the Tumor and Serum of Patients with Gastric Carcinoma

Tin-Lap Lee; Wai K. Leung; Michael W. Y. Chan; Enders K. W. Ng; Joanna H. M. Tong; Kwok-Wai Lo; S. C. Sydney Chung; Joseph J. Y. Sung; Ka-Fai To

Abstract

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Regular Articles

Clinical Trials

Prognostic Significance of Adoptive Immunotherapy with Tumor-associated Lymphocytes in Patients with Advanced Gastric Cancer: A Randomized Trial 1

Koji Kono; Akihiro Takahashi; Fumiko Ichihara; Hideki Amemiya; Hidehiko Iizuka; Hideki Fujii; Takayoshi Sekikawa; Yoshiro Matsumoto

Abstract

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A Short-Term Dietary Supplementation of High Doses of Vitamin E Increases T Helper 1 Cytokine Production in Patients with Advanced Colorectal Cancer 1

Karl-Johan Malmberg; Rodica Lenkei; Max Petersson; Tomas Ohlum; Fumiko Ichihara; Bengt Glimelius; Jan-Erik Frödin; Giuseppe Masucci; Rolf Kiessling

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A Phase I Study with an Anti-CD30 Ricin A-Chain Immunotoxin (Ki-4.dgA) in Patients with Refractory CD30⁺ Hodgkin’s and Non-Hodgkin’s Lymphoma 1

Roland Schnell; Oliver Staak; Peter Borchmann; Christine Schwartz; Bärbel Matthey; Hinrich Hansen; John Schindler; Victor Ghetie; Ellen S. Vitetta; Volker Diehl; Andreas Engert

Abstract

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Alterations in the Frequency of Dendritic Cell Subsets in the Peripheral Circulation of Patients with Squamous Cell Carcinomas of the Head and Neck 1

Thomas K. Hoffmann; Jan Müller-Berghaus; Robert L. Ferris; Jonas T. Johnson; Walter J. Storkus; Theresa L. Whiteside

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Reverse Transcription-Polymerase Chain Reaction Detection of Prostate-specific Antigen, Prostate-specific Membrane Antigen, and Prostate Stem Cell Antigen in One Milliliter of Peripheral Blood: Value for the Staging of Prostate Cancer

Noboru Hara; Takashi Kasahara; Takashi Kawasaki; Vladimir Bilim; Kenji Obara; Kota Takahashi; Yoshihiko Tomita

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A Novel Gene from the Human Endogenous Retrovirus K Expressed in Transformed Cells 1

Vivienne Armbruester; Marlies Sauter; Ellen Krautkraemer; Eckart Meese; Anya Kleiman; Barbara Best; Klaus Roemer; Nikolaus Mueller-Lantzsch

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Expression of Cell-Cycle-regulated Proteins pRb2/p130, p107, p27^kip1, p53, mdm-2, and Ki-67 (MIB-1) in Prostatic Gland Adenocarcinoma 1

Pier Paolo Claudio; Alessandra Zamparelli; Fernando U. Garcia; Luigi Claudio; Giuseppe Ammirati; Antonio Farina; Alessandro Bovicelli; Giuseppe Russo; Giovan Giacomo Giordano; David E. McGinnis; Antonio Giordano; Gaetano Cardi

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Changes in Microvessel Density As Assessed by CD34 Antibodies after Primary Chemotherapy in Human Breast Cancer 1

Alberto Bottini; Alfredo Berruti; Alessandra Bersiga; Maria Pia Brizzi; Giovanni Allevi; Giovanna Bolsi; Sergio Aguggini; Antonio Brunelli; Enrico Betri; Daniele Generali; Lorena Scaratti; Giovanni Bertoli; Palmiro Alquati; Luigi Dogliotti

Abstract

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Insulin-like Growth Factor I Receptor Activity in Human Medulloblastomas 1

Luis Del Valle; Sahnila Enam; Adam Lassak; Jin Yiang Wang; Sidney Croul; Kamel Khalili; Krzysztof Reiss

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Overexpression of Hypoxia-inducible Factor 1α Is Associated with an Unfavorable Prognosis in Lymph Node-positive Breast Cancer

Monika Schindl; Sebastian F. Schoppmann; Hellmut Samonigg; Hubert Hausmaninger; Werner Kwasny; Michael Gnant; Raimund Jakesz; Ernst Kubista; Peter Birner; Georg Oberhuber; the Austrian Breast Colorectal Cancer Study Group

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Smad4 and Transforming Growth Factor β1 Expression in Patients with Squamous Cell Carcinoma of the Esophagus 1

Shoji Natsugoe; Che Xiangming; Masataka Matsumoto; Hiroshi Okumura; Saburo Nakashima; Hironori Sakita; Sumiya Ishigami; Masamichi Baba; Sonshin Takao; Takashi Aikou

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Expression Profile of Genes in Non-Small Cell Lung Carcinomas from Long-Term Surviving Patients

Manfred Volm; Reet Koomägi; Jürgen Mattern; Thomas Efferth

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Evaluation of the Family History Collection Process and the Accuracy of Cancer Reporting among a Series of Women with Endometrial Cancer 1

Jennifer Ivanovich; Sheri Babb; Paul Goodfellow; David Mutch; Thomas Herzog; Janet Rader; Alison Whelan

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Cyclooxygenase-2 Expression Is a Novel Prognostic Factor in Malignant Mesothelioma 1

John G. Edwards; Stephen P. Faux; Simon M. Plummer; Keith R. Abrams; Rosemary A. Walker; David A. Waller; Kenneth J. O’Byrne

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The Prognostic Value of Angiogenesis and Metastasis-related Genes for Progression of Transitional Cell Carcinoma of the Renal Pelvis and Ureter

Keiji Inoue; Masayuki Kamada; Joel W. Slaton; Satoshi Fukata; Chiaki Yoshikawa; Pheroze Tamboli; Colin P. N. Dinney; Taro Shuin

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Detection of Circulating Breast Tumor Cells by Differential Expression of Marker Genes 1

Astrid J. Bosma; Britta Weigelt; A. Caro Lambrechts; Onno J. H. M. Verhagen; Roelof Pruntel; Augustinus A. M. Hart; Sjoerd Rodenhuis; Laura J. van ’t Veer

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Prognostic Significance of Preoperative Molecular Serum Analysis in Renal Cancer

Mark L. Gonzalgo; Claus F. Eisenberger; Shing M. Lee; Bruce J. Trock; Fray F. Marshall; Steven Hortopan; David Sidransky; Mark P. Schoenberg

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Loss of DCC Gene Expression Is of Prognostic Importance in Acute Myelogenous Leukemia

Koiti Inokuchi; Hiroki Yamaguchi; Hideki Hanawa; Sakae Tanosaki; Kayo Nakamura; Miki Tarusawa; Koichi Miyake; Takashi Shimada; Kazuo Dan

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Prognostic Significance of Metallothionein in Human Gastrointestinal Cancer 1

A. Miranda L. Janssen; Wim van Duijn; Frank J. G. M. Kubben; Gerrit Griffioen; Cornelis B. H. W. Lamers; Johan H. J. M. van Krieken; Cornelis J. H. van de Velde; Hein W. Verspaget

Abstract

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DNA Methylation Patterns at Relapse in Adult Acute Lymphocytic Leukemia 1

Guillermo Garcia-Manero; Carlos Bueso-Ramos; Jerry Daniel; Jason Williamson; Hagop M. Kantarjian; Jean-Pierre J. Issa

Abstract

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Experimental Therapeutics, Preclinical Pharmacology

Adenoviral-mediated Expression of MMAC/PTEN Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells 1

Michael A. Davies; Sun J. Kim; Nila U. Parikh; Zhongyun Dong; Corazon D. Bucana; Gary E. Gallick

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Soluble Coxsackievirus Adenovirus Receptor Is a Putative Inhibitor of Adenoviral Gene Transfer in the Tumor Milieu 1

Ray M. Bernal; Sherven Sharma; Brian K. Gardner; Joanne T. Douglas; Jeffrey M. Bergelson; Steven M. Dubinett; Raj K. Batra

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The Neurotrophin-Trk Receptor Axes Are Critical for the Growth and Progression of Human Prostatic Carcinoma and Pancreatic Ductal Adenocarcinoma Xenografts in Nude Mice

Sheila J. Miknyoczki; Weihua Wan; Hong Chang; Pawel Dobrzanski; Bruce A. Ruggeri; Craig A. Dionne; Karen Buchkovich

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Synthetic Matrix Metalloproteinase Inhibitors Inhibit Growth of Established Breast Cancer Osteolytic Lesions and Prolong Survival in Mice

Bent Winding; Róisín NicAmhlaoibh; Henriette Misander; Pernille Høegh-Andersen; Thomas Levin Andersen; Claus Holst-Hansen; Anne-Marie Heegaard; Niels Tækker Foged; Nils Brünner; Jean-Marie Delaissé

Abstract

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Augmentation of Sodium Butyrate-induced Apoptosis by Phosphatidylinositol 3′-Kinase Inhibition in the KM20 Human Colon Cancer Cell Line 1

Qingding Wang; Nan Li; Xiaofu Wang; Myung M. Kim; B. Mark Evers

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Heterogeneity in Interleukin-13 Receptor Expression and Subunit Structure in Squamous Cell Carcinoma of Head and Neck: Differential Sensitivity to Chimeric Fusion Proteins Comprised of Interleukin-13 and a Mutated Form of Pseudomonas Exotoxin 1

Bharat H. Joshi; Koji Kawakami; Pamela Leland; Raj K. Puri

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The in Vitro and in Vivo Effects of 2-(4-Morpholinyl)-8-phenyl-chromone (LY294002), a Specific Inhibitor of Phosphatidylinositol 3′-Kinase, in Human Colon Cancer Cells 1

Shuho Semba; Nanami Itoh; Masafumi Ito; Masaru Harada; Mitsunori Yamakawa

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Thalidomide Metabolism by the CYP2C Subfamily 1

Yuichi Ando; Eiichi Fuse; William D. Figg

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Antitumor Activity of the Novel Vascular Targeting Agent ZD6126 in a Panel of Tumor Models

David C. Blakey; F. Russell Westwood; Mike Walker; Gareth D. Hughes; Peter D. Davis; Sue E. Ashton; Anderson J. Ryan

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A Preclinical Model of Minimal Residual Cancer in the Muscle Highlights Challenges Associated with Adenovirus-mediated p53 Gene Transfer

Roth Oakley; Elaine Phillips; Richard Hooper; Deborah Wilson; Max Partridge

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Effects of a New Clinically Relevant Antiestrogen (GW5638) Related to Tamoxifen on Breast and Endometrial Cancer Growth in Vivo1

Rita C. Dardes; Ruth M. O’Regan; Csaba Gajdos; Simon P. Robinson; David Bentrem; Alex De Los Reyes; V. Craig Jordan

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Establishment and Characterization of Acquired Resistance to the Farnesyl Protein Transferase Inhibitor R115777 in a Human Colon Cancer Cell Line 1

Victoria Smith; Martin G. Rowlands; Elaine Barrie; Paul Workman; Lloyd R. Kelland

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Observation of Molecular Changes of a Necrotic Tissue from a Murine Carcinoma by Fourier-Transform Infrared Microspectroscopy 1

Tetsushi Yamada; Norio Miyoshi; Toru Ogawa; Kenichi Akao; Masaru Fukuda; Toshiyuki Ogasawara; Yoshimasa Kitagawa; Kazuo Sano

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Letters to the Editor

Correspondence re: B. Molnar et al., Circulating Tumor Cell Clusters in the Peripheral Blood of Colorectal Cancer Patients. Clin. Cancer Res., 7: 4080–4085, 2001.

George Tsavellas; Andy Huang

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Reply

Bela Molnar; Andras Ladanyi; Lajos Flóró; Lenke Tankó; Lydia Sréter; Zsolt Tulassay

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Issues

Review

The Biology Behind

The Expanding Role of PTEN in Neoplasia: A Molecule for All Seasons?1: Commentary re: M. A. Davies, et al., Adenoviral-mediated Expression of MMAC/PTEN Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells. Clin. Cancer Res., 8: 1904–1914, 2002.

The Cooperative Group Bulletin Board

Advances in Brief

Experimental Therapeutics, Preclinical Pharmacology

Molecular Oncology, Markers, Clinical Correlates

Regular Articles

Clinical Trials

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Letters to the Editor

Email alerts

AACR Journals

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