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Report from the FDA

Approval Summary for Imatinib Mesylate Capsules in the Treatment of Chronic Myelogenous Leukemia

Martin H. Cohen; Grant Williams; John R. Johnson; John Duan; Jogarao Gobburu; Atiqur Rahman; Kimberly Benson; John Leighton; Sung K. Kim; Rebecca Wood; Mark Rothmann; Gang Chen; Khin Maung U; Ann M. Staten; Richard Pazdur

Abstract

View articletitled, Approval Summary for Imatinib Mesylate Capsules in the Treatment of Chronic Myelogenous Leukemia

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The Cooperative Group Bulletin Board

Cooperative Group Tissue Banks As Research Resources: The Cancer and Leukemia Group B Tissue Repositories 1

Richard L. Schilsky; Lynn M. Dressler; Donna Bucci; Laura Monovich; Scott Jewell; Saul Suster; Michael A. Caligiuri; Philip W. Kantoff; Carolyn Compton

Extract

View articletitled, Cooperative Group Tissue Banks As Research Resources: The Cancer and Leukemia Group B Tissue Repositories<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Review

Transcription Factors and Neoplasia: Vistas in Novel Drug Design

Mihalis V. Karamouzis; Vassilis G. Gorgoulis; Athanasios G. Papavassiliou

Abstract

View articletitled, Transcription Factors and Neoplasia: Vistas in Novel Drug Design

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The Biology Behind

Heat Shock Protein 90 Inhibition by 17-Allylamino-17- demethoxygeldanamycin: A Novel Therapeutic Approach for Treating Hormone-refractory Prostate Cancer: Commentary re: D. B. Solit et al., 17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and Her-2/neu and Inhibits the Growth of Prostate Cancer Xenografts. Clin. Cancer Res., 8: 986–993, 2002.

Len Neckers

Extract

View articletitled, Heat Shock Protein 90 Inhibition by 17-Allylamino-17- demethoxygeldanamycin: A Novel Therapeutic Approach for Treating Hormone-refractory Prostate Cancer: Commentary re: D. B. Solit et al., 17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and Her-2/neu and Inhibits the Growth of Prostate Cancer Xenografts. Clin. Cancer Res., 8: 986–993, 2002.

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Advances in Brief

T-Cell Responses against Tyrosinase 368–376(370D) Peptide in HLA∗A0201⁺ Melanoma Patients: Randomized Trial Comparing Incomplete Freund’s Adjuvant, Granulocyte Macrophage Colony-stimulating Factor, and QS-21 as Immunological Adjuvants 1

Susanne G. Schaed; Virginia M. Klimek; Katherine S. Panageas; Cristina M. Musselli; Leah Butterworth; Wen-Jen Hwu; Philip O. Livingston; Linda Williams; Jonathan J. Lewis; Alan N. Houghton; Paul B. Chapman

Abstract

View articletitled, T-Cell Responses against Tyrosinase 368–376(370D) Peptide in HLA∗A0201+ Melanoma Patients: Randomized Trial Comparing Incomplete Freund’s Adjuvant, Granulocyte Macrophage Colony-stimulating Factor, and QS-21 as Immunological Adjuvants<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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p53 Mutations in Leukemia and Myelodysplastic Syndrome after Ovarian Cancer 1

Debra G. B. Leonard; Lois B. Travis; Kathakali Addya; Graca M. Dores; Eric J. Holowaty; Kjell Bergfeldt; David Malkin; Betsy A. Kohler; Charles F. Lynch; Tom Wiklund; Marilyn Stovall; Per Hall; Eero Pukkala; Diana J. Slater; Carolyn A. Felix

Abstract

View articletitled, p53 Mutations in Leukemia and Myelodysplastic Syndrome after Ovarian Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and HER-2/neu and Inhibits the Growth of Prostate Cancer Xenografts 1

David B. Solit; Fuzhong F. Zheng; Maria Drobnjak; Pamela N. Münster; Brian Higgins; David Verbel; Glenn Heller; William Tong; Carlos Cordon-Cardo; David B. Agus; Howard I. Scher; Neal Rosen

Abstract

View articletitled, 17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and HER-2/neu and Inhibits the Growth of Prostate Cancer Xenografts<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enhanced Antitumor Activity of Anti-epidermal Growth Factor Receptor Monoclonal Antibody IMC-C225 in Combination with Irinotecan (CPT-11) against Human Colorectal Tumor Xenografts

Marie C. Prewett; Andrea T. Hooper; Rajiv Bassi; Lee M. Ellis; Harlan W. Waksal; Daniel J. Hicklin

Abstract

View articletitled, Enhanced Antitumor Activity of Anti-epidermal Growth Factor Receptor Monoclonal Antibody IMC-C225 in Combination with Irinotecan (CPT-11) against Human Colorectal Tumor Xenografts

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Regular Articles

Clinical Trials

Phase I Trial of a Novel Diphtheria Toxin/Granulocyte Macrophage Colony-stimulating Factor Fusion Protein (DT₃₈₈GMCSF) for Refractory or Relapsed Acute Myeloid Leukemia 1

Arthur E. Frankel; Bayard L. Powell; Philip D. Hall; L. Douglas Case; Robert J. Kreitman

Abstract

View articletitled, Phase I Trial of a Novel Diphtheria Toxin/Granulocyte Macrophage Colony-stimulating Factor Fusion Protein (DT388GMCSF) for Refractory or Relapsed Acute Myeloid Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunization of Cancer Patients with a HER-2/neu, HLA-A2 Peptide, p369–377, Results in Short-lived Peptide-specific Immunity 1

Keith L. Knutson; Kathy Schiffman; Martin A. Cheever; Mary L. Disis

Abstract

View articletitled, Immunization of Cancer Patients with a HER-2/neu, HLA-A2 Peptide, p369–377, Results in Short-lived Peptide-specific Immunity<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Induction of p53-specific Immune Responses in Colorectal Cancer Patients Receiving a Recombinant ALVAC-p53 Candidate Vaccine 1

Sjoerd H. van der Burg; Anand G Menon; Anke Redeker; Marie-Claude Bonnet; Jan Wouter Drijfhout; Rob A. E. M. Tollenaar; Cornelis J. H. van de Velde; Philippe Moingeon; Peter J. K. Kuppen; Rienk Offringa; Cornelis J. M. Melief

Abstract

View articletitled, Induction of p53-specific Immune Responses in Colorectal Cancer Patients Receiving a Recombinant ALVAC-p53 Candidate Vaccine<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Encapsulated Plasmid DNA Treatment for Human Papillomavirus 16-associated Anal Dysplasia: A Phase I Study of ZYC101 1

Barbara Klencke; Mark Matijevic; Robert G. Urban; Janet L. Lathey; Mary Lynne Hedley; Michael Berry; Joe Thatcher; Vivian Weinberg; Jennifer Wilson; Teresa Darragh; Naomi Jay; Maria Da Costa; Joel M. Palefsky

Abstract

View articletitled, Encapsulated Plasmid DNA Treatment for Human Papillomavirus 16-associated Anal Dysplasia: A Phase I Study of ZYC101<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I and Pharmacokinetic Study of ABI-007, a Cremophor-free, Protein-stabilized, Nanoparticle Formulation of Paclitaxel 1

Nuhad K. Ibrahim; Neil Desai; Sewa Legha; Patrick Soon-Shiong; Richard L. Theriault; Edgardo Rivera; Bita Esmaeli; Sigrid E. Ring; Agop Bedikian; Gabriel N. Hortobagyi; Julie A. Ellerhorst

Abstract

View articletitled, Phase I and Pharmacokinetic Study of ABI-007, a Cremophor-free, Protein-stabilized, Nanoparticle Formulation of Paclitaxel<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Impact of Two Weekly Schedules of Oral Eniluracil Given with Fluorouracil and Leucovorin on the Duration of Dihydropyrimidine Dehydrogenase Inhibition

Bruce Keith; Xiao-Du Guo; Suzanne Zentko; Nancy Harold; Barbara Schuler; Mary Quinn; Jeremy Shapiro; Jean L. Grem

Abstract

View articletitled, Impact of Two Weekly Schedules of Oral Eniluracil Given with Fluorouracil and Leucovorin on the Duration of Dihydropyrimidine Dehydrogenase Inhibition

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Treatment of Advanced Breast Cancer with Docetaxel and Gemcitabine with and without Human Granulocyte Colony-stimulating Factor 1

Gabriela V. Kornek; Karin Haider; Werner Kwasny; Markus Raderer; Birgit Schüll; Thomas Payrits; Dieter Depisch; Erwin Kovats; Fritz Lang; Werner Scheithauer

Abstract

View articletitled, Treatment of Advanced Breast Cancer with Docetaxel and Gemcitabine with and without Human Granulocyte Colony-stimulating Factor<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I/Pilot Study of Sequential Doxorubicin/Vinorelbine: Effects on p53 and Microtubule-associated Protein 4 1

Judy Bash-Babula; Deborah Toppmeyer; Marie Labassi; Janice Reidy; Michelle Orlick; Rachelle Senzon; Elizabeth Alli; Thomas Kearney; David August; Weichung Shih; Jin-Ming Yang; William N. Hait

Abstract

View articletitled, A Phase I/Pilot Study of Sequential Doxorubicin/Vinorelbine: Effects on p53 and Microtubule-associated Protein 4<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Trial of the Farnesyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Lung and Head and Neck Cancer 1

Stephen M. Hahn; Eric J. Bernhard; William Regine; Mohammed Mohiuddin; Daniel G. Haller; James P. Stevenson; Debbie Smith; Barnali Pramanik; Joel Tepper; Thomas F. DeLaney; Krystina D. Kiel; Briggs Morrison; Paul Deutsch; Ruth J. Muschel; W. Gillies McKenna

Abstract

View articletitled, A Phase I Trial of the Farnesyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Lung and Head and Neck Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Evaluation of Paclitaxel in Adjuvant Chemotherapy for Patients with Operable Breast Cancer: Preliminary Data of a Prospective Randomized Trial 1

Abstract

View articletitled, Evaluation of Paclitaxel in Adjuvant Chemotherapy for Patients with Operable Breast Cancer: Preliminary Data of a Prospective Randomized Trial<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Pamidronate Induces Modifications of Circulating Angiogenetic Factors in Cancer Patients

Daniele Santini; Bruno Vincenzi; Giuseppe Avvisati; Giordano Dicuonzo; Fabrizio Battistoni; Michele Gavasci; Alfredo Salerno; Vincenzo Denaro; Giuseppe Tonini

Abstract

View articletitled, Pamidronate Induces Modifications of Circulating Angiogenetic Factors in Cancer Patients

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Detection of Circulating Cytokeratin-positive Cells in the Blood of Breast Cancer Patients Using Immunomagnetic Enrichment and Digital Microscopy

Thomas E. Witzig; Blaise Bossy; Teresa Kimlinger; Patrick C. Roche; James N. Ingle; Clive Grant; John Donohue; Vera J. Suman; Douglas Harrington; Jose Torre-Bueno; Kenneth D. Bauer

Abstract

View articletitled, Detection of Circulating Cytokeratin-positive Cells in the Blood of Breast Cancer Patients Using Immunomagnetic Enrichment and Digital Microscopy

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Intestinal Trefoil Factor: A Marker of Poor Prognosis in Gastric Carcinoma 1

Takasuke Yamachika; J. Lawrence Werther; Carol Bodian; Mark Babyatsky; Masae Tatematsu; Yoshitaka Yamamura; Anli Chen; Steven Itzkowitz

Abstract

View articletitled, Intestinal Trefoil Factor: A Marker of Poor Prognosis in Gastric Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Dysregulation of PTEN and Protein Kinase B Is Associated with Glioma Histology and Patient Survival 1

Ralph P. Ermoian; Constance S. Furniss; Kathleen R. Lamborn; Daniel Basila; Mitchel S. Berger; Alexander R. Gottschalk; M. Kelly Nicholas; David Stokoe; Daphne A. Haas-Kogan

Abstract

View articletitled, Dysregulation of PTEN and Protein Kinase B Is Associated with Glioma Histology and Patient Survival<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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HER-2 Amplification and Topoisomerase IIα Gene Aberrations as Predictive Markers in Node-positive Breast Cancer Patients Randomly Treated Either with an Anthracycline-based Therapy or with Cyclophosphamide, Methotrexate, and 5-Fluorouracil 1

Angelo Di Leo; David Gancberg; Denis Larsimont; Minna Tanner; Tero Jarvinen; Ghizlane Rouas; Stella Dolci; Jean-Yves Leroy; Marianne Paesmans; Jorma Isola; Martine J. Piccart

Abstract

View articletitled, HER-2 Amplification and Topoisomerase IIα Gene Aberrations as Predictive Markers in Node-positive Breast Cancer Patients Randomly Treated Either with an Anthracycline-based Therapy or with Cyclophosphamide, Methotrexate, and 5-Fluorouracil<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Impact of TP53 Mutations and P53 Protein Overexpression in Supratentorial WHO Grade II Astrocytomas and Oligoastrocytomas 1

Aurelia Peraud; Friedrich W. Kreth; Otmar D. Wiestler; Paul Kleihues; Hans-Jürgen Reulen

Abstract

View articletitled, Prognostic Impact of TP53 Mutations and P53 Protein Overexpression in Supratentorial WHO Grade II Astrocytomas and Oligoastrocytomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Inhibition of Infiltration and Angiogenesis by Thrombospondin-1 in Papillary Thyroid Carcinoma 1

Katsuhiro Tanaka; Hiroshi Sonoo; Junichi Kurebayashi; Tsunehisa Nomura; Sumiko Ohkubo; Yutaka Yamamoto; Shigeru Yamamoto

Abstract

View articletitled, Inhibition of Infiltration and Angiogenesis by Thrombospondin-1 in Papillary Thyroid Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Serum and Cytosol of Tumor Tissue from Patients with Primary Breast Cancer 1

Rikke Riisbro; Ib J. Christensen; Timo Piironen; Michael Greenall; Berthe Larsen; Ross W. Stephens; Cheng Han; Gunilla Høyer-Hansen; Kenneth Smith; Nils Brünner; Adrian L. Harris

Abstract

View articletitled, Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Serum and Cytosol of Tumor Tissue from Patients with Primary Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Doppler Ultrasonography of the Uterine Artery and the Response to Chemotherapy in Patients with Gestational Trophoblastic Tumors 1

Roshan Agarwal; Sarah Strickland; Iain A. McNeish; Daksha C. Patel; Marianne Foskett; Joe E. Boultbee; Edward S. Newlands; Michael J. Seckl

Abstract

View articletitled, Doppler Ultrasonography of the Uterine Artery and the Response to Chemotherapy in Patients with Gestational Trophoblastic Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Ki-67 Staining Is an Independent Correlate of Biochemical Failure in Prostate Cancer Treated with Radiotherapy 1

Didier Cowen; Patricia Troncoso; Vincent S. Khoo; Gunar K. Zagars; Andrew C. von Eschenbach; Marvin L. Meistrich; Alan Pollack

Abstract

View articletitled, Ki-67 Staining Is an Independent Correlate of Biochemical Failure in Prostate Cancer Treated with Radiotherapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Development and Validation of a Method for Using Breast Core Needle Biopsies for Gene Expression Microarray Analyses 1

Abstract

View articletitled, Development and Validation of a Method for Using Breast Core Needle Biopsies for Gene Expression Microarray Analyses<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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High Expression of Wilms’ Tumor Suppressor Gene Predicts Poor Prognosis in Breast Cancer Patients 1

Yasuo Miyoshi; Akiko Ando; Chiyomi Egawa; Tetsuya Taguchi; Yasuhiro Tamaki; Hiroya Tamaki; Haruo Sugiyama; Shinzaburo Noguchi

Abstract

View articletitled, High Expression of Wilms’ Tumor Suppressor Gene Predicts Poor Prognosis in Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Maspin Expression Profile in Human Prostate Cancer (CaP) and in Vitro Induction of Maspin Expression by Androgen Ablation

Zhiqiang Zou; Wei Zhang; Denise Young; Martin G. Gleave; Paul Rennie; Theresa Connell; Roger Connelly; Judd Moul; Shiv Srivastava; Isabell Sesterhenn

Abstract

View articletitled, Maspin Expression Profile in Human Prostate Cancer (CaP) and in Vitro Induction of Maspin Expression by Androgen Ablation

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Lack of PTEN Expression in Non-Small Cell Lung Cancer Could Be Related to Promoter Methylation 1

Jean-Charles Soria; Ho-Young Lee; Janet I. Lee; Luo Wang; Jean-Pierre Issa; Bonnie L. Kemp; Diane D. Liu; Jonathan M. Kurie; Li Mao; Fadlo R. Khuri

Abstract

View articletitled, Lack of PTEN Expression in Non-Small Cell Lung Cancer Could Be Related to Promoter Methylation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Differential Assessment of Vascular Survival Ability and Tumor Angiogenic Activity in Colorectal Cancer

Alexandra Giatromanolaki; Efthimios Sivridis; George Minopoulos; Alexandros Polychronidis; Constantinos Manolas; Constantinos Simopoulos; Michael I. Koukourakis

Abstract

View articletitled, Differential Assessment of Vascular Survival Ability and Tumor Angiogenic Activity in Colorectal Cancer

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p53 Mutation Arising in Arg72 Allele in the Tumorigenesis and Development of Carcinoma of the Urinary Tract 1

Mutsuo Furihata; Tamotsu Takeuchi; Manabu Matsumoto; Atsushi Kurabayashi; Yuji Ohtsuki; Naotami Terao; Morimasa Kuwahara; Taro Shuin

Abstract

View articletitled, p53 Mutation Arising in Arg72 Allele in the Tumorigenesis and Development of Carcinoma of the Urinary Tract<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Failure of BRCA1 Dysfunction to Alter Ovarian Cancer Survival 1

Richard E. Buller; Mark S. Shahin; John P. Geisler; Melanie Zogg; Barry R. De Young; Charles S. Davis

Abstract

View articletitled, Failure of BRCA1 Dysfunction to Alter Ovarian Cancer Survival<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Real-Time Quantitative PCR Demonstrates Low Prevalence of Human Papillomavirus Type 16 in Premalignant and Malignant Lesions of the Oral Cavity 1

Patrick K. Ha; Sara I. Pai; William H. Westra; Maura L. Gillison; Betty C. Tong; David Sidransky; Joseph A. Califano

Abstract

View articletitled, Real-Time Quantitative PCR Demonstrates Low Prevalence of Human Papillomavirus Type 16 in Premalignant and Malignant Lesions of the Oral Cavity<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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DNA Sequence Losses on Chromosomes 11p and 18q Are Associated with Clinical Outcome in Lymph Node-negative Ductal Breast Cancer 1

Athanassios Dellas; Joachim Torhorst; Elisabeth Schultheiss; Michael J. Mihatsch; Holger Moch

Abstract

View articletitled, DNA Sequence Losses on Chromosomes 11p and 18q Are Associated with Clinical Outcome in Lymph Node-negative Ductal Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Oral (1→3),(1→4)-β-d-Glucan Synergizes with Antiganglioside GD2 Monoclonal Antibody 3F8 in the Therapy of Neuroblastoma 1

Nai-Kong V. Cheung; Shakeel Modak

Abstract

View articletitled, Oral (1→3),(1→4)-β-d-Glucan Synergizes with Antiganglioside GD2 Monoclonal Antibody 3F8 in the Therapy of Neuroblastoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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In Vivo Pharmacokinetic Features, Toxicity Profile, and Chemosensitizing Activity of α-Cyano-β-hydroxy-β- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a Novel Antileukemic Agent Targeting Bruton’s Tyrosine Kinase

Fatih M. Uckun; Yaguo Zheng; Marina Cetkovic-Cvrlje; Alexei Vassilev; Elizabeth Lisowski; Barbara Waurzyniak; Hao Chen; Randy Carpenter; Chun-Lin Chen

Abstract

View articletitled, In Vivo Pharmacokinetic Features, Toxicity Profile, and Chemosensitizing Activity of α-Cyano-β-hydroxy-β- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a Novel Antileukemic Agent Targeting Bruton’s Tyrosine Kinase

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Induction of Apoptosis by Bexarotene in Cutaneous T-Cell Lymphoma Cells: Relevance to Mechanism of Therapeutic Action 1

Chunlei Zhang; Parul Hazarika; Xiao Ni; Douglas A. Weidner; Madeleine Duvic

Abstract

View articletitled, Induction of Apoptosis by Bexarotene in Cutaneous T-Cell Lymphoma Cells: Relevance to Mechanism of Therapeutic Action<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Detoxification of the Polyamine Analogue N¹-Ethyl-N¹¹-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by Polyamine Oxidase 1

Kathryn R. Lawson; Sarah Marek; Jennifer A. Linehan; Patrick M. Woster; Robert A. Casero, Jr.; Claire M. Payne; Eugene W. Gerner

Abstract

View articletitled, Detoxification of the Polyamine Analogue N1-Ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by Polyamine Oxidase<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of PTEN Increases Sensitivity to SN-38, an Active Metabolite of the Topoisomerase I Inhibitor Irinotecan, in Ovarian Cancer Cells

Yasushi Saga; Hiroaki Mizukami; Mitsuaki Suzuki; Takahiro Kohno; Masashi Urabe; Keiya Ozawa; Ikuo Sato

Abstract

View articletitled, Overexpression of PTEN Increases Sensitivity to SN-38, an Active Metabolite of the Topoisomerase I Inhibitor Irinotecan, in Ovarian Cancer Cells

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Inhibition of Angiogenesis by the Antiepidermal Growth Factor Receptor Antibody ImClone C225 in Androgen-independent Prostate Cancer Growing Orthotopically in Nude Mice 1

Takashi Karashima; Paul Sweeney; Joel W. Slaton; Sun J. Kim; Daniel Kedar; Jonathan I. Izawa; Zhen Fan; Curtis Pettaway; Daniel J. Hicklin; Taro Shuin; Colin P. N. Dinney

Abstract

View articletitled, Inhibition of Angiogenesis by the Antiepidermal Growth Factor Receptor Antibody ImClone C225 in Androgen-independent Prostate Cancer Growing Orthotopically in Nude Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Erythropoietin Restores the Antitumor Effectiveness of Photodynamic Therapy in Mice with Chemotherapy- induced Anemia 1

Jakub Gołab; Dominika Olszewska; Paweł Mróz; Katarzyna Kozar; Rafał Kamiński; Ahmad Jalili; Marek Jakóbisiak

Abstract

View articletitled, Erythropoietin Restores the Antitumor Effectiveness of Photodynamic Therapy in Mice with Chemotherapy- induced Anemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of HER-2/Neu in Uterine Serous Papillary Cancer 1

Alessandro D. Santin; Stefania Bellone; Murat Gokden; Michela Palmieri; Donna Dunn; Jamshed Agha; Juan J. Roman; Laura Hutchins; Sergio Pecorelli; Timothy O’Brien; Martin J. Cannon; Groesbeck P. Parham

Abstract

View articletitled, Overexpression of HER-2/Neu in Uterine Serous Papillary Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Bradykinin Antagonist Dimer, CU201, Inhibits the Growth of Human Lung Cancer Cell Lines in Vitro and in Vivo and Produces Synergistic Growth Inhibition in Combination with Other Antitumor Agents 1

Daniel C. Chan; Lajos Gera; John M. Stewart; Barbara Helfrich; Tom Limin Zhao; Wan Yong Feng; Kenneth K. Chan; Joseph M. Covey; Paul A. Bunn, Jr.

Abstract

View articletitled, Bradykinin Antagonist Dimer, CU201, Inhibits the Growth of Human Lung Cancer Cell Lines in Vitro and in Vivo and Produces Synergistic Growth Inhibition in Combination with Other Antitumor Agents<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Nuclear Receptor Agonists As Potential Differentiation Therapy Agents for Human Osteosarcoma 1

Rex C. Haydon; Lan Zhou; Tao Feng; Benjamin Breyer; Hongwei Cheng; Wei Jiang; Akira Ishikawa; Terrance Peabody; Anthony Montag; Michael A. Simon; Tong-Chuan He

Abstract

View articletitled, Nuclear Receptor Agonists As Potential Differentiation Therapy Agents for Human Osteosarcoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Selective Exclusion by the Polyamine Transporter as a Mechanism for Differential Radioprotection of Amifostine Derivatives 1

Herson I. Quiñones; Alan F. List; Eugene W. Gerner

Abstract

View articletitled, Selective Exclusion by the Polyamine Transporter as a Mechanism for Differential Radioprotection of Amifostine Derivatives<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Modulation of Marrow Proliferation and Chemosensitivity by Tumor-produced Cytokines from Syngeneic Pancreatic Tumor Lines 1

Rosalyn D. Blumenthal; Albert Reising; Evelyn Leon; David M. Goldenberg

Abstract

View articletitled, Modulation of Marrow Proliferation and Chemosensitivity by Tumor-produced Cytokines from Syngeneic Pancreatic Tumor Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Letters to the Editor

Correspondence re: M. Follen et al., A Randomized Clinical Trial of 4-Hydroxyphenylretinamide for High-Grade Squamous Intraepithelial Lesions of the Cervix. Clin. Cancer Res., 7: 3356–3365, 2001 1

Franca Formelli

Extract

View articletitled, Correspondence re: M. Follen et al., A Randomized Clinical Trial of 4-Hydroxyphenylretinamide for High-Grade Squamous Intraepithelial Lesions of the Cervix. Clin. Cancer Res., 7: 3356–3365, 2001<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Reply

Michele Follen; Herbert A. Fritsche

Extract

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Correspondence re: Raida, M. et al., Prevalence of a Common Point Mutation in the Dihydropyrimidine Dehydrogenase (DPD) Gene within the 5′-Splice Donor Site of Intron 14 in Patients with Severe 5-Fluorouracil (5-FU)-related Toxicity Compared with Controls. Clin. Cancer Res., 7: 2832–2839, 2001.

Federico Innocenti; Mark J. Ratain

Extract

View articletitled, Correspondence re: Raida, M. et al., Prevalence of a Common Point Mutation in the Dihydropyrimidine Dehydrogenase (DPD) Gene within the 5′-Splice Donor Site of Intron 14 in Patients with Severe 5-Fluorouracil (5-FU)-related Toxicity Compared with Controls. Clin. Cancer Res., 7: 2832–2839, 2001.

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Detlev Behnke; Martin Raida; Kay-Oliver Kliche; Uwe Pichlmeier

Extract

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