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Volume 8, Issue 11

1 November 2002

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorials
The Biology Behind
Advances in Brief
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology
Correction

Editorials

Targeting Multiple Biological Pathways as a Strategy to Improve the Treatment of Cancer

Michael S. O’Reilly

The Biology Behind

To Arrest or Not To G₂-M Cell-Cycle Arrest: Commentary re: A. K. Tyagi et al., Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicin-induced Growth Inhibition, G₂-M Arrest, and Apoptosis. Clin. Cancer Res., 8: 3512–3519, 2002.

Robert S. DiPaola

Advances in Brief

Clinical Trials

In Vivo Validation of 3′deoxy-3′-[¹⁸F]fluorothymidine ([¹⁸F]FLT) as a Proliferation Imaging Tracer in Humans: Correlation of [¹⁸F]FLT Uptake by Positron Emission Tomography with Ki-67 Immunohistochemistry and Flow Cytometry in Human Lung Tumors 1

Hubert Vesselle; John Grierson; Mark Muzi; Jeffrey M. Pugsley; Rodney A. Schmidt; Peter Rabinowitz; Lanell M. Peterson; Eric Vallières; Douglas E. Wood

Molecular Oncology, Markers, Clinical Correlates

Methylation Profiles of Sporadic Ovarian Tumors and nonmalignant Ovaries from High-Risk Women 1

Asha Rathi; Arvind K. Virmani; John O. Schorge; Keren J. Elias; Riichiroh Maruyama; John D. Minna; Samuel C. Mok; Luc Girard; David A. Fishman; Adi F. Gazdar

Detection of JC Polyomavirus DNA Sequences and Cellular Localization of T-Antigen and Agnoprotein in Oligodendrogliomas 1

Luis Del Valle; Sahnila Enam; César Lara; Carlos Ortiz-Hidalgo; Christos D. Katsetos; Kamel Khalili

Experimental Therapeutics, Preclinical Pharmacology

Inhibition of Human Telomerase Enhances the Effect of the Tyrosine Kinase Inhibitor, Imatinib, in BCR-ABL-positive Leukemia Cells 1

Tetsuzo Tauchi; Akihiro Nakajima; Goro Sashida; Takashi Shimamoto; Junko H. Ohyashiki; Kenji Abe; Kohtaro Yamamoto; Kazuma Ohyashiki

The Presence of the Adenovirus E3 Region Improves the Oncolytic Potency of Conditionally Replicative Adenoviruses 1

Kaori Suzuki; Ramón Alemany; Masato Yamamoto; David T. Curiel

Regular Articles

Clinical Trials

A Detailed Evaluation of Cardiac Toxicity: A Phase II Study of Doxorubicin and One- or Three-Hour-Infusion Paclitaxel in Patients with Metastatic Breast Cancer 1

Sharon H. Giordano; Daniel J. Booser; James L. Murray; Nuhad K. Ibrahim; Zia U. Rahman; Vicente Valero; Richard L. Theriault; Marguerite F. Rosales; Edgardo Rivera; Debbie Frye; Michael Ewer; Nelson G. Ordonez; Aman U. Buzdar; Gabriel N. Hortobagyi

Immunotherapy of Metastatic Renal Cell Carcinoma with Tumor Lysate-pulsed Autologous Dendritic Cells 1

Lorenz Höltl; Claudia Zelle-Rieser; Hubert Gander; Christine Papesh; Reinhold Ramoner; Georg Bartsch; Hermann Rogatsch; Adel L. Barsoum; Joseph H. Coggin, Jr.; Martin Thurnher

Dose-dependent Effect of Thalidomide on Overall Survival in Relapsed Multiple Myeloma

Kai Neben; Thomas Moehler; Axel Benner; Alwin Kraemer; Gerlinde Egerer; Anthony D. Ho; Hartmut Goldschmidt

Interleukin 12 Immunotherapy after Autologous Stem Cell Transplantation for Hematological Malignancies 1

Michael J. Robertson; David Pelloso; Rafat Abonour; Robert A. Hromas; Robert P. Nelson, Jr.; Lisa Wood; Kenneth Cornetta

Dendritic Cells Pulsed with HER-2/neu-derived Peptides Can Induce Specific T-Cell Responses in Patients with Gastric Cancer 1

Koji Kono; Akihiro Takahashi; Hidemitsu Sugai; Hideki Fujii; A. Raja Choudhury; Rolf Kiessling; Yoshiro Matsumoto

Reinfusion of Unprocessed, Granulocyte Colony-stimulating Factor-stimulated Whole Blood Allows Dose Escalation of ¹⁸⁶Relabeled Chimeric Monoclonal Antibody U36 Radioimmunotherapy in a Phase I Dose Escalation Study 1

David R. Colnot; Gert J. Ossenkoppele; Jan C. Roos; Jasper J. Quak; Remco de Bree; Pontus K. Börjesson; Peter C. Huijgens; Gordon B. Snow; Guus A. M. S. van Dongen

Toxicity, Immunogenicity, and Induction of E75-specific Tumor-lytic CTLs by HER-2 Peptide E75 (369–377) Combined with Granulocyte Macrophage Colony-stimulating Factor in HLA-A2+ Patients with Metastatic Breast and Ovarian Cancer 1

James L. Murray; Michael E. Gillogly; Donna Przepiorka; Hannah Brewer; Nuhad K. Ibrahim; Daniel J. Booser; Gabriel N. Hortobagyi; Andrzej P. Kudelka; Kenneth H. Grabstein; Martin A. Cheever; Constantin G. Ioannides

Cancer Biology, Immunology, Cytokines

Vasculogenesis Plays a Role in the Growth of Ewing’s Sarcoma in Vivo1

Marcela F. Bolontrade; Rong-Rong Zhou; Eugenie S. Kleinerman

Suppression of Tumorigenesis and Induction of p15^ink4b by Smad4/DPC4 in Human Pancreatic Cancer Cells 1

Bailu Peng; Jason B. Fleming; Tara Breslin; Ana M. Grau; Shuichi Fojioka; James L. Abbruzzese; Douglas B. Evans; Dan Ayers; Kyle Wathen; Tianai Wu; Kimberly D. Robertson; Paul J. Chiao

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Elevated Skp2 Protein Expression in Human Prostate Cancer: Association with Loss of the Cyclin-dependent Kinase Inhibitor p27 and PTEN and with Reduced Recurrence-free Survival 1

Guang Yang; Gustavo Ayala; Angelo De Marzo; Weihua Tian; Anna Frolov; Thomas M. Wheeler; Timothy C. Thompson; J. Wade Harper

Pattern of Hormone Receptor Status of Secondary Contralateral Breast Cancers in Patients Receiving Adjuvant Tamoxifen

Thomas Bachleitner-Hofmann; Barbara Pichler-Gebhard; Margarethe Rudas; Michael Gnant; Susanne Taucher; Daniela Kandioler; Elisabeth Janschek; Peter Dubsky; Sebastian Roka; Emanuel Sporn; Raimund Jakesz

Outcome in Prostate Cancer: Association with Endothelial Nitric Oxide Synthase Glu-Asp298 Polymorphism at Exon 7 1

Rui M. Medeiros; Antonio Morais; André Vasconcelos; Sandra Costa; Daniela Pinto; Jorge Oliveira; Paula Ferreira; Carlos Lopes

Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer 1

Giuseppe Di Lorenzo; Giampaolo Tortora; Francesco P. D’Armiento; Gaetano De Rosa; Stefania Staibano; Riccardo Autorino; Massimo D’Armiento; Michele De Laurentiis; Sabino De Placido; Giuseppe Catalano; A. Raffaele Bianco; Fortunato Ciardiello

p16 and p53 Protein Expression as Prognostic Indicators of Survival and Disease Recurrence from Head and Neck Cancer 1

Stacy A. Geisler; Andrew F. Olshan; Mark C. Weissler; Jainwen Cai; William K. Funkhouser; Joanna Smith; Katie Vick

Prognostic and Predictive Value of Epidermal Growth Factor Receptor in Recurrent Breast Cancer

Shinichi Tsutsui; Akemi Kataoka; Shinji Ohno; Shigeru Murakami; Junko Kinoshita; Yoichi Hachitanda

Alterations of the hSNF5/INI1 Gene in Central Nervous System Atypical Teratoid/Rhabdoid Tumors and Renal and Extrarenal Rhabdoid Tumors 1

Jaclyn A. Biegel; Lu Tan; Fan Zhang; Luanne Wainwright; Pierre Russo; Lucy B. Rorke

Screening of N-ras Codon 61 Mutations in Paired Primary and Metastatic Cutaneous Melanomas: Mutations Occur Early and Persist throughout Tumor Progression 1

Katarina Omholt; Sofia Karsberg; Anton Platz; Lena Kanter; Ulrik Ringborg; Johan Hansson

Prognostic Score of Gastric Cancer Determined by cDNA Microarray 1

Hiroshi Inoue; Ayumi Matsuyama; Koshi Mimori; Hiroaki Ueo; Masaki Mori

The Influence of Dendritic Cell Infiltration and Vascular Endothelial Growth Factor Expression on the Prognosis of Non-Small Cell Lung Cancer

Naoko Inoshima; Yoichi Nakanishi; Takahiro Minami; Miiru Izumi; Koichi Takayama; Ichiro Yoshino; Nobuyuki Hara

Reduced Nuclear Expression of Transcription Factor AP-2 Associates with Aggressive Breast Cancer 1

Johanna Pellikainen; Vesa Kataja; Kirsi Ropponen; Jari Kellokoski; Timo Pietiläinen; Jan Böhm; Matti Eskelinen; Veli-Matti Kosma

Experimental Therapeutics, Preclinical Pharmacology

Brain Tumors in Mice Are Susceptible to Blockade of Epidermal Growth Factor Receptor (EGFR) with the Oral, Specific, EGFR-Tyrosine Kinase Inhibitor ZD1839 (Iressa)1

Amy B. Heimberger; Chris A. Learn; Gary E. Archer; Roger E. McLendon; Tracy A. Chewning; Frank L. Tuck; John B. Pracyk; Allan H. Friedman; Henry S. Friedman; Darell D. Bigner; John H. Sampson

Interleukin 4 Receptor on Human Lung Cancer: A Molecular Target for Cytotoxin Therapy 1

Mariko Kawakami; Koji Kawakami; Vitaly A. Stepensky; Richard A. Maki; Howard Robin; Wayne Muller; Syed R. Husain; Raj K. Puri

Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicin-induced Growth Inhibition, G₂-M Arrest, and Apoptosis 1

Anil K. Tyagi; Rana P. Singh; Chapla Agarwal; Daniel C. F. Chan; Rajesh Agarwal

Antitumor Activity of SS(dsFv)PE38 and SS1(dsFv)PE38, Recombinant Antimesothelin Immunotoxins against Human Gynecologic Cancers Grown in Organotypic Culture in Vitro1

Raffit Hassan; Megan R. Lerner; Doris Benbrook; Stan A. Lightfoot; Daniel J. Brackett; Qing-Cheng Wang; Ira Pastan

The Cyclin-dependent Kinase Inhibitor Flavopiridol Induces Apoptosis in Multiple Myeloma Cells through Transcriptional Repression and Down-Regulation of Mcl-1 1

Ivana Gojo; Bin Zhang; Robert G. Fenton

Suppression of Malignant Glioma Recurrence in a Newly Developed Animal Model by Endogenous Inhibitors 1

Lorenzo Bello; Carlo Giussani; Giorgio Carrabba; Mauro Pluderi; Valeria Lucini; Marilou Pannacci; Dario Caronzolo; Giustino Tomei; Roberto Villani; Francesco Scaglione; Rona S. Carroll; Andreas Bikfalvi

Antitumor Activity of UCN-01 in Carcinomas of the Head and Neck Is Associated with Altered Expression of Cyclin D3 and p27^KIP1

Vyomesh Patel; Tyler Lahusen; Chidchanok Leethanakul; Tadashi Igishi; Marcus Kremer; Leticia Quintanilla-Martinez; John F. Ensley; Edward A. Sausville; J. Silvio Gutkind; Adrian M. Senderowicz

Adenovirus Vector-mediated Overexpression of a Truncated Form of the p65 Nuclear Factor κB cDNA in Dendritic Cells Enhances Their Function Resulting in Immune-mediated Suppression of Preexisting Murine Tumors 1

Jay M. Lee; Ali Mahtabifard; Reiko Yamada; Ronald G. Crystal; Robert J. Korst

Enhanced Antiangiogenic Therapy of Squamous Cell Carcinoma by Combined Endostatin and Epidermal Growth Factor Receptor-Antisense Therapy 1

Mengfeng Li; Caisheng Ye; Chong Feng; Frank Riedel; Xiaoning Liu; Qing Zeng; Jennifer Rubin Grandis

Zinc Inhibits Nuclear Factor-κB Activation and Sensitizes Prostate Cancer Cells to Cytotoxic Agents

Robert G. Uzzo; Paul Leavis; William Hatch; Vladimir L. Gabai; Nickolai Dulin; Nadezhda Zvartau; Vladimir M. Kolenko

Inhibition of Platelet-derived Growth Factor-mediated Proliferation of Osteosarcoma Cells by the Novel Tyrosine Kinase Inhibitor STI571 1

Eric C. McGary; Kristy Weber; Lisa Mills; Michelle Doucet; Valerie Lewis; Dina Chelouche Lev; Isaiah J. Fidler; Menashe Bar-Eli

Blockade of the Epidermal Growth Factor Receptor Signaling Inhibits Angiogenesis Leading to Regression of Human Renal Cell Carcinoma Growing Orthotopically in Nude Mice 1

Daniel Kedar; Cheryl H. Baker; Jerald J. Killion; Colin P. N. Dinney; Isaiah J. Fidler

Dietary Modulation of Pregnancy Estrogen Levels and Breast Cancer Risk among Female Rat Offspring 1

Leena Hilakivi-Clarke; Elisabeth Cho; Ana Cabanes; Sonia DeAssis; Susan Olivo; William Helferich; Marc E. Lippman; Robert Clarke

Pharmacokinetics, Toxicity, and Efficacy of Ends-modified raf Antisense Oligodeoxyribonucleotide Encapsulated in a Novel Cationic Liposome 1

Prafulla C. Gokhale; Chuanbo Zhang; Joseph T. Newsome; Jin Pei; Imran Ahmad; Aquilur Rahman; Anatoly Dritschilo; Usha N. Kasid

Correction

Correction for vol. 8, p. 2812

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