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Issues

Volume 8, Issue 10
1 October 2002
Issue Cover
All Issues
ISSN 1078-0432
EISSN 1557-3265

The Biology Behind

Nuclear Matrix Proteins as Proteomic Markers of Preneoplastic and Cancer Lesions : Commentary re: G. Brunagel et al., Nuclear Matrix Protein Alterations Associated with Colon Cancer Metastasis to the Liver. Clin. Cancer Res., 8: 3039–3045, 2002.
Donald S. Coffey
View articletitled, Nuclear Matrix Proteins as Proteomic Markers of Preneoplastic and Cancer Lesions <span class="subtitle-colon">: </span><span class="subtitle">Commentary re: G. Brunagel <strong><em>et al.</em></strong>, Nuclear Matrix Protein Alterations Associated with Colon Cancer Metastasis to the Liver. Clin. Cancer Res., <strong><em>8:</em></strong> 3039–3045, 2002.</span>
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Report from the FDA

Approval Summary: Imatinib Mesylate in the Treatment of Metastatic and/or Unresectable Malignant Gastrointestinal Stromal Tumors1
Ramzi Dagher; Martin Cohen; Gene Williams; Mark Rothmann; Jogarao Gobburu; Gabriel Robbie; Atiqur Rahman; Gang Chen; Ann Staten; Donna Griebel; Richard Pazdur
View articletitled, Approval Summary<span class="subtitle-colon">: </span><span class="subtitle">Imatinib Mesylate in the Treatment of Metastatic and/or Unresectable Malignant Gastrointestinal Stromal Tumors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>
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Advances in Brief

Molecular Oncology, Markers, Clinical Correlates
Nuclear Matrix Protein Alterations Associated with Colon Cancer Metastasis to the Liver1
Gisela Brünagel; Robert E. Schoen; Anthony J. Bauer; Barbara N. Vietmeier; Robert H. Getzenberg
View articletitled, Nuclear Matrix Protein Alterations Associated with Colon Cancer Metastasis to the Liver<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Expression of Eukaryotic Initiation Factor 4E in Atypical Adenomatous Hyperplasia and Adenocarcinoma of the Human Peripheral Lung1
Nobuhiko Seki; Tasaburo Takasu; Koichi Mandai; Masao Nakata; Hideyuki Saeki; Yuji Heike; Ichiro Takata; Yoshihiko Segawa; Toshiaki Hanafusa; Kenji Eguchi
View articletitled, Expression of Eukaryotic Initiation Factor 4E in Atypical Adenomatous Hyperplasia and Adenocarcinoma of the Human Peripheral Lung<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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ERBB Receptor Signaling Promotes Ependymoma Cell Proliferation and Represents a Potential Novel Therapeutic Target for This Disease1
Richard J. Gilbertson; Lyndsay Bentley; Roberto Hernan; Teemu T. Junttila; Adrian J. Frank; Hannu Haapasalo; Michele Connelly; Cynthia Wetmore; Tom Curran; Klaus Elenius; David W. Ellison
View articletitled, ERBB Receptor Signaling Promotes Ependymoma Cell Proliferation and Represents a Potential Novel Therapeutic Target for This Disease<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Prognostic Significance of Signal Transducer and Activator of Transcription 1 Activation in Breast Cancer1
Andreas Widschwendter; Sibylle Tonko-Geymayer; Thomas Welte; Günter Daxenbichler; Christian Marth; Wolfgang Doppler
View articletitled, Prognostic Significance of Signal Transducer and Activator of Transcription 1 Activation in Breast Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Regular Articles

Clinical Trials
A Phase II Pilot Trial of Concurrent Biochemotherapy with Cisplatin, Vinblastine, Temozolomide, Interleukin 2, and IFN-α2B in Patients with Metastatic Melanoma1
Michael B. Atkins; Jared A. Gollob; Jeffrey A. Sosman; David F. McDermott; Linda Tutin; Patricia Sorokin; Robert A. Parker; James W. Mier
View articletitled, A Phase II Pilot Trial of Concurrent Biochemotherapy with Cisplatin, Vinblastine, Temozolomide, Interleukin 2, and IFN-α2B in Patients with Metastatic Melanoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Phase I Trial of an Infrared Pulsed Laser Device in Patients with Advanced Neoplasias1
Luis A. Santana-Blank; Elizabeth Rodríguez-Santana; Fernando Vargas; Heberto Reyes; Pablo Fernández-Andrade; Saide Rukos; Karin E. Santana-Rodríguez
View articletitled, Phase I Trial of an Infrared Pulsed Laser Device in Patients with Advanced Neoplasias<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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A Phase I Trial of the Single-Chain Immunotoxin SGN-10 (BR96 sFv-PE40) in Patients with Advanced Solid Tumors1
James A. Posey; Mohammad B. Khazaeli; Michael A. Bookman; Anahit Nowrouzi; William E. Grizzle; Jennifer Thornton; Delicia E. Carey; Jennifer M. Lorenz; Amy P. Sing; Clay B. Siegall; Albert F. LoBuglio; Mansoor N. Saleh
View articletitled, A Phase I Trial of the Single-Chain Immunotoxin SGN-10 (BR96 sFv-PE40) in Patients with Advanced Solid Tumors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Phase I and Pharmacokinetic Trial of the Proapoptotic Sulindac Analog CP-461 in Patients with Advanced Cancer1
Weijing Sun; James P. Stevenson; James M. Gallo; Maryann Redlinger; Daniel Haller; Kenneth Algazy; Bruce Giantonio; Hector Alila; Peter J. O’Dwyer
View articletitled, Phase I and Pharmacokinetic Trial of the Proapoptotic Sulindac Analog CP-461 in Patients with Advanced Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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A Phase II Breast Cancer Chemoprevention Trial of Oral α-Difluoromethylornithine: Breast Tissue, Imaging, and Serum and Urine Biomarkers1
Carol J. Fabian; Bruce F. Kimler; Deborah A. Brady; Matthew S. Mayo; C. H. Joseph Chang; John A. Ferraro; Carola M. Zalles; Annette L. Stanton; Shahla Masood; William E. Grizzle; Norman F. Boyd; Dora W. Arneson; Karen A. Johnson
View articletitled, A Phase II Breast Cancer Chemoprevention Trial of Oral α-Difluoromethylornithine<span class="subtitle-colon">: </span><span class="subtitle">Breast Tissue, Imaging, and Serum and Urine Biomarkers<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>
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Research Articles

Molecular Oncology, Markers, Clinical Correlates
Identification of Gene Expression Profiles That Segregate Patients with Childhood Leukemia1
Philip J. Moos; Elizabeth A. Raetz; Marlee A. Carlson; Aniko Szabo; Fiona E. Smith; Cheryl Willman; Qi Wei; Stephen P. Hunger; William L. Carroll
View articletitled, Identification of Gene Expression Profiles That Segregate Patients with Childhood Leukemia<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Inducible Nitric Oxide Synthase and Survivin Messenger RNA Expression in Hepatocellular Carcinoma
Masahide Ikeguchi; Tsuyoshi Ueta; Yoshiaki Yamane; Yasuaki Hirooka; Nobuaki Kaibara
View articletitled, Inducible Nitric Oxide Synthase and Survivin Messenger RNA Expression in Hepatocellular Carcinoma
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Signaling Abnormalities, Apoptosis, and Reduced Proliferation of Circulating and Tumor-infiltrating Lymphocytes in Patients with Oral Carcinoma1
Torsten E. Reichert; Laura Strauss; Eva M. Wagner; William Gooding; Theresa L. Whiteside
View articletitled, Signaling Abnormalities, Apoptosis, and Reduced Proliferation of Circulating and Tumor-infiltrating Lymphocytes in Patients with Oral Carcinoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Tissue Content of Hydroxyestrogens in Relation to Survival of Breast Cancer Patients1
Luigi A. M. Castagnetta; Orazia M. Granata; Adele Traina; Barbara Ravazzolo; Maria Amoroso; Monica Miele; Vincenzo Bellavia; Biagio Agostara; Giuseppe Carruba
View articletitled, Tissue Content of Hydroxyestrogens in Relation to Survival of Breast Cancer Patients<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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K-ras Mutation, p53 Overexpression, and Microsatellite Instability in Biliary Tract Cancers: A Population-based Study in China
Asif Rashid; Takashi Ueki; Yu-Tang Gao; Patrick Scott Houlihan; Charita Wallace; Bing-Sheng Wang; Ming-Chang Shen; Jie Deng; Ann W. Hsing
View articletitled, K-<strong><em>ras</em></strong> Mutation, p53 Overexpression, and Microsatellite Instability in Biliary Tract Cancers<span class="subtitle-colon">: </span><span class="subtitle">A Population-based Study in China</span>
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Aberrant Methylation of Multiple Genes and Clinicopathological Features in Oral Squamous Cell Carcinoma1
Kazuhiro Ogi; Minoru Toyota; Mutsumi Ohe-Toyota; Nobuyuki Tanaka; Makoto Noguchi; Tomoko Sonoda; Geniku Kohama; Takashi Tokino
View articletitled, Aberrant Methylation of Multiple Genes and Clinicopathological Features in Oral Squamous Cell Carcinoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Coexpression of Parathyroid Hormone Related Protein and Its Receptor in Early Breast Cancer Predicts Poor Patient Survival1
Richard Linforth; Neil Anderson; Richard Hoey; Tania Nolan; Sarah Downey; Gerard Brady; Linda Ashcroft; Nigel Bundred
View articletitled, Coexpression of Parathyroid Hormone Related Protein and Its Receptor in Early Breast Cancer Predicts Poor Patient Survival<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Investigation in Liver Tissues and Cell Lines of the Transcription of 13 Genes Mapping to the 16q24 Region That Are Frequently Deleted in Hepatocellular Carcinoma
Philippe Riou; Raphaël Saffroy; Jérome Comoy; Marine Gross-Goupil; Jean-Paul Thiéry; Jean-François Emile; Daniel Azoulay; Dominique Piatier-Tonneau; Antoinette Lemoine; Brigitte Debuire
View articletitled, Investigation in Liver Tissues and Cell Lines of the Transcription of 13 Genes Mapping to the 16q24 Region That Are Frequently Deleted in Hepatocellular Carcinoma
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Human Papillomavirus Type 16 and Squamous Cell Carcinoma of the Head and Neck1
Elin Ringström; Edward Peters; Masayuki Hasegawa; Marshall Posner; Mei Liu; Karl T. Kelsey
View articletitled, Human Papillomavirus Type 16 and Squamous Cell Carcinoma of the Head and Neck<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Preoperative Serum Vascular Endothelial Growth Factor Levels: Significance in Ovarian Cancer1
Brian C. Cooper; Justine M. Ritchie; Carrie L. W. Broghammer; Jeremy Coffin; Joel I. Sorosky; Richard E. Buller; Mary J. C. Hendrix; Anil K. Sood
View articletitled, Preoperative Serum Vascular Endothelial Growth Factor Levels<span class="subtitle-colon">: </span><span class="subtitle">Significance in Ovarian Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>
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Clonotypic Myeloma Cells Able to Xenograft Myeloma to Nonobese Diabetic Severe Combined Immunodeficient Mice Copurify with CD34+ Hematopoietic Progenitors1
Linda M. Pilarski; Andrew R. Belch
View articletitled, Clonotypic Myeloma Cells Able to Xenograft Myeloma to Nonobese Diabetic Severe Combined Immunodeficient Mice Copurify with CD34<sup>+</sup> Hematopoietic Progenitors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Overexpression of the Peripheral Benzodiazepine Receptor Is a Relevant Prognostic Factor in Stage III Colorectal Cancer1
Kerstin Maaser; Patricia Grabowski; Andreas P. Sutter; Michael Höpfner; Hans-Dieter Foss; Harald Stein; Gerd Berger; Moshe Gavish; Martin Zeitz; Hans Scherübl
View articletitled, Overexpression of the Peripheral Benzodiazepine Receptor Is a Relevant Prognostic Factor in Stage III Colorectal Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Experimental Therapeutics, Preclinical Pharmacology
Thioredoxin Reductase Plays a Critical Role in IFN Retinoid-mediated Tumor-Growth Control in Vivo1
Daniel J. Lindner; Xinrong Ma; Jiadi Hu; Sreenivasu Karra; Dhananjaya V. Kalvakolanu
View articletitled, Thioredoxin Reductase Plays a Critical Role in IFN Retinoid-mediated Tumor-Growth Control <strong><em>in Vivo</em></strong><sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Identification of an Antigenic Epitope for Helper T Lymphocytes from Carcinoembryonic Antigen1
Hiroya Kobayashi; Ryusuke Omiya; Marta Ruiz; Eduardo Huarte; Pablo Sarobe; Juan José Lasarte; Maite Herraiz; Bruno Sangro; Jesús Prieto; Francisco Borras-Cuesta; Esteban Celis
View articletitled, Identification of an Antigenic Epitope for Helper T Lymphocytes from Carcinoembryonic Antigen<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Antibody to Vascular Endothelial Growth Factor Slows Growth of an Androgen-independent Xenograft Model of Prostate Cancer1
William D. Fox; Brian Higgins; Krista M. Maiese; Marija Drobnjak; Carlos Cordon-Cardo; Howard I. Scher; David B. Agus
View articletitled, Antibody to Vascular Endothelial Growth Factor Slows Growth of an Androgen-independent Xenograft Model of Prostate Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Leukotriene B4 Receptor Antagonist LY293111 Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells1
Wei-Gang Tong; Xian-Zhong Ding; Rene Hennig; Richard C. Witt; Jens Standop; Parviz M. Pour; Thomas E. Adrian
View articletitled, Leukotriene B4 Receptor Antagonist LY293111 Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Tumor Suppression through Angiogenesis Inhibition by SUIT-2 Pancreatic Cancer Cells Genetically Engineered to Secrete NK41
Michiyo Saimura; Eishi Nagai; Kazuhiro Mizumoto; Naoki Maehara; Yohji A. Minamishima; Mitsuo Katano; Kunio Matsumoto; Toshikazu Nakamura; Masao Tanaka
View articletitled, Tumor Suppression through Angiogenesis Inhibition by SUIT-2 Pancreatic Cancer Cells Genetically Engineered to Secrete NK4<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Enhancement of Antitumor Activity of Ionizing Radiation by Combined Treatment with the Selective Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor ZD1839 (Iressa)1
Cataldo Bianco; Giampaolo Tortora; Roberto Bianco; Roberta Caputo; Bianca Maria Veneziani; Rosa Caputo; Vincenzo Damiano; Teresa Troiani; Gabriella Fontanini; David Raben; Stefano Pepe; A. Raffaele Bianco; Fortunato Ciardiello
View articletitled, Enhancement of Antitumor Activity of Ionizing Radiation by Combined Treatment with the Selective Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor ZD1839 (Iressa)<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Blockade of Insulin-like Growth Factor I Receptor Function Inhibits Growth and Angiogenesis of Colon Cancer1
Niels Reinmuth; Wenbiao Liu; Fan Fan; Young D. Jung; Syed A. Ahmad; Oliver Stoeltzing; Corazon D. Bucana; Robert Radinsky; Lee M. Ellis
View articletitled, Blockade of Insulin-like Growth Factor I Receptor Function Inhibits Growth and Angiogenesis of Colon Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Prevention and Treatment of Experimental Breast Cancer with the Combination of a New Selective Estrogen Receptor Modulator, Arzoxifene, and a New Rexinoid, LG 1002681
Nanjoo Suh; William W. Lamph; Andrew L. Glasebrook; Timothy A. Grese; Alan D. Palkowitz; Charlotte R. Williams; Renee Risingsong; M. Rendi Farris; Richard A. Heyman; Michael B. Sporn
View articletitled, Prevention and Treatment of Experimental Breast Cancer with the Combination of a New Selective Estrogen Receptor Modulator, Arzoxifene, and a New Rexinoid, LG 100268<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Enhanced Radiation Sensitivity in Prostate Cancer by Inhibition of the Cell Survival Protein Clusterin1
Tobias Zellweger; Kim Chi; Hideaki Miyake; Hans Adomat; Satoshi Kiyama; Kirsten Skov; Martin E. Gleave
View articletitled, Enhanced Radiation Sensitivity in Prostate Cancer by Inhibition of the Cell Survival Protein Clusterin<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Antihuman Epidermal Growth Factor Receptor 2 Antibody Herceptin Inhibits Autocrine Motility Factor (AMF) Expression and Potentiates Antitumor Effects of AMF Inhibitors1
Amjad H. Talukder; Rozita Bagheri-Yarmand; Ruth R. E. Williams; Jiannis Ragoussis; Rakesh Kumar; Avraham Raz
View articletitled, Antihuman Epidermal Growth Factor Receptor 2 Antibody Herceptin Inhibits Autocrine Motility Factor (AMF) Expression and Potentiates Antitumor Effects of AMF Inhibitors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Proapoptotic and Antitumor Activities of Adenovirus-mediated p202 Gene Transfer1
Yi Ding; Yong Wen; Bill Spohn; Li Wang; Weiya Xia; Ka Yin Kwong; Ruping Shao; Zheng Li; Gabriel N. Hortobagyi; Mien-Chie Hung; Duen-Hwa Yan
View articletitled, Proapoptotic and Antitumor Activities of Adenovirus-mediated p202 Gene Transfer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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Ad-IFNγ Induces Antiproliferative and Antitumoral Responses in Malignant Mesothelioma1
Florence Gattacceca; Yannick Pilatte; Christian Billard; Isabelle Monnet; Sylviane Moritz; Jérôme Le Carrou; Marc Eloit; Marie-Claude Jaurand
View articletitled, Ad-IFNγ Induces Antiproliferative and Antitumoral Responses in Malignant Mesothelioma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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