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The Biology Behind

The Prognostic and Predictive Values of ECD-HER-2 1

William N. Hait

View articletitled, The Prognostic and Predictive Values of ECD-HER-2<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Editorials

Is Circulating HER-2 More Than Just a Tumor Marker?

Jose Baselga

Extract

View articletitled, Is Circulating HER-2 More Than Just a Tumor Marker?

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Prostaglandin E Synthase: Another Enzyme in the Cyclooxygenase Pathway Driving Epithelial Cancer?

Jonathan M. Kurie; Raymond N. Dubois

Extract

View articletitled, Prostaglandin E Synthase: Another Enzyme in the Cyclooxygenase Pathway Driving Epithelial Cancer?

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Minireview

Practical Guidelines for the Management of Biochemotherapy-related Toxicity in Melanoma

Antonio C. Buzaid; Michael Atkins

Abstract

View articletitled, Practical Guidelines for the Management of Biochemotherapy-related Toxicity in Melanoma

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Review

Advances in Aromatase Inhibition: Clinical Efficacy and Tolerability in the Treatment of Breast Cancer

Aman Buzdar; Anthony Howell

Extract

View articletitled, Advances in Aromatase Inhibition: Clinical Efficacy and Tolerability in the Treatment of Breast Cancer

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Advances in Brief

PTEN Mutation Located Only Outside Exons 5, 6, and 7 Is an Independent Predictor of Favorable Survival in Endometrial Carcinomas

Takeo Minaguchi; Hiroyuki Yoshikawa; Katsutoshi Oda; Tomomi Ishino; Toshiharu Yasugi; Takashi Onda; Shunsuke Nakagawa; Koji Matsumoto; Kei Kawana; Yuji Taketani

Abstract

View articletitled, PTEN Mutation Located Only Outside Exons 5, 6, and 7 Is an Independent Predictor of Favorable Survival in Endometrial Carcinomas

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HER-2/neu (p185neu) Protein Expression in the Natural or Treated History of Prostate Cancer 1

Iman Osman; Howard I. Scher; Marija Drobnjak; David Verbel; Michael Morris; David Agus; Jeffrey S. Ross; Carlos Cordon-Cardo

Abstract

View articletitled, HER-2/neu (p185neu) Protein Expression in the Natural or Treated History of Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Comprehensive Allelotyping of Human Intrahepatic Cholangiocarcinoma 1

Hirohito Momoi; Hiroshi Okabe; Tatsuhiko Kamikawa; Seiji Satoh; Iwao Ikai; Masayuki Yamamoto; Akira Nakagawara; Yasuyuki Shimahara; Yoshio Yamaoka; Manabu Fukumoto

Abstract

View articletitled, Comprehensive Allelotyping of Human Intrahepatic Cholangiocarcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regular Articles

Clinical Trials

Tamoxifen Modulates the Expression of Ki67, Apoptosis, and Microvessel Density in Cervical Cancer

Gabriella Ferrandina; Franco O. Ranelletti; Luigi M. Larocca; Nicola Maggiano; Erika Fruscella; Francesco Legge; Giuseppe Santeusanio; Alessandro Bombonati; Salvatore Mancuso; Giovanni Scambia

Abstract

View articletitled, Tamoxifen Modulates the Expression of Ki67, Apoptosis, and Microvessel Density in Cervical Cancer

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Virus-directed, Enzyme Prodrug Therapy with Nitroimidazole Reductase: A Phase I and Pharmacokinetic Study of its Prodrug, CB1954 1

Guy Chung-Faye; Daniel Palmer; David Anderson; Joanna Clark; Mandy Downes; Joanna Baddeley; Syed Hussain; Philip I. Murray; Peter Searle; Leonard Seymour; Peter A. Harris; David Ferry; David J. Kerr

Abstract

View articletitled, Virus-directed, Enzyme Prodrug Therapy with Nitroimidazole Reductase: A Phase I and Pharmacokinetic Study of its Prodrug, CB1954<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

Soluble Type II Transforming Growth Factor-β (TGF-β) Receptor Inhibits TGF-β Signaling in COLO-357 Pancreatic Cancer Cells in Vitro and Attenuates Tumor Formation 1

Melissa A. Rowland-Goldsmith; Haruhisa Maruyama; Toshiyuki Kusama; Sonia Ralli; Murray Korc

Abstract

View articletitled, Soluble Type II Transforming Growth Factor-β (TGF-β) Receptor Inhibits TGF-β Signaling in COLO-357 Pancreatic Cancer Cells in Vitro and Attenuates Tumor Formation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prostate Cancer Cells (LNCaP) Generated after Long-Term Interleukin 6 (IL-6) Treatment Express IL-6 and Acquire an IL-6 Partially Resistant Phenotype 1

Alfred Hobisch; Reinhold Ramoner; Dietmar Fuchs; Sonia Godoy-Tundidor; Georg Bartsch; Helmut Klocker; Zoran Culig

Abstract

View articletitled, Prostate Cancer Cells (LNCaP) Generated after Long-Term Interleukin 6 (IL-6) Treatment Express IL-6 and Acquire an IL-6 Partially Resistant Phenotype<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Inducible Prostaglandin E Synthase Is Overexpressed in Non-Small Cell Lung Cancer 1

Kazuhiko Yoshimatsu; Nasser K. Altorki; Dragan Golijanin; Fan Zhang; Per-Johan Jakobsson; Andrew J. Dannenberg; Kotha Subbaramaiah

Abstract

View articletitled, Inducible Prostaglandin E Synthase Is Overexpressed in Non-Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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High Plasma Basic Fibroblast Growth Factor Concentration Is Associated with Response to Thalidomide in Progressive Multiple Myeloma

Kai Neben; Thomas Moehler; Gerlinde Egerer; Alwin Kraemer; Jens Hillengass; Axel Benner; Anthony D. Ho; Hartmut Goldschmidt

Abstract

View articletitled, High Plasma Basic Fibroblast Growth Factor Concentration Is Associated with Response to Thalidomide in Progressive Multiple Myeloma

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Fas Ligand Expression by Neoplastic T Lymphocytes Mediates Elimination of CD8+ Cytotoxic T Lymphocytes in Mycosis Fungoides: A Potential Mechanism of Tumor Immune Escape?1

Xiao Ni; Parul Hazarika; Chunlei Zhang; Rakhashandra Talpur; Madeleine Duvic

Abstract

View articletitled, Fas Ligand Expression by Neoplastic T Lymphocytes Mediates Elimination of CD8+ Cytotoxic T Lymphocytes in Mycosis Fungoides: A Potential Mechanism of Tumor Immune Escape?<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Interleukin 8 Is an Autocrine Growth Factor and a Surrogate Marker for Kaposi’s Sarcoma 1

Rizwan Masood; Jie Cai; Anil Tulpule; Tong Zheng; Ann Hamilton; Sanjai Sharma; Byron M. Espina; D. Lynne Smith; Parkash S. Gill

Abstract

View articletitled, Interleukin 8 Is an Autocrine Growth Factor and a Surrogate Marker for Kaposi’s Sarcoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Circulating HER-2/erbB-2/c-neu (HER-2) Extracellular Domain as a Prognostic Factor in Patients with Metastatic Breast Cancer: Cancer and Leukemia Group B Study 8662 1

Daniel F. Hayes; Hideko Yamauchi; Gloria Broadwater; Constance T. Cirrincione; Stephen P. Rodrigue; Donald A. Berry; Jerry Younger; Lawrence L. Panasci; Frederick Millard; David B. Duggan; Larry Norton; I. Craig Henderson

Abstract

View articletitled, Circulating HER-2/erbB-2/c-neu (HER-2) Extracellular Domain as a Prognostic Factor in Patients with Metastatic Breast Cancer: Cancer and Leukemia Group B Study 8662<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Minichromosome Maintenance Protein 2 Expression in Prostate: Characterization and Association with Outcome after Therapy for Cancer 1

Maxwell V. Meng; Gary D. Grossfeld; Gareth H. Williams; Stephen Dilworth; Kai Stoeber; Thaddeus W. Mulley; Vivian Weinberg; Peter R. Carroll; Thea D. Tlsty

Abstract

View articletitled, Minichromosome Maintenance Protein 2 Expression in Prostate: Characterization and Association with Outcome after Therapy for Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Vascular Endothelial Growth Factor and Cellular Chemotaxis: A Possible Autocrine Pathway in Adult T-Cell Leukemia Cell Invasion

Toshihisa Hayashibara; Yasuaki Yamada; Takayuki Miyanishi; Hiroyuki Mori; Tatsuroh Joh; Takahiro Maeda; Naoki Mori; Tetsuo Maita; Shimeru Kamihira; Masao Tomonaga

Abstract

View articletitled, Vascular Endothelial Growth Factor and Cellular Chemotaxis: A Possible Autocrine Pathway in Adult T-Cell Leukemia Cell Invasion

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Molecular Detection of Prostate Cancer in Urine by GSTP1 Hypermethylation 1

Paul Cairns; Manel Esteller; James G. Herman; Mark Schoenberg; Carmen Jeronimo; Montserrat Sanchez-Cespedes; Nan-Haw Chow; Marc Grasso; Li Wu; William B. Westra; David Sidransky

Abstract

View articletitled, Molecular Detection of Prostate Cancer in Urine by GSTP1 Hypermethylation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prostate Epithelium-derived Ets Transcription Factor mRNA Is Overexpressed in Human Breast Tumors and Is A Candidate Breast Tumor Marker and A Breast Tumor Antigen 1

Ali Ghadersohi; Ashwani K. Sood

Abstract

View articletitled, Prostate Epithelium-derived Ets Transcription Factor mRNA Is Overexpressed in Human Breast Tumors and Is A Candidate Breast Tumor Marker and A Breast Tumor Antigen<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Characteristics of Prostate Cancer in an Analysis of Linkage to Four Putative Susceptibility Loci 1

Ellen L. Goode; Janet L. Stanford; Mette A. Peters; Marta Janer; Mark Gibbs; Suzanne Kolb; Michael D. Badzioch; Leroy Hood; Elaine A. Ostrander; Gail P. Jarvik

Abstract

View articletitled, Clinical Characteristics of Prostate Cancer in an Analysis of Linkage to Four Putative Susceptibility Loci<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Accumulation of Angiostatin-like Fragments in Human Prostate Carcinoma 1

Toshiro Migita; Yoshinao Oda; Seiji Naito; Wataru Morikawa; Michihiko Kuwano; Masazumi Tsuneyoshi

Abstract

View articletitled, The Accumulation of Angiostatin-like Fragments in Human Prostate Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Impact of Proteolytic Factors (Urokinase-Type Plasminogen Activator, Plasminogen Activator Inhibitor 1, and Cathepsins B, D, and L) in Primary Breast Cancer Reflects Effects of Adjuvant Systemic Therapy 1

Nadia Harbeck; Uta Alt; Ursula Berger; Achim Krüger; Christoph Thomssen; Fritz Jänicke; Heinz Höfler; Ronald E. Kates; Manfred Schmitt

Abstract

View articletitled, Prognostic Impact of Proteolytic Factors (Urokinase-Type Plasminogen Activator, Plasminogen Activator Inhibitor 1, and Cathepsins B, D, and L) in Primary Breast Cancer Reflects Effects of Adjuvant Systemic Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Frequent Hypermethylation of the 5′ CpG Island of E-Cadherin in Esophageal Adenocarcinoma

Paul G. Corn; Elisabeth I. Heath; Richard Heitmiller; Franz Fogt; Arlene A. Forastiere; James G. Herman; Tsung-Teh Wu

Abstract

View articletitled, Frequent Hypermethylation of the 5′ CpG Island of E-Cadherin in Esophageal Adenocarcinoma

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Epidermal Growth Factor Receptor Expression and Activation in Nonseminomatous Germ Cell Tumors 1

Mauro Moroni; Silvio Veronese; Roberta Schiavo; Ornella Carminati; Boe S. Sorensen; Marcello Gambacorta; Salvatore Siena

Abstract

View articletitled, Epidermal Growth Factor Receptor Expression and Activation in Nonseminomatous Germ Cell Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Reduction of p12^DOC-1 Expression Is a Negative Prognostic Indicator in Patients with Surgically Resected Oral Squamous Cell Carcinoma 1

Satoru Shintani; Mariko Mihara; Nagaaki Terakado; Yuuji Nakahara; Tomohiro Matsumura; Yohko Kohno; Hiroe Ohyama; Jim McBride; Ralph Kent; Randy Todd; Takanori Tsuji; David T. W. Wong

Abstract

View articletitled, Reduction of p12DOC-1 Expression Is a Negative Prognostic Indicator in Patients with Surgically Resected Oral Squamous Cell Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Variations in 5-Fluorouracil Concentrations of Colorectal Tissues as Compared with Dihydropyrimidine Dehydrogenase (DPD) Enzyme Activities and DPD Messenger RNA Levels 1

Motoko Tanaka-Nozaki; Masahiko Onda; Noritake Tanaka; Shunji Kato

Abstract

View articletitled, Variations in 5-Fluorouracil Concentrations of Colorectal Tissues as Compared with Dihydropyrimidine Dehydrogenase (DPD) Enzyme Activities and DPD Messenger RNA Levels<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Early Growth Response Gene EGR-1 Behaves as a Suppressor Gene That Is Down-Regulated Independent of ARF/Mdm2 but not p53 Alterations in Fresh Human Gliomas 1

Antonella Calogero; Antonietta Arcella; Giorgia De Gregorio; Antonio Porcellini; Dan Mercola; Chaoting Liu; Vincenza Lombari; Massimo Zani; Giuseppe Giannini; Franco Maria Gagliardi; Riccardo Caruso; Alberto Gulino; Luigi Frati; Giuseppe Ragona

Abstract

View articletitled, The Early Growth Response Gene EGR-1 Behaves as a Suppressor Gene That Is Down-Regulated Independent of ARF/Mdm2 but not p53 Alterations in Fresh Human Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Genetic Alterations in TP53 in Recurrent Urothelial Cancer: A Longitudinal Study

Guido Dalbagni; Zhi-Ping Ren; Harry Herr; Carlos Cordon-Cardo; Victor Reuter

Abstract

View articletitled, Genetic Alterations in TP53 in Recurrent Urothelial Cancer: A Longitudinal Study

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Isolation of Human Antibodies against the Central DNA Binding Domain of p53 from an Individual with Colorectal Cancer Using Antibody Phage Display

David W. J. Coomber; Robyn L. Ward

Abstract

View articletitled, Isolation of Human Antibodies against the Central DNA Binding Domain of p53 from an Individual with Colorectal Cancer Using Antibody Phage Display

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Image Analysis of Microvessel Surface Area Predicts Radiosensitivity in Early-Stage Laryngeal Carcinoma Treated with Radiotherapy 1

Tomoyuki Kamijo; Tomoyuki Yokose; Takahiro Hasebe; Hiroyuki Yonou; Ryuichi Hayashi; Satoshi Ebihara; Atsushi Ochiai

Abstract

View articletitled, Image Analysis of Microvessel Surface Area Predicts Radiosensitivity in Early-Stage Laryngeal Carcinoma Treated with Radiotherapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of HRad17 mRNA in Human Breast Cancer: Correlation with Lymph Node Metastasis

Akemi Kataoka; Noriaki Sadanaga; Koshi Mimori; Hiroaki Ueo; Graham F. Barnard; Keizo Sugimachi; Daniel Auclair; Lan Bo Chen; Masaki Mori

Abstract

View articletitled, Overexpression of HRad17 mRNA in Human Breast Cancer: Correlation with Lymph Node Metastasis

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Detection of Epithelial Messenger RNA in the Plasma of Breast Cancer Patients Is Associated with Poor Prognosis Tumor Characteristics 1

Jose M. Silva; Gemma Dominguez; Javier Silva; Jose M. Garcia; Antonio Sanchez; Oscar Rodriguez; Mariano Provencio; Pilar España; Felix Bonilla

Abstract

View articletitled, Detection of Epithelial Messenger RNA in the Plasma of Breast Cancer Patients Is Associated with Poor Prognosis Tumor Characteristics<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Thrombospondin-1 and -2 Messenger RNA Expression in Invasive Cervical Cancer: Correlation with Angiogenesis and Prognosis

Junichi Kodama; Ichiro Hashimoto; Noriko Seki; Atsushi Hongo; Mitsuo Yoshinouchi; Hiroyuki Okuda; Takafumi Kudo

Abstract

View articletitled, Thrombospondin-1 and -2 Messenger RNA Expression in Invasive Cervical Cancer: Correlation with Angiogenesis and Prognosis

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Prevalence of a Common Point Mutation in the Dihydropyrimidine Dehydrogenase (DPD) Gene within the 5′-Splice Donor Site of Intron 14 in Patients with Severe 5-Fluorouracil (5-FU)- related Toxicity Compared with Controls 1

Martin Raida; Wolfgang Schwabe; Peter Häusler; André B. P. Van Kuilenburg; Albert H. Van Gennip; Detlev Behnke; Klaus Höffken

Abstract

View articletitled, Prevalence of a Common Point Mutation in the Dihydropyrimidine Dehydrogenase (DPD) Gene within the 5′-Splice Donor Site of Intron 14 in Patients with Severe 5-Fluorouracil (5-FU)- related Toxicity Compared with Controls<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Treatment with Low-Dose Interferon-α Restores the Balance between Matrix Metalloproteinase-9 and E-Cadherin Expression in Human Transitional Cell Carcinoma of the Bladder 1

Joel W. Slaton; Takashi Karashima; Paul Perrotte; Keiji Inoue; Sun J. Kim; Jonathan Izawa; Daniel Kedar; David J. McConkey; Randall Millikan; Paul Sweeney; Chiaki Yoshikawa; Taro Shuin; Colin P. N. Dinney

Abstract

View articletitled, Treatment with Low-Dose Interferon-α Restores the Balance between Matrix Metalloproteinase-9 and E-Cadherin Expression in Human Transitional Cell Carcinoma of the Bladder<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Targeting of Cytotoxic Somatostatin Analog AN-238 to Somatostatin Receptor Subtypes 5 and/or 3 in Experimental Pancreatic Cancers 1

Karoly Szepeshazi; Andrew V. Schally; Gabor Halmos; Baodong Sun; Francine Hebert; Balazs Csernus; Attila Nagy

Abstract

View articletitled, Targeting of Cytotoxic Somatostatin Analog AN-238 to Somatostatin Receptor Subtypes 5 and/or 3 in Experimental Pancreatic Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Augmentation of Antitumor Activity of an Antibody-Interleukin 2 Immunocytokine with Chemotherapeutic Agents

Sylvia A. Holden; Yan Lan; Ana Maria Pardo; John S. Wesolowski; Stephen D. Gillies

Abstract

View articletitled, Augmentation of Antitumor Activity of an Antibody-Interleukin 2 Immunocytokine with Chemotherapeutic Agents

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Bone Marrow-derived Cells Contribute to Tumor Neovasculature and, When Modified to Express an Angiogenesis Inhibitor, Can Restrict Tumor Growth in Mice 1

Andrew M. Davidoff; Catherine Y. C. Ng; Peggy Brown; Margaret A. Leary; William W. Spurbeck; Junfang Zhou; Edwin Horwitz; Elio F. Vanin; Arthur W. Nienhuis

Abstract

View articletitled, Bone Marrow-derived Cells Contribute to Tumor Neovasculature and, When Modified to Express an Angiogenesis Inhibitor, Can Restrict Tumor Growth in Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effect of Progesterone on the Invasive Properties and Tumor Growth of Progesterone Receptor-transfected Breast Cancer Cells MDA-MB-231 1

Valerie C. L. Lin; Aw Swee Eng; Ng Eng Hen; Esther H. L. Ng; Sanaul H. Chowdhury

Abstract

View articletitled, Effect of Progesterone on the Invasive Properties and Tumor Growth of Progesterone Receptor-transfected Breast Cancer Cells MDA-MB-231<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Synergistic Inhibition of Human Lung Cancer Cell Growth by Adenovirus-mediated Wild-Type p53 Gene Transfer in Combination with Docetaxel and Radiation Therapeutics in Vitro and in Vivo1

Masahiko Nishizaki; Raymond E. Meyn; Lawrence B. Levy; Edward N. Atkinson; R. Allen White; Jack A. Roth; Lin Ji

Abstract

View articletitled, Synergistic Inhibition of Human Lung Cancer Cell Growth by Adenovirus-mediated Wild-Type p53 Gene Transfer in Combination with Docetaxel and Radiation Therapeutics in Vitro and in Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin 1

Caroline R. Weinstein-Oppenheimer; Carlos F. Henríquez-Roldán; Julianne M. Davis; Patrick M. Navolanic; Oussama A. Saleh; Linda S. Steelman; Richard A. Franklin; Penni J. Robinson; Martin McMahon; James A. McCubrey

Abstract

View articletitled, Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Sensitivity of Soft Tissue Sarcoma Cell Lines to Chemotherapeutic Agents: Identification of Ecteinascidin-743 as a Potent Cytotoxic Agent 1

Wei Wei Li; Naoto Takahashi; Suresh Jhanwar; Carlos Cordon-Cardo; Yaroslav Elisseyeff; Jose Jimeno; Glynn Faircloth; Joseph R. Bertino

Abstract

View articletitled, Sensitivity of Soft Tissue Sarcoma Cell Lines to Chemotherapeutic Agents: Identification of Ecteinascidin-743 as a Potent Cytotoxic Agent<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of β-Tubulin Isotypes in Human Ovarian Carcinoma Xenografts and in a Sub-Panel of Human Cancer Cell Lines from the NCI-Anticancer Drug Screen: Correlation with Sensitivity to Microtubule Active Agents 1

Maria Ines Nicoletti; Giorgio Valoti; Paraskevi Giannakakou; Zhirong Zhan; Jon-Hyeok Kim; Valeria Lucchini; Fabio Landoni; Joseph G. Mayo; Raffaella Giavazzi; Tito Fojo

Abstract

View articletitled, Expression of β-Tubulin Isotypes in Human Ovarian Carcinoma Xenografts and in a Sub-Panel of Human Cancer Cell Lines from the NCI-Anticancer Drug Screen: Correlation with Sensitivity to Microtubule Active Agents<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pharmacokinetic/Pharmacodynamic Study of ZD9331, a Nonpolyglutamatable Inhibitor of Thymidylate Synthase, in a Murine Model Following Two Curative Administration Schedules 1

G. Wynne Aherne; Anthea Hardcastle; Emma Ward; Donna Dobinson; Thomas Crompton; Melanie Valenti; Lisa Brunton; Ann L. Jackman

Abstract

View articletitled, Pharmacokinetic/Pharmacodynamic Study of ZD9331, a Nonpolyglutamatable Inhibitor of Thymidylate Synthase, in a Murine Model Following Two Curative Administration Schedules<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Issues

The Biology Behind

Editorials

Minireview

Review

Advances in Brief

Regular Articles

Clinical Trials

Cancer Biology, Immunology, Cytokines

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

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