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The Biology Behind

Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters : Commentary re: P. Münster et al., Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner. Clin. Cancer Res., 7: 2228–2236, 2001.

View articletitled, Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters : Commentary re: P. Münster et al., Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner. Clin. Cancer Res., 7: 2228–2236, 2001.

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Minireviews

Current Clinical and Laboratory Strategies to Augment the Efficacy of Immunotherapy in Multiple Myeloma 1

Marcus Gorschlüter; Carsten Ziske; Axel Glasmacher; Ingo G. H. Schmidt-Wolf

Abstract

View articletitled, Current Clinical and Laboratory Strategies to Augment the Efficacy of Immunotherapy in Multiple Myeloma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Advances in Brief

Influence of Cellular Factors and Pharmacokinetics on the Formation of Platinum-DNA Adducts in Leukocytes of Children Receiving Cisplatin Therapy 1

Gareth J. Veal; Cinara Dias; Lisa Price; Annie Parry; Julie Errington; Juliet Hale; Andrew D. J. Pearson; Alan V. Boddy; David R. Newell; Michael J. Tilby

Abstract

View articletitled, Influence of Cellular Factors and Pharmacokinetics on the Formation of Platinum-DNA Adducts in Leukocytes of Children Receiving Cisplatin Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Identification of Differentially Expressed Genes in Esophageal Squamous Cell Carcinoma (ESCC) by cDNA Expression Array: Overexpression of Fra-1, Neogenin, Id-1, and CDC25B Genes in ESCC 1

Ying Chuan Hu; King Yin Lam; Simon Law; John Wong; Gopesh Srivastava

Abstract

View articletitled, Identification of Differentially Expressed Genes in Esophageal Squamous Cell Carcinoma (ESCC) by cDNA Expression Array: Overexpression of Fra-1, Neogenin, Id-1, and CDC25B Genes in ESCC<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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p53 Mutation in Plasma DNA and Its Prognostic Value in Breast Cancer Patients 1

Zhi-Ming Shao; Jun Wu; Zhen-Zhou Shen; Mai Nguyen

Abstract

View articletitled, p53 Mutation in Plasma DNA and Its Prognostic Value in Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner 1: See The Biology Behind: E. A. Sausville, Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters. Clin. Cancer Res., 7: 2155–2158, 2001.

Pamela N. Münster; Andrea Basso; David Solit; Larry Norton; Neal Rosen

Abstract

View articletitled, Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>: See The Biology Behind: E. A. Sausville, Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters. Clin. Cancer Res., 7: 2155–2158, 2001.

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Pan-trk Inhibition Decreases Metastasis and Enhances Host Survival in Experimental Models as a Result of Its Selective Induction of Apoptosis of Prostate Cancer Cells 1

Ashani T. Weeraratna; Susan L. Dalrymple; John C. Lamb; Samuel R. Denmeade; Sheila Miknyoczki; Craig A. Dionne; John T. Isaacs

Abstract

View articletitled, Pan-trk Inhibition Decreases Metastasis and Enhances Host Survival in Experimental Models as a Result of Its Selective Induction of Apoptosis of Prostate Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regular Articles

Clinical Trials

Phase I Trial of Gemcitabine Combined with Radiation for the Treatment of Locally Advanced Pancreatic Adenocarcinoma 1

Robert A. Wolff; Douglas B. Evans; Diane M. Gravel; Renato Lenzi; Peter W. T. Pisters; Jeffrey E. Lee; Nora A. Janjan; Chusilp Charnsangavej; James L. Abbruzzese

Abstract

View articletitled, Phase I Trial of Gemcitabine Combined with Radiation for the Treatment of Locally Advanced Pancreatic Adenocarcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Dose-reduced Conditioning and Allogeneic Hematopoietic Stem Cell Transplantation from Unrelated Donors in 42 Patients

Martin Bornhäuser; Christian Thiede; Uwe Platzbecker; Andreas Jenke; Anett Helwig; Runa Plettig; Jens Freiberg-Richter; Christoph Röllig; Gabriele Geissler; Karin Lutterbeck; Uta Oelschlagel; Gerhard Ehninger

Abstract

View articletitled, Dose-reduced Conditioning and Allogeneic Hematopoietic Stem Cell Transplantation from Unrelated Donors in 42 Patients

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Classic Kaposi’s Sarcoma Associated with Human Herpesvirus 8 Infection in a 13-Year-Old Male: A Case Report

Heather J. Landau; Bernard J. Poiesz; Samalima Dube; Jeffrey A. Bogart; Leonard B. Weiner; Abdul-Kader Souid

Abstract

View articletitled, Classic Kaposi’s Sarcoma Associated with Human Herpesvirus 8 Infection in a 13-Year-Old Male: A Case Report

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Meningioma Treated with Interferon-α, Evaluated with [¹¹C]-l-Methionine Positron Emission Tomography 1

Carin Muhr; Olafur Gudjonsson; Anders Lilja; Magdalena Hartman; Zhi-Jia Zhang; Bengt Långström

Abstract

View articletitled, Meningioma Treated with Interferon-α, Evaluated with [11C]-l-Methionine Positron Emission Tomography<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Dendritic Cell Vaccination with MAGE Peptide Is A Novel Therapeutic Approach for Gastrointestinal Carcinomas 1

Noriaki Sadanaga; Hideki Nagashima; Kohjiro Mashino; Kouichirou Tahara; Hiroshi Yamaguchi; Mitsuhiko Ohta; Tatsuo Fujie; Fumiaki Tanaka; Hiroshi Inoue; Kazutou Takesako; Tsuyoshi Akiyoshi; Masaki Mori

Abstract

View articletitled, Dendritic Cell Vaccination with MAGE Peptide Is A Novel Therapeutic Approach for Gastrointestinal Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase II Study of Direct Intralesional Gene Transfer of Allovectin-7, an HLA-B7/β2-Microglobulin DNA-Liposome Complex, in Patients with Metastatic Melanoma 1

Alison T. Stopeck; Amanda Jones; Evan M. Hersh; John A. Thompson; Deborah M. Finucane; John C. Gutheil; Rene Gonzalez

Abstract

View articletitled, Phase II Study of Direct Intralesional Gene Transfer of Allovectin-7, an HLA-B7/β2-Microglobulin DNA-Liposome Complex, in Patients with Metastatic Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Dose Escalation and Bioavailability Study of Oral Sodium Phenylbutyrate in Patients with Refractory Solid Tumor Malignancies 1

Jill Gilbert; Sharyn D. Baker; M. Katherine Bowling; Louise Grochow; W. Douglas Figg; Yelena Zabelina; Ross C. Donehower; Michael A. Carducci

Abstract

View articletitled, A Phase I Dose Escalation and Bioavailability Study of Oral Sodium Phenylbutyrate in Patients with Refractory Solid Tumor Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pharmacodynamic Model of Topotecan-induced Time Course of Neutropenia 1

William C. Zamboni; David Z. D’Argenio; Clinton F. Stewart; Tom MacVittie; Brian J. Delauter; Ann M. Farese; Douglas M. Potter; Nacole M. Kubat; David Tubergen; Merrill J. Egorin

Abstract

View articletitled, Pharmacodynamic Model of Topotecan-induced Time Course of Neutropenia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Temozolomide: The Effect of Once- and Twice-a-Day Dosing on Tumor Tissue Levels of the DNA Repair Protein O⁶-Alkylguanine-DNA-Alkyltransferase 1

Timothy P. Spiro; Lili Liu; Susan Majka; John Haaga; James K. V. Willson; Stanton L. Gerson

Abstract

View articletitled, Temozolomide: The Effect of Once- and Twice-a-Day Dosing on Tumor Tissue Levels of the DNA Repair Protein O6-Alkylguanine-DNA-Alkyltransferase<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Differential Degradation Rates of Inactivated Alkyltransferase in Blood Mononuclear Cells and Tumors of Patients after Treatment with O⁶-Benzylguanine 1

Lili Liu; Timothy P. Spiro; Xiusheng Qin; Susan Majka; John Haaga; Jane Schupp; James K. V. Willson; Stanton L. Gerson

Abstract

View articletitled, Differential Degradation Rates of Inactivated Alkyltransferase in Blood Mononuclear Cells and Tumors of Patients after Treatment with O6-Benzylguanine<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cisplatin, Etoposide, and Paclitaxel with Granulocyte Colony-Stimulating Factor in Untreated Patients with Extensive-Stage Small Cell Lung Cancer: A Phase II Trial of the Southwest Oncology Group 1^,2

Karen Kelly; Laura Lovato; Paul A. Bunn, Jr.; Robert B. Livingston; Jeffrey Zangmeister; Sarah A. Taylor; Debasish Roychowdhury; John J. Crowley; David R. Gandara

Abstract

View articletitled, Cisplatin, Etoposide, and Paclitaxel with Granulocyte Colony-Stimulating Factor in Untreated Patients with Extensive-Stage Small Cell Lung Cancer: A Phase II Trial of the Southwest Oncology Group<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a><a href="javascript:;" reveal-id="FN2" data-open="FN2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">,2</a>

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Impact of the Putative Differentiating Agent Sodium Phenylbutyrate on Myelodysplastic Syndromes and Acute Myeloid Leukemia 1

Steven D. Gore; Li-Jun Weng; Suoping Zhai; William D. Figg; Ross C. Donehower; George J. Dover; Michael Grever; Constance A. Griffin; Louise B. Grochow; Eric K. Rowinsky; Yelena Zabalena; Anita L. Hawkins; Kathleen Burks; Carole B. Miller

Abstract

View articletitled, Impact of the Putative Differentiating Agent Sodium Phenylbutyrate on Myelodysplastic Syndromes and Acute Myeloid Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Research Articles

Molecular Oncology

Increased Incidence of Luteinizing Hormone-releasing Hormone Receptor Gene Messenger RNA Expression in Hormone-refractory Human Prostate Cancers

Bernd Straub; Markus Müller; Hans Krause; Mark Schrader; Carsten Goessl; Rüdiger Heicappell; Kurt Miller

Abstract

View articletitled, Increased Incidence of Luteinizing Hormone-releasing Hormone Receptor Gene Messenger RNA Expression in Hormone-refractory Human Prostate Cancers

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Matrix Metalloproteinase-1 Promoter Polymorphism 1G/2G Is Correlated with Colorectal Cancer Invasiveness

Giorgio Ghilardi; Maria Luisa Biondi; Jacopo Mangoni; Simona Leviti; Marco DeMonti; Emma Guagnellini; Roberto Scorza

Abstract

View articletitled, Matrix Metalloproteinase-1 Promoter Polymorphism 1G/2G Is Correlated with Colorectal Cancer Invasiveness

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Proliferation, Apoptosis, and Survival in High-Level Microsatellite Instability Sporadic Colorectal Cancer 1

Julie M. Michael-Robinson; Lynne E. Reid; David M. Purdie; A-E. Biemer-Hüttmann; Michael D. Walsh; Nirmala Pandeya; Lisa A. Simms; Joanne P. Young; Barbara A. Leggett; Jeremy R. Jass; Graham L. Radford-Smith

Abstract

View articletitled, Proliferation, Apoptosis, and Survival in High-Level Microsatellite Instability Sporadic Colorectal Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Re-Evaluation of Carcinoembryonic Antigen (CEA) as a Serum Marker for Breast Cancer: A Prospective Longitudinal Study 1

Fiorella Guadagni; Patrizia Ferroni; Sandro Carlini; Sabrina Mariotti; Antonella Spila; Simona Aloe; Roberta D’Alessandro; Maria Daniela Carone; Americo Cicchetti; Andrea Ricciotti; Irene Venturo; Pasquale Perri; Franco Di Filippo; Francesco Cognetti; Claudio Botti; Mario Roselli

Abstract

View articletitled, A Re-Evaluation of Carcinoembryonic Antigen (CEA) as a Serum Marker for Breast Cancer: A Prospective Longitudinal Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Human Kallikrein 4 (KLK4) Is Highly Expressed in Serous Ovarian Carcinomas 1

Ying Dong; Aneel Kaushal; Loan Bui; Simon Chu; Peter J. Fuller; Jim Nicklin; Hemamali Samaratunga; Judith A. Clements

Abstract

View articletitled, Human Kallikrein 4 (KLK4) Is Highly Expressed in Serous Ovarian Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Value of Human Kallikrein 10 Expression in Epithelial Ovarian Carcinoma

Liu-Ying Luo; Dionyssios Katsaros; Andreas Scorilas; Stefano Fracchioli; Roberta Piccinno; Irene A. Rigault de la Longrais; David J. C. Howarth; Eleftherios P. Diamandis

Abstract

View articletitled, Prognostic Value of Human Kallikrein 10 Expression in Epithelial Ovarian Carcinoma

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Higher Human Kallikrein Gene 4 (KLK4) Expression Indicates Poor Prognosis of Ovarian Cancer Patients

Christina V. Obiezu; Andreas Scorilas; Dionyssios Katsaros; Marco Massobrio; George M. Yousef; Stefano Fracchioli; Irene A. Rigault de la Longrais; Riccardo Arisio; Eleftherios P. Diamandis

Abstract

View articletitled, Higher Human Kallikrein Gene 4 (KLK4) Expression Indicates Poor Prognosis of Ovarian Cancer Patients

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Prognostic and Pathologic Significance of Quantitative Protein Expression Profiling in Human Gliomas 1

Arnab Chakravarti; Meaghan A. Delaney; Elizabeth Noll; Peter McL. Black; Jay S. Loeffler; Alona Muzikansky; Nicholas J. Dyson

Abstract

View articletitled, Prognostic and Pathologic Significance of Quantitative Protein Expression Profiling in Human Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increased Expression of Matrix Metalloproteinases (MMP)-2, MMP-9, and the Urokinase-Type Plasminogen Activator Is Associated with Progression from Benign to Advanced Ovarian Cancer 1

Barbara Schmalfeldt; Dieter Prechtel; Kathrin Härting; Kerstin Späthe; Stefan Rutke; Elisabeth Konik; Rafael Fridman; Ursula Berger; Manfred Schmitt; Walther Kuhn; Ernst Lengyel

Abstract

View articletitled, Increased Expression of Matrix Metalloproteinases (MMP)-2, MMP-9, and the Urokinase-Type Plasminogen Activator Is Associated with Progression from Benign to Advanced Ovarian Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of the Endostatin Gene in Epithelial Ovarian Cancer

Kohkichi Hata; Ritsuto Fujiwaki; Kentaro Nakayama; Kohji Miyazaki

Abstract

View articletitled, Expression of the Endostatin Gene in Epithelial Ovarian Cancer

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Genetic Changes in Paired Atypical and Usual Ductal Hyperplasia of the Breast by Comparative Genomic Hybridization 1

Gyungyub Gong; Sandy DeVries; Karen L. Chew; Imok Cha; Britt-Marie Ljung; Frederic M. Waldman

Abstract

View articletitled, Genetic Changes in Paired Atypical and Usual Ductal Hyperplasia of the Breast by Comparative Genomic Hybridization<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Gelsolin as a Negative Prognostic Factor and Effector of Motility in erbB-2-positive Epidermal Growth Factor Receptor-positive Breast Cancers 1

Ann D. Thor; Susan M. Edgerton; Shuqing Liu; Dan H. Moore, II; David J. Kwiatkowski

Abstract

View articletitled, Gelsolin as a Negative Prognostic Factor and Effector of Motility in erbB-2-positive Epidermal Growth Factor Receptor-positive Breast Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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MYC Messenger RNA Expression Predicts Survival Outcome in Childhood Primitive Neuroectodermal Tumor/Medulloblastoma 1

Michael A. Grotzer; Michael D. Hogarty; Anna J. Janss; Xueyuan Liu; Huaquing Zhao; Angelika Eggert; Leslie N. Sutton; Lucy B. Rorke; Garrett M. Brodeur; Peter C. Phillips

Abstract

View articletitled, MYC Messenger RNA Expression Predicts Survival Outcome in Childhood Primitive Neuroectodermal Tumor/Medulloblastoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Biological Behavior of Human Breast Cancer Micrometastases 1

Nancy Klauber-DeMore; Kimberly J. Van Zee; Irina Linkov; Patrick I. Borgen; William L. Gerald

Abstract

View articletitled, Biological Behavior of Human Breast Cancer Micrometastases<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Her-2/neu Overexpression in Muscle-invasive Urothelial Carcinoma of the Bladder: Prognostic Significance and Comparative Analysis in Primary and Metastatic Tumors 1

Rafael E. Jimenez; Maha Hussain; Fernando J. Bianco, Jr.; Ulka Vaishampayan; Pam Tabazcka; Wael A. Sakr; J. Edson Pontes; David P. Wood, Jr.; David J. Grignon

Abstract

View articletitled, Her-2/neu Overexpression in Muscle-invasive Urothelial Carcinoma of the Bladder: Prognostic Significance and Comparative Analysis in Primary and Metastatic Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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HER-2/neu and Urokinase-Type Plasminogen Activator and Its Inhibitor in Breast Cancer 1

Gottfried Konecny; Michael Untch; Jane Arboleda; Cindy Wilson; Stephen Kahlert; Berit Boettcher; Margrit Felber; Malgorzota Beryt; Sandra Lude; Hermann Hepp; Dennis Slamon; Mark Pegram

Abstract

View articletitled, HER-2/neu and Urokinase-Type Plasminogen Activator and Its Inhibitor in Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Significance of Cyclin B1 Protein Expression in Squamous Cell Carcinoma of the Tongue 1

Khaled A. Hassan; Adel K. El-Naggar; Jean-Charles Soria; Dian Liu; Waun K. Hong; Li Mao

Abstract

View articletitled, Clinical Significance of Cyclin B1 Protein Expression in Squamous Cell Carcinoma of the Tongue<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Fluorescence in Situ Hybridization Evaluation of c-erbB-2 Gene Amplification and Chromosomal Anomalies in Bladder Cancer 1

Jun-ichi Ohta; Yasuhide Miyoshi; Hiroji Uemura; Kiyoshi Fujinami; Kunihisa Mikata; Masahiko Hosaka; Yoko Tokita; Yoshinobu Kubota

Abstract

View articletitled, Fluorescence in Situ Hybridization Evaluation of c-erbB-2 Gene Amplification and Chromosomal Anomalies in Bladder Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of X-linked Inhibitor of Apoptosis as a Novel Prognostic Marker in Radically Resected Non-Small Cell Lung Cancer Patients 1

Carlos G. Ferreira; Paul van der Valk; Simone W. Span; Inge Ludwig; Egbert F. Smit; Frank A. E. Kruyt; Herbert M. Pinedo; Harm van Tinteren; Giuseppe Giaccone

Abstract

View articletitled, Expression of X-linked Inhibitor of Apoptosis as a Novel Prognostic Marker in Radically Resected Non-Small Cell Lung Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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AKT-1, -2, and -3 are Expressed in Both Normal and Tumor Tissues of the Lung, Breast, Prostate, and Colon

Michael J. Zinda; Mac A. Johnson; Jonathan D. Paul; Candice Horn; Bruce W. Konicek; Zhao Hai Lu; George Sandusky; James E. Thomas; Blake Lee Neubauer; Mei T. Lai; Jeremy R. Graff

Abstract

View articletitled, AKT-1, -2, and -3 are Expressed in Both Normal and Tumor Tissues of the Lung, Breast, Prostate, and Colon

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Death-associated Protein 3 (Dap-3) Is Overexpressed in Invasive Glioblastoma Cells in Vivo and in Glioma Cell Lines with Induced Motility Phenotype in Vitro1

Luigi Mariani; Christian Beaudry; Wendy S. McDonough; Dominique B. Hoelzinger; Elzbieta Kaczmarek; Francisco Ponce; Stephen W. Coons; Alf Giese; Rolf W. Seiler; Michael E. Berens

Abstract

View articletitled, Death-associated Protein 3 (Dap-3) Is Overexpressed in Invasive Glioblastoma Cells in Vivo and in Glioma Cell Lines with Induced Motility Phenotype in Vitro<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Synergistic Effects of the Fenretinide (4-HPR) and Anti-CD20 Monoclonal Antibodies on Apoptosis Induction of Malignant Human B Cells 1

Daming Shan; Ajay K. Gopal; Oliver W. Press

Abstract

View articletitled, Synergistic Effects of the Fenretinide (4-HPR) and Anti-CD20 Monoclonal Antibodies on Apoptosis Induction of Malignant Human B Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications 1

Enrique Casado; Jesus Gomez-Navarro; Masato Yamamoto; Yasuo Adachi; Candace J. Coolidge; Waleed O. Arafat; Shannon D. Barker; Minghui H. Wang; Parameshwar J. Mahasreshti; Akseli Hemminki; Manuel Gonzalez-Baron; Mack N. Barnes; Terri B. Pustilnik; Gene P. Siegal; Ronald D. Alvarez; David T. Curiel

Abstract

View articletitled, Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Analysis of Cross-Resistance of the Selective Estrogen Receptor Modulators Arzoxifene (LY353381) and LY117018 in Tamoxifen-stimulated Breast Cancer Xenografts 1

Jennifer MacGregor Schafer; Eun-Sook Lee; Rita C. Dardes; David Bentrem; Ruth M. O’Regan; Alexander De Los Reyes; V. Craig Jordan

Abstract

View articletitled, Analysis of Cross-Resistance of the Selective Estrogen Receptor Modulators Arzoxifene (LY353381) and LY117018 in Tamoxifen-stimulated Breast Cancer Xenografts<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Selective Activation of Apoptosis Program by S-p-bromobenzylglutathione Cyclopentyl Diester in Glyoxalase I-overexpressing Human Lung Cancer Cells 1

Hiroshi Sakamoto; Tetsuo Mashima; Shigeo Sato; Yuichi Hashimoto; Takao Yamori; Takashi Tsuruo

Abstract

View articletitled, Selective Activation of Apoptosis Program by S-p-bromobenzylglutathione Cyclopentyl Diester in Glyoxalase I-overexpressing Human Lung Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Stable Transfection of Urokinase-Type Plasminogen Activator Antisense Construct Modulates Invasion of Human Glioblastoma Cells 1

Sanjeeva Mohanam; Sushma L. Jasti; Sudha R. Kondraganti; Nirmala Chandrasekar; Yoshiaki Kin; Gregory N. Fuller; Sajani S. Lakka; Athanassios P. Kyritsis; Dzung H. Dinh; William C. Olivero; Meena Gujrati; W. K. A. Yung; Jasti S. Rao

Abstract

View articletitled, Stable Transfection of Urokinase-Type Plasminogen Activator Antisense Construct Modulates Invasion of Human Glioblastoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Flavopiridol Increases Sensitization to Gemcitabine in Human Gastrointestinal Cancer Cell Lines and Correlates with Down-Regulation of Ribonucleotide Reductase M2 Subunit 1

Christoph P. Jung; Monica V. Motwani; Gary K. Schwartz

Abstract

View articletitled, Flavopiridol Increases Sensitization to Gemcitabine in Human Gastrointestinal Cancer Cell Lines and Correlates with Down-Regulation of Ribonucleotide Reductase M2 Subunit<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis 1

Giampaolo Tortora; Rosa Caputo; Vincenzo Damiano; Roberto Bianco; Gabriella Fontanini; Sabina Cuccato; Sabino De Placido; A. Raffaele Bianco; Fortunato Ciardiello

Abstract

View articletitled, Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Inhibition of Insulin-like Growth Factor Signaling Pathways in Mammary Gland by Pure Antiestrogen ICI 182,780 1

T. W. Chan; M. Pollak; Hung Huynh

Abstract

View articletitled, Inhibition of Insulin-like Growth Factor Signaling Pathways in Mammary Gland by Pure Antiestrogen ICI 182,780<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Hammerhead Ribozyme Suppresses Expression of Hepatocyte Growth Factor/Scatter Factor Receptor c-MET and Reduces Migration and Invasiveness of Breast Cancer Cells 1

Wen G. Jiang; David Grimshaw; Jane Lane; Tracey A. Martin; Roger Abounder; John Laterra; Robert E. Mansel

Abstract

View articletitled, A Hammerhead Ribozyme Suppresses Expression of Hepatocyte Growth Factor/Scatter Factor Receptor c-MET and Reduces Migration and Invasiveness of Breast Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Optimization for the Blockade of Epidermal Growth Factor Receptor Signaling for Therapy of Human Pancreatic Carcinoma 1

Carmen C. Solorzano; Cheryl H. Baker; Rachel Tsan; Peter Traxler; Pamela Cohen; Elisabeth Buchdunger; Jerry J. Killion; Isaiah J. Fidler

Abstract

View articletitled, Optimization for the Blockade of Epidermal Growth Factor Receptor Signaling for Therapy of Human Pancreatic Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Marked Antitumor Activity of a New Potent Acronycine Derivative in Orthotopic Models of Human Solid Tumors

Nicolas Guilbaud; Laurence Kraus-Berthier; Florence Meyer-Losic; Virginie Malivet; Christine Chacun; Michel Jan; François Tillequin; Sylvie Michel; Michel Koch; Bruno Pfeiffer; Ghanem Atassi; John Hickman; Alain Pierré

Abstract

View articletitled, Marked Antitumor Activity of a New Potent Acronycine Derivative in Orthotopic Models of Human Solid Tumors

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Radiosensitization by Gemcitabine in p53 Wild-Type and Mutant MCF-7 Breast Carcinoma Cell Lines 1

Blaine W. Robinson; Donna S. Shewach

Abstract

View articletitled, Radiosensitization by Gemcitabine in p53 Wild-Type and Mutant MCF-7 Breast Carcinoma Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Novel Tubulin-binding Drug BTO-956 Inhibits R3230Ac Mammary Carcinoma Growth and Angiogenesis in Fischer 344 Rats 1

Siqing Shan; A. Craig Lockhart; Wilfred Y. Saito; A. Merrill Knapp; Keith R. Laderoute; Mark W. Dewhirst

Abstract

View articletitled, The Novel Tubulin-binding Drug BTO-956 Inhibits R3230Ac Mammary Carcinoma Growth and Angiogenesis in Fischer 344 Rats<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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