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Editorial

New Feature: “The Cooperative Group Bulletin Board”

John Mendelsohn

View articletitled, New Feature: “The Cooperative Group Bulletin Board”

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Soluble Fas and Cancer

Laurie Owen-Schaub

Extract

View articletitled, Soluble Fas and Cancer

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Cyclooxygenease-2 and Hepatocellular Carcinoma: Is It a Target for Prevention?1

Raymond N. DuBois

Extract

View articletitled, Cyclooxygenease-2 and Hepatocellular Carcinoma: Is It a Target for Prevention?<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Biology Behind

Are Solid Tumor Anti-Idiotype Vaccines Ready for Prime Time?: Commentary re: U. Wagner et al., Immunological Consolidation of Ovarian Carcinoma Recurrences with Monoclonal Anti-Idiotype Antibody ACA125: Immune Responses and Survival in Palliative Treatment. Clin. Cancer Res., 7: 1154–1162, 2001.

Kenneth A. Foon; Malaya Bhattacharya-Chatterjee

Extract

View articletitled, Are Solid Tumor Anti-Idiotype Vaccines Ready for Prime Time?: Commentary re: U. Wagner et al., Immunological Consolidation of Ovarian Carcinoma Recurrences with Monoclonal Anti-Idiotype Antibody ACA125: Immune Responses and Survival in Palliative Treatment. Clin. Cancer Res., 7: 1154–1162, 2001.

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The Cooperative Group Bulletin Board

The Organization and Accomplishments of the American College of Radiology Imaging Network: Progress in Its Second Year of Existence

Bruce J. Hillman

Extract

View articletitled, The Organization and Accomplishments of the American College of Radiology Imaging Network: Progress in Its Second Year of Existence

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Minireview

Biomarkers for Early Detection of Colon Cancer

Sudhir Srivastava; Mukesh Verma; Donald E. Henson

Abstract

View articletitled, Biomarkers for Early Detection of Colon Cancer

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Review

Assays for Monitoring Cellular Immune Responses to Active Immunotherapy of Cancer 1

Timothy M. Clay; Amy C. Hobeika; Paul J. Mosca; H. Kim Lyerly; Michael A. Morse

Abstract

View articletitled, Assays for Monitoring Cellular Immune Responses to Active Immunotherapy of Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Advances in Brief

Modulation of Irinotecan-induced Diarrhea by Cotreatment with Neomycin in Cancer Patients 1

Diederik F. S. Kehrer; Alex Sparreboom; Jaap Verweij; Peter de Bruijn; Corine A. Nierop; Jacqueline van de Schraaf; Elisabeth J. Ruijgrok; Maja J. A. de Jonge

Abstract

View articletitled, Modulation of Irinotecan-induced Diarrhea by Cotreatment with Neomycin in Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Intraoperative Immunophotodetection for Radical Resection of Cancers: Evaluation in an Experimental Model 1

Marian Gutowski; Magali Carcenac; Didier Pourquier; Christian Larroque; Bernard Saint-Aubert; Philippe Rouanet; André Pèlegrin

Abstract

View articletitled, Intraoperative Immunophotodetection for Radical Resection of Cancers: Evaluation in an Experimental Model<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

Lethal Outcome of a Patient with a Complete Dihydropyrimidine Dehydrogenase (DPD) Deficiency after Administration of 5-Fluorouracil: Frequency of the Common IVS14+1G>A Mutation Causing DPD Deficiency 1

André B. P. van Kuilenburg; Erik W. Muller; Janet Haasjes; Rutger Meinsma; Lida Zoetekouw; Hans R. Waterham; Frank Baas; Dick J. Richel; Albert H. van Gennip

Abstract

View articletitled, Lethal Outcome of a Patient with a Complete Dihydropyrimidine Dehydrogenase (DPD) Deficiency after Administration of 5-Fluorouracil: Frequency of the Common IVS14+1G>A Mutation Causing DPD Deficiency<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunological Consolidation of Ovarian Carcinoma Recurrences with Monoclonal Anti-Idiotype Antibody ACA125: Immune Responses and Survival in Palliative Treatment 1: See The Biology Behind: K. A. Foon and M. Bhattacharya-Chatterjee, Are Solid Tumor Anti-Idiotype Vaccines Ready for Prime Time? Clin. Cancer Res., 7:1112–1115, 2001.

Uwe Wagner; Siegmund Köhler; Silke Reinartz; Patrick Giffels; Jens Huober; Kirsten Renke; Harald Schlebusch; Hans-Jürgen Biersack; Volker Möbus; Rolf Kreienberg; Thomas Bauknecht; Dieter Krebs; Diethelm Wallwiener

Abstract

View articletitled, Immunological Consolidation of Ovarian Carcinoma Recurrences with Monoclonal Anti-Idiotype Antibody ACA125: Immune Responses and Survival in Palliative Treatment<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>: See The Biology Behind: K. A. Foon and M. Bhattacharya-Chatterjee, Are Solid Tumor Anti-Idiotype Vaccines Ready for Prime Time? Clin. Cancer Res., 7:1112–1115, 2001.

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Alteration of Interleukin 2 (IL-2) Pharmacokinetics and Function by IL-2 Antibodies Induced after Treatment of Colorectal Carcinoma Patients with a Combination of Monoclonal Antibody 17-1A, Granulocyte Macrophage Colony-Stimulating Factor, and IL-2 1

Anna-Lena Hjelm Skog; Meenu Wadhwa; Moustapha Hassan; Baback Gharizadeh; Chris Bird; Peter Ragnhammar; Robin Thorpe; Håkan Mellstedt

Abstract

View articletitled, Alteration of Interleukin 2 (IL-2) Pharmacokinetics and Function by IL-2 Antibodies Induced after Treatment of Colorectal Carcinoma Patients with a Combination of Monoclonal Antibody 17-1A, Granulocyte Macrophage Colony-Stimulating Factor, and IL-2<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effects of Hydroxyurea on Extrachromosomal DNA in Patients with Advanced Ovarian Carcinomas 1

Eric Raymond; Sandrine Faivre; Geoffrey Weiss; John McGill; Karen Davidson; Elzbieta Izbicka; John G. Kuhn; Craig Allred; Gary M. Clark; Daniel D. Von Hoff

Abstract

View articletitled, Effects of Hydroxyurea on Extrachromosomal DNA in Patients with Advanced Ovarian Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Influence of Granulocyte Macrophage Colony-Stimulating Factor and Prior Chemotherapy on the Immunological Response to a Vaccine (ALVAC-CEA B7.1) in Patients with Metastatic Carcinoma 1

Margaret von Mehren; Philip Arlen; James Gulley; André Rogatko; Harry S. Cooper; Neal J. Meropol; R. Katharine Alpaugh; Monica Davey; Susan McLaughlin; Mary T. Beard; Kwong Y. Tsang; Jeffrey Schlom; Louis M. Weiner

Abstract

View articletitled, The Influence of Granulocyte Macrophage Colony-Stimulating Factor and Prior Chemotherapy on the Immunological Response to a Vaccine (ALVAC-CEA B7.1) in Patients with Metastatic Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Reduction of Paclitaxel-induced Peripheral Neuropathy with Glutamine 1

Linda Vahdat; Kyriakos Papadopoulos; Dale Lange; Shelby Leuin; Elizabeth Kaufman; Diana Donovan; Deborah Frederick; Emilia Bagiella; Amy Tiersten; Gwen Nichols; Thomas Garrett; David Savage; Karen Antman; Charles S. Hesdorffer; Casilda Balmaceda

Abstract

View articletitled, Reduction of Paclitaxel-induced Peripheral Neuropathy with Glutamine<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Trial of the Angiogenesis Inhibitor TNP-470 for Progressive Androgen-independent Prostate Cancer 1

Christopher J. Logothetis; Kenneth K. Wu; Laury D. Finn; Danai Daliani; William Figg; Habib Ghaddar; Jordan U. Gutterman

Abstract

View articletitled, Phase I Trial of the Angiogenesis Inhibitor TNP-470 for Progressive Androgen-independent Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Epidermal Growth Factor Receptor-targeted Therapy with C225 and Cisplatin in Patients with Head and Neck Cancer 1

Dong M. Shin; Nicholas J. Donato; Roman Perez-Soler; Hyung Ju C. Shin; Ji Y. Wu; Peter Zhang; Kristie Lawhorn; Fadlo R. Khuri; Bonnie S. Glisson; Jeffrey Myers; Gary Clayman; David Pfister; John Falcey; Harlan Waksal; John Mendelsohn; Waun Ki Hong

Abstract

View articletitled, Epidermal Growth Factor Receptor-targeted Therapy with C225 and Cisplatin in Patients with Head and Neck Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Trial of ISIS 5132, an Antisense Oligonucleotide Inhibitor of c-raf-1, Administered by 24-hour Weekly Infusion to Patients with Advanced Cancer 1

Charles M. Rudin; Jon Holmlund; Gini F. Fleming; Sridhar Mani; Walter M. Stadler; Philip Schumm; Brett P. Monia; Joseph F. Johnston; Richard Geary; Rosie Z. Yu; T. Jesse Kwoh; F. Andrew Dorr; Mark J. Ratain

Abstract

View articletitled, Phase I Trial of ISIS 5132, an Antisense Oligonucleotide Inhibitor of c-raf-1, Administered by 24-hour Weekly Infusion to Patients with Advanced Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Trial of Doxorubicin, Paclitaxel, and Valspodar (PSC 833), a Modulator of Multidrug Resistance 1

Ranjana Advani; George A. Fisher; Bert L. Lum; John Hausdorff; Joanne Halsey; Manuel Litchman; Branimir I. Sikic

Abstract

View articletitled, A Phase I Trial of Doxorubicin, Paclitaxel, and Valspodar (PSC 833), a Modulator of Multidrug Resistance<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Influence of Neoadjuvant Anastrozole (Arimidex) on Intratumoral Estrogen Levels and Proliferation Markers in Patients with Locally Advanced Breast Cancer 1

Jürgen Geisler; Simone Detre; Hildegunn Berntsen; Lars Ottestad; Bernt Lindtjørn; Mitch Dowsett; Per Eystein Lønning

Abstract

View articletitled, Influence of Neoadjuvant Anastrozole (Arimidex) on Intratumoral Estrogen Levels and Proliferation Markers in Patients with Locally Advanced Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Trial of Intratumoral Liposome E1A Gene Therapy in Patients with Recurrent Breast and Head and Neck Cancer 1

George H. Yoo; Mien-Chie Hung; Gabriel Lopez-Berestein; Susan LaFollette; John F. Ensley; Mary Carey; Eric Batson; Thomas C. Reynolds; James L. Murray

Abstract

View articletitled, Phase I Trial of Intratumoral Liposome E1A Gene Therapy in Patients with Recurrent Breast and Head and Neck Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Pharmacokinetic Trial and Correlative in Vitro Phase II Tumor Kinetic Study of Apomine (SR-45023A), a Novel Oral Biphosphonate Anticancer Drug 1

David S. Alberts; Alton V. Hallum III; Mary Stratton-Custis; Dava J. Garcia; Mary Gleason-Guzman; Sydney E. Salmon; Pedro Santabarbara; Eric J. Niesor; Simon Floret; Craig L. Bentzen

Abstract

View articletitled, Phase I Pharmacokinetic Trial and Correlative in Vitro Phase II Tumor Kinetic Study of Apomine (SR-45023A), a Novel Oral Biphosphonate Anticancer Drug<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase 1B Study of Subcutaneously Administered Interleukin 2 in Combination with 13-cis Retinoic Acid as Maintenance Therapy in Advanced Cancer 1

Francesco Recchia; Sandro De Filippis; Michele Rosselli; Gaetano Saggio; Alisia Cesta; Luca Fumagalli; Silvio Rea

Abstract

View articletitled, Phase 1B Study of Subcutaneously Administered Interleukin 2 in Combination with 13-cis Retinoic Acid as Maintenance Therapy in Advanced Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology

Circulating Transforming Growth Factor β1 as a Predictor of Liver Metastasis after Resection in Colorectal Cancer

Hirofumi Tsushima; Nobuyuki Ito; Shinji Tamura; Yukihiko Matsuda; Masami Inada; Iwao Yabuuchi; Yasuharu Imai; Ryuichi Nagashima; Hiroyuki Misawa; Hiroaki Takeda; Yuji Matsuzawa; Sumio Kawata

Abstract

View articletitled, Circulating Transforming Growth Factor β1 as a Predictor of Liver Metastasis after Resection in Colorectal Cancer

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Relation of Vascular Endothelial Growth Factor Production to Expression and Regulation of Hypoxia-inducible Factor-1α and Hypoxia-inducible Factor-2α in Human Bladder Tumors and Cell Lines 1

Adam Jones; Chisato Fujiyama; Christine Blanche; John W. Moore; Sue Fuggle; David Cranston; Roy Bicknell; Adrian. L. Harris

Abstract

View articletitled, Relation of Vascular Endothelial Growth Factor Production to Expression and Regulation of Hypoxia-inducible Factor-1α and Hypoxia-inducible Factor-2α in Human Bladder Tumors and Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Collocation of Androgen Receptor Gene Mutations in Prostate Cancer 1

Grant Buchanan; Norman M. Greenberg; Howard I. Scher; Jonathan M. Harris; Villis R. Marshall; Wayne D. Tilley

Abstract

View articletitled, Collocation of Androgen Receptor Gene Mutations in Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increased Soluble CD95 (sFas/CD95) Serum Level Correlates with Poor Prognosis in Melanoma Patients

Selma Ugurel; Gunter Rappl; Wolfgang Tilgen; Uwe Reinhold

Abstract

View articletitled, Increased Soluble CD95 (sFas/CD95) Serum Level Correlates with Poor Prognosis in Melanoma Patients

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Significant Correlation between Interleukin 10 Expression and Vascularization through Angiopoietin/TIE2 Networks in Non-small Cell Lung Cancer 1

Hiroyuki Hatanaka; Yoshiyuki Abe; Masao Naruke; Tetsuji Tokunaga; Yoshiro Oshika; Tsutomu Kawakami; Hideo Osada; Junko Nagata; Jun-ichiro Kamochi; Takashi Tsuchida; Hiroshi Kijima; Hitoshi Yamazaki; Hiroshi Inoue; Yoshito Ueyama; Masato Nakamura

Abstract

View articletitled, Significant Correlation between Interleukin 10 Expression and Vascularization through Angiopoietin/TIE2 Networks in Non-small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Tumor-Suppressor Effect of Interferon Regulatory Factor-1 in Human Hepatocellular Carcinoma 1

Yoshinori Moriyama; Shuhei Nishiguchi; Akihiro Tamori; Noritoshi Koh; Yoshihisa Yano; Shoji Kubo; Kazuhiro Hirohashi; Shuzo Otani

Abstract

View articletitled, Tumor-Suppressor Effect of Interferon Regulatory Factor-1 in Human Hepatocellular Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Clinicopathological Significance of Heparanase and Basic Fibroblast Growth Factor Expressions in Hepatocellular Carcinoma

Osama N. El-Assal; Akira Yamanoi; Takashi Ono; Hitoshi Kohno; Naofumi Nagasue

Abstract

View articletitled, The Clinicopathological Significance of Heparanase and Basic Fibroblast Growth Factor Expressions in Hepatocellular Carcinoma

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Cervical Dysplasia, Ploidy, and Human Papillomavirus Status Correlate with Loss of Fhit Expression 1

Andrea Vecchione; Nicola Zanesi; Giorgio Trombetta; Debora French; Paolo Visca; Tiziana Pisani; Claudio Botti; Aldo Vecchione; Carlo M. Croce; Rita Mancini

Abstract

View articletitled, Cervical Dysplasia, Ploidy, and Human Papillomavirus Status Correlate with Loss of Fhit Expression<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of DT-Diaphorase and Cytochrome P450 Reductase Correlates with Mitomycin C Activity in Human Bladder Tumors 1

Yuebo Gan; Yiqun Mo; John E. Kalns; Jie Lu; Katherine Danenberg; Peter Danenberg; M. Guill Wientjes; Jessie L-S. Au

Abstract

View articletitled, Expression of DT-Diaphorase and Cytochrome P450 Reductase Correlates with Mitomycin C Activity in Human Bladder Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of p8 Is Inversely Correlated with Apoptosis in Pancreatic Cancer 1

Shi-Bing Su; Yoshiharu Motoo; Juan Lucio Iovanna; Patrice Berthézène; Min-Jue Xie; Hisatsugu Mouri; Koushiro Ohtsubo; Fujitsugu Matsubara; Norio Sawabu

Abstract

View articletitled, Overexpression of p8 Is Inversely Correlated with Apoptosis in Pancreatic Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Coexpression of Inducible Nitric Oxide Synthase and COX-2 in Hepatocellular Carcinoma and Surrounding Liver: Possible Involvement of COX-2 in the Angiogenesis of Hepatitis C Virus-positive Cases

Md. Atiqur Rahman; Dipok Kumar Dhar; Emi Yamaguchi; Seiji Maruyama; Takashi Sato; Hikota Hayashi; Takashi Ono; Akira Yamanoi; Hitoshi Kohno; Naofumi Nagasue

Abstract

View articletitled, Coexpression of Inducible Nitric Oxide Synthase and COX-2 in Hepatocellular Carcinoma and Surrounding Liver: Possible Involvement of COX-2 in the Angiogenesis of Hepatitis C Virus-positive Cases

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Expression of MUC1 Mucins in the Subserosal Layer Correlates with Postsurgical Prognosis of Pathological Tumor Stage 2 Carcinoma of the Gallbladder 1

Toru Kawamoto; Junichi Shoda; Tatsuro Irimura; Naoki Miyahara; Masato Furukawa; Tetsuya Ueda; Toru Asano; Masahito Kano; Naoto Koike; Katashi Fukao; Naomi Tanaka; Takeshi Todoroki

Abstract

View articletitled, Expression of MUC1 Mucins in the Subserosal Layer Correlates with Postsurgical Prognosis of Pathological Tumor Stage 2 Carcinoma of the Gallbladder<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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P53 Alteration and Microsatellite Instability Have Predictive Value for Survival Benefit from Chemotherapy in Stage III Colorectal Carcinoma 1

Hany Elsaleh; Brenda Powell; Kieran McCaul; Fabienne Grieu; Ryan Grant; David Joseph; Barry Iacopetta

Abstract

View articletitled, P53 Alteration and Microsatellite Instability Have Predictive Value for Survival Benefit from Chemotherapy in Stage III Colorectal Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Extensive Micrometastases to Lymph Nodes as a Marker for Rapid Recurrence of Colorectal Cancer: A Study of Lymphatic Mapping 1

Yasuhiro Miyake; Hirofumi Yamamoto; Yoshiyuki Fujiwara; Masayuki Ohue; Yurika Sugita; Naohiro Tomita; Mitsugu Sekimoto; Nariaki Matsuura; Hitoshi Shiozaki; Morito Monden

Abstract

View articletitled, Extensive Micrometastases to Lymph Nodes as a Marker for Rapid Recurrence of Colorectal Cancer: A Study of Lymphatic Mapping<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Loss of Heterozygosity at 19q13.3 Is Associated with Locally Aggressive Neuroblastoma 1

Jaume Mora; Nai-Kong V. Cheung; Lishi Chen; Jing Qin; William Gerald

Abstract

View articletitled, Loss of Heterozygosity at 19q13.3 Is Associated with Locally Aggressive Neuroblastoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Direct Stimulation of Apoptotic Signaling by Soluble Apo2L/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Leads to Selective Killing of Glioma Cells 1

Ian F. Pollack; Melanie Erff; Avi Ashkenazi

Abstract

View articletitled, Direct Stimulation of Apoptotic Signaling by Soluble Apo2L/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Leads to Selective Killing of Glioma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Tumor-Suppressive Effects of Neutral Endopeptidase in Androgen-independent Prostate Cancer Cells 1

Jie Dai; Ruoqian Shen; Makoto Sumitomo; Jonathan S. Goldberg; Yiping Geng; Daniel Navarro; Su Xu; Jason A. Koutcher; Mark Garzotto; C. Thomas Powell; David M. Nanus

Abstract

View articletitled, Tumor-Suppressive Effects of Neutral Endopeptidase in Androgen-independent Prostate Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Frederine, a New and Promising Protector Against Doxorubicin-induced Cardiotoxicity

Frédérique A. A. van Acker; Epie Boven; Klaas Kramer; Guido R. M. M. Haenen; Aalt Bast; Wim J. F. van der Vijgh

Abstract

View articletitled, Frederine, a New and Promising Protector Against Doxorubicin-induced Cardiotoxicity

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Interleukin 2-Antibody and Tumor Necrosis Factor-Antibody Fusion Proteins Induce Different Antitumor Immune Responses in Vivo1

Oliver Christ; Siegfried Matzku; Christa Burger; Margot Zöller

Abstract

View articletitled, Interleukin 2-Antibody and Tumor Necrosis Factor-Antibody Fusion Proteins Induce Different Antitumor Immune Responses in Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enforced Expression of Wild-Type p53 Curtails the Transcription of the O⁶-Methylguanine-DNA Methyltransferase Gene in Human Tumor Cells and Enhances Their Sensitivity to Alkylating Agents 1

Kalkunte S. Srivenugopal; Jiang Shou; Srinivas R. S. Mullapudi; Frederick F. Lang, Jr.; Jasti S. Rao; Francis Ali-Osman

Abstract

View articletitled, Enforced Expression of Wild-Type p53 Curtails the Transcription of the O6-Methylguanine-DNA Methyltransferase Gene in Human Tumor Cells and Enhances Their Sensitivity to Alkylating Agents<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of Cyclooxygenase-2 (COX-2) in Hepatocellular Carcinoma and Growth Inhibition of Hepatoma Cell Lines by a COX-2 Inhibitor, NS-398 1

Si Hyun Bae; Eun Sun Jung; Young Min Park; Boo Sung Kim; Byung Kee Kim; Dong Goo Kim; Wang Shick Ryu

Abstract

View articletitled, Expression of Cyclooxygenase-2 (COX-2) in Hepatocellular Carcinoma and Growth Inhibition of Hepatoma Cell Lines by a COX-2 Inhibitor, NS-398<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Novel Proteasome Inhibitor PS-341 Inhibits Activation of Nuclear Factor-κB, Cell Survival, Tumor Growth, and Angiogenesis in Squamous Cell Carcinoma 1

John B. Sunwoo; Zhong Chen; Gang Dong; Ning Yeh; Caren Crowl Bancroft; Edward Sausville; Julian Adams; Peter Elliott; Carter Van Waes

Abstract

View articletitled, Novel Proteasome Inhibitor PS-341 Inhibits Activation of Nuclear Factor-κB, Cell Survival, Tumor Growth, and Angiogenesis in Squamous Cell Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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BMS-247550: A Novel Epothilone Analog with a Mode of Action Similar to Paclitaxel but Possessing Superior Antitumor Efficacy

Francis Y. F. Lee; Robert Borzilleri; Craig R. Fairchild; Soong-Hoon Kim; Byron H. Long; Carmen Reventos-Suarez; Gregory D. Vite; William C. Rose; Robert A. Kramer

Abstract

View articletitled, BMS-247550: A Novel Epothilone Analog with a Mode of Action Similar to Paclitaxel but Possessing Superior Antitumor Efficacy

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Synergy of the Protein Farnesyltransferase Inhibitor SCH66336 and Cisplatin in Human Cancer Cell Lines 1

Alex A. Adjei; Jenny N. Davis; Laura M. Bruzek; Charles Erlichman; Scott H. Kaufmann

Abstract

View articletitled, Synergy of the Protein Farnesyltransferase Inhibitor SCH66336 and Cisplatin in Human Cancer Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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p53-independent Induction of Apoptosis in Human Melanoma Cells by a bcl-2/bcl-xL Bispecific Antisense Oligonucleotide 1

Mary Strasberg Rieber; Uwe Zangemeister-Wittke; Manuel Rieber

Abstract

View articletitled, p53-independent Induction of Apoptosis in Human Melanoma Cells by a bcl-2/bcl-xL Bispecific Antisense Oligonucleotide<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effects of Dietary Curcumin on Glutathione S-Transferase and Malondialdehyde-DNA Adducts in Rat Liver and Colon Mucosa: Relationship with Drug Levels¹

Ricky A. Sharma; Christopher R. Ireson; Richard D. Verschoyle; Kirsti A. Hill; Marion L. Williams; Chiara Leuratti; Margaret M. Manson; Lawrence J. Marnett; William P. Steward; Andreas Gescher

Abstract

View articletitled, Effects of Dietary Curcumin on Glutathione S-Transferase and Malondialdehyde-DNA Adducts in Rat Liver and Colon Mucosa: Relationship with Drug Levels1

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Inhibition of Growth Factor Production and Angiogenesis in Human Cancer Cells by ZD1839 (Iressa),1 a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor²

Fortunato Ciardiello; Rosa Caputo; Roberto Bianco; Vincenzo Damiano; Gabriella Fontanini; Sabina Cuccato; Sabino De Placido; A. Raffaele Bianco; Giampaolo Tortora

Abstract

View articletitled, Inhibition of Growth Factor Production and Angiogenesis in Human Cancer Cells by ZD1839 (Iressa),<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a> a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor<a href="javascript:;" reveal-id="FN2" data-open="FN2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">2</a>

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Resveratrol Causes WAF-1/p21-mediated G₁-phase Arrest of Cell Cycle and Induction of Apoptosis in Human Epidermoid Carcinoma A431 Cells 1

Nihal Ahmad; Vaqar M. Adhami; Farrukh Afaq; Denise K. Feyes; Hasan Mukhtar

Abstract

View articletitled, Resveratrol Causes WAF-1/p21-mediated G1-phase Arrest of Cell Cycle and Induction of Apoptosis in Human Epidermoid Carcinoma A431 Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

Deficiency of Caspase-3 in MCF7 Cells Blocks Bax-mediated Nuclear Fragmentation but not Cell Death 1

Shunsuke Kagawa; Jian Gu; Tsuyoshi Honda; Timothy J. McDonnell; Stephen G. Swisher; Jack A. Roth; Bingliang Fang

Abstract

View articletitled, Deficiency of Caspase-3 in MCF7 Cells Blocks Bax-mediated Nuclear Fragmentation but not Cell Death<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Letters to the Editor

Correspondence re: M. L. George et al., Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging? Clin. Cancer Res., 6: 3147–3152, 2000.

R. Salgado; P. B. Vermeulen; E. Van Marck; I. Benoy; L. Dirix

Extract

View articletitled, Correspondence re: M. L. George et al., Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging? Clin. Cancer Res., 6: 3147–3152, 2000.

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Reply

Mark George; Suzanne Eccles; Gary Box; Matthew Tutton; Muti Abulafi; Ian Swift

Extract

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Inhibition of Growth Factor Production and Angiogenesis in Human Cancer Cells by ZD1839 (Iressa),1 a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor2

Cancer Biology, Immunology, Cytokines

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Inhibition of Growth Factor Production and Angiogenesis in Human Cancer Cells by ZD1839 (Iressa),1 a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor²