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Cellular Immunity and Immunotheraphy of Cancer

The Biology Behind

The Diverse Role of the ETS Family of Transcription Factors in Cancer: Commentary re: B. Davidson, Ets-1 Messenger RNA Expression Is a Novel Marker of Poor Survival in Ovarian Carcinoma. Clin. Cancer Res., 7: 551–557, 2001.

D. Gary Gilliland

View articletitled, The Diverse Role of the ETS Family of Transcription Factors in Cancer: Commentary re: B. Davidson, Ets-1 Messenger RNA Expression Is a Novel Marker of Poor Survival in Ovarian Carcinoma. Clin. Cancer Res., 7: 551–557, 2001.

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Minireviews

Chlorambucil Drug Resistance in Chronic Lymphocytic Leukemia: The Emerging Role of DNA Repair 1

Lawrence Panasci; Jean-Pierre Paiement; Garyfallia Christodoulopoulos; Alexandre Belenkov; Areti Malapetsa; Raquel Aloyz

Abstract

View articletitled, Chlorambucil Drug Resistance in Chronic Lymphocytic Leukemia: The Emerging Role of DNA Repair<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Lymphangiogenesis and Tumor Metastasis: Myth or Reality?1

Michael S. Pepper

Abstract

View articletitled, Lymphangiogenesis and Tumor Metastasis: Myth or Reality?<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Advances in Brief

AIS Overexpression in Advanced Esophageal Cancer

Kenji Hibi; Hiroshi Nakayama; Masumi Taguchi; Yasushi Kasai; Katsuki Ito; Seiji Akiyama; Akimasa Nakao

Abstract

View articletitled, AIS Overexpression in Advanced Esophageal Cancer

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Prognostic Significance of Periodic Acid-Schiff-positive Patterns in Primary Cutaneous Melanoma 1

Michael A. Warso; Andrew J. Maniotis; Xue Chen; Dibyen Majumdar; Minu K. Patel; Anne Shilkaitis; Tapas K. Das Gupta; Robert Folberg

Abstract

View articletitled, Prognostic Significance of Periodic Acid-Schiff-positive Patterns in Primary Cutaneous Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

A Phase I Dose-ranging Trial of Monthly Infusions of Zoledronic Acid for the Treatment of Osteolytic Bone Metastases 1

James R. Berenson; Robert A. Vescio; Lee S. Rosen; Joseph M. VonTeichert; Margie Woo; Regina Swift; Allison Savage; Elise Givant; Mieke Hupkes; Harold Harvey; Allan Lipton

Abstract

View articletitled, A Phase I Dose-ranging Trial of Monthly Infusions of Zoledronic Acid for the Treatment of Osteolytic Bone Metastases<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Study of CNI-1493, an Inhibitor of Cytokine Release, in Combination with High-Dose Interleukin-2 in Patients with Renal Cancer and Melanoma 1

Michael B. Atkins; Bruce Redman; James Mier; Jared Gollob; Jeffrey Weber; Jeffrey Sosman; Bret L MacPherson; Terry Plasse

Abstract

View articletitled, A Phase I Study of CNI-1493, an Inhibitor of Cytokine Release, in Combination with High-Dose Interleukin-2 in Patients with Renal Cancer and Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Delayed Sodium Thiosulfate as an Otoprotectant Against Carboplatin-induced Hearing Loss in Patients with Malignant Brain Tumors 1

Nancy D. Doolittle; Leslie L. Muldoon; Robert E. Brummett; Rose Marie Tyson; Cynthia Lacy; Joseph S. Bubalo; Dale F. Kraemer; Michael C. Heinrich; James A. Henry; Edward A. Neuwelt

Abstract

View articletitled, Delayed Sodium Thiosulfate as an Otoprotectant Against Carboplatin-induced Hearing Loss in Patients with Malignant Brain Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I and Pharmacological Study of Two Schedules of the Antifolate Edatrexate in Combination with Cisplatin 1

Scott A. Laurie; David G. Pfister; Mark G. Kris; William P. Tong; Greg Chronowski; Katherine M. W. Pisters; Robert T. Heelan; Francis M. Sirotnak

Abstract

View articletitled, Phase I and Pharmacological Study of Two Schedules of the Antifolate Edatrexate in Combination with Cisplatin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Interferon α-2a Therapy in 18 Hemangioblastomas 1

Mika Niemelä; Hanna Mäenpää; Petri Salven; Paula Summanen; Kristiina Poussa; Leila Laatikainen; Juha Jääskeläinen; Heikki Joensuu

Abstract

View articletitled, Interferon α-2a Therapy in 18 Hemangioblastomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effect of Food on the Oral Bioavailability of UFT and Leucovorin in Cancer Patients

Bharat Damle; Farhad Ravandi; Sanjeev Kaul; Daryl Sonnichsen; Irene Ferreira; Donald Brooks; David Stewart; David Alberts; Richard Pazdur

Abstract

View articletitled, Effect of Food on the Oral Bioavailability of UFT and Leucovorin in Cancer Patients

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Molecular Oncology, Markers, Clinical Correlates

Association of Serum Endoglin with Metastasis in Patients with Colorectal, Breast, and Other Solid Tumors, and SuppressiveEffect of Chemotherapy on the Serum Endoglin 1

Norihiko Takahashi; Rika Kawanishi-Tabata; Akinao Haba; Masahiro Tabata; Yuro Haruta; Hilda Tsai; Ben K. Seon

Abstract

View articletitled, Association of Serum Endoglin with Metastasis in Patients with Colorectal, Breast, and Other Solid Tumors, and SuppressiveEffect of Chemotherapy on the Serum Endoglin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Microscopic Analysis and Significance of Vascular Architectural Complexity in Renal Cell Carcinoma

Edmond Sabo; Albina Boltenko; Yanina Sova; Avi Stein; Shira Kleinhaus; Murray B. Resnick

Abstract

View articletitled, Microscopic Analysis and Significance of Vascular Architectural Complexity in Renal Cell Carcinoma

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Are Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Prognostic Indicators in Pediatric Patientswith Malignant Solid Tumors?

Marie-Dominique Tabone; Judith Landman-Parker; Brigitte Arcil; Marie-Claude Coudert; Iliana Gerota; Marc Benbunan; Guy Leverger; Christine Dosquet

Abstract

View articletitled, Are Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Prognostic Indicators in Pediatric Patientswith Malignant Solid Tumors?

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Overexpression of the Cell Cycle Inhibitor p16^INK4A in High-grade Prostatic Intraepithelial Neoplasia Predicts Early Relapse in Prostate Cancer Patients 1

Susan M. Henshall; David I. Quinn; C. Soon Lee; Darren R. Head; David Golovsky; Phillip C. Brenner; Warick Delprado; Phillip D. Stricker; John J. Grygiel; Robert L. Sutherland

Abstract

View articletitled, Overexpression of the Cell Cycle Inhibitor p16INK4A in High-grade Prostatic Intraepithelial Neoplasia Predicts Early Relapse in Prostate Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Ets-1 Messenger RNA Expression Is a Novel Marker of Poor Survival in Ovarian Carcinoma

Ben Davidson; Reuven Reich; Iris Goldberg; Walter H. Gotlieb; Juri Kopolovic; Aasmund Berner; Gilad Ben-Baruch; Magne Bryne; Jahn M. Nesland

Abstract

View articletitled, Ets-1 Messenger RNA Expression Is a Novel Marker of Poor Survival in Ovarian Carcinoma

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Overexpression of Cyclooxygenase-2 in Squamous Cell Carcinoma of the Urinary Bladder 1

Tsutomu Shirahama; Chohei Sakakura

Abstract

View articletitled, Overexpression of Cyclooxygenase-2 in Squamous Cell Carcinoma of the Urinary Bladder<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Prognostic Value of Molecular Marker Analysis in Patients Treated with Trimodality Therapy for Esophageal Cancer

David H. Harpole, Jr.; Mary-Beth Moore; James E. Herndon, II; Thomas Aloia; Thomas A. D’Amico; Thomas Sporn; Allyson Parr; Ilona Linoila; Carmen Allegra

Abstract

View articletitled, The Prognostic Value of Molecular Marker Analysis in Patients Treated with Trimodality Therapy for Esophageal Cancer

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Expression of Tissue Factor Pathway Inhibitor 2 Inversely Correlates during the Progression of Human Gliomas 1

Chilukuri N. Rao; Sajani S. Lakka; Yoshiaki Kin; Santhi D. Konduri; Gregory N. Fuller; Sanjeeva Mohanam; Jasti S. Rao

Abstract

View articletitled, Expression of Tissue Factor Pathway Inhibitor 2 Inversely Correlates during the Progression of Human Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Detection of Epidermal Growth Factor Receptor mRNA in Peripheral Blood: A New Marker of Circulating Neoplastic Cells in Bladder Cancer Patients 1

Paola Gazzaniga; Orietta Gandini; Laura Giuliani; Massimo Magnanti; Angela Gradilone; Ida Silvestri; Walter Gianni; Michele Gallucci; Luigi Frati; Anna Maria Aglianò

Abstract

View articletitled, Detection of Epidermal Growth Factor Receptor mRNA in Peripheral Blood: A New Marker of Circulating Neoplastic Cells in Bladder Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Aberrant Methylation during Cervical Carcinogenesis 1

Arvind K. Virmani; Carolyn Muller; Asha Rathi; Sabine Zoechbauer-Mueller; Michael Mathis; Adi F. Gazdar

Abstract

View articletitled, Aberrant Methylation during Cervical Carcinogenesis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Multiple Detection of Genetic Alterations in Tumors and Stool

Claudia Rengucci; Pasquale Maiolo; Luca Saragoni; Wainer Zoli; Dino Amadori; Daniele Calistri

Abstract

View articletitled, Multiple Detection of Genetic Alterations in Tumors and Stool

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Frequent Down-Regulation of E-cadherin by Genetic and Epigenetic Changes in the Malignant Progression of Hepatocellular Carcinomas 1

Takuya Matsumura; Reiko Makino; Keiji Mitamura

Abstract

View articletitled, Frequent Down-Regulation of E-cadherin by Genetic and Epigenetic Changes in the Malignant Progression of Hepatocellular Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Detection of p53 Gene Mutations in Human Esophageal Squamous Cell Carcinomas Using a p53 Yeast Functional Assay: Possible Difference in Esophageal Carcinogenesis Between the Young and the Elderly Group

Eiki Okuda; Harushi Osugi; Keiichirou Morimura; Nobuyasu Takada; Masashi Takemura; Shoji Fukushima; Masayuki Higashino; Hiroaki Kinoshita

Abstract

View articletitled, Detection of p53 Gene Mutations in Human Esophageal Squamous Cell Carcinomas Using a p53 Yeast Functional Assay: Possible Difference in Esophageal Carcinogenesis Between the Young and the Elderly Group

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Detection of Head and Neck Squamous Cell Carcinoma among Exfoliated Oral Mucosal Cells by Microsatellite Analysis 1

Michael F. Spafford; Wayne M. Koch; Andre L. Reed; Joseph A. Califano; Li H. Xu; Claus F. Eisenberger; Linwah Yip; Paul L. Leong; Li Wu; Shixi X. Liu; Carmen Jerónimo; William H. Westra; David Sidransky

Abstract

View articletitled, Detection of Head and Neck Squamous Cell Carcinoma among Exfoliated Oral Mucosal Cells by Microsatellite Analysis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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O⁶-Methylguanine-DNA Methyltransferase in Pediatric Primary Brain Tumors: Relation to Patient and Tumor Characteristics 1

Michael S. Bobola; Mitchel S. Berger; Richard G. Ellenbogen; Theodore S. Roberts; J. Russell Geyer; John R. Silber

Abstract

View articletitled, O6-Methylguanine-DNA Methyltransferase in Pediatric Primary Brain Tumors: Relation to Patient and Tumor Characteristics<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Screening for and Identification of Novel Agents Directed at Renal Cell Carcinoma 1

Susan D. Mertins; Timothy G. Myers; Melinda Hollingshead; Donald Dykes; Esther Bodde; Pauline Tsai; Christine A. Jefferis; Ruchi Gupta; W. Marston Linehan; Michael Alley; Susan E. Bates

Abstract

View articletitled, Screening for and Identification of Novel Agents Directed at Renal Cell Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antiangiogenic and Antitumor Effects of a Protein Kinase Cβ Inhibitor in Human T98G Glioblastoma Multiforme Xenografts

Beverly A. Teicher; Krishna Menon; Enrique Alvarez; Elizabeth Galbreath; Chuan Shih; Margaret Faul

Abstract

View articletitled, Antiangiogenic and Antitumor Effects of a Protein Kinase Cβ Inhibitor in Human T98G Glioblastoma Multiforme Xenografts

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Combined Targeting of Adenoviruses to Integrins and Epidermal Growth Factor Receptors Increases Gene Transfer into Primary Glioma Cells and Spheroids 1

Jacques Grill; Victor W. Van Beusechem; Paul Van Der Valk; Clemens M. F. Dirven; Angelique Leonhart; Djain S. Pherai; Hidde J. Haisma; Herbert M. Pinedo; David T. Curiel; Winald R. Gerritsen

Abstract

View articletitled, Combined Targeting of Adenoviruses to Integrins and Epidermal Growth Factor Receptors Increases Gene Transfer into Primary Glioma Cells and Spheroids<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Photodynamic Therapy in the Canine Prostate Using Motexafin Lutetium

R. Alex Hsi; Amy Kapatkin; John Strandberg; Timothy Zhu; Theodor Vulcan; Michael Solonenko; Carmen Rodriguez; John Chang; Mark Saunders; Nicole Mason; Stephen Hahn

Abstract

View articletitled, Photodynamic Therapy in the Canine Prostate Using Motexafin Lutetium

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Down-Regulation of Galectin-3 Suppresses Tumorigenicity of Human Breast Carcinoma Cells 1

Yuichiro Honjo; Pratima Nangia-Makker; Hidenori Inohara; Avraham Raz

Abstract

View articletitled, Down-Regulation of Galectin-3 Suppresses Tumorigenicity of Human Breast Carcinoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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UCN-01 Suppresses E2F-1 Mediated by Ubiquitin-proteasome-dependent Degradation 1

Chung-Tsen Hsueh; Yu-Chung Wu; Gary K. Schwartz

Abstract

View articletitled, UCN-01 Suppresses E2F-1 Mediated by Ubiquitin-proteasome-dependent Degradation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Involvement of Microsomal Cytochrome P450 and Cytosolic Thymidine Phosphorylase in 5-Fluorouracil Formation from Tegafur in Human Liver 1

Tomoko Komatsu; Hiroshi Yamazaki; Noriaki Shimada; Sekio Nagayama; Yasuro Kawaguchi; Miki Nakajima; Tsuyoshi Yokoi

Abstract

View articletitled, Involvement of Microsomal Cytochrome P450 and Cytosolic Thymidine Phosphorylase in 5-Fluorouracil Formation from Tegafur in Human Liver<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Radiosensitization of Malignant Glioma Cells through Overexpression of Dominant-Negative Epidermal Growth Factor Receptor 1

Guido Lammering; Kristoffer Valerie; Peck-Sun Lin; Ross B. Mikkelsen; Joseph N. Contessa; Jeffrey P. Feden; Julie Farnsworth; Paul Dent; Rupert K. Schmidt-Ullrich

Abstract

View articletitled, Radiosensitization of Malignant Glioma Cells through Overexpression of Dominant-Negative Epidermal Growth Factor Receptor<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Growth-inhibitory Effects of CD40 Ligand (CD154) and Its Endogenous Expression in Human Breast Cancer 1

Alex W. Tong; Maria H. Papayoti; George Netto; Drew T. Armstrong; Guido Ordonez; J. Mark Lawson; Marvin J. Stone

Abstract

View articletitled, Growth-inhibitory Effects of CD40 Ligand (CD154) and Its Endogenous Expression in Human Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antitumor Effects of a Novel Phenoxazine Derivative on Human Leukemia Cell Lines in Vitro and in Vivo

Takashi Shimamoto; Akio Tomoda; Ryoji Ishida; Kazuma Ohyashiki

Abstract

View articletitled, Antitumor Effects of a Novel Phenoxazine Derivative on Human Leukemia Cell Lines in Vitro and in Vivo

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Inhibition of Interleukin 10 by Rituximab Results in Down-Regulation of Bcl-2 and Sensitization of B-cell Non-Hodgkin’s Lymphoma to Apoptosis 1

Steve Alas; Christos Emmanouilides; Benjamin Bonavida

Abstract

View articletitled, Inhibition of Interleukin 10 by Rituximab Results in Down-Regulation of Bcl-2 and Sensitization of B-cell Non-Hodgkin’s Lymphoma to Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Squalamine Treatment of Human Tumors in nu/nu Mice Enhances Platinum-based Chemotherapies 1

Jon I. Williams; Steven Weitman; Cristina M. Gonzalez; Carita H. Jundt; Jennifer Marty; Stephanie D. Stringer; Kenneth J. Holroyd; Michael P. McLane; Qiming Chen; Michael Zasloff; Daniel D. Von Hoff

Abstract

View articletitled, Squalamine Treatment of Human Tumors in nu/nu Mice Enhances Platinum-based Chemotherapies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

Hepatocyte Growth Factor Modulates Vascular Endothelial-cadherin Expression in Human Endothelial Cells 1

Tracey A. Martin; Robert Mansel; Wen Guom Jiang

Abstract

View articletitled, Hepatocyte Growth Factor Modulates Vascular Endothelial-cadherin Expression in Human Endothelial Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Epidemiology

Increased Risk of Incident Pancreatic Cancer Among First-degree Relatives of Patients with Familial Pancreatic Cancer 1

Anne C. Tersmette; Gloria M. Petersen; G. Johan A. Offerhaus; Florence C. Falatko; Kieran A. Brune; Michael Goggins; Ester Rozenblum; Robb E. Wilentz; Charles J. Yeo; John L. Cameron; Scott E. Kern; Ralph H. Hruban

Abstract

View articletitled, Increased Risk of Incident Pancreatic Cancer Among First-degree Relatives of Patients with Familial Pancreatic Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Meeting Report

NIH Symposium Summary: Organ Preservation Therapies for Squamous Cancers of the Head and Neck

Barbara A. Conley; Richard Cumberlin; Ann Sandberg; Beth Solomon; Carter Van Waes

Extract

View articletitled, NIH Symposium Summary: Organ Preservation Therapies for Squamous Cancers of the Head and Neck

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Correction

Extract

View articletitled, Correction

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Cellular Immunity and Immunotherapy of Cancer

Introduction: A Decade in the Life of Tumor Immunology

Olivera J. Finn; Michael T. Lotze

View articletitled, Introduction: A Decade in the Life of Tumor Immunology

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Tumor Antigens and Tumor-specific Immunity

WT1-specific Serum Antibodies in Patients with Leukemia ¹

Alexander Gaiger; Lauren Carter; Hildegard Greinix; Darrick Carter; Patricia D. McNeill; Raymond L. Houghton; Charisa D. Cornellison; Thomas S. Vedvick; Yasir A. W. Skeiky; Martin A. Cheever

Abstract

View articletitled, WT1-specific Serum Antibodies in Patients with Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CD8⁺ T-Cell Response to NY-ESO-1: Relative Antigenicity and in Vitro Immunogenicity of Natural and Analogue Sequences ¹

Pedro Romero; Valerie Dutoit; Verena Rubio-Godoy; Danielle Liénard; Daniel Speiser; Philippe Guillaume; Katerina Servis; Donata Rimoldi; Jean-Charles Cerottini; Danila Valmori

Abstract

View articletitled, CD8+ T-Cell Response to NY-ESO-1: Relative Antigenicity and in Vitro Immunogenicity of Natural and Analogue Sequences<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A New Strategy for Tumor Antigen Discovery Based on in Vitro Priming of Naïve T Cells with Dendritic Cells ¹

Henry Kao; Andrew A. Amoscato; Pawel Ciborowski; Olivera J. Finn

Abstract

View articletitled, A New Strategy for Tumor Antigen Discovery Based on in Vitro Priming of Naïve T Cells with Dendritic Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Biochemical Characterization of the Soluble Form of Tumor Antigen MUC1 Isolated from Sera and Ascites Fluid of Breast and Pancreatic Cancer Patients ¹

Pamela Beatty; Franz-Georg Hanisch; Donna Beer Stolz; Olivera J. Finn; Pawel Ciborowski

Abstract

View articletitled, Biochemical Characterization of the Soluble Form of Tumor Antigen MUC1 Isolated from Sera and Ascites Fluid of Breast and Pancreatic Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Human T-Cell Responses to HLA-A-restricted High Binding Affinity Peptides of Human Papillomavirus Type 18 Proteins E6 and E7 ¹

Michael P. Rudolf; Stephen Man; Cornelis J. M. Melief; Alessandro Sette; W. Martin Kast

Abstract

View articletitled, Human T-Cell Responses to HLA-A-restricted High Binding Affinity Peptides of Human Papillomavirus Type 18 Proteins E6 and E7<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expansion and Functional Maturation of Human Tumor Antigen-specific CD8⁺ T Cells after Vaccination with Antigenic Peptide ¹

Mikaël J. Pittet; Daniel E. Speiser; Danielle Liénard; Danila Valmori; Philippe Guillaume; Valérie Dutoit; Donata Rimoldi; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero

Abstract

View articletitled, Expansion and Functional Maturation of Human Tumor Antigen-specific CD8+ T Cells after Vaccination with Antigenic Peptide<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of CD56 by Human Papillomavirus E7-specific CD8+ Cytotoxic T Lymphocytes Correlates with Increased Intracellular Perforin Expression and Enhanced Cytotoxicity against HLA-A2-matched Cervical Tumor Cells ¹

Alessandro D. Santin; Paul L. Hermonat; Antonella Ravaggi; Stefania Bellone; Juan J. Roman; Sudheer Jayaprabhu; Sergio Pecorelli; Groesbeck P. Parham; Martin J. Cannon

Abstract

View articletitled, Expression of CD56 by Human Papillomavirus E7-specific CD8+ Cytotoxic T Lymphocytes Correlates with Increased Intracellular Perforin Expression and Enhanced Cytotoxicity against HLA-A2-matched Cervical Tumor Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Lack of Ignorance to Tumor Antigens: Evaluation Using Nominal Antigen Transfection and T-Cell Receptor Transgenic Lymphocytes in Lyons-Parish Analysis—Implications for Tumor Tolerance ¹

Bruce W. S. Robinson; Bernadette M. Scott; Richard A. Lake; Phillip A. Stumbles; Delia J. Nelson; Scott Fisher; Amanda L Marzo

Abstract

View articletitled, Lack of Ignorance to Tumor Antigens: Evaluation Using Nominal Antigen Transfection and T-Cell Receptor Transgenic Lymphocytes in Lyons-Parish Analysis—Implications for Tumor Tolerance<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Surrogate Markers of Antitumor Responses: In Vitro Activation of T Cells by Autologous Tumor Peptides

Karen Zier; Jean-Marie Maddux; Kristen Johnson; Max Sung; John Mandeli; Lea Eisenbach; Myron Schwartz

Abstract

View articletitled, Surrogate Markers of Antitumor Responses: In Vitro Activation of T Cells by Autologous Tumor Peptides

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Genetic Approach to Insight into the Immunobiology of Human Dendritic Cells and Identification of CD84-H1, a Novel CD84 Homologue ¹

Weiping Zhang; Tao Wan; Nan Li; Zhenglong Yuan; Long He; Xuejun Zhu; Min Yu; Xuetao Cao

Abstract

View articletitled, Genetic Approach to Insight into the Immunobiology of Human Dendritic Cells and Identification of CD84-H1, a Novel CD84 Homologue<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunotherapy of Tumors/Animal Models

Inhibition of Mammary Carcinogenesis by Systemic Interleukin 12 or pl85^neu DNA Vaccination in Her-2/neu Transgenic BALB/c Mice ¹

Emma Di Carlo; Stefania Rovero; Katia Boggio; Elena Quaglino; Augusto Amici; Arianna Smorlesi; Guido Forni; Piero Musiani

Abstract

View articletitled, Inhibition of Mammary Carcinogenesis by Systemic Interleukin 12 or pl85neu DNA Vaccination in Her-2/neu Transgenic BALB/c Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Recombinant Human Papillomavirus Type 16 E7 Protein as a Model Antigen to Study the Vaccine Potential in Control and E7 Transgenic Mice ¹

Catherine M. Gérard; Nathalie Baudson; Kirsty Kraemer; Catherine Ledent; Drew Pardoll; Claudine Bruck

Abstract

View articletitled, Recombinant Human Papillomavirus Type 16 E7 Protein as a Model Antigen to Study the Vaccine Potential in Control and E7 Transgenic Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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MUC1-specific Cytotoxic T Lymphocytes Eradicate Tumors When Adoptively Transferred in Vivo

Pinku Mukherjee; Amelia R. Ginardi; Teresa L. Tinder; Christopher J. Sterner; Sandra J. Gendler

Abstract

View articletitled, MUC1-specific Cytotoxic T Lymphocytes Eradicate Tumors When Adoptively Transferred in Vivo

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Protective Immunity against Human Carcinoembryonic Antigen (CEA) Induced by an Oral DNA Vaccine in CEA-transgenic Mice ¹

Rong Xiang; Steve Silletti; Holger N. Lode; Carrie S. Dolman; J. Michael Ruehlmann; Andreas G. Niethammer; Ursula Pertl; Stephen D. Gillies; F. James Primus; Ralph A. Reisfeld

Abstract

View articletitled, Protective Immunity against Human Carcinoembryonic Antigen (CEA) Induced by an Oral DNA Vaccine in CEA-transgenic Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Dendritic Cells, Loaded with Recombinant Bacteria Expressing Tumor Antigens, Induce a Protective Tumor-specific Response ¹

Maria Rescigno; Barbara Valzasina; Roberto Bonasio; Matteo Urbano; Paola Ricciardi-Castagnoli

Abstract

View articletitled, Dendritic Cells, Loaded with Recombinant Bacteria Expressing Tumor Antigens, Induce a Protective Tumor-specific Response<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Tracking the Common Ancestry of Antigenically Distinct Cancer Variants ¹

Karin Schreiber; Terry H. Wu; W. Martin Kast; Hans Schreiber

Abstract

View articletitled, Tracking the Common Ancestry of Antigenically Distinct Cancer Variants<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Murine Model for the Effects of Pelvic Radiation and Cisplatin Chemotherapy on Human Papillomavirus Vaccine Efficacy ¹

Laurie A. Small; Diane M. Da Silva; Karin E. de Visser; Markwin P. Velders; Susan G. Fisher; Ronald K. Potkul; W. Martin Kast

Abstract

View articletitled, A Murine Model for the Effects of Pelvic Radiation and Cisplatin Chemotherapy on Human Papillomavirus Vaccine Efficacy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Engineering Enhancement of Immune Responses to DNA-based Vaccines in a Prostate Cancer Model in Rhesus Macaques through the Use of Cytokine Gene Adjuvants ¹

J. Joseph Kim; Joo-Sung Yang; Kesen Dang; Kelledy H. Manson; David B. Weiner

Abstract

View articletitled, Engineering Enhancement of Immune Responses to DNA-based Vaccines in a Prostate Cancer Model in Rhesus Macaques through the Use of Cytokine Gene Adjuvants<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Visualization of Immunotoxin-mediated Tumor Cell Death in Vivo¹

Heidi A. Erickson; Richard L. Reinhardt; John B. Hermanson; Angela Panoskaltsis-Mortari; Christopher A. Pennell

Abstract

View articletitled, Visualization of Immunotoxin-mediated Tumor Cell Death in Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunotherapy of Tumors/Clinical Trials

Immunization of HLA-A2⁺ Melanoma Patients with MAGE-3 or MelanA Peptide-pulsed Autologous Peripheral Blood Mononuclear Cells Plus Recombinant Human Interleukin 12 ¹

Thomas F. Gajewski; Francesca Fallarino; Andrew Ashikari; Matthew Sherman

Abstract

View articletitled, Immunization of HLA-A2+ Melanoma Patients with MAGE-3 or MelanA Peptide-pulsed Autologous Peripheral Blood Mononuclear Cells Plus Recombinant Human Interleukin 12<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Detection of CD4 T-Cell Responses to a Tumor Vaccine by Cytokine Flow Cytometry ¹

Holden T. Maecker; Susanne Auffermann-Gretzinger; Laurel E. Nomura; Arcangelo Liso; Debra K. Czerwinski; Ronald Levy

Abstract

View articletitled, Detection of CD4 T-Cell Responses to a Tumor Vaccine by Cytokine Flow Cytometry<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Analysis of a Natural Immune Response against Tumor Antigens in a Melanoma Survivor: Lessons Applicable to Clinical Trial Evaluations ¹

Galina Yamshchikov; Lee Thompson; William G. Ross; Holly Galavotti; William Aquila; Donna Deacon; Jennifer Caldwell; James W. Patterson; Donald F. Hunt; Craig L. Slingluff, Jr.

Abstract

View articletitled, Analysis of a Natural Immune Response against Tumor Antigens in a Melanoma Survivor: Lessons Applicable to Clinical Trial Evaluations<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Intrathecal Cytotoxic T-Cell Immunotherapy for Metastatic Leptomeningeal Melanoma ¹

Annette R. Clemons-Miller; Gurkamal S. Chatta; Laura Hutchins; Edgardo J. Angtuaco; Antonella Ravaggi; Alessandro D. Santin; Martin J. Cannon

Abstract

View articletitled, Intrathecal Cytotoxic T-Cell Immunotherapy for Metastatic Leptomeningeal Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Tumor-mediated Immune Suppression

Systemic and Local Immunosuppression in Pancreatic Cancer Patients ¹

Wolfram von Bernstorff; Martina Voss; Susanne Freichel; Andreas Schmid; Ilka Vogel; Claudia Jöhnk; Doris Henne-Bruns; Bernd Kremer; Holger Kalthoff

Abstract

View articletitled, Systemic and Local Immunosuppression in Pancreatic Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Suppressed T-Cell Receptor ζ Chain Expression and Cytokine Production in Pancreatic Cancer Patients ¹

Jan Schmielau; Michael A. Nalesnik; Olivera J. Finn

Abstract

View articletitled, Suppressed T-Cell Receptor ζ Chain Expression and Cytokine Production in Pancreatic Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Tumor-induced Sensitivity to Apoptosis in T Cells from Patients with Renal Cell Carcinoma: Role of Nuclear Factor-κB Suppression ¹

James H. Finke; Patricia Rayman; Roshini George; Charles S. Tannenbaum; Vladimir Kolenko; Robert Uzzo; Andrew C. Novick; Ronald M. Bukowski

Abstract

View articletitled, Tumor-induced Sensitivity to Apoptosis in T Cells from Patients with Renal Cell Carcinoma: Role of Nuclear Factor-κB Suppression<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Decreased ζ Chain Expression and Apoptosis in CD3⁺ Peripheral Blood T Lymphocytes of Patients with Melanoma

Grzegorz Dworacki; Norbert Meidenbauer; Iris Kuss; Thomas K. Hoffmann; William Gooding; Michael Lotze; Theresa L. Whiteside

Abstract

View articletitled, Decreased ζ Chain Expression and Apoptosis in CD3+ Peripheral Blood T Lymphocytes of Patients with Melanoma

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l-Arginine Regulates the Expression of the T-Cell Receptor ζ Chain (CD3ζ) in Jurkat Cells ¹

Faramaz Taheri; Juan B. Ochoa; Zahra Faghiri; Kirk Culotta; Hae-Joon Park; Michael S. Lan; Arnold H. Zea; Augusto C. Ochoa

Abstract

View articletitled, l-Arginine Regulates the Expression of the T-Cell Receptor ζ Chain (CD3ζ) in Jurkat Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Relative Resistance of Fresh Isolates of Melanoma to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis ¹

Tam Nguyen; Xu Dong Zhang; Peter Hersey

Abstract

View articletitled, Relative Resistance of Fresh Isolates of Melanoma to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Tumor Necrosis Factor-α-promoted Expression of Bcl-2 and Inhibition of Mitochondrial Cytochrome c Release Mediate Resistance of Mature Dendritic Cells to Melanoma-induced Apoptosis ¹

Clemens Esche; Galina V. Shurin; John M. Kirkwood; Gui-Qiang Wang; Hannah Rabinowich; Georgi Pirtskhalaishvili; Michael R. Shurin

Abstract

View articletitled, Tumor Necrosis Factor-α-promoted Expression of Bcl-2 and Inhibition of Mitochondrial Cytochrome c Release Mediate Resistance of Mature Dendritic Cells to Melanoma-induced Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Dendritic Cells Prolong Tumor-specific T-Cell Survival and Effector Function after Interaction with Tumor Targets ¹

Robbie B. Mailliard; Michael T. Lotze

Abstract

View articletitled, Dendritic Cells Prolong Tumor-specific T-Cell Survival and Effector Function after Interaction with Tumor Targets<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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