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Editorial

Stealth Liposomes and Tumor Targeting: One Step Further in the Quest for the Magic Bullet

Alberto A. Gabizon

Extract

View articletitled, Stealth Liposomes and Tumor Targeting: One Step Further in the Quest for the Magic Bullet

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The Clinical Implications of Gemcitabine Radiosensitization

Todd H. Doyle; Francoise Mornex; W. Gillies McKenna

Extract

View articletitled, The Clinical Implications of Gemcitabine Radiosensitization

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Why Drugs Fail: Of Mice and Men Revisited

Chris H. Takimoto

Extract

View articletitled, Why Drugs Fail: Of Mice and Men Revisited

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Clinical Trials

Phase I and Pharmacokinetic Study of Ecteinascidin 743 Administered as a 72-Hour Continuous Intravenous Infusion in Patients with Solid Malignancies 1

David P. Ryan; Jeffrey G. Supko; J. Paul Eder; Michael V. Seiden; George Demetri; Thomas J. Lynch; Alan J. Fischman; John Davis; Jose Jimeno; Jeffrey W. Clark

Abstract

View articletitled, Phase I and Pharmacokinetic Study of Ecteinascidin 743 Administered as a 72-Hour Continuous Intravenous Infusion in Patients with Solid Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effective Targeting of Solid Tumors in Patients With Locally Advanced Cancers by Radiolabeled Pegylated Liposomes

Kevin J. Harrington; Sima Mohammadtaghi; Paul S. Uster; Daphne Glass; A. Michael Peters; Richard G. Vile; J. Simon W. Stewart

Abstract

View articletitled, Effective Targeting of Solid Tumors in Patients With Locally Advanced Cancers by Radiolabeled Pegylated Liposomes

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The Toxicity of Deglycosylated Ricin A Chain-containing Immunotoxins in Patients with Non-Hodgkin’s Lymphoma Is Exacerbated by Prior Radiotherapy: A Retrospective Analysis of Patients in Five Clinical Trials 1

John Schindler; Edward Sausville; Richard Messmann; Jonathan W. Uhr; Ellen S. Vitetta

Abstract

View articletitled, The Toxicity of Deglycosylated Ricin A Chain-containing Immunotoxins in Patients with Non-Hodgkin’s Lymphoma Is Exacerbated by Prior Radiotherapy: A Retrospective Analysis of Patients in Five Clinical Trials<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Multiple High-Grade Bronchial Dysplasia and Squamous Cell Carcinoma: Concordant and Discordant Mutations 1

Jay O. Boyle; Fulvio Lonardo; Jeffrey H. Chang; David Klimstra; Valerie Rusch; Ethan Dmitrovsky

Abstract

View articletitled, Multiple High-Grade Bronchial Dysplasia and Squamous Cell Carcinoma: Concordant and Discordant Mutations<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regulation of the Urokinase-type Plasminogen Activator Receptor Gene in Different Grades of Human Glioma Cell Lines 1

Anuradha Bhattacharya; Sajani S. Lakka; Sanjeeva Mohanam; Douglas Boyd; Jasti S. Rao

Abstract

View articletitled, Regulation of the Urokinase-type Plasminogen Activator Receptor Gene in Different Grades of Human Glioma Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Preserved Smad4 Expression in the Transforming Growth Factor β Signaling Pathway Is a Favorable Prognostic Factor in Patients with Advanced Gastric Cancer 1

Che Xiangming; Shoji Natsugoe; Sonshin Takao; Shuichi Hokita; Sumiya Ishigami; Gen Tanabe; Masamichi Baba; Kazunao Kuroshima; Takashi Aikou

Abstract

View articletitled, Preserved Smad4 Expression in the Transforming Growth Factor β Signaling Pathway Is a Favorable Prognostic Factor in Patients with Advanced Gastric Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Search for Mouse Mammary Tumor Virus-like env Sequences in Cancer and Normal Breast from the Same Individuals 1

Stella M. Melana; James F. Holland; Beatriz G-T. Pogo

Abstract

View articletitled, Search for Mouse Mammary Tumor Virus-like env Sequences in Cancer and Normal Breast from the Same Individuals<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Correlation of Tissue and Plasma RANTES Levels with Disease Course in Patients with Breast or Cervical Cancer

Yukie Niwa; Hirohiko Akamatsu; Hayato Niwa; Hajime Sumi; Yukio Ozaki; Akio Abe

Abstract

View articletitled, Correlation of Tissue and Plasma RANTES Levels with Disease Course in Patients with Breast or Cervical Cancer

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Overexpression of p53 in Tumor-distant Epithelia of Head and Neck Cancer Patients Is Associated with an Increased Incidence of Second Primary Carcinoma 1

Nils Homann; Matthias Nees; Christian Conradt; Andreas Dietz; Hagen Weidauer; Heinz Maier; Franz X. Bosch

Abstract

View articletitled, Overexpression of p53 in Tumor-distant Epithelia of Head and Neck Cancer Patients Is Associated with an Increased Incidence of Second Primary Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cloning and Characterization of a Novel Gene, DRH1, Down-Regulated in Advanced Human Hepatocellular Carcinoma 1

Yoshiya Yamamoto; Michiie Sakamoto; Gen Fujii; Kengo Kanetaka; Masahiro Asaka; Setsuo Hirohashi

Abstract

View articletitled, Cloning and Characterization of a Novel Gene, DRH1, Down-Regulated in Advanced Human Hepatocellular Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Mutations of PTEN/MMAC1 in Primary Prostate Cancers from Chinese Patients 1

Jin-Tang Dong; Chang-Ling Li; Tavis W. Sipe; Henry F. Frierson, Jr.

Abstract

View articletitled, Mutations of PTEN/MMAC1 in Primary Prostate Cancers from Chinese Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of p8 in Human Pancreatic Cancer 1

Shi-Bing Su; Yoshiharu Motoo; Juan Lucio Iovanna; Min-Jue Xie; Hisatsugu Mouri; Koushiro Ohtsubo; Yasushi Yamaguchi; Hiroyuki Watanabe; Takashi Okai; Fujitsugu Matsubara; Norio Sawabu

Abstract

View articletitled, Expression of p8 in Human Pancreatic Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

The Role of Apoptosis in 2′,2′-Difluoro-2′-deoxycytidine (Gemcitabine)-mediated Radiosensitization 1

Theodore S. Lawrence; Mary A. Davis; Amanda Hough; Alnawaz Rehemtulla

Abstract

View articletitled, The Role of Apoptosis in 2′,2′-Difluoro-2′-deoxycytidine (Gemcitabine)-mediated Radiosensitization<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Interactions between 2-Fluoroadenine 9-β-d-Arabinofuranoside and the Kinase Inhibitor UCN-01 in Human Leukemia and Lymphoma Cells 1

Sarah Harvey; Roy Decker; Yun Dai; Gregory Schaefer; Lin Tang; Lora Kramer; Paul Dent; Steven Grant

Abstract

View articletitled, Interactions between 2-Fluoroadenine 9-β-d-Arabinofuranoside and the Kinase Inhibitor UCN-01 in Human Leukemia and Lymphoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Activating Transcription Factor 2-derived Peptides Alter Resistance of Human Tumor Cell Lines to Ultraviolet Irradiation and Chemical Treatment 1

Anindita Bhoumik; Vladimir Ivanov; Ze’ev Ronai

Abstract

View articletitled, Activating Transcription Factor 2-derived Peptides Alter Resistance of Human Tumor Cell Lines to Ultraviolet Irradiation and Chemical Treatment<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Possible Mechanisms of Diarrheal Side Effects Associated with the Use of a Novel Chemotherapeutic Agent, Flavopiridol 1

Melissa E. S. Kahn; Adrian Senderowicz; Edward A. Sausville; Kim E. Barrett

Abstract

View articletitled, Possible Mechanisms of Diarrheal Side Effects Associated with the Use of a Novel Chemotherapeutic Agent, Flavopiridol<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cotreatment with STI-571 Enhances Tumor Necrosis Factor α-related Apoptosis-inducing Ligand (TRAIL or Apo-2L)- induced Apoptosis of Bcr-Abl-positive Human Acute Leukemia Cells

Ramadevi Nimmanapalli; Mercedes Porosnicu; Diep Nguyen; Elizabeth Worthington; Erica O’Bryan; Charles Perkins; Kapil Bhalla

Abstract

View articletitled, Cotreatment with STI-571 Enhances Tumor Necrosis Factor α-related Apoptosis-inducing Ligand (TRAIL or Apo-2L)- induced Apoptosis of Bcr-Abl-positive Human Acute Leukemia Cells

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Relation between 9-Aminocamptothecin Systemic Exposure and Tumor Response in Human Solid Tumor Xenografts 1

Mark N. Kirstein; Peter J. Houghton; Pamela J. Cheshire; Lois B. Richmond; Audrey K. Smith; Suzan K. Hanna; Clinton F. Stewart

Abstract

View articletitled, Relation between 9-Aminocamptothecin Systemic Exposure and Tumor Response in Human Solid Tumor Xenografts<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Retinoid Receptor Expression and Its Correlation to Retinoid Sensitivity in Non-M3 Acute Myeloid Leukemia Blast Cells 1

Sören Lehmann; Crister Paul; Hans Törmä

Abstract

View articletitled, Retinoid Receptor Expression and Its Correlation to Retinoid Sensitivity in Non-M3 Acute Myeloid Leukemia Blast Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Preclinical Evaluation of Motexafin Lutetium-mediated Intraperitoneal Photodynamic Therapy in a Canine Model

Greg M. Griffin; Timothy Zhu; Michael Solonenko; Fabio Del Piero; Amy Kapakin; Theresa M. Busch; Arjun Yodh; Glenn Polin; Todd Bauer; Douglas Fraker; Stephen M. Hahn

Abstract

View articletitled, Preclinical Evaluation of Motexafin Lutetium-mediated Intraperitoneal Photodynamic Therapy in a Canine Model

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Genistein Potentiates the Radiation Effect on Prostate Carcinoma Cells 1

Gilda G. Hillman; Jeffrey D. Forman; Omer Kucuk; Mark Yudelev; Richard L. Maughan; Johanna Rubio; Andrey Layer; Samuel Tekyi-Mensah; Judith Abrams; Fazlul H. Sarkar

Abstract

View articletitled, Genistein Potentiates the Radiation Effect on Prostate Carcinoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Combination of Standard Cytotoxic Agents with Polyamine Analogues in the Treatment of Breast Cancer Cell Lines 1

Hillary A. Hahm; Valerie R. Dunn; Kimberly A. Butash; Wendy L. Deveraux; Patrick M. Woster; Robert A. Casero, Jr.; Nancy E. Davidson

Abstract

View articletitled, Combination of Standard Cytotoxic Agents with Polyamine Analogues in the Treatment of Breast Cancer Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Efficacy of Treatment with Antisense Oligonucleotides Complementary to Immunoglobulin Sequences of bcl-2/Immunoglobulin Fusion Transcript in a t(14;18) Human Lymphoma-scid Mouse Model 1

Mitchell R. Smith; Tao Xie; Zhao-Zong Zhou; Indira Joshi

Abstract

View articletitled, Efficacy of Treatment with Antisense Oligonucleotides Complementary to Immunoglobulin Sequences of bcl-2/Immunoglobulin Fusion Transcript in a t(14;18) Human Lymphoma-scid Mouse Model<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Combination of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Actinomycin D Induces Apoptosis Even in TRAIL-resistant Human Pancreatic Cancer Cells 1

Hosei Matsuzaki; Bruno M. Schmied; Alexis Ulrich; Jens Standop; Matthias B. Schneider; Surinder K. Batra; Kathleen S. Picha; Parviz M. Pour

Abstract

View articletitled, Combination of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Actinomycin D Induces Apoptosis Even in TRAIL-resistant Human Pancreatic Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Tamoxifen Modulates Apoptotic Pathways in Primary Endometrial Cell Cultures

Rodica Stackievicz; Liat Drucker; Judith Radnay; Yoram Beyth; Shai Yarkoni; Ilan Cohen

Abstract

View articletitled, Tamoxifen Modulates Apoptotic Pathways in Primary Endometrial Cell Cultures

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Thresholds of O⁶-Alkylguanine-DNA Alkyltransferase which Confer Significant Resistance of Human Glial Tumor Xenografts to Treatment with 1,3-Bis(2-chloroethyl)-1-nitrosourea or Temozolomide 1

Demetrius M. Kokkinakis; Dora B. Bocangel; S. Clifford Schold; Robert C. Moschel; Anthony E. Pegg

Abstract

View articletitled, Thresholds of O6-Alkylguanine-DNA Alkyltransferase which Confer Significant Resistance of Human Glial Tumor Xenografts to Treatment with 1,3-Bis(2-chloroethyl)-1-nitrosourea or Temozolomide<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

Cyclooxygenase-2 Is Overexpressed in Human Cervical Cancer 1

Swati Kulkarni; Janet S. Rader; Fan Zhang; Helen Liapis; Alane T. Koki; Jaime L. Masferrer; Kotha Subbaramaiah; Andrew J. Dannenberg

Abstract

View articletitled, Cyclooxygenase-2 Is Overexpressed in Human Cervical Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Coexpression of Proangiogenic Factors IL-8 and VEGF by Human Head and Neck Squamous Cell Carcinoma Involves Coactivation by MEK-MAPK and IKK-NF-κB Signal Pathways 1

Caren C. Bancroft; Zhong Chen; Gang Dong; John B. Sunwoo; Ning Yeh; Catherine Park; Carter Van Waes

Abstract

View articletitled, Coexpression of Proangiogenic Factors IL-8 and VEGF by Human Head and Neck Squamous Cell Carcinoma Involves Coactivation by MEK-MAPK and IKK-NF-κB Signal Pathways<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Letter to the Editor

Correspondence re: M. L. George et al., Correlation of Plasma and Serum Vascular Endothelial Growth Factor Levels with Platelet Count in Colorectal Cancer: Clinical Evidence of Platelet Scavenging? Clin. Cancer Res., 6: 3147–3152, 2000.

Eberhard Gunsilius; Joerg Tschmelitsch; Andreas. L. Petzer

Extract

View articletitled, Correspondence re: M. L. George et al., Correlation of Plasma and Serum Vascular Endothelial Growth Factor Levels with Platelet Count in Colorectal Cancer: Clinical Evidence of Platelet Scavenging? Clin. Cancer Res., 6: 3147–3152, 2000.

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Reply

Mark George; Suzanne Eccles; Gary Box; Matthew Tutton; Muti Abulafi; Ian Swift

Extract

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Correspondence re: C. F. M. Sier et al., Enhanced Urinary Gelatinase Activities (Matrix Metalloproteinases 2 and 9) Are Associated with Early-Stage Bladder Carcinoma: A Comparison with Clinically Used Tumor Markers. Clin. Cancer Res., 6: 2333–2340, 2000.1

Susanne Gerhards; Frank Koenig; Dmitri Daniltchenko; Steffen Hauptmann; Dietmar Schnorr; Stefan A. Loening

Extract

View articletitled, Correspondence re: C. F. M. Sier et al., Enhanced Urinary Gelatinase Activities (Matrix Metalloproteinases 2 and 9) Are Associated with Early-Stage Bladder Carcinoma: A Comparison with Clinically Used Tumor Markers. Clin. Cancer Res., 6: 2333–2340, 2000.<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Reply

Cornelis F. M. Sier; Jan H. Verheijen; Natascha van Lent; Roeland Hanemaaijer

Extract

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Issues

Editorial

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Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Cancer Biology, Immunology, Cytokines

Letter to the Editor

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