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Issues

Volume 6, Issue 9
1 September 2000
Clinical Cancer Research Cover Image for Volume 6, Issue 9
All Issues
ISSN 1078-0432
EISSN 1557-3265

Editorial

Need and Potential for Predictive Tests of Hepatic Metabolism of Anticancer Drugs
Clinton F. Stewart; Erin G. Schuetz
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Editorials

Insights into the Pharmacokinetics and Pharmacodynamics of Irinotecan
Mark J. Ratain
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Minireview

The Development of Conditionally Replicative Adenoviruses for Cancer Therapy1
David T. Curiel
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Advances in Brief

Flavopiridol Metabolism in Cancer Patients Is Associated with the Occurrence of Diarrhea1
Federico Innocenti; Walter M. Stadler; Lalitha Iyer; Jacqueline Ramírez; Everett E. Vokes; Mark J. Ratain
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A Phase I Trial of a Human Papillomavirus (HPV) Peptide Vaccine for Women with High-Grade Cervical and Vulvar Intraepithelial Neoplasia Who Are HPV 16 Positive1
Laila Muderspach; Sharon Wilczynski; Linda Roman; Liz Bade; Juan Felix; L. A. Small; W. Martin Kast; Grace Fascio; Verna Marty; Jeffrey Weber
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Clinical Relevance of the Lung Resistance Protein in Diffuse Large B-Cell Lymphomas1
Martin Filipits; Ulrich Jaeger; Ingrid Simonitsch; Claudia Chizzali-Bonfadin; Harald Heinzl; Robert Pirker
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KAI1 Protein Is Down-Regulated during the Progression of Human Breast Cancer1
Xiaohong Yang; Lisa Wei; Careen Tang; Rebecca Slack; Elizabeth Montgomery; Marc Lippman
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Elevated Caveolin-1 Levels in African-American versus White-American Prostate Cancer1
Guang Yang; Josephine Addai; Michael Ittmann; Thomas M. Wheeler; Timothy C. Thompson
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Compensatory Stabilization of RIIβ Protein, Cell Cycle Deregulation, and Growth Arrest in Colon and Prostate Carcinoma Cells by Antisense-directed Down-Regulation of Protein Kinase A RIα Protein
Maria Nesterova; Kohei Noguchi; Yun Gyu Park; Youl Nam Lee; Yoon S. Cho-Chung
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Clinical Trials

Phase II Trial of Interleukin 2, Interferon α, and 5-Fluorouracil in Metastatic Renal Cell Cancer: A Cytokine Working Group Study1
Janice P. Dutcher; Theodore Logan; Michael Gordon; Jeffrey Sosman; Geoffrey Weiss; Kim Margolin; Terry Plasse; James Mier; Michael Lotze; Joseph Clark; Michael Atkins
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Factors Involved in Prolongation of the Terminal Disposition Phase of SN-38: Clinical and Experimental Studies1
Diederik F. S. Kehrer; Wataru Yamamoto; Jaap Verweij; Maja J. A. de Jonge; Peter de Bruijn; Alex Sparreboom
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Oral Paclitaxel and Concurrent Cyclosporin A: Targeting Clinically Relevant Systemic Exposure to Paclitaxel1
Carolyn D. Britten; Sharyn D. Baker; Louis J. Denis; Thomas Johnson; Ronald Drengler; Lillian L. Siu; Ken Duchin; John Kuhn; Eric K. Rowinsky
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Outcomes of Dysplastic Nodules in Human Cirrhotic Liver: A Clinicopathological Study
Shuichi Seki; Hiroki Sakaguchi; Takuya Kitada; Akihiro Tamori; Tadashi Takeda; Norifumi Kawada; Daiki Habu; Kazuki Nakatani; Shuhei Nishiguchi; Susumu Shiomi
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A Phase I/II Trial of Paclitaxel, Carboplatin, and Gemcitabine in Untreated Patients with Advanced Non-Small Cell Lung Cancer1
Karen Kelly; Nadine Mikhaeel-Kamel; Zhaoxing Pan; James Murphy; Sheila Prindiville; Paul A. Bunn, Jr.
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Optimizing the Erythromycin Breath Test for Use in Cancer Patients1
Laurent P. Rivory; Kellie Slaviero; J. Paul Seale; Janelle M. Hoskins; Michael Boyer; Philip J. Beale; Michael J. Millward; James F. Bishop; Stephen J. Clarke
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Phase III Evaluation of Octreotide versus Chemotherapy with 5-Fluorouracil or 5-Fluorouracil Plus Leucovorin in Advanced Exocrine Pancreatic Cancer: A North Central Cancer Treatment Group Study1
Patrick A. Burch; Margaret Block; Georgene Schroeder; John W. Kugler; Daniel J. Sargent; Theodore A. Braich; James A. Mailliard; John C. Michalak; Alan K. Hatfield; Keith Wright; Steven A. Kuross
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Phase I and Pharmacokinetic Study of 10-Propargyl-10-deazaaminopterin, a New Antifolate1
Lee M. Krug; Kenneth K. Ng; Mark G. Kris; Vincent A. Miller; William Tong; Robert T. Heelan; Larry Leon; Denis Leung; Jean Kelly; F. M. Sirotnak
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Molecular Oncology, Markers, Clinical Correlates

p53 Mutations in Primary and Metastatic Tumors and Circulating Tumor Cells from Colorectal Carcinoma Patients1
Zulfiqar A. J. Khan; Sonja K. Jonas; Nadia Le-Marer; Hitesh Patel; Richard Q. Wharton; Antonio Tarragona; Angela Ivison; Timothy G. Allen-Mersh
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Loss of Fhit Expression in Invasive Cervical Carcinomas and Intraepithelial Lesions Associated with Invasive Disease1
Denise C. Connolly; David L. Greenspan; Rong Wu; Xiaodan Ren; Rodney L. Dunn; Keerti V. Shah; Ronald W. Jones; F. Xavier Bosch; Nubia Muñoz; Kathleen R. Cho
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CDKN2A Mutation and Deletion Status in Thin and Thick Primary Melanoma1
Adrian R. Cachia; James O. Indsto; Kathryn M. McLaren; Graham J. Mann; Mark J. Arends
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Frequent p15 Promoter Methylation in Tumor and Peripheral Blood from Hepatocellular Carcinoma Patients1
Ivy H. N. Wong; Y. M. Dennis Lo; Winnie Yeo; Wan Y. Lau; Philip J. Johnson
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Molecular Heterogeneity and Function of EWS-WT1 Fusion Transcripts in Desmoplastic Small Round Cell Tumors1
Jun Liu; Marion M. Nau; Jimmy C. Yeh; Carmen J. Allegra; Edward Chu; John J. Wright
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Expression of Stromal Cell-derived Factor 1 and CXCR4 Ligand Receptor System in Pancreatic Cancer: A Possible Role for Tumor Progression
Takatomo Koshiba; Ryo Hosotani; Yoshiharu Miyamoto; Jun Ida; Shoichiro Tsuji; Sanae Nakajima; Michiya Kawaguchi; Hiroyuki Kobayashi; Ryuichiro Doi; Toshiyuki Hori; Nobutaka Fujii; Masayuki Imamura
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Abnormal Expression of the ATM and TP53 Genes in Sporadic Breast Carcinomas1
Sandra Angèle; Isabelle Treilleux; Philippe Tanière; Ghyslaine Martel-Planche; Michèle Vuillaume; Christiane Bailly; Alain Brémond; Ruggero Montesano; Janet Hall
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Angiogenin Expression in Human Colorectal Cancer: The Role of Focal Macrophage Infiltration
Tsuyoshi Etoh; Kenji Shibuta; Graham F. Barnard; Seigo Kitano; Masaki Mori
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Reliable and Sensitive Analysis of Occult Bone Marrow Metastases Using Automated Cellular Imaging
Kenneth D. Bauer; Jose de la Torre-Bueno; Ingo J. Diel; Debra Hawes; William J. Decker; Carl Priddy; Blaise Bossy; Susan Ludmann; Karen Yamamoto; Aneal S. Masih; Froilan P. Espinoza; Douglas S. Harrington
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Frequency of Apoptosis of Tumor-infiltrating Lymphocytes Induced by Fas Counterattack in Human Colorectal Carcinoma and Its Correlation with Prognosis
Kazuya Okada; Ko Komuta; Satoshi Hashimoto; Sumihiro Matsuzaki; Takashi Kanematsu; Takehiko Koji
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Refinement of Regions with Allelic Loss on Chromosome 18p11.2 and 18q12.2 in Esophageal Squamous Cell Carcinoma1
Jayaprakash D. Karkera; Saleh Ayache; Rodman J. Ransome, Jr.; Marvin A. Jackson; Ahmed F. Elsayem; Rajagopalan Sridhar; Sevilla D. Detera-Wadleigh; Robert G. Wadleigh
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Expression of a Subset of Steroid Receptor Cofactors Is Associated with Progesterone Receptor Expression in Meningiomas1
Rona S. Carroll; Myles Brown; Jianping Zhang; James DiRenzo; Jaime Font De Mora; Peter McL. Black
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Serum Soluble Fas Level as a Prognostic Factor in Patients with Gynecological Malignancies1
Ryo Konno; Tadao Takano; Shinji Sato; Akira Yajima
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Clinicopathological Features and Overexpression of Matrix Metalloproteinases in Intramucosal Gastric Carcinoma with Lymph Node Metastasis
Akira Kabashima; Yoshihiko Maehara; Yoshihiro Kakeji; Hideo Baba; Tadashi Koga; Keizo Sugimachi
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Evaluation of Two New Urinary Tumor Markers: Bladder Tumor Fibronectin and Cytokeratin 18 for the Diagnosis of Bladder Cancer1
Marta Sánchez-Carbayo; Manuel Urrutia; Jose Manuel González de Buitrago; Juan Alejandro Navajo
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The Role of nm23-H1 in the Progression of Transitional Cell Bladder Cancer1
Nan-Haw Chow; Hsiao-Sheng Liu; Shih-Huang Chan
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Msh2, Mlh1, Fhit, p53, Bcl-2, and Bax Expression in Invasive and in Situ Squamous Cell Carcinoma of the Uterine Cervix1
Enrico Giarnieri,Rita Mancini,Tiziana Pisani,Mauro Alderisio, andAldo Vecchione
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Methylation of hMLH1 in a Population-based Series of Endometrial Carcinomas1
Helga B. Salvesen; Nicola MacDonald; Andy Ryan; Ole Erik Iversen; Ian J. Jacobs; Lars A. Akslen; Soma Das
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Levels of Cyclin D1 and D3 in Malignant Melanoma: Deregulated Cyclin D3 Expression Is Associated with Poor Clinical Outcome in Superficial Melanoma1
Vivi Ann Flørenes; Ragnar S. Faye; Gunhild M. Mælandsmo; Jahn M. Nesland; Ruth Holm
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Experimental Therapeutics, Preclinical Pharmacology

Therapeutic Efficacy of Anti-Lewisy Humanized 3S193 Radioimmunotherapy in a Breast Cancer Model: Enhanced Activity When Combined with Taxol Chemotherapy
Kerrie Clarke; Fook-Thean Lee; Martin W. Brechbiel; Fiona E. Smyth; Lloyd J. Old; Andrew M. Scott
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Epitope-specific Antibody Response to HT-1080 Fibrosarcoma Cells by Mimotope Immunization1
Mikhail Popkov; Salwa Sidrac-Ghali; Valery Alakhov; Rosemonde Mandeville
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Topical Delivery of 13-cis-Retinoic Acid by Inhalation Up-Regulates Expression of Rodent Lung but not Liver Retinoic Acid Receptors
Da Li Wang; Melissa Marko; Alan R. Dahl; Kory S. Engelke; Michael E. Placke; Anthony R. Imondi; James L. Mulshine; Luigi M. De Luca
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Leucovorin Rescue from Raltitrexed (Tomudex)-induced Antiproliferative Effects: In Vitro Cell Line and in Vivo Mouse Studies1
D. C. Farrugia; G. W. Aherne; L. Brunton; S. J. Clarke; A. L. Jackman
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Alterations in Polyamine Catabolic Enzymes in Human Breast Cancer Tissue1
Heather M. Wallace; Jane Duthie; Deborah M. Evans; Scott Lamond; Kirstie M. Nicoll; Steven D. Heys
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Plasma and Cerebrospinal Fluid Pharmacokinetics of O6-Benzylguanine and Analogues in Nonhuman Primates1
Lina Long; Stacey L. Berg; Sandip K. Roy; Cindy L. McCully; Hee-Won Song-Yoo; Robert C. Moschel; Frank M. Balis; M. Eileen Dolan
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Preclinical Study of the Systemic Toxicity and Pharmacokinetics of 5-Iodo-2-deoxypyrimidinone-2′-deoxyribose as a Radiosensitizing Prodrug in Two, Non-Rodent Animal Species: Implications for Phase I Study Design1
Timothy J. Kinsella; Jane E. Schupp; Thomas W. Davis; Suzanne E. Berry; Hwa-Shin Hwang; Kathy Warren; Frank Balis; John Barnett; Howard Sands
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Treatment of Anthracycline Extravasation with Dexrazoxane1
Seppo W. Langer; Maxwell Sehested; Peter Buhl Jensen
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The Mechanism of Transport of the Multitargeted Antifolate (MTA) and Its Cross-resistance Pattern in Cells with Markedly Impaired Transport of Methotrexate1
Rongbao Zhao; Solomon Babani; Feng Gao; Laibin Liu; I. David Goldman
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9-cis-Retinoic Acid Suppresses Mammary Tumorigenesis in C3(1)-Simian Virus 40 T Antigen-transgenic Mice1
Kendall Wu; Hee-Tae Kim; Jenny L. Rodriquez; Deborah Munoz-Medellin; Syed K. Mohsin; Susan G. Hilsenbeck; William W. Lamph; Marco M. Gottardis; Michael A. Shirley; John G. Kuhn; Jeff E. Green; Powel H. Brown
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Co-administration of Probenecid, an Inhibitor of a cMOAT/MRP- like Plasma Membrane ATPase, Greatly Enhanced the Efficacy of a New 10-Deazaaminopterin against Human Solid Tumors in Vivo1
F. M. Sirotnak; H. Guido Wendel; William G. B. Bornmann; William P. Tong; Vincent A. Miller; Howard I. Scher; Mark G. Kris
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Intranasal Therapy with an Adenoviral Vector Containing the Murine Interleukin-12 Gene Eradicates Osteosarcoma Lung Metastases1
Laura L. Worth; Shu-Fang Jia; Zhichao Zhou; Ling Chen; Eugenie S. Kleinerman
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Lack of Multicellular Drug Resistance Observed in Human Ovarian and Prostate Carcinoma Treated with the Proteasome Inhibitor PS-3411
Andrea Frankel; Shan Man; Peter Elliott; Julian Adams; Robert S. Kerbel
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Perforin-mediated Lysis of Tumor Cells by Mycobacterium Bovis Bacillus Calmette-Guérin-activated Killer Cells1
Sven Brandau; Henrik Suttmann; Josef Riemensberger; Ulrike Seitzer; Judith Arnold; Christoph Durek; Dieter Jocham; Hans-Dieter Flad; Andreas Böhle
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Antiangiogenic and Antitumor Activity of Anti-Epidermal Growth Factor Receptor C225 Monoclonal Antibody in Combination with Vascular Endothelial Growth Factor Antisense Oligonucleotide in Human GEO Colon Cancer Cells1
Fortunato Ciardiello; Roberto Bianco; Vincenzo Damiano; Gabriella Fontanini; Rosa Caputo; Grazia Pomatico; Sabino De Placido; A. Raffaele Bianco; John Mendelsohn; Giampaolo Tortora
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Hyperthermia Increases Accumulation of Technetium-99m-labeled Liposomes in Feline Sarcomas1
Mark L. Matteucci; Gopal Anyarambhatla; Gary Rosner; Chieko Azuma; Paul E. Fisher; Mark W. Dewhirst; David Needham; Donald E. Thrall
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Early Caspase Activation in Leukemic Cells Subject to Etoposide-induced G2-M Arrest: Evidence of Commitment to Apoptosis Rather Than Mitotic Cell Death1
Robert J. Sleiman; Bernard W. Stewart
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In Vitro Evaluation of Schedule-dependent Interactions between Docetaxel and Doxorubicin against Human Breast and Ovarian Cancer Cells1
Su Zeng; Yao Zu Chen; Liwu Fu; Korey R. Johnson; Weimin Fan
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In Vitro and in Vivo Pharmacological Characterizations of the Antitumor Properties of Two New Olivacine Derivatives, S16020-2 and S30972-11
Hugues Malonne; Sophie Farinelle; Christine Decaestecker; Laurence Gordower; Jeanine Fontaine; Françoise Chaminade; Jean-Marie Saucier; Ghanem Atassi; Robert Kiss
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Cancer Biology, Immunology, Cytokines

Reactive Oxygen Species Are Critical for the Growth and Differentiation of Medullary Thyroid Carcinoma Cells1
Hyo Chol Ha; Arunthathi Thiagalingam; Barry D. Nelkin; Robert A. Casero, Jr.
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HET/SAF-B Overexpression Causes Growth Arrest and Multinuclearity and Is Associated with Aneuploidy in Human Breast Cancer1
Steven M. Townson; Toby Sullivan; QingPing Zhang; Gary M. Clark; C. Kent Osborne; Adrian V. Lee; Steffi Oesterreich
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Correction

Correction
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