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Issues
1 July 2000
ISSN 1078-0432
EISSN 1557-3265
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Advances in Brief
BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin1
Carla Manzotti; Graziella Pratesi; Ernesto Menta; Roberto Di Domenico; Ennio Cavalletti; Heinz H. Fiebig; Lloyd R. Kelland; Nicholas Farrell; Donatella Polizzi; Rosanna Supino; Gabriella Pezzoni; Franco Zunino
Treatment of Human Metastatic Transitional Cell Carcinoma of the Bladder in a Murine Model with the Anti-Vascular Endothelial Growth Factor Receptor Monoclonal Antibody DC101 and Paclitaxel1
Keiji Inoue; Joel W. Slaton; Darren W. Davis; Daniel J. Hicklin; David J. McConkey; Takashi Karashima; Robert Radinsky; Colin P. N. Dinney
Clinical Trials
A Dose-Escalation and Pharmacokinetic Study of Subcutaneously Administered Recombinant Human Interleukin 12 and Its Biological Effects in Japanese Patients with Advanced Malignancies
Ryuzo Ohno; Yoshiyuki Yamaguchi; Tetsuya Toge; Toshiaki Kinouchi; Toshihiko Kotake; Masahiko Shibata; Yoshio Kiyohara; Shigeo Ikeda; Iwao Fukui; Akira Gohchi; Yasuyuki Sugiyama; Shigetoyo Saji; Shouichi Hazama; Masaaki Oka; Kazunori Ohnishi; Yasuo Ohhashi; Shigeru Tsukagoshi; Tetsuo Taguchi
Pharmacokinetic and Pharmacodynamic Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG20341
Howard L. McLeod; James Cassidy; Robert H. Powrie; David G. Priest; Mark A. Zorbas; Timothy W. Synold; Stephen Shibata; Darcy Spicer; Donald Bissett; Yazdi K. Pithavala; Mary A. Collier; Linda J. Paradiso; John D. Roberts
Molecular Oncology, Markers, Clinical Correlates
p53 but not bcl-2 Immunostaining Is Predictive of Poor Clinical Complete Response to Primary Chemotherapy in Breast Cancer Patients1
Alberto Bottini; Alfredo Berruti; Alessandra Bersiga; Maria Pia Brizzi; Antonio Brunelli; Gabriella Gorzegno; Bianca DiMarco; Sergio Aguggini; Giovanna Bolsi; Fernando Cirillo; Luciano Filippini; Enrico Betri; Giovanni Bertoli; Palmiro Alquati; Luigi Dogliotti
Expression of Vascular Endothelial Growth Factor Can Predict Event-free Survival in Stage II Colon Cancer
Stefano Cascinu; Maria Pia Staccioli; Giampietro Gasparini; Paolo Giordani; Vincenzo Catalano; Roberto Ghiselli; Cristina Rossi; Anna Maria Baldelli; Francesco Graziano; Vittorio Saba; Pietro Muretto; Giuseppina Catalano
Experimental Therapeutics, Preclinical Pharmacology
Induction of Apoptosis in Human Esophageal Cancer Cells by Sequential Transfer of the Wild-Type p53 and E2F-1 Genes: Involvement of p53 Accumulation via ARF-mediated MDM2 Down-Regulation1
Takahiro Itoshima; Toshiyoshi Fujiwara; Toshihiko Waku; Jianghua Shao; Masafumi Kataoka; Wendell G. Yarbrough; Ta-Jen Liu; Jack A. Roth; Noriaki Tanaka; Masashi Kodama
Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines1
Carol A. Delaney; Lan-Z Wang; Suzanne Kyle; Alex W. White; A. Hilary Calvert; Nicola J. Curtin; Barbara W. Durkacz; Zdenek Hostomsky; David R. Newell
Augmentation of Antitumor Activity of 5-Fluorouracil by Interferon α Is Associated with Up-Regulation of p27Kip1 in Human Hepatocellular Carcinoma Cells1
Hidetoshi Eguchi; Hiroaki Nagano; Hirofumi Yamamoto; Atsushi Miyamoto; Motoi Kondo; Keizo Dono; Shoji Nakamori; Koji Umeshita; Masato Sakon; Morito Monden
Antitumor Efficacy, Pharmacokinetics, and Biodistribution of NX 211: A Low-Clearance Liposomal Formulation of Lurtotecan
David L. Emerson; Ray Bendele; Eric Brown; SuMing Chiang; John P. Desjardins; Larry C. Dihel; Stan C. Gill; Marta Hamilton; Jeremy D. LeRay; Lotus Moon-McDermott; Karen Moynihan; Frank C. Richardson; Blake Tomkinson; Michael J. Luzzio; David Baccanari
Cancer Biology, Immunology, Cytokines
Opposing Effects of Hypoxia on Expression of the Angiogenic Inhibitor Thrombospondin 1 and the Angiogenic Inducer Vascular Endothelial Growth Factor1
Keith R. Laderoute; Rodolfo M. Alarcon; Michael D. Brody; Joy M. Calaoagan; Eunice Y. Chen; A. Merrill Knapp; Zhong Yun; Nicholas C. Denko; Amato J. Giaccia
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