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Volume 6, Issue 7

1 July 2000

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Minireview
Advances in Brief
Clinical Trials
Molecular Oncology, Markers, Clinical Correlates
Experimental Therapeutics, Preclinical Pharmacology
Cancer Biology, Immunology, Cytokines

Minireview

Temozolomide and Treatment of Malignant Glioma 1

Henry S. Friedman; Tracy Kerby; Hilary Calvert

Advances in Brief

Role of Intestinal P-glycoprotein in the Plasma and Fecal Disposition of Docetaxel in Humans 1

Lia van Zuylen; Jaap Verweij; Kees Nooter; Eric Brouwer; Gerrit Stoter; Alex Sparreboom

Molecular Changes in the Bronchial Epithelium of Patients with Small Cell Lung Cancer 1

Ignacio I. Wistuba; Jarett Berry; Carmen Behrens; Anirban Maitra; Narayan Shivapurkar; Sara Milchgrub; Bruce Mackay; John D. Minna; Adi F. Gazdar

Intranodal Antitumor Immunocyte Infiltration in Node-negative Gastric Cancers

Sumiya Ishigami; Shoji Natsugoe; Shuichi Hokita; Che Xiangming; Kuniaki Aridome; Hirofumi Iwashige; Koki Tokuda; Akihiro Nakajo; Futoshi Miyazono; Takashi Aikou

Detection of Bladder Cancer Using a Novel Nuclear Matrix Protein, BLCA-4 1

Badrinath R. Konety; Thu-Suong T. Nguyen; Rajiv Dhir; Roger S. Day; Michael J. Becich; Walter M. Stadler; Robert H. Getzenberg

BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin 1

Carla Manzotti; Graziella Pratesi; Ernesto Menta; Roberto Di Domenico; Ennio Cavalletti; Heinz H. Fiebig; Lloyd R. Kelland; Nicholas Farrell; Donatella Polizzi; Rosanna Supino; Gabriella Pezzoni; Franco Zunino

Treatment of Human Metastatic Transitional Cell Carcinoma of the Bladder in a Murine Model with the Anti-Vascular Endothelial Growth Factor Receptor Monoclonal Antibody DC101 and Paclitaxel 1

Keiji Inoue; Joel W. Slaton; Darren W. Davis; Daniel J. Hicklin; David J. McConkey; Takashi Karashima; Robert Radinsky; Colin P. N. Dinney

Clinical Trials

Combination Immunotherapy of Relapsed or Refractory Low-Grade or Follicular Non-Hodgkin’s Lymphoma with Rituximab and Interferon-α-2a 1

Thomas A. Davis; David G. Maloney; Antonio J. Grillo-López; Christine A. White; Michael E. Williams; George J. Weiner; Sue Dowden; Ronald Levy

Induction of Ab3 and Ab3′ Antibody Was Associated with Long-Term Survival after Anti-G_D2 Antibody Therapy of Stage 4 Neuroblastoma 1

Nai-Kong V. Cheung; Hong-fen Guo; Glenn Heller; Irene Y. Cheung

A Dose-Escalation and Pharmacokinetic Study of Subcutaneously Administered Recombinant Human Interleukin 12 and Its Biological Effects in Japanese Patients with Advanced Malignancies

Ryuzo Ohno; Yoshiyuki Yamaguchi; Tetsuya Toge; Toshiaki Kinouchi; Toshihiko Kotake; Masahiko Shibata; Yoshio Kiyohara; Shigeo Ikeda; Iwao Fukui; Akira Gohchi; Yasuyuki Sugiyama; Shigetoyo Saji; Shouichi Hazama; Masaaki Oka; Kazunori Ohnishi; Yasuo Ohhashi; Shigeru Tsukagoshi; Tetsuo Taguchi

Phase II Trial of Paclitaxel by 96-Hour Continuous Infusion in Combination with Cisplatin for Patients with Advanced Non-Small Cell Lung Cancer

O. S. Breathnach; M. S. Georgiadis; B. S. Schuler; P. Pizzella; V. Llorens; V. Kasturi; S. M. Steinberg; K. O’Neil; C. H. Takimoto; Bruce E. Johnson

Pharmacokinetic and Pharmacodynamic Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG2034 1

Howard L. McLeod; James Cassidy; Robert H. Powrie; David G. Priest; Mark A. Zorbas; Timothy W. Synold; Stephen Shibata; Darcy Spicer; Donald Bissett; Yazdi K. Pithavala; Mary A. Collier; Linda J. Paradiso; John D. Roberts

Inter- and Intrapatient Variability in Oral Topotecan Pharmacokinetics: Implications for Body-Surface Area Dosage Regimens

Walter J. Loos; Hans Gelderblom; Alex Sparreboom; Jaap Verweij; Maja J. A. de Jonge

Bayesian Estimate of Vinorelbine Pharmacokinetic Parameters in Elderly Patients with Advanced Metastatic Cancer

Amélie Gauvin; Frédéric Pinguet; Stéphane Culine; Cécile Astre; Roberto Gomeni; Françoise Bressolle

Molecular Oncology, Markers, Clinical Correlates

High Telomerase Activity Is an Independent Prognostic Indicator of Poor Outcome in Colorectal Cancer 1

Naokuni Tatsumoto; Eiso Hiyama; Yoshiaki Murakami; Yuji Imamura; Jerry W. Shay; Yuichiro Matsuura; Takashi Yokoyama

Serum Interleukin 6 as a Prognostic Factor in Patients with Prostate Cancer 1

Jun Nakashima; Masaaki Tachibana; Yutaka Horiguchi; Mototsugu Oya; Takashi Ohigashi; Hirotaka Asakura; Masaru Murai

Thymidylate Synthase Expression Correlates Closely with E2F1 Expression in Colon Cancer 1

Mitsuko Kasahara; Yasuo Takahashi; Toshihito Nagata; Satoshi Asai; Teruo Eguchi; Yukimoto Ishii; Masashi Fujii; Koichi Ishikawa

Differences in 20q13.2 Copy Number between Colorectal Cancers with and without Liver Metastasis

Shigekazu Hidaka; Toru Yasutake; Hiroaki Takeshita; Masamichi Kondo; Takashi Tsuji; Atsushi Nanashima; Terumitu Sawai; Hiroyuki Yamaguchi; Tohru Nakagoe; Hiroyoshi Ayabe; Yutaka Tagawa

Detection of Minimal Residual Cancer to Investigate Why Oral Tumors Recur Despite Seemingly Adequate Treatment

Max Partridge; Shu-Rui Li; Stelios Pateromichelakis; Rebecca Francis; E. Phillips; Xiao Hong Huang; Fis Tesfa-Selase; John D. Langdon

Differential Expression of Matrix Metalloproteinase (MMP)-2, MMP-9, and Membrane Type 1-MMP in Hepatocellular and Pancreatic Adenocarcinoma: Implications for Tumor Progression and Clinical Prognosis 1

Marko Määttä; Ylermi Soini; Annikki Liakka; Helena Autio-Harmainen

Regulation of Disease-Progression Genes in Human Gastric Carcinoma Cells by Interleukin 8 1

Yasuhiko Kitadai; Ken Haruma; Naofumi Mukaida; Yasukazu Ohmoto; Norimasa Matsutani; Wataru Yasui; Shigeru Yamamoto; Koji Sumii; Goro Kajiyama; Isaiah J. Fidler; Eiichi Tahara

Analytical Variables of Reverse Transcription-Polymerase Chain Reaction-based Detection of Disseminated Prostate Cancer Cells 1

Alfred Zippelius; Ralf Lutterbüse; Gert Riethmüller; Klaus Pantel

p53 but not bcl-2 Immunostaining Is Predictive of Poor Clinical Complete Response to Primary Chemotherapy in Breast Cancer Patients 1

Alberto Bottini; Alfredo Berruti; Alessandra Bersiga; Maria Pia Brizzi; Antonio Brunelli; Gabriella Gorzegno; Bianca DiMarco; Sergio Aguggini; Giovanna Bolsi; Fernando Cirillo; Luciano Filippini; Enrico Betri; Giovanni Bertoli; Palmiro Alquati; Luigi Dogliotti

Mutations of the INI1 Rhabdoid Tumor Suppressor Gene in Medulloblastomas and Primitive Neuroectodermal Tumors of the Central Nervous System 1

Jaclyn A. Biegel; Benjamin Fogelgren; Jun-Ying Zhou; C. David James; Anna J. Janss; Jeffrey C. Allen; David Zagzag; Corey Raffel; Lucy B. Rorke

Expression of Gonadotropin and Activin Receptor Messenger Ribonucleic Acid in Human Ovarian Epithelial Neoplasms 1

Takashi Minegishi; Takashi Kameda; Takashi Hirakawa; Kazuko Abe; Mari Tano; Yoshito Ibuki

Comparison of Telomerase Activity in Bladder Carcinoma and Exfoliated Cells Collected in Urine and Bladder Washings, Using a Quantitative Assay

Stefania Gelmini; Alfonso Crisci; Benedetta Salvadori; Mario Pazzagli; Cesare Selli; Claudio Orlando

INK4a Gene Expression and Methylation in Primary Breast Cancer: Overexpression of p16^INK4a Messenger RNA Is a Marker of Poor Prognosis 1

Rina Hui; R. Douglas Macmillan; Frances S. Kenny; Elizabeth A. Musgrove; Roger W. Blamey; Robert I. Nicholson; John F. R. Robertson; Robert L. Sutherland

Monoclonality of Multifocal Myxoid Liposarcoma: Confirmation by Analysis of TLS-CHOP or EWS-CHOP Rearrangements

Cristina R. Antonescu; Abul Elahi; John H. Healey; Murray F. Brennan; Man Yee Lui; Jonathan Lewis; Suresh C. Jhanwar; James M. Woodruff; Marc Ladanyi

Human Leukocyte Antigen Class I Allelic and Haplotype Loss in Squamous Cell Carcinoma of the Head and Neck: Clinical and Immunogenetic Consequences

Jennifer Rubin Grandis; Dewayne M. Falkner; Mona F. Melhem; William E. Gooding; Stephanie D. Drenning; Penelope A. Morel

Expression of Vascular Endothelial Growth Factor Can Predict Event-free Survival in Stage II Colon Cancer

Stefano Cascinu; Maria Pia Staccioli; Giampietro Gasparini; Paolo Giordani; Vincenzo Catalano; Roberto Ghiselli; Cristina Rossi; Anna Maria Baldelli; Francesco Graziano; Vittorio Saba; Pietro Muretto; Giuseppina Catalano

Expression of the Hypoxically Regulated Angiogenic Factor Adrenomedullin Correlates with Uterine Leiomyoma Vascular Density 1

Stephen Hague; Lyna Zhang; Martin K. Oehler; Sanjiv Manek; Ian Z. MacKenzie; Roy Bicknell; Margaret C. P. Rees

Relationship between Chromosomal Instability and Intratumoral Regional DNA Ploidy Heterogeneity in Primary Gastric Cancers 1

Tomoko Furuya; Tetsuji Uchiyama; Takuo Murakami; Atsushi Adachi; Shigeto Kawauchi; Atsunori Oga; Takashi Hirano; Kohsuke Sasaki

Expression of Vascular Endothelial Growth Factor and Microvessel Density in Head and Neck Tumorigenesis 1

Kyung Tae; Adel K. El-Naggar; Enise Yoo; Lei Feng; J. Jack Lee; Waun Ki Hong; Walter N. Hittelman; Dong M. Shin

Experimental Therapeutics, Preclinical Pharmacology

Tumor Irradiation Enhances the Tumor-specific Distribution of Poly(l-glutamic acid)-conjugated Paclitaxel and Its Antitumor Efficacy 1

Chun Li; Shi Ke; Qing-Ping Wu; Wayne Tansey; Nancy Hunter; Lara M. Buchmiller; Luka Milas; Chusilp Charnsangavej; Sidney Wallace

Immunotoxins with Increased Activity against Epidermal Growth Factor Receptor vIII-expressing Cells Produced by Antibody Phage Display

Richard Beers; Partha Chowdhury; Darell Bigner; Ira Pastan

Delayed Micromolar Elevation in Intracellular Calcium Precedes Induction of Apoptosis in Thapsigargin-treated Breast Cancer Cells 1

Christian Jackisch; Hillary A. Hahm; Bertrand Tombal; Diane McCloskey; Kimberly Butash; Nancy E. Davidson; Samuel R. Denmeade

Induction of Apoptosis in Human Esophageal Cancer Cells by Sequential Transfer of the Wild-Type p53 and E2F-1 Genes: Involvement of p53 Accumulation via ARF-mediated MDM2 Down-Regulation 1

Takahiro Itoshima; Toshiyoshi Fujiwara; Toshihiko Waku; Jianghua Shao; Masafumi Kataoka; Wendell G. Yarbrough; Ta-Jen Liu; Jack A. Roth; Noriaki Tanaka; Masashi Kodama

Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines 1

Carol A. Delaney; Lan-Z Wang; Suzanne Kyle; Alex W. White; A. Hilary Calvert; Nicola J. Curtin; Barbara W. Durkacz; Zdenek Hostomsky; David R. Newell

Demethylating Reagent 5-Azacytidine Inhibits Telomerase Activity in Human Prostate Cancer Cells through Transcriptional Repression of hTERT

Yasuhide Kitagawa; Satoru Kyo; Masahiro Takakura; Taro Kanaya; Kiyoshi Koshida; Mikio Namiki; Masaki Inoue

9-Nitrocamptothecin Liposome Aerosol Treatment of Melanoma and Osteosarcoma Lung Metastases in Mice 1

Nadezhda V. Koshkina; Eugenie S. Kleinerman; Clifford Waldrep; Shu-Fang Jia; Laura L. Worth; Brian E. Gilbert; Vernon Knight

Augmentation of Antitumor Activity of 5-Fluorouracil by Interferon α Is Associated with Up-Regulation of p27^Kip1 in Human Hepatocellular Carcinoma Cells 1

Hidetoshi Eguchi; Hiroaki Nagano; Hirofumi Yamamoto; Atsushi Miyamoto; Motoi Kondo; Keizo Dono; Shoji Nakamori; Koji Umeshita; Masato Sakon; Morito Monden

Molecular and Pharmacokinetic Properties Associated with the Therapeutics of Bcl-2 Antisense Oligonucleotide G3139 Combined with Free and Liposomal Doxorubicin 1

Daniel E. Lopes de Menezes; Norma Hudon; Natashia McIntosh; Lawrence D. Mayer

Antitumor Efficacy, Pharmacokinetics, and Biodistribution of NX 211: A Low-Clearance Liposomal Formulation of Lurtotecan

David L. Emerson; Ray Bendele; Eric Brown; SuMing Chiang; John P. Desjardins; Larry C. Dihel; Stan C. Gill; Marta Hamilton; Jeremy D. LeRay; Lotus Moon-McDermott; Karen Moynihan; Frank C. Richardson; Blake Tomkinson; Michael J. Luzzio; David Baccanari

Effectiveness of Combined Interleukin 2 and B7.1 Vaccination Strategy Is Dependent on the Sequence and Order: A Liposome-mediated Gene Therapy Treatment for Bladder Cancer 1

William A. Larchian; Yutaka Horiguchi; Smita K. Nair; William R. Fair; Warren D. W. Heston; Eli Gilboa

A Polyphenolic Fraction from Grape Seeds Causes Irreversible Growth Inhibition of Breast Carcinoma MDA-MB468 Cells by Inhibiting Mitogen-activated Protein Kinases Activation and Inducing G₁ Arrest and Differentiation 1

Chapla Agarwal; Yogesh Sharma; Jifu Zhao; Rajesh Agarwal

Effects of SU101 in Combination with Cytotoxic Agents on the Growth of Subcutaneous Tumor Xenografts

Laurie M. Strawn; Fairooz Kabbinavar; Donna P. Schwartz; Elaina Mann; Laura K. Shawver; Dennis J. Slamon; Julie M. Cherrington

Cancer Biology, Immunology, Cytokines

Opposing Effects of Hypoxia on Expression of the Angiogenic Inhibitor Thrombospondin 1 and the Angiogenic Inducer Vascular Endothelial Growth Factor 1

Keith R. Laderoute; Rodolfo M. Alarcon; Michael D. Brody; Joy M. Calaoagan; Eunice Y. Chen; A. Merrill Knapp; Zhong Yun; Nicholas C. Denko; Amato J. Giaccia

Changes in E2F Binding after Phenylbutyrate-induced Differentiation of Caco-2 Colon Cancer Cells 1

Qing Mei Wang; Rena Feinman; Fatah Kashanchi; Jean Marie Houghton; George P. Studzinski; Lawrence E. Harrison

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