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Editorial

Molecular Imaging in Oncology: The Diagnostic Imaging “Revolution”

Steven M. Larson

Extract

View articletitled, Molecular Imaging in Oncology: The Diagnostic Imaging “Revolution”

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Are We Ready to Use Surrogate End Points and Surrogate Tissues to Evaluate Response to Chemopreventive and Therapeutic Intervention?

Reuben Lotan

Extract

View articletitled, Are We Ready to Use Surrogate End Points and Surrogate Tissues to Evaluate Response to Chemopreventive and Therapeutic Intervention?

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Review

Detection of Mutated KRAS2 Sequences as Tumor Markers in Plasma/Serum of Patients with Gastrointestinal Cancer

George D. Sorenson

Abstract

View articletitled, Detection of Mutated KRAS2 Sequences as Tumor Markers in Plasma/Serum of Patients with Gastrointestinal Cancer

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Gain-of-Function Mutations in the Tumor Suppressor Gene p53

Monique G. C. T. van Oijen; Pieter J. Slootweg

Abstract

View articletitled, Gain-of-Function Mutations in the Tumor Suppressor Gene p53

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Advances in Brief

Rapid in Vivo Monitoring of Chemotherapeutic Response Using Weighted Sodium Magnetic Resonance Imaging 1

Richard P. Kline; Ed X. Wu; Daniel P. Petrylak; Matthias Szabolcs; Philip O. Alderson; Myron L. Weisfeldt; Paul Cannon; Jose Katz

Abstract

View articletitled, Rapid in Vivo Monitoring of Chemotherapeutic Response Using Weighted Sodium Magnetic Resonance Imaging<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Intratumoral Administration of Recombinant Circularly Permuted Interleukin-4-Pseudomonas Exotoxin in Patients with High-Grade Glioma 1

Robert W. Rand; Robert J. Kreitman; Nicholas Patronas; Frederick Varricchio; Ira Pastan; Raj K. Puri

Abstract

View articletitled, Intratumoral Administration of Recombinant Circularly Permuted Interleukin-4-Pseudomonas Exotoxin in Patients with High-Grade Glioma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Modulation of Radiation Response after Epidermal Growth Factor Receptor Blockade in Squamous Cell Carcinomas: Inhibition of Damage Repair, Cell Cycle Kinetics, and Tumor Angiogenesis 1

Shyh-Min Huang; Paul M. Harari

Abstract

View articletitled, Modulation of Radiation Response after Epidermal Growth Factor Receptor Blockade in Squamous Cell Carcinomas: Inhibition of Damage Repair, Cell Cycle Kinetics, and Tumor Angiogenesis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Priming Tissue-specific Cellular Immunity in a Phase I Trial of Autologous Dendritic Cells for Prostate Cancer 1

Patrick A. Burch; Jami K. Breen; Jan C. Buckner; Dennis A. Gastineau; Judith A. Kaur; Reiner L. Laus; Douglas J. Padley; Madhusudan V. Peshwa; Henry C. Pitot; Ronald L. Richardson; Bouwien J. Smits; Pitsata Sopapan; George Strang; Frank H. Valone; Stanimir Vuk-Pavlović

Abstract

View articletitled, Priming Tissue-specific Cellular Immunity in a Phase I Trial of Autologous Dendritic Cells for Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Quantitative Analysis of Circulating Tumor Cells in Peripheral Blood of Osteosarcoma Patients Using Osteoblast-specific Messenger RNA Markers: A Pilot Study 1

Ivy H. N. Wong; Andrew T. Chan; Philip J. Johnson

Abstract

View articletitled, Quantitative Analysis of Circulating Tumor Cells in Peripheral Blood of Osteosarcoma Patients Using Osteoblast-specific Messenger RNA Markers: A Pilot Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

High Microvascular Blood Volume Is Associated with High Glucose Uptake and Tumor Angiogenesis in Human Gliomas 1

Hannu J. Aronen; Francisco S. Pardo; David N. Kennedy; John W. Belliveau; Scott D. Packard; Dora W. Hsu; Frederick H. Hochberg; Alan J. Fischman; Bruce R. Rosen

Abstract

View articletitled, High Microvascular Blood Volume Is Associated with High Glucose Uptake and Tumor Angiogenesis in Human Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase II Pilot Trial of Concurrent Biochemotherapy with Cisplatin, Vinblastine, Dacarbazine, Interleukin 2, and Interferon α-2B in Patients with Metastatic Melanoma 1

David F. McDermott; James W. Mier; Donald P. Lawrence; Marcel R. M. van den Brink; Marquerite A. Clancy; Krista M. Rubin; Michael B. Atkins

Abstract

View articletitled, A Phase II Pilot Trial of Concurrent Biochemotherapy with Cisplatin, Vinblastine, Dacarbazine, Interleukin 2, and Interferon α-2B in Patients with Metastatic Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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T Cell Adoptive Immunotherapy of Newly Diagnosed Gliomas 1

Gregory E. Plautz; David W. Miller; Gene H. Barnett; Glen H. J. Stevens; Scott Maffett; Julian Kim; Peter A. Cohen; Suyu Shu

Abstract

View articletitled, T Cell Adoptive Immunotherapy of Newly Diagnosed Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pilot Study of a Dual Gene Recombinant Avipox Vaccine Containing Both Carcinoembryonic Antigen (CEA) and B7.1 Transgenes in Patients with Recurrent CEA-expressing Adenocarcinomas 1

Margaret von Mehren; Philip Arlen; Kwong Y. Tsang; André Rogatko; Neal Meropol; Harry S. Cooper; Monica Davey; Susan McLaughlin; Jeffrey Schlom; Louis M. Weiner

Abstract

View articletitled, Pilot Study of a Dual Gene Recombinant Avipox Vaccine Containing Both Carcinoembryonic Antigen (CEA) and B7.1 Transgenes in Patients with Recurrent CEA-expressing Adenocarcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Effects of Neoadjuvant Anastrozole (Arimidex) on Tumor Volume in Postmenopausal Women with Breast Cancer: A Randomized, Double-Blind, Single-Center Study 1

J. Michael Dixon; Lorna Renshaw; Chris Bellamy; Mary Stuart; Guido Hoctin-Boes; William R. Miller

Abstract

View articletitled, The Effects of Neoadjuvant Anastrozole (Arimidex) on Tumor Volume in Postmenopausal Women with Breast Cancer: A Randomized, Double-Blind, Single-Center Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Dose-finding and Pharmacokinetic Trial of Irinotecan Hydrochloride (CPT-11) Using a Once-Every-Three-Week Dosing Schedule for Patients with Advanced Solid Tumor Malignancy 1

Henry C. Pitot; Richard M. Goldberg; Joel M. Reid; Jeff A. Sloan; Pam Atherton Skaff; Charles Erlichman; Joseph Rubin; Patrick A. Burch; Alex A. Adjei; Steven A. Alberts; Larry J. Schaaf; Gary Elfring; Langdon L. Miller

Abstract

View articletitled, Phase I Dose-finding and Pharmacokinetic Trial of Irinotecan Hydrochloride (CPT-11) Using a Once-Every-Three-Week Dosing Schedule for Patients with Advanced Solid Tumor Malignancy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Determination of Intermediate Biomarker Expression Levels by Quantitative Reverse Transcription-Polymerase Chain Reaction in Oral Mucosa of Cancer Patients Treated with Liarozole 1

Qing Zeng; David C. Smith; Todd J. Suscovich; William E. Gooding; Donald L. Trump; Jennifer Rubin Grandis

Abstract

View articletitled, Determination of Intermediate Biomarker Expression Levels by Quantitative Reverse Transcription-Polymerase Chain Reaction in Oral Mucosa of Cancer Patients Treated with Liarozole<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Imaging of Soft-Tissue Tumors Using l-3-[Iodine-123]Iodo-α-methyl-tyrosine Single Photon Emission Computed Tomography: Comparison with Proliferative and Mitotic Activity, Cellularity, and Vascularity 1

Pieter L. Jager; Boudewijn E. C. Plaat; Elisabeth G. E. de Vries; Willemina M. Molenaar; Willem Vaalburg; D. Albertus Piers; Harald J. Hoekstra

Abstract

View articletitled, Imaging of Soft-Tissue Tumors Using l-3-[Iodine-123]Iodo-α-methyl-tyrosine Single Photon Emission Computed Tomography: Comparison with Proliferative and Mitotic Activity, Cellularity, and Vascularity<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antiproliferative Effects of Idoxifene in a Placebo-controlled Trial in Primary Human Breast Cancer

Mitch Dowsett; J. Michael Dixon; Kieran Horgan; Janine Salter; Margaret Hills; Eileen Harvey

Abstract

View articletitled, Antiproliferative Effects of Idoxifene in a Placebo-controlled Trial in Primary Human Breast Cancer

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Clinical and Biological Effects of Intraperitoneal Injections of Recombinant Interferon-γ and Recombinant Interleukin 2 with or without Tumor-infiltrating Lymphocytes in Patients with Ovarian or Peritoneal Carcinoma 1

Ralph S. Freedman; Andrzej P. Kudelka; John J. Kavanagh; Claire Verschraegen; Creighton L. Edwards; Micheal Nash; Lawrence Levy; Edward N. Atkinson; Hua-Zhong Zhang; Bohuslav Melichar; Rebecca Patenia; Stacie Templin; Wanza Scott; Chris D. Platsoucas

Abstract

View articletitled, Clinical and Biological Effects of Intraperitoneal Injections of Recombinant Interferon-γ and Recombinant Interleukin 2 with or without Tumor-infiltrating Lymphocytes in Patients with Ovarian or Peritoneal Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Dose-finding and Pharmacologic Study of Chronic Oral Idarubicin Therapy in Metastatic Breast Cancer Patients 1

Giuseppe Toffoli; Roberto Sorio; Paola Aita; Diana Crivellari; Giuseppe Corona; Alessandra Bearz; Isabel Robieux; Anna Maria Colussi; Franco Stocco; Mauro Boiocchi

Abstract

View articletitled, Dose-finding and Pharmacologic Study of Chronic Oral Idarubicin Therapy in Metastatic Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Trial of Oral 2′-Deoxy-2′-methylidenecytidine: On a Daily × 14-day Schedule 1

Noriyuki Masuda; Kaoru Matsui; Nobuyuki Yamamoto; Toshiji Nogami; Kazuhiko Nakagawa; Shunichi Negoro; Kouji Takeda; Nobuhide Takifuji; Masaji Yamada; Shinzoh Kudoh; Teruyoshi Okuda; Shinjiroh Nemoto; Kanako Ogawa; Hiroshi Myobudani; Shinichi Nihira; Masahiro Fukuoka

Abstract

View articletitled, Phase I Trial of Oral 2′-Deoxy-2′-methylidenecytidine: On a Daily × 14-day Schedule<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Relative Expression of Type IV Collagenase, E-cadherin, and Vascular Endothelial Growth Factor/Vascular Permeability Factor in Prostatectomy Specimens Distinguishes Organ-confined from Pathologically Advanced Prostate Cancers 1

Hiroki Kuniyasu; Patricia Troncoso; Dennis Johnston; Corazon D. Bucana; Eiichi Tahara; Isaiah J. Fidler; Curtis A. Pettaway

Abstract

View articletitled, Relative Expression of Type IV Collagenase, E-cadherin, and Vascular Endothelial Growth Factor/Vascular Permeability Factor in Prostatectomy Specimens Distinguishes Organ-confined from Pathologically Advanced Prostate Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Extracellular Catalytic Subunit Activity of the cAMP-dependent Protein Kinase in Prostate Cancer 1

Mary Ellen Cvijic; Tsunekazu Kita; Weichung Shih; Robert S. DiPaola; Khew-Voon Chin

Abstract

View articletitled, Extracellular Catalytic Subunit Activity of the cAMP-dependent Protein Kinase in Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Comparison of Potential Markers of Farnesyltransferase Inhibition 1

Alex A. Adjei; Jenny N. Davis; Charles Erlichman; Phyllis A. Svingen; Scott H. Kaufmann

Abstract

View articletitled, Comparison of Potential Markers of Farnesyltransferase Inhibition<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Genetic Detection for Micrometastasis in Lymph Node of Biliary Tract Carcinoma 1

Jiro Okami; Keizo Dohno; Masato Sakon; Kyoko Iwao; Terumasa Yamada; Hirofumi Yamamoto; Yoshiyuki Fujiwara; Hiroaki Nagano; Koji Umeshita; Nariaki Matsuura; Shoji Nakamori; Morito Monden

Abstract

View articletitled, Genetic Detection for Micrometastasis in Lymph Node of Biliary Tract Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enhanced Urinary Gelatinase Activities (Matrix Metalloproteinases 2 and 9) Are Associated with Early-Stage Bladder Carcinoma: A Comparison with Clinically Used Tumor Markers 1

Cornelis F. M. Sier; Giovanni Casetta; Jan H. Verheijen; Alessandro Tizzani; Vittorio Agape; Janko Kos; Francesco Blasi; Roeland Hanemaaijer

Abstract

View articletitled, Enhanced Urinary Gelatinase Activities (Matrix Metalloproteinases 2 and 9) Are Associated with Early-Stage Bladder Carcinoma: A Comparison with Clinically Used Tumor Markers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinicopathological Significance of Fragile Histidine Triad Transcription Protein Expression in Endometrial Carcinomas 1

Tomoya Segawa; Toshiyuki Sasagawa; Kiyofumi Saijoh; Masaki Inoue

Abstract

View articletitled, Clinicopathological Significance of Fragile Histidine Triad Transcription Protein Expression in Endometrial Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Matrix Metalloproteinase 9 and the Epidermal Growth Factor Signal Pathway in Operable Non-Small Cell Lung Cancer 1

Giles Cox; J. Louise Jones; Kenneth J. O’Byrne

Abstract

View articletitled, Matrix Metalloproteinase 9 and the Epidermal Growth Factor Signal Pathway in Operable Non-Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Circulating HER2 Extracellular Domain and Resistance to Chemotherapy in Advanced Breast Cancer 1

Ramon Colomer; Sagrario Montero; Ana Lluch; Belén Ojeda; Agustí Barnadas; Antonio Casado; Bartomeu Massutí; Hernán Cortés-Funes; Belén Lloveras

Abstract

View articletitled, Circulating HER2 Extracellular Domain and Resistance to Chemotherapy in Advanced Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Presence of Soluble c-erbB-2 in Saliva and Serum among Women with Breast Carcinoma: A Preliminary Study 1

Charles Streckfus; Lenora Bigler; Tracy Dellinger; Xaoli Dai; Albert Kingman; J. Tate Thigpen

Abstract

View articletitled, The Presence of Soluble c-erbB-2 in Saliva and Serum among Women with Breast Carcinoma: A Preliminary Study<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of BAX in Plasma Cell Dyscrasias 1

Stephen Renner; Jeffrey Weisz; Stanislaw Krajewski; Maryla Krajewska; John C. Reed; Alan Lichtenstein

Abstract

View articletitled, Expression of BAX in Plasma Cell Dyscrasias<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Noninvasive Diagnosis of Bladder Carcinoma by Enzyme-linked Immunosorbent Assay Detection of CD44 Isoforms in Exfoliated Urothelia

Anthony C. Woodman; Steve Goodison; Marcus Drake; Jeremy Noble; David Tarin

Abstract

View articletitled, Noninvasive Diagnosis of Bladder Carcinoma by Enzyme-linked Immunosorbent Assay Detection of CD44 Isoforms in Exfoliated Urothelia

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Detection by Denaturant Gradient Gel Electrophoresis of Tumor-specific Mutations in Biopsies and Relative Bronchoalveolar Lavage Fluid from Resectable Non-Small Cell Lung Cancer

Gianluigi Ferretti; Giuseppe Curigliano; Ugo Pastorino; Achille Cittadini; Giovanna Flamini; Maria Grazia Calabrò; Tommaso De Pas; Laura Orlando; Mario Mandalà; Marco Colleoni; Lorenzo Spaggiari; Pier Luigi Granone; Gabriella Pagliari; Filippo de Braud; Nicola Fazio; Aron Goldhirsch

Abstract

View articletitled, Detection by Denaturant Gradient Gel Electrophoresis of Tumor-specific Mutations in Biopsies and Relative Bronchoalveolar Lavage Fluid from Resectable Non-Small Cell Lung Cancer

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Increased Expression of an ATP-binding Cassette Superfamily Transporter, Multidrug Resistance Protein 2, in Human Colorectal Carcinomas 1

Eiji Hinoshita; Takeshi Uchiumi; Ken-ichi Taguchi; Naoko Kinukawa; Masazumi Tsuneyoshi; Yoshihiko Maehara; Keizo Sugimachi; Michihiko Kuwano

Abstract

View articletitled, Increased Expression of an ATP-binding Cassette Superfamily Transporter, Multidrug Resistance Protein 2, in Human Colorectal Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Inducible Nitric Oxide Synthase Expression, Apoptosis, and Angiogenesis in in Situ and Invasive Breast Carcinomas 1

Merja Vakkala; Katriina Kahlos; Essi Lakari; Paavo Pääkkö; Vuokko Kinnula; Ylermi Soini

Abstract

View articletitled, Inducible Nitric Oxide Synthase Expression, Apoptosis, and Angiogenesis in in Situ and Invasive Breast Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunohistochemical Analyses of Focal Adhesion Kinase Expression in Benign and Malignant Human Breast and Colon Tissues: Correlation with Preinvasive and Invasive Phenotypes 1

William G. Cance; Janet E. Harris; Mary V. Iacocca; Elizabeth Roche; XiHui Yang; Jinli Chang; Stephen Simkins; LiHui Xu

Abstract

View articletitled, Immunohistochemical Analyses of Focal Adhesion Kinase Expression in Benign and Malignant Human Breast and Colon Tissues: Correlation with Preinvasive and Invasive Phenotypes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cyclooxygenase-2 Expression Is Up-Regulated in Transitional Cell Carcinoma and Its Preneoplastic Lesions in the Human Urinary Bladder 1

Tsutomu Shirahama

Abstract

View articletitled, Cyclooxygenase-2 Expression Is Up-Regulated in Transitional Cell Carcinoma and Its Preneoplastic Lesions in the Human Urinary Bladder<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of Vascular Endothelial Growth Factors A, B, C, and D and Their Relationships to Lymph Node Status in Lung Adenocarcinoma 1

Toshiro Niki; Sanae Iba; Masahide Tokunou; Tesshi Yamada; Yoshihiro Matsuno; Setsuo Hirohashi

Abstract

View articletitled, Expression of Vascular Endothelial Growth Factors A, B, C, and D and Their Relationships to Lymph Node Status in Lung Adenocarcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Association between Polymorphism in p21^Waf1/Cip1 Cyclin-dependent Kinase Inhibitor Gene and Human Oral Cancer 1

Ranju Ralhan; Sandhya Agarwal; Meera Mathur; Bohdan Wasylyk; Anurag Srivastava

Abstract

View articletitled, Association between Polymorphism in p21Waf1/Cip1 Cyclin-dependent Kinase Inhibitor Gene and Human Oral Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Production and Pro-Apoptotic Activity of Soluble CD95 Ligand in Pancreatic Carcinoma 1

Graziella Bellone; Carlo Smirne; Anna Carbone; Katia Mareschi; Luca Dughera; Enzo C. Farina; Oscar Alabiso; Guido Valente; Giorgio Emanuelli; Ulrich Rodeck

Abstract

View articletitled, Production and Pro-Apoptotic Activity of Soluble CD95 Ligand in Pancreatic Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Calpain Inhibitor II Induces Caspase-dependent Apoptosis in Human Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma Cells as Well as Some Solid Tumor Cells

De-Min Zhu; Fatih M. Uckun

Abstract

View articletitled, Calpain Inhibitor II Induces Caspase-dependent Apoptosis in Human Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma Cells as Well as Some Solid Tumor Cells

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Antimetastatic Intraoperative Chemotherapy of Human Colon Tumors in the Livers of Nude Mice

Babak Rashidi; Zili An; Fang-Xian Sun; A. R. Moossa; Robert M. Hoffman

Abstract

View articletitled, Antimetastatic Intraoperative Chemotherapy of Human Colon Tumors in the Livers of Nude Mice

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Successful Treatment of Intracranial Gliomas in Rat by Oligodeoxynucleotides Containing CpG Motifs 1

Antoine F. Carpentier; Jun Xie; Karima Mokhtari; Jean-Yves Delattre

Abstract

View articletitled, Successful Treatment of Intracranial Gliomas in Rat by Oligodeoxynucleotides Containing CpG Motifs<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cytotoxic Chemotherapy Regimens That Increase Dose per Cycle (Dose Intensity) by Extending Daily Dosing from 5 Consecutive Days to 28 Consecutive Days and Beyond 1

Kristan A. Keyes; Beatriz Albella; Patricia M. LoRusso; Juan A. Bueren; Ralph E. Parchment

Abstract

View articletitled, Cytotoxic Chemotherapy Regimens That Increase Dose per Cycle (Dose Intensity) by Extending Daily Dosing from 5 Consecutive Days to 28 Consecutive Days and Beyond<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Constitutive and Lysophosphatidic Acid (LPA)-induced LPA Production: Role of Phospholipase D and Phospholipase A₂ 1

Astrid M. Eder; Takayo Sasagawa; Muling Mao; Junken Aoki; Gordon B. Mills

Abstract

View articletitled, Constitutive and Lysophosphatidic Acid (LPA)-induced LPA Production: Role of Phospholipase D and Phospholipase A2<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Eradication of Human Non-Hodgkin’s Lymphoma in SCID Mice by BCL-2 Antisense Oligonucleotides Combined with Low-Dose Cyclophosphamide 1

Richard J. Klasa; Marcel B. Bally; Rebecca Ng; James H. Goldie; Randy D. Gascoyne; Frances M. P. Wong

Abstract

View articletitled, Eradication of Human Non-Hodgkin’s Lymphoma in SCID Mice by BCL-2 Antisense Oligonucleotides Combined with Low-Dose Cyclophosphamide<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Relationship between Intracellular and Extracellular pH in Spontaneous Canine Tumors 1

Deborah M. Prescott; H. Cecil Charles; Jean M. Poulson; Rodney L. Page; Donald E. Thrall; Zeljko Vujaskovic; Mark W. Dewhirst

Abstract

View articletitled, The Relationship between Intracellular and Extracellular pH in Spontaneous Canine Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Oral Antisense that Targets Protein Kinase A Cooperates with Taxol and Inhibits Tumor Growth, Angiogenesis, and Growth Factor Production 1

Giampaolo Tortora; Roberto Bianco; Vincenzo Damiano; Gabriella Fontanini; Sabino De Placido; A. Raffaele Bianco; Fortunato Ciardiello

Abstract

View articletitled, Oral Antisense that Targets Protein Kinase A Cooperates with Taxol and Inhibits Tumor Growth, Angiogenesis, and Growth Factor Production<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enhancement of Intrinsic Tumor Cell Radiosensitivity Induced by a Selective Cyclooxygenase-2 Inhibitor

Cordula Petersen; Sven Petersen; Luka Milas; Frederick F. Lang; Philip J. Tofilon

Abstract

View articletitled, Enhancement of Intrinsic Tumor Cell Radiosensitivity Induced by a Selective Cyclooxygenase-2 Inhibitor

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Purging of Epithelial Tumor Cells from Peripheral Blood Stem Cells by Means of the Bispecific Antibody BIS-1 1

Carolien P. Schröder; Bart-Jan Kroesen; Lou F. M. H. de Leij; Elisabeth G. E. de Vries

Abstract

View articletitled, Purging of Epithelial Tumor Cells from Peripheral Blood Stem Cells by Means of the Bispecific Antibody BIS-1<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pegylated Liposomes Have Potential as Vehicles for Intratumoral and Subcutaneous Drug Delivery

Kevin J. Harrington; Gail Rowlinson-Busza; Konstantinos N. Syrigos; Paul S. Uster; Richard G. Vile; J. Simon W. Stewart

Abstract

View articletitled, Pegylated Liposomes Have Potential as Vehicles for Intratumoral and Subcutaneous Drug Delivery

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Comparison of Thymidylate Synthase (TS) Protein Up-Regulation after Exposure to TS Inhibitors in Normal and Tumor Cell Lines and Tissues 1

Sarah J. Welsh; Jenny Titley; Lisa Brunton; Melanie Valenti; Paul Monaghan; Ann L. Jackman; G. Wynne Aherne

Abstract

View articletitled, Comparison of Thymidylate Synthase (TS) Protein Up-Regulation after Exposure to TS Inhibitors in Normal and Tumor Cell Lines and Tissues<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Novel Bispecific Antisense Oligonucleotide Inhibiting Both bcl-2 and bcl-xL Expression Efficiently Induces Apoptosis in Tumor Cells 1

Uwe Zangemeister-Wittke; Siân H. Leech; Robert A. Olie; A. Paula Simões-Wüst; Oliver Gautschi; Gerd H. Luedke; François Natt; Robert Häner; Pierre Martin; Jonathan Hall; Carlo M. Nalin; Rolf A. Stahel

Abstract

View articletitled, A Novel Bispecific Antisense Oligonucleotide Inhibiting Both bcl-2 and bcl-xL Expression Efficiently Induces Apoptosis in Tumor Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

An Orthotopic Mouse Model of Remetastasis of Human Colon Cancer Liver Metastasis

Babak Rashidi; Reza Gamagami; Aaron Sasson; Fang Xian Sun; Jack Geller; A. R. Moossa; Robert M. Hoffman

Abstract

View articletitled, An Orthotopic Mouse Model of Remetastasis of Human Colon Cancer Liver Metastasis

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The Relevance of Cell Proliferation, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor Production to Angiogenesis and Tumorigenicity in Human Glioma Cell Lines 1

Li Dao Ke; Yue-Xi Shi; Seock-Ah Im; Xiashan Chen; W. K. Alfred Yung

Abstract

View articletitled, The Relevance of Cell Proliferation, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor Production to Angiogenesis and Tumorigenicity in Human Glioma Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Nuclear Factor-κB Activity Correlates with Growth, Angiogenesis, and Metastasis of Human Melanoma Cells in Nude Mice 1

Suyun Huang; Ariel DeGuzman; Corazon D. Bucana; Isaiah J. Fidler

Abstract

View articletitled, Nuclear Factor-κB Activity Correlates with Growth, Angiogenesis, and Metastasis of Human Melanoma Cells in Nude Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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