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Editorial

Can Molecular Assessment Improve Classification of Head and Neck Premalignancy?

Li Mao

Extract

View articletitled, Can Molecular Assessment Improve Classification of Head and Neck Premalignancy?

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Modulation of Molecular Targets to Enhance Radiation

Paul M. Harari; Shyh-Min Huang

Extract

View articletitled, Modulation of Molecular Targets to Enhance Radiation

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Minireview

Targeted Toxins

Arthur E. Frankel; Robert J. Kreitman; Edward A. Sausville

Abstract

View articletitled, Targeted Toxins

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Advances in Brief

Molecular Determinants of Response to TRAIL in Killing of Normal and Cancer Cells 1

Kunhong Kim; Michael J. Fisher; Shi-Qiong Xu; Wafik S. El-Deiry

Abstract

View articletitled, Molecular Determinants of Response to TRAIL in Killing of Normal and Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Genetic Progression and Clonal Relationship of Recurrent Premalignant Head and Neck Lesions

Joseph Califano; William H. Westra; Glenn Meininger; Russel Corio; Wayne M. Koch; David Sidransky

Abstract

View articletitled, Genetic Progression and Clonal Relationship of Recurrent Premalignant Head and Neck Lesions

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Characterization of Intracellular Prostate-specific Antigen from Laser Capture Microdissected Benign and Malignant Prostatic Epithelium

David K. Ornstein; Chad Englert; John W. Gillespie; Cloud P. Paweletz; W. Marston Linehan; Michael R. Emmert-Buck; Emanuel F. Petricoin, III

Abstract

View articletitled, Characterization of Intracellular Prostate-specific Antigen from Laser Capture Microdissected Benign and Malignant Prostatic Epithelium

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Use of Allelic Loss to Predict Malignant Risk for Low-grade Oral Epithelial Dysplasia 1

Miriam P. Rosin; Xing Cheng; Catherine Poh; Wan L. Lam; Yongqian Huang; John Lovas; Ken Berean; Joel B. Epstein; Robert Priddy; Nhu D. Le; Lewei Zhang

Abstract

View articletitled, Use of Allelic Loss to Predict Malignant Risk for Low-grade Oral Epithelial Dysplasia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

Successful Surgical Removal of Occult Metastases of Medullary Thyroid Carcinoma Recurrences with the Help of Immunoscintigraphy and Radioimmunoguided Surgery 1

Claire de Labriolle-Vaylet; Pierre Cattan; Emile Sarfati; Michel Wioland; Claire Billotey; Claude Brochériou; Eric Rouvier; Anne de Roquancourt; William Rostène; Serge Askienazy; Jacques Barbet; Gérard Milhaud; Anne Gruaz-Guyon

Abstract

View articletitled, Successful Surgical Removal of Occult Metastases of Medullary Thyroid Carcinoma Recurrences with the Help of Immunoscintigraphy and Radioimmunoguided Surgery<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Remission Induction with Retinoic Acid and Anti-CD33 Monoclonal Antibody HuM195 in Acute Promyelocytic Leukemia 1

Joseph G. Jurcic; Tony DeBlasio; Larry Dumont; Tzy-Jyun Yao; David A. Scheinberg

Abstract

View articletitled, Molecular Remission Induction with Retinoic Acid and Anti-CD33 Monoclonal Antibody HuM195 in Acute Promyelocytic Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Angiogenesis, Thymidine Phosphorylase, and Resistance of Squamous Cell Head and Neck Cancer to Cytotoxic and Radiation Therapy 1

Michael I. Koukourakis; Alexandra Giatromanolaki; George Fountzilas; Efthimios Sivridis; Kevin C. Gatter; Adrian L. Harris

Abstract

View articletitled, Angiogenesis, Thymidine Phosphorylase, and Resistance of Squamous Cell Head and Neck Cancer to Cytotoxic and Radiation Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Clinical and Pharmacokinetic Study of Perillyl Alcohol Administered Four Times a Day 1

Gregory H. Ripple; Michael N. Gould; Rhoda Z. Arzoomanian; Dona Alberti; Chris Feierabend; Kris Simon; Kim Binger; Kendra D. Tutsch; Marcia Pomplun; Amy Wahamaki; Rebecca Marnocha; George Wilding; Howard H. Bailey

Abstract

View articletitled, Phase I Clinical and Pharmacokinetic Study of Perillyl Alcohol Administered Four Times a Day<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Study of ONO-4007, a Synthetic Analogue of the Lipid A Moiety of Bacterial Lipopolysaccharide 1

Johann Sebastian de Bono; Angus George Dalgleish; James Carmichael; Joseph Diffley; Fiona Jane Lofts; David Fyffe; Susan Ellard; Robert J. Gordon; Charles J. Brindley; Thomas Ronald Jeffrey Evans

Abstract

View articletitled, Phase I Study of ONO-4007, a Synthetic Analogue of the Lipid A Moiety of Bacterial Lipopolysaccharide<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase II Trial of Yttrium-90-DOTA-Biotin Pretargeted by NR-LU-10 Antibody/Streptavidin in Patients with Metastatic Colon Cancer 1

Susan J. Knox; Michael L. Goris; Margaret Tempero; Paul L. Weiden; Louis Gentner; Hazel Breitz; Gregory P. Adams; Donald Axworthy; Sally Gaffigan; Kyle Bryan; Darrell R. Fisher; David Colcher; Ivan D. Horak; Louis M. Weiner

Abstract

View articletitled, Phase II Trial of Yttrium-90-DOTA-Biotin Pretargeted by NR-LU-10 Antibody/Streptavidin in Patients with Metastatic Colon Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Modulation of Clinical Drug Resistance in a B Cell Lymphoma Patient by the Protein Kinase Inhibitor 7-Hydroxystaurosporine: Presentation of a Novel Therapeutic Paradigm

Wyndham H. Wilson; Lynn Sorbara; William D. Figg; Erik K. Mont; Edward Sausville; Katherine E. Warren; Frank M. Balis; Ken Bauer; Mark Raffeld; Adrian M. Senderowicz; Anne Monks

Abstract

View articletitled, Modulation of Clinical Drug Resistance in a B Cell Lymphoma Patient by the Protein Kinase Inhibitor 7-Hydroxystaurosporine: Presentation of a Novel Therapeutic Paradigm

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A Neoadjuvant Clinical Trial in Colorectal Cancer Patients of the Human Anti-Idiotypic Antibody 105AD7, Which Mimics CD55 1

Lindy G. Durrant; Charles Maxwell-Armstrong; Declan Buckley; Schwann Amin; R. Adrian Robins; James Carmichael; John H. Scholefield

Abstract

View articletitled, A Neoadjuvant Clinical Trial in Colorectal Cancer Patients of the Human Anti-Idiotypic Antibody 105AD7, Which Mimics CD55<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effect of Food on the Pharmacokinetics of Oral MMI270B (CGS 27023A), a Novel Matrix Metalloproteinase Inhibitor

Ferry A. L. M. Eskens; Nicky C. Levitt; Alex Sparreboom; Les Choi; Richard Mather; Jaap Verweij; Adrian L. Harris

Abstract

View articletitled, Effect of Food on the Pharmacokinetics of Oral MMI270B (CGS 27023A), a Novel Matrix Metalloproteinase Inhibitor

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Molecular Oncology, Markers, Clinical Correlates

Detection and Analysis of Cancer Cells in Blood and Bone Marrow Using a Rare Event Imaging System 1

Stine-Kathrein Kraeft; Rebecca Sutherland; Laura Gravelin; Guan-Hong Hu; Louis H. Ferland; Paul Richardson; Anthony Elias; Lan Bo Chen

Abstract

View articletitled, Detection and Analysis of Cancer Cells in Blood and Bone Marrow Using a Rare Event Imaging System<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Significance of Mutations to Different Structural and Functional Regions of the p53 Gene in Breast Cancer 1

Brenda Powell; Richie Soong; Barry Iacopetta; Ram Seshadri; Duncan R. Smith

Abstract

View articletitled, Prognostic Significance of Mutations to Different Structural and Functional Regions of the p53 Gene in Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Quantitation of hTERT Gene Expression in Sporadic Breast Tumors with a Real-Time Reverse Transcription-Polymerase Chain Reaction Assay 1

Ivan Bièche; Catherine Noguès; Valérie Paradis; Martine Olivi; Pierre Bedossa; Rosette Lidereau; Michel Vidaud

Abstract

View articletitled, Quantitation of hTERT Gene Expression in Sporadic Breast Tumors with a Real-Time Reverse Transcription-Polymerase Chain Reaction Assay<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Altered Expression of β-Catenin in Renal Cell Cancer and Transitional Cell Cancer with the Absence of β-catenin Gene Mutations 1

Vladimir Bilim; Takashi Kawasaki; Akiyoshi Katagiri; Shun-ji Wakatsuki; Kota Takahashi; Yoshihiko Tomita

Abstract

View articletitled, Altered Expression of β-Catenin in Renal Cell Cancer and Transitional Cell Cancer with the Absence of β-catenin Gene Mutations<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Serum Total and Free Prostate-specific Antigen for Breast Cancer Diagnosis in Women 1

Margot H. Black; Maurizia Giai; Riccardo Ponzone; Piero Sismondi; He Yu; Eleftherios P. Diamandis

Abstract

View articletitled, Serum Total and Free Prostate-specific Antigen for Breast Cancer Diagnosis in Women<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Loss of Imprinting of the IGF-II and H19 Genes in Epithelial Ovarian Cancer 1

Chun-Ling Chen; Sin-Ming Ip; Danny Cheng; Ling-Chui Wong; Hextan Y. S. Ngan

Abstract

View articletitled, Loss of Imprinting of the IGF-II and H19 Genes in Epithelial Ovarian Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Epigenetic Regulation of Gene Expression in Cervical Cancer Cells by the Tumor Microenvironment 1

Nicholas Denko; Cornelia Schindler; Albert Koong; Keith Laderoute; Christopher Green; Amato Giaccia

Abstract

View articletitled, Epigenetic Regulation of Gene Expression in Cervical Cancer Cells by the Tumor Microenvironment<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunohistochemically Detected Thymidylate Synthase in Colorectal Cancer: An Independent Prognostic Factor of Survival 1

David Edler; Ulf Kressner; Peter Ragnhammar; Patrick G. Johnston; Inger Magnusson; Bengt Glimelius; Lars Påhlman; Gudrun Lindmark; Henric Blomgren

Abstract

View articletitled, Immunohistochemically Detected Thymidylate Synthase in Colorectal Cancer: An Independent Prognostic Factor of Survival<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enhanced GBX2 Expression Stimulates Growth of Human Prostate Cancer Cells via Transcriptional Up-Regulation of the Interleukin 6 Gene 1

Allen C. Gao; Wei Lou; John T. Isaacs

Abstract

View articletitled, Enhanced GBX2 Expression Stimulates Growth of Human Prostate Cancer Cells via Transcriptional Up-Regulation of the Interleukin 6 Gene<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Vitamin D Receptor Polymorphisms Are Associated with Altered Prognosis in Patients with Malignant Melanoma 1

Peter E. Hutchinson; Joy E. Osborne; John T. Lear; Andrew G. Smith; P. William Bowers; Paul N. Morris; Peter W. Jones; Christopher York; Richard C. Strange; Anthony A. Fryer

Abstract

View articletitled, Vitamin D Receptor Polymorphisms Are Associated with Altered Prognosis in Patients with Malignant Melanoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cysteine Proteinase Inhibitors Stefin A, Stefin B, and Cystatin C in Sera from Patients with Colorectal Cancer: Relation to Prognosis 1

Janko Kos; Marta Krašovec; Nina Cimerman; Hans Jørgen Nielsen; Ib Jarle Christensen; Nils Brünner

Abstract

View articletitled, Cysteine Proteinase Inhibitors Stefin A, Stefin B, and Cystatin C in Sera from Patients with Colorectal Cancer: Relation to Prognosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression Levels of Estrogen Receptor-α, Estrogen Receptor-β, Coactivators, and Corepressors in Breast Cancer 1

Junichi Kurebayashi; Takemi Otsuki; Hironori Kunisue; Katsuhiko Tanaka; Shigeru Yamamoto; Hiroshi Sonoo

Abstract

View articletitled, Expression Levels of Estrogen Receptor-α, Estrogen Receptor-β, Coactivators, and Corepressors in Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increased Expression of Cyclooxygenase-2 Protein in Human Gastric Carcinoma

Ho Yeong Lim; Hee Jae Joo; Jin Hyuk Choi; Jong Wook Yi; Mal Sook Yang; Do Yeun Cho; Hyun Soo Kim; Dong Ki Nam; Kyi Beom Lee; Hugh Chul Kim

Abstract

View articletitled, Increased Expression of Cyclooxygenase-2 Protein in Human Gastric Carcinoma

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p53 Gene Mutations Are Associated with Shortened Survival in Patients with Advanced Non-small Cell Lung Cancer: An Analysis of Medically Managed Patients 1

Isao Murakami; Keiko Hiyama; Shinichi Ishioka; Michio Yamakido; Fumiyoshi Kasagi; Yasuyuki Yokosaki

Abstract

View articletitled, p53 Gene Mutations Are Associated with Shortened Survival in Patients with Advanced Non-small Cell Lung Cancer: An Analysis of Medically Managed Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Serum Tumor Marker CA 125 Is an Early and Sensitive Indicator of Veno-Occlusive Disease in Children Undergoing Bone Marrow Transplantation 1

Jari Petäjä; Sari Pitkänen; Kim Vettenranta; Anders Fasth; Markku Heikinheimo

Abstract

View articletitled, Serum Tumor Marker CA 125 Is an Early and Sensitive Indicator of Veno-Occlusive Disease in Children Undergoing Bone Marrow Transplantation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Mutational Analysis of the Transforming Growth Factor β Receptor Type II Gene in Hereditary Nonpolyposis Colorectal Cancer and Early-onset Colorectal Cancer Patients 1

Ki-Hyuk Shin; Young Jin Park; Jae-Gahb Park

Abstract

View articletitled, Mutational Analysis of the Transforming Growth Factor β Receptor Type II Gene in Hereditary Nonpolyposis Colorectal Cancer and Early-onset Colorectal Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Topological Analysis of p21^WAF1/CIP1 Expression in Esophageal Squamous Dysplasia

Yasuhiro Shirakawa; Yoshio Naomoto; Masashi Kimura; Ryuichi Kawashima; Tomoki Yamatsuji; Takahiko Tamaki; Madoka Hamada; Minoru Haisa; Noriaki Tanaka

Abstract

View articletitled, Topological Analysis of p21WAF1/CIP1 Expression in Esophageal Squamous Dysplasia

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Expression of Protein Gene Product 9.5 and Tyrosine Hydroxylase in Childhood Small Round Cell Tumors 1

Yinglin Wang; Peggy Einhorn; Timothy J. Triche; Robert C. Seeger; C. Patrick Reynolds

Abstract

View articletitled, Expression of Protein Gene Product 9.5 and Tyrosine Hydroxylase in Childhood Small Round Cell Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Implication of Microsatellite Alteration Profiles in Early-Stage Non-small Cell Lung Cancer 1

Xiao Zhou; Bonnie L. Kemp; Fadlo R. Khuri; Diane Liu; Jack J. Lee; Weiguo Wu; Waun Ki Hong; Li Mao

Abstract

View articletitled, Prognostic Implication of Microsatellite Alteration Profiles in Early-Stage Non-small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Neurotensin Receptor-1 mRNA Analysis in Normal Pancreas and Pancreatic Disease

Li Wang; Helmut Friess; Zhaowen Zhu; Hans Graber; Arthur Zimmermann; Murray Korc; Jean-Claude Reubi; Markus W. Büchler

Abstract

View articletitled, Neurotensin Receptor-1 mRNA Analysis in Normal Pancreas and Pancreatic Disease

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Vascular Endothelial Growth Factor Expression in Untreated Osteosarcoma Is Predictive of Pulmonary Metastasis and Poor Prognosis 1

Mitsunori Kaya; Takuro Wada; Tomohiro Akatsuka; Satoshi Kawaguchi; Satoshi Nagoya; Masanobu Shindoh; Fumihiro Higashino; Fumie Mezawa; Futoshi Okada; Seiichi Ishii

Abstract

View articletitled, Vascular Endothelial Growth Factor Expression in Untreated Osteosarcoma Is Predictive of Pulmonary Metastasis and Poor Prognosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cathepsin B, a Prognostic Indicator in Lymph Node-negative Breast Carcinoma Patients: Comparison with Cathepsin D, Cathepsin L, and Other Clinical Indicators 1

Tamara T. Lah; Miha Čerc̆ek; Andrej Blejec; Janko Kos; Ella Gorodetsky; Robert Somers; Ierachmiel Daskal

Abstract

View articletitled, Cathepsin B, a Prognostic Indicator in Lymph Node-negative Breast Carcinoma Patients: Comparison with Cathepsin D, Cathepsin L, and Other Clinical Indicators<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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In Multiple Myeloma, Circulating Hyperdiploid B Cells Have Clonotypic Immunoglobulin Heavy Chain Rearrangements and May Mediate Spread of Disease 1

Linda M. Pilarski; Nadia V. Giannakopoulos; Agnieszka J. Szczepek; Anna M. Masellis; Michael J. Mant; Andrew R. Belch

Abstract

View articletitled, In Multiple Myeloma, Circulating Hyperdiploid B Cells Have Clonotypic Immunoglobulin Heavy Chain Rearrangements and May Mediate Spread of Disease<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Significance of Neuron-specific Enolase Levels before and during Therapy for Small Cell Lung Cancer 1

James A. Bonner; Jeff A. Sloan; Kendrith M. Rowland, Jr.; George G. Klee; John W. Kugler; James A. Mailliard; Martin Wiesenfeld; James E. Krook; Andrew W. Maksymiuk; Edward G. Shaw; Randolph S. Marks; Edith A. Perez

Abstract

View articletitled, Significance of Neuron-specific Enolase Levels before and during Therapy for Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Alterations in the Expression of the DNA Repair/Redox Enzyme APE/ref-1 in Epithelial Ovarian Cancers 1

David H. Moore; Helen Michael; Renee Tritt; Stephen H. Parsons; Mark R. Kelley

Abstract

View articletitled, Alterations in the Expression of the DNA Repair/Redox Enzyme APE/ref-1 in Epithelial Ovarian Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Bladder Cancer: Allelic Deletions at and around the Retinoblastoma Tumor Suppressor Gene in Relation to Stage and Grade 1

Takashi Wada; Jari Louhelainen; Kari Hemminki; Jan Adolfsson; Hans Wijkström; Ulf Norming; Erik Borgström; Johan Hansson; Bengt Sandstedt; Gunnar Steineck

Abstract

View articletitled, Bladder Cancer: Allelic Deletions at and around the Retinoblastoma Tumor Suppressor Gene in Relation to Stage and Grade<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prediction of Clinical Outcome from Primary Tamoxifen by Expression of Biologic Markers in Breast Cancer Patients 1

Jenny Chang; Trevor J. Powles; D. Craig Allred; Sue E. Ashley; Andreas Makris; R. Kate Gregory; C. Kent Osborne; Mitch Dowsett

Abstract

View articletitled, Prediction of Clinical Outcome from Primary Tamoxifen by Expression of Biologic Markers in Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enhancement of Angiogenesis, Tumor Growth, and Metastasis by Transfection of Vascular Endothelial Growth Factor into LoVo Human Colon Cancer Cell Line

Yoko Kondo; Shigeki Arii; Akira Mori; Masaharu Furutani; Tsutomu Chiba; Masayuki Imamura

Abstract

View articletitled, Enhancement of Angiogenesis, Tumor Growth, and Metastasis by Transfection of Vascular Endothelial Growth Factor into LoVo Human Colon Cancer Cell Line

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Experimental Therapeutics, Preclinical Pharmacology

The Combined Use of an Immunotoxin and a Radioimmunoconjugate to Treat Disseminated Human B-Cell Lymphoma in Immunodeficient Mice 1

Bih-Rong Wei; Maria-Ana Ghetie; Ellen S. Vitetta

Abstract

View articletitled, The Combined Use of an Immunotoxin and a Radioimmunoconjugate to Treat Disseminated Human B-Cell Lymphoma in Immunodeficient Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Methionine Depletion Enhances the Antitumoral Efficacy of Cytotoxic Agents in Drug-resistant Human Tumor Xenografts 1

F. Poirson-Bichat; R. A. Bras Gonçalves; L. Miccoli; B. Dutrillaux; M. F. Poupon

Abstract

View articletitled, Methionine Depletion Enhances the Antitumoral Efficacy of Cytotoxic Agents in Drug-resistant Human Tumor Xenografts<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prolonged Response to Antisense Cyclin D1 in a Human Squamous Cancer Xenograft Model 1

Edward R. Sauter; Meenhard Herlyn; Shao-Chen Liu; Samuel Litwin; John A. Ridge

Abstract

View articletitled, Prolonged Response to Antisense Cyclin D1 in a Human Squamous Cancer Xenograft Model<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Characterization of an Ovarian Carcinoma Cell Line Resistant to Cisplatin and Flavopiridol 1

Keith C. Bible; Scott A. Boerner; Kathryn Kirkland; Kari L. Anderl; Duane Bartelt, Jr.; Phyllis A. Svingen; Timothy J. Kottke; Yean K. Lee; Steven Eckdahl; Paul G. Stalboerger; Robert B. Jenkins; Scott H. Kaufmann

Abstract

View articletitled, Characterization of an Ovarian Carcinoma Cell Line Resistant to Cisplatin and Flavopiridol<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Mismatch Repair and p53 Independently Affect Sensitivity to N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea 1

Gabriele Aquilina; Sabrina Ceccotti; Simone Martinelli; Silvia Soddu; Marco Crescenzi; Pauline Branch; Peter Karran; Margherita Bignami

Abstract

View articletitled, Mismatch Repair and p53 Independently Affect Sensitivity to N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Induction of Apoptosis in Malignant B Cells by Phenylbutyrate or Phenylacetate in Combination with Chemotherapeutic Agents 1

Thomas E. Witzig; Michael Timm; Mary Stenson; Phyllis A. Svingen; Scott H. Kaufmann

Abstract

View articletitled, Induction of Apoptosis in Malignant B Cells by Phenylbutyrate or Phenylacetate in Combination with Chemotherapeutic Agents<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Hairy Cell Leukemia, a B-Cell Neoplasm That Is Particularly Sensitive to the Cytotoxic Effect of Anti-Tac(Fv)-PE38 (LMB-2)

David H. Robbins; Inger Margulies; Maryalice Stetler-Stevenson; Robert J. Kreitman

Abstract

View articletitled, Hairy Cell Leukemia, a B-Cell Neoplasm That Is Particularly Sensitive to the Cytotoxic Effect of Anti-Tac(Fv)-PE38 (LMB-2)

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In Vivo Enhancement of Tumor Radioresponse by C225 Antiepidermal Growth Factor Receptor Antibody 1

Luka Milas; Kathy Mason; Nancy Hunter; Sven Petersen; Michitaka Yamakawa; Kian Ang; John Mendelsohn; Zhen Fan

Abstract

View articletitled, In Vivo Enhancement of Tumor Radioresponse by C225 Antiepidermal Growth Factor Receptor Antibody<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regression of U-87 MG Human Glioblastomas in Nude Mice after Treatment with a Cytotoxic Somatostatin Analog AN-238 1

Hippokratis Kiaris; Andrew V. Schally; Attila Nagy; Baodong Sun; Karoly Szepeshazi; Gabor Halmos

Abstract

View articletitled, Regression of U-87 MG Human Glioblastomas in Nude Mice after Treatment with a Cytotoxic Somatostatin Analog AN-238<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of Bax Enhances Antitumor Activity of Chemotherapeutic Agents in Human Head and Neck Squamous Cell Carcinoma 1

Bin Guo; Shousong Cao; Károly Tóth; Rami G. Azrak; Youcef M. Rustum

Abstract

View articletitled, Overexpression of Bax Enhances Antitumor Activity of Chemotherapeutic Agents in Human Head and Neck Squamous Cell Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Treatment of Isografted 9L Rat Brain Tumors with β-5-o-Carboranyl-2′-Deoxyuridine Neutron Capture Therapy 1

Raymond F. Schinazi; Selwyn J. Hurwitz; Irina Liberman; Amy S. Juodawlkis; Phillip Tharnish; Junxing Shi; Dennis C. Liotta; Jeffrey A. Coderre; Jeffrey Olson

Abstract

View articletitled, Treatment of Isografted 9L Rat Brain Tumors with β-5-o-Carboranyl-2′-Deoxyuridine Neutron Capture Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Topoisomerase I Inhibitor DX-8951f Is Active in a Severe Combined Immunodeficient Mouse Model of Human Acute Myelogenous Leukemia

Norbert Vey; Francis J. Giles; Hagop Kantarjian; Terry L. Smith; Miloslav Beran; Sima Jeha

Abstract

View articletitled, The Topoisomerase I Inhibitor DX-8951f Is Active in a Severe Combined Immunodeficient Mouse Model of Human Acute Myelogenous Leukemia

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In Vitro and in Vivo Activity of Protein Kinase C Inhibitor Chelerythrine Chloride Induces Tumor Cell Toxicity and Growth Delay in Vivo1

Steven J. Chmura; M. Eileen Dolan; Amy Cha; Helena J. Mauceri; Donald W. Kufe; Ralph R. Weichselbaum

Abstract

View articletitled, In Vitro and in Vivo Activity of Protein Kinase C Inhibitor Chelerythrine Chloride Induces Tumor Cell Toxicity and Growth Delay in Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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