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Editorial

Innovations in Phase 1 Trial Design: Where Do We Go Next?

Jerry M. Collins

Extract

View articletitled, Innovations in Phase 1 Trial Design: Where Do We Go Next?

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Minireview

Molecular Assays for the Diagnosis of Minimal Residual Head-and-Neck Cancer: Methods, Reliability, Pitfalls, and Solutions

Vida M. M. van Houten; Maarten P. Tabor; Michiel W. M. van den Brekel; Fedor Denkers; Richard G. A. Wishaupt; J. Alain Kummer; Gordon B. Snow; Ruud H. Brakenhoff

Abstract

View articletitled, Molecular Assays for the Diagnosis of Minimal Residual Head-and-Neck Cancer: Methods, Reliability, Pitfalls, and Solutions

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Advances in Brief

Detection of Circulating Cancer Cells with von Hippel-Lindau Gene Mutation in Peripheral Blood of Patients with Renal Cell Carcinoma 1

Shingo Ashida; Heiwa Okuda; Masakazu Chikazawa; Masanobu Tanimura; Osamu Sugita; Yukio Yamamoto; Syoichiro Nakamura; Masatoshi Moriyama; Taro Shuin

Abstract

View articletitled, Detection of Circulating Cancer Cells with von Hippel-Lindau Gene Mutation in Peripheral Blood of Patients with Renal Cell Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Telomerase RNA as a Detection Marker in the Serum of Breast Cancer Patients 1

Xu qi Chen; Hervé Bonnefoi; Marie-Françoise Pelte; Jacqueline Lyautey; Christine Lederrey; Sina Movarekhi; Pierre Schaeffer; Hugh E. Mulcahy; Pierre Meyer; Maurice Stroun; Philippe Anker

Abstract

View articletitled, Telomerase RNA as a Detection Marker in the Serum of Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antisense Inhibition of hMLH1 Is Not Sufficient for Loss of DNA Mismatch Repair Function in the HCT116+Chromosome 3 Cell Line 1

Dharam P. Chauhan; Qinghua Yang; John M. Carethers; Giancarlo Marra; Christina L. Chang; Sherman M. Chamberlain; C. Richard Boland

Abstract

View articletitled, Antisense Inhibition of hMLH1 Is Not Sufficient for Loss of DNA Mismatch Repair Function in the HCT116+Chromosome 3 Cell Line<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Adenovirus 5 Early Region 1A Does Not Induce Expression of the Ewing Sarcoma Fusion Product EWS-FLI1 in Breast and Ovarian Cancer Cell Lines 1

Funda Meric; Yong Liao; Wei-Ping Lee; Raphael E. Pollock; Mien-Chie Hung

Abstract

View articletitled, Adenovirus 5 Early Region 1A Does Not Induce Expression of the Ewing Sarcoma Fusion Product EWS-FLI1 in Breast and Ovarian Cancer Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

Lung Cancer Proliferation Correlates with [F-18]Fluorodeoxyglucose Uptake by Positron Emission Tomography 1

Hubert Vesselle; Rodney A. Schmidt; Jeffrey M. Pugsley; Melissa Li; Steve G. Kohlmyer; Eric Vallières; Douglas E. Wood

Abstract

View articletitled, Lung Cancer Proliferation Correlates with [F-18]Fluorodeoxyglucose Uptake by Positron Emission Tomography<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effect of 13-cis-Retinoic Acid on Serum Prostate-specific Antigen Levels in Patients with Recurrent Prostate Cancer after Radical Prostatectomy 1

Moshe Shalev; Timothy C. Thompson; Anna Frolov; Scott M. Lippman; Waun Ki Hong; Herbert Fritsche; Dov Kadmon

Abstract

View articletitled, Effect of 13-cis-Retinoic Acid on Serum Prostate-specific Antigen Levels in Patients with Recurrent Prostate Cancer after Radical Prostatectomy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Bioavailability Study of Oral Liquid and Tablet Forms of α-Difluoromethylornithine 1

Paul P. Carbone; Jeffrey A. Douglas; James Thomas; Kendra Tutsch; Marcia Pomplun; Mary Hamielec; Diane Pauk

Abstract

View articletitled, Bioavailability Study of Oral Liquid and Tablet Forms of α-Difluoromethylornithine<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Radioimmunotherapy Trial Evaluating ⁹⁰Yttrium-labeled Anti-Carcinoembryonic Antigen (CEA) Chimeric T84.66 in Patients with Metastatic CEA-producing Malignancies 1

Jeffrey Y. C. Wong; David Z. Chu; Dave M. Yamauchi; Lawrence E. Williams; An Liu; Sharon Wilczynski; Anna M. Wu; John E. Shively; James H. Doroshow; Andrew A. Raubitschek

Abstract

View articletitled, A Phase I Radioimmunotherapy Trial Evaluating 90Yttrium-labeled Anti-Carcinoembryonic Antigen (CEA) Chimeric T84.66 in Patients with Metastatic CEA-producing Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Green Tea Polyphenol Treatment to Human Skin Prevents Formation of Ultraviolet Light B-induced Pyrimidine Dimers in DNA 1

Santosh K. Katiyar; Anaibelith Perez; Hasan Mukhtar

Abstract

View articletitled, Green Tea Polyphenol Treatment to Human Skin Prevents Formation of Ultraviolet Light B-induced Pyrimidine Dimers in DNA<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Chronic Daily Low Dose of 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in Patients with Previously Resected Colon Polyps and First-Degree Female Relatives of Breast Cancer Patients 1

Al B. Benson, III; Olufunmilayo I. Olopade; Mark J. Ratain; Alfred Rademaker; Sohrab Mobarhan; Lisa Stucky-Marshall; Suzanne French; M. Eileen Dolan

Abstract

View articletitled, Chronic Daily Low Dose of 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in Patients with Previously Resected Colon Polyps and First-Degree Female Relatives of Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase III Randomized Study of Postradiotherapy Chemotherapy with α-Difluoromethylornithine-Procarbazine, N-(2-Chloroethyl)-N′-cyclohexyl-N-nitrosurea, Vincristine (DFMO-PCV) Versus PCV for Glioblastoma Multiforme 1

Victor A. Levin; Joon H. Uhm; Kurt A. Jaeckle; Ali Choucair; Patrick J. Flynn; W. K. Alfred Yung; Michael D. Prados; Janet M. Bruner; Susan M. Chang; Athanassios P. Kyritsis; Mary Jo Gleason; Kenneth R. Hess

Abstract

View articletitled, Phase III Randomized Study of Postradiotherapy Chemotherapy with α-Difluoromethylornithine-Procarbazine, N-(2-Chloroethyl)-N′-cyclohexyl-N-nitrosurea, Vincristine (DFMO-PCV) Versus PCV for Glioblastoma Multiforme<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I and Pharmacologic Evaluation of the DNA Intercalator CI-958 in Patients with Advanced Solid Tumors 1

E. Claire Dees; Lloyd R. Whitfield; William R. Grove; Sue Rummel; Louise B. Grochow; Ross C. Donehower

Abstract

View articletitled, A Phase I and Pharmacologic Evaluation of the DNA Intercalator CI-958 in Patients with Advanced Solid Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Unexpected Cytokines in Serum of Malignant Melanoma Patients during Sequential Biochemotherapy 1

Elizabeth A. Grimm; Christine M. Smid; J. Jack Lee; Chi-Hong Tseng; Omar Eton; Antonio C. Buzaid

Abstract

View articletitled, Unexpected Cytokines in Serum of Malignant Melanoma Patients during Sequential Biochemotherapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Loss of B7.2 (CD86) and Intracellular Adhesion Molecule 1 (CD54) Expression Is Associated with Decreased Tumor-infiltrating T Lymphocytes in Diffuse B-cell Large-cell Lymphoma 1

Alison T. Stopeck; Andrea Gessner; Thomas P. Miller; Evan M. Hersh; Cynthia S. Johnson; Haiyan Cui; Yvette Frutiger; Thomas M. Grogan

Abstract

View articletitled, Loss of B7.2 (CD86) and Intracellular Adhesion Molecule 1 (CD54) Expression Is Associated with Decreased Tumor-infiltrating T Lymphocytes in Diffuse B-cell Large-cell Lymphoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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p73 Gene Expression in Ovarian Cancer Tissues and Cell Lines

Chun-Ling Chen; Sin-Ming Ip; Danny Cheng; Ling-Chui Wong; Hextan Y. S. Ngan

Abstract

View articletitled, p73 Gene Expression in Ovarian Cancer Tissues and Cell Lines

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Expression of Cancer Testis Genes in Human Brain Tumors 1

Ugur Sahin; Michael Koslowski; Özlem Türeci; Thomas Eberle; Carsten Zwick; Bernd Romeike; Jean-Richard Moringlane; Karl Schwechheimer; Wolfgang Feiden; Michael Pfreundschuh

Abstract

View articletitled, Expression of Cancer Testis Genes in Human Brain Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Heterogeneity in the Clinical Phenotype of TP53 Mutations in Breast Cancer Patients 1

Jan Alsner; Mette Yilmaz; Per Guldberg; Lise Lotte Hansen; Jens Overgaard

Abstract

View articletitled, Heterogeneity in the Clinical Phenotype of TP53 Mutations in Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Contrasted Frequencies of p53 Accumulation in the Two Age Groups of North African Nasopharyngeal Carcinomas 1

Ahmed Khabir; Abdelmasid Sellami; Mohamed Sakka; Abdel Monem Ghorbel; Jamel Daoud; Mounir Frikha; Mohamed M. Drira; Pierre Busson; Rachid Jlidi

Abstract

View articletitled, Contrasted Frequencies of p53 Accumulation in the Two Age Groups of North African Nasopharyngeal Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Functional Evaluation of p53 and PTEN Gene Mutations in Gliomas 1

Hideaki Kato; Shunsuke Kato; Toshihiro Kumabe; Yukihiko Sonoda; Takashi Yoshimoto; Satoshi Kato; Shuang-Yin Han; Takao Suzuki; Hiroyuki Shibata; Ryunosuke Kanamaru; Chikashi Ishioka

Abstract

View articletitled, Functional Evaluation of p53 and PTEN Gene Mutations in Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of Matrix Metalloproteinase 2 Predicts Unfavorable Outcome in Early-Stage Non-Small Cell Lung Cancer 1

Bernward Passlick; Wulf Sienel; Rita Seen-Hibler; Werner Wöckel; Olaf Thetter; Wolf Mutschler; Klaus Pantel

Abstract

View articletitled, Overexpression of Matrix Metalloproteinase 2 Predicts Unfavorable Outcome in Early-Stage Non-Small Cell Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Identification of β-Tubulin Isoforms as Tumor Antigens in Neuroblastoma

Latha Prasannan; David E. Misek; Robert Hinderer; Jean Michon; James D. Geiger; Samir M. Hanash

Abstract

View articletitled, Identification of β-Tubulin Isoforms as Tumor Antigens in Neuroblastoma

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WT1 Splicing Alterations in Wilms’ Tumors 1

Dominique Baudry; Muriel Hamelin; Marie-Odile Cabanis; Jean-Christophe Fournet; Marie-France Tournade; Sabine Sarnacki; Claudine Junien; Cécile Jeanpierre

Abstract

View articletitled, WT1 Splicing Alterations in Wilms’ Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Acquired Expression of p27 Is a Favorable Prognostic Indicator in Patients with Hepatocellular Carcinoma 1

Michelangelo Fiorentino; Annalisa Altimari; Antonia D’Errico; Barry Cukor; Chiara Barozzi; Massimo Loda; Walter Franco Grigioni

Abstract

View articletitled, Acquired Expression of p27 Is a Favorable Prognostic Indicator in Patients with Hepatocellular Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Different Patterns of Allelic Loss (Loss of Heterozygosity) in Recurrent Human Pituitary Tumors Provide Evidence for Multiclonal Origins 1

Richard N. Clayton; Marija Pfeifer; A. Brew Atkinson; Paul Belchetz; John A. H. Wass; Effie Kyrodimou; Mark Vanderpump; David Simpson; John Bicknell; William E. Farrell

Abstract

View articletitled, Different Patterns of Allelic Loss (Loss of Heterozygosity) in Recurrent Human Pituitary Tumors Provide Evidence for Multiclonal Origins<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Nonhistological Diagnosis of Human Cerebral Tumors by 1H Magnetic Resonance Spectroscopy and Amino Acid Analysis¹

José M. Roda; José M. Pascual; Fernando Carceller; Francisco González-Llanos; Antonio Pérez-Higueras; Juan Solivera; Laura Barrios; Sebastián Cerdán

Abstract

View articletitled, Nonhistological Diagnosis of Human Cerebral Tumors by <a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>H Magnetic Resonance Spectroscopy and Amino Acid Analysis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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High Frequency of Clonally Related Tumors in Cases of Multiple Synchronous Lung Cancers as Revealed by Molecular Diagnosis 1

Shigeki Shimizu; Yasushi Yatabe; Takashi Koshikawa; Nobuhiro Haruki; Shunzo Hatooka; Masayuki Shinoda; Motokazu Suyama; Makoto Ogawa; Nobuyuki Hamajima; Ryuzo Ueda; Takashi Takahashi; Tetsuya Mitsudomi

Abstract

View articletitled, High Frequency of Clonally Related Tumors in Cases of Multiple Synchronous Lung Cancers as Revealed by Molecular Diagnosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Genomic Aberrations in Human Hepatocellular Carcinomas of Differing Etiologies 1

Nathalie Wong; Paul Lai; Elizabeth Pang; Lai-Fan Fung; Zhong Sheng; Vanesse Wong; Weiping Wang; Yoshitake Hayashi; Elizabeth Perlman; Shao Yuna; Joseph W-Y. Lau; Philip J. Johnson

Abstract

View articletitled, Genomic Aberrations in Human Hepatocellular Carcinomas of Differing Etiologies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Presence of Human Papilloma Virus in Tumor Tissue from Children with Retinoblastoma: An Alternative Mechanism for Tumor Development 1

Manuela Orjuela; Veronica Ponce Castaneda; Cecilia Ridaura; Evelia Lecona; Carlos Leal; David H. Abramson; Irene Orlow; William Gerald; Carlos Cordon-Cardo

Abstract

View articletitled, Presence of Human Papilloma Virus in Tumor Tissue from Children with Retinoblastoma: An Alternative Mechanism for Tumor Development<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Racial Differences in the Prognostic Usefulness of MUC1 and MUC2 in Colorectal Adenocarcinomas

Upender Manne; Heidi L. Weiss; William E. Grizzle

Abstract

View articletitled, Racial Differences in the Prognostic Usefulness of MUC1 and MUC2 in Colorectal Adenocarcinomas

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Loss of Estrogen Receptor (ER) Expression in Endometrial Tumors Is Not Associated with de Novo Methylation of the 5′ End of the ER Gene 1

Jason R. Navari; Philip Y. Roland; Pacita Keh; Helga B. Salvesen; Lars A. Akslen; Ole E. Iversen; Soma Das; Rajul Kothari; Susan Howey; Benette Phillips

Abstract

View articletitled, Loss of Estrogen Receptor (ER) Expression in Endometrial Tumors Is Not Associated with de Novo Methylation of the 5′ End of the ER Gene<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Evolution of Loss of Heterozygosity on Chromosome 17 during the Progression to Barrett’s Adenocarcinoma Involves a Unique Combination of Target Sites in Individual Specimens 1

Julie R. Dunn; Julie Garde; Kevin Dolan; John R. Gosney; Beverly C. Oates; Alastair J. M. Watson; Patricia Fielding; John K. Field

Abstract

View articletitled, The Evolution of Loss of Heterozygosity on Chromosome 17 during the Progression to Barrett’s Adenocarcinoma Involves a Unique Combination of Target Sites in Individual Specimens<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Human Breast Cancer Susceptibility to Paclitaxel Therapy Is Independent of Bcl-2 Expression 1

Susan M. Poelman; Moses O. Adeyanju; Maria-Antonia Robertson; Wendy M. Recant; Theodore Karrison; Gini F. Fleming; Olufunmilayo I. Olopade; Suzanne D. Conzen

Abstract

View articletitled, Human Breast Cancer Susceptibility to Paclitaxel Therapy Is Independent of Bcl-2 Expression<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of Prostate-specific Membrane Antigen in Transitional Cell Carcinoma of the Bladder: Prognostic Value?1

Jean-Luc Gala; Sylvain Loric; Yves Guiot; Samuel Ray Denmeade; Alyssa Gady; Francis Brasseur; Michel Heusterspreute; Pascal Eschwège; Philippe De Nayer; Paul Van Cangh; Bertrand Tombal

Abstract

View articletitled, Expression of Prostate-specific Membrane Antigen in Transitional Cell Carcinoma of the Bladder: Prognostic Value?<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Significance of p53 Alterations in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis 1

T. Mitsudomi; N. Hamajima; M. Ogawa; T. Takahashi

Abstract

View articletitled, Prognostic Significance of p53 Alterations in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cyclooxygenase-2 Expression Correlates with Tumor Neovascularization and Prognosis in Human Colorectal Carcinoma Patients

Reiko Masunaga; Hitoshi Kohno; Dipok Kumar Dhar; Satoshi Ohno; Muneaki Shibakita; Syoichi Kinugasa; Hiroshi Yoshimura; Mitsuo Tachibana; Hirofumi Kubota; Naofumi Nagasue

Abstract

View articletitled, Cyclooxygenase-2 Expression Correlates with Tumor Neovascularization and Prognosis in Human Colorectal Carcinoma Patients

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Evaluation of Serum KL-6, a Mucin-like Glycoprotein, as a Tumor Marker for Breast Cancer

Yoshinari Ogawa; Tetsuro Ishikawa; Katsumi Ikeda; Bunzo Nakata; Tetsuji Sawada; Kana Ogisawa; Yasuyuki Kato; Kosei Hirakawa

Abstract

View articletitled, Evaluation of Serum KL-6, a Mucin-like Glycoprotein, as a Tumor Marker for Breast Cancer

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Prognostic Significance of p27^KIP1 Protein and Ki-67 Growth Fraction in Non-small Cell Lung Cancers

Fumihiro Hommura; Hirotoshi Dosaka-Akita; Takayuki Mishina; Motoi Nishi; Tetsuya Kojima; Hiromitsu Hiroumi; Shigeaki Ogura; Michio Shimizu; Hiroyuki Katoh; Yoshikazu Kawakami

Abstract

View articletitled, Prognostic Significance of p27KIP1 Protein and Ki-67 Growth Fraction in Non-small Cell Lung Cancers

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Study of Dose Escalation and Sequence Switching of Administration of the Combination of Docetaxel and Doxorubicin in Advanced Breast Cancer

Kuniaki Itoh; Yasutsuna Sasaki; Hirofumi Fujii; Hironobu Minami; Tomoko Ohtsu; Hisashi Wakita; Tadahiko Igarashi; Yuko Watanabe; Yusuke Onozawa; Masaki Kashimura; Yasuo Ohashi

Abstract

View articletitled, Study of Dose Escalation and Sequence Switching of Administration of the Combination of Docetaxel and Doxorubicin in Advanced Breast Cancer

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Analysis of Genetic Polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese Patients with Therapy-related Leukemia/Myelodysplastic Syndrome and de novo Acute Myeloid Leukemia 1

Abstract

View articletitled, Analysis of Genetic Polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese Patients with Therapy-related Leukemia/Myelodysplastic Syndrome and de novo Acute Myeloid Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of Retinoblastoma Protein Predicts Decreased Survival and Correlates with Loss of p16^INK4 Protein in Gallbladder Carcinomas 1

Ya-Zhou Shi; Ai-Min Hui; Xin Li; Tadatoshi Takayama; Masatoshi Makuuchi

Abstract

View articletitled, Overexpression of Retinoblastoma Protein Predicts Decreased Survival and Correlates with Loss of p16INK4 Protein in Gallbladder Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Prostate Cancer Gene Therapy: Comparison of Adenovirus-mediated Expression of Interleukin 12 with Interleukin 12 plus B7-1 for in Situ Gene Therapy and Gene-modified, Cell-based Vaccines 1

Gerald W. Hull; Mark A. McCurdy; Yasutomo Nasu; Chris H. Bangma; Guang Yang; Satoru Shimura; Hon-Man Lee; Jianxiang Wang; Justin Albani; Shin Ebara; Takefumi Sato; Terry L. Timme; Timothy C. Thompson

Abstract

View articletitled, Prostate Cancer Gene Therapy: Comparison of Adenovirus-mediated Expression of Interleukin 12 with Interleukin 12 plus B7-1 for in Situ Gene Therapy and Gene-modified, Cell-based Vaccines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antitumor Activity of Temozolomide Combined with Irinotecan Is Partly Independent of O⁶-Methylguanine-DNA Methyltransferase and Mismatch Repair Phenotypes in Xenograft Models 1

Peter J. Houghton; Clinton F. Stewart; Pamela J. Cheshire; Lois B. Richmond; Mark N. Kirstein; Catherine A. Poquette; Ming Tan; Henry S. Friedman; Thomas P. Brent

Abstract

View articletitled, Antitumor Activity of Temozolomide Combined with Irinotecan Is Partly Independent of O6-Methylguanine-DNA Methyltransferase and Mismatch Repair Phenotypes in Xenograft Models<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pediatric Rhabdomyosarcoma Cell Lines Are Resistant to Fas-induced Apoptosis and Highly Sensitive to TRAIL-induced Apoptosis 1

Istvan Petak; Leslie Douglas; David M. Tillman; Reka Vernes; Janet A. Houghton

Abstract

View articletitled, Pediatric Rhabdomyosarcoma Cell Lines Are Resistant to Fas-induced Apoptosis and Highly Sensitive to TRAIL-induced Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Efficacy of a Broad-spectrum Sunscreen to Protect Engineered Human Skin from Tissue and DNA Damage Induced by Solar Ultraviolet Exposure 1

Vickram Bissonauth; Régen Drouin; David L. Mitchell; Marc Rhainds; Joël Claveau; Mahmoud Rouabhia

Abstract

View articletitled, The Efficacy of a Broad-spectrum Sunscreen to Protect Engineered Human Skin from Tissue and DNA Damage Induced by Solar Ultraviolet Exposure<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cyclic GMP Mediates Apoptosis Induced by Sulindac Derivatives via Activation of c-Jun NH₂-Terminal Kinase 1 1

Jae-Won Soh; Yuehua Mao; Min-Gab Kim; Rifat Pamukcu; Han Li; Gary A. Piazza; W. Joseph Thompson; I. Bernard Weinstein

Abstract

View articletitled, Cyclic GMP Mediates Apoptosis Induced by Sulindac Derivatives via Activation of c-Jun NH2-Terminal Kinase 1<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Neutron Radiation Enhances Cisplatin Cytotoxicity Independently of Apoptosis in Human Head and Neck Carcinoma Cells 1

Harold E. Kim; Mary Ann Krug; Inn Han; John Ensley; George H. Yoo; Jeffrey D. Forman; Hyeong-Reh Choi Kim

Abstract

View articletitled, Neutron Radiation Enhances Cisplatin Cytotoxicity Independently of Apoptosis in Human Head and Neck Carcinoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Temozolomide Delivered by Intracerebral Microinfusion is Safe and Efficacious Against Malignant Gliomas in Rats 1

Amy B. Heimberger; Gary E. Archer; Roger E. McLendon; Christine Hulette; Allan H. Friedman; Henry S. Friedman; Darell D. Bigner; John H. Sampson

Abstract

View articletitled, Temozolomide Delivered by Intracerebral Microinfusion is Safe and Efficacious Against Malignant Gliomas in Rats<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Schedule-dependent Activity of Temozolomide plus CPT-11 against a Human Central Nervous System Tumor-derived Xenograft 1

Vikas J. Patel; Gertrude B. Elion; Peter J. Houghton; Stephen Keir; Anthony E. Pegg; Stewart P. Johnson; M. Eileen Dolan; Darell D. Bigner; Henry S. Friedman

Abstract

View articletitled, Schedule-dependent Activity of Temozolomide plus CPT-11 against a Human Central Nervous System Tumor-derived Xenograft<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effective Treatment of Metastatic MDA-MB-435 Human Estrogen-independent Breast Carcinomas with a Targeted Cytotoxic Analogue of Luteinizing Hormone-releasing Hormone AN-207 1

Ioulia Chatzistamou; Andrew V. Schally; Attila Nagy; Patricia Armatis; Karoly Szepeshazi; Gabor Halmos

Abstract

View articletitled, Effective Treatment of Metastatic MDA-MB-435 Human Estrogen-independent Breast Carcinomas with a Targeted Cytotoxic Analogue of Luteinizing Hormone-releasing Hormone AN-207<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Letters to the Editor

Reply

Gijsbert C. de Gast

Extract

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Correspondence re: G. C. de Gast et al., Phase I Trial of Combined Immunotherapy with Subcutaneous Granulocyte Macrophage Colony-stimulating Factor, Low-Dose Interleukin 2, and Interferon α in Progressive Metastatic Melanoma and Renal Cell Carcinoma. Clin. Cancer Res., 6: 1267–1272, 2000.

Robert T. O’Donnell

Extract

View articletitled, Correspondence re: G. C. de Gast et al., Phase I Trial of Combined Immunotherapy with Subcutaneous Granulocyte Macrophage Colony-stimulating Factor, Low-Dose Interleukin 2, and Interferon α in Progressive Metastatic Melanoma and Renal Cell Carcinoma. Clin. Cancer Res., 6: 1267–1272, 2000.

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Reply

Aristide Floridi

Extract

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Correspondence re: M. Fanciulli et al., Energy Metabolism of Human LoVo Colon Carcinoma Cells: Correlation to Drug Resistance and Influence of Lonidamine. Clin. Cancer Res., 6: 1590–1597, 2000.

Ofer Kaplan

Extract

View articletitled, Correspondence re: M. Fanciulli et al., Energy Metabolism of Human LoVo Colon Carcinoma Cells: Correlation to Drug Resistance and Influence of Lonidamine. Clin. Cancer Res., 6: 1590–1597, 2000.

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Nonhistological Diagnosis of Human Cerebral Tumors by 1H Magnetic Resonance Spectroscopy and Amino Acid Analysis1

Experimental Therapeutics, Preclinical Pharmacology

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Nonhistological Diagnosis of Human Cerebral Tumors by 1H Magnetic Resonance Spectroscopy and Amino Acid Analysis¹