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Issues

Volume 6, Issue 1
1 January 2000
Clinical Cancer Research Cover Image for Volume 6, Issue 1
All Issues
ISSN 1078-0432
EISSN 1557-3265

Advances in Brief

Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper, Antiangiogenic Agent: Phase I Study1
George J. Brewer; Robert D. Dick; Damanjit K. Grover; Virginia LeClaire; Michael Tseng; Max Wicha; Kenneth Pienta; Bruce G. Redman; Thierry Jahan; Vernon K. Sondak; Myla Strawderman; Gerald LeCarpentier; Sofia D. Merajver
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Cyclin E Expression, a Potential Prognostic Marker for Non-Small Cell Lung Cancers
Takayuki Mishina; Hirotoshi Dosaka-Akita; Fumihiro Hommura; Motoi Nishi; Tetsuya Kojima; Shigeaki Ogura; Michio Shimizu; Hiroyuki Katoh; Yoshikazu Kawakami
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Effects of the Polyamine Analogues N1-Ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-Ethyl-N11-((cycloheptyl)methyl)-4,8- diazaundecane in Human Prostate Cancer Cells1
Diane E. McCloskey; Patrick M. Woster; Robert A. Casero, Jr.; Nancy E. Davidson
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Clinical Trials

Specific Cytolytic T-Cell Responses to Human CEA from Patients Immunized with Recombinant Avipox-CEA Vaccine
MingZhu Zhu; John Marshall; David Cole; Jeffrey Schlom; Kwong Y. Tsang
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Human Autoantibodies to Carcinoembryonic Antigen (CEA) Induced by a Vaccinia-CEA Vaccine1
Robert M. Conry; Karen O. Allen; Seung-won Lee; Susan E. Moore; Denise R. Shaw; Albert F. LoBuglio
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A Phase I and Pharmacokinetic Study of the Mitochondrial-specific Rhodacyanine Dye Analog MKT 0771
Carolyn D. Britten; Eric K. Rowinsky; Sharyn D. Baker; Geoffrey R. Weiss; Lon Smith; Joseph Stephenson; Mace Rothenberg; Leslie Smetzer; Jeffrey Cramer; William Collins; Daniel D. Von Hoff; S. Gail Eckhardt
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TP53 Mutation and p53 Overexpression for Prediction of Response to Neoadjuvant Treatment in Breast Cancer Patients1
Daniela Kandioler-Eckersberger; Carmen Ludwig; Margarethe Rudas; Sonja Kappel; Elisabeth Janschek; Catharina Wenzel; Hermine Schlagbauer-Wadl; Martina Mittlböck; Michael Gnant; Günter Steger; Raimund Jakesz
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A Phase I and Pharmacokinetic Study of Melphalan Using a 24-hour Continuous Infusion in Patients with Advanced Malignancies
Frédéric Pinguet; Stéphane Culine; Françoise Bressolle; Cécile Astre; Marie-Pierre Serre; Claude Chevillard; Michel Fabbro
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A Phase I and Pharmacokinetic Study of Docetaxel Administered in Combination with Continuous Intravenous Infusion of 5-Fluorouracil in Patients with Advanced Solid Tumors1
Eric Van Den Neste; Dominique de Valeriola; Joseph Kerger; Harry Bleiberg; Zlatko Kusenda; Christiane Brassinne; Sylvie Bartholomeus; Jean Selleslags; Philippe Hennebert; Hilda Wythouck; Isabelle Cazenave; Florence Lefresne-Soulas; Martine Piccart
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Cyclophosphamide and Carboplatin and Selective Consolidation in Advanced Seminoma
Robert J. Amato; Randall Millikan; Dania Daliani; Lori Wood; Christopher Logothetis; Alan Pollack
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Phase I Trial of Exisulind (Sulindac Sulfone, FGN-1) as a Chemopreventive Agent in Patients with Familial Adenomatous Polyposis1
Rosalind van Stolk; Gary Stoner; William L. Hayton; Kenneth Chan; Barry DeYoung; Laura Kresty; Brian H. Kemmenoe; Paul Elson; Lisa Rybicki; James Church; Kim Provencher; Denise McLain; Ernest Hawk; Ben Fryer; Gary Kelloff; Ram Ganapathi; G. Thomas Budd
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Patients Treated with Antitumor Drugs Displaying Neurological Deficits Are Characterized by a Low Circulating Level of Nerve Growth Factor1
Stefano De Santis; Andrea Pace; Loredana Bove; Francesco Cognetti; Francesca Properzi; Marco Fiore; Viviana Triaca; Antonella Savarese; Maria Domenica Simone; Bruno Jandolo; Luigi Manzione; Luigi Aloe
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Molecular Oncology, Markers, Clinical Correlates

Significance of Integrin α5 Gene Expression as a Prognostic Factor in Node-negative Non-Small Cell Lung Cancer1
Masashi Adachi; Toshihiko Taki; Masahiko Higashiyama; Nobuoki Kohno; Haruhiko Inufusa; Masayuki Miyake
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Identification and Localization of the Cytokine SDF1 and Its Receptor, CXC Chemokine Receptor 4, to Regions of Necrosis and Angiogenesis in Human Glioblastoma
Sandra A. Rempel; Steve Dudas; Shugang Ge; Jorge A. Gutiérrez
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Correlations Among p53, Her-2/neu, and ras Overexpression and Aneuploidy by Multiparameter Flow Cytometry in Human Breast Cancer: Evidence for a Common Phenotypic Evolutionary Pattern in Infiltrating Ductal Carcinomas1
Charles A. Smith; Agnese A. Pollice; Ling-Ping Gu; Kathryn A. Brown; Sarita G. Singh; Laura E. Janocko; Ronald Johnson; Thomas Julian; David Hyams; Norman Wolmark; Lillian Sweeney; Jan F. Silverman; Stanley E. Shackney
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Expression of survivin and Its Relationship to Loss of Apoptosis in Breast Carcinomas
Keitaro Tanaka; Shinji Iwamoto; Goki Gon; Takehiro Nohara; Mitsuhiko Iwamoto; Nobuhiko Tanigawa
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Cyclooxygenase-2 Expression Is Related to Prostaglandin Biosynthesis and Angiogenesis in Human Gastric Cancer
Kazuhiko Uefuji; Takashi Ichikura; Hidetaka Mochizuki
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The Prognostic Value of Angiogenesis by Chalkley Counting in a Confirmatory Study Design on 836 Breast Cancer Patients1
Steinbjørn Hansen; Dorthe A. Grabau; Flemming B. Sørensen; Martin Bak; Werner Vach; Carsten Rose
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Serum β-2 Microglobulin Levels Are a Significant Prognostic Factor in Philadelphia Chromosome-positive Chronic Myelogenous Leukemia
Jose Rodriguez; Jorge Cortes; Moshe Talpaz; Susan O’Brien; Terry L. Smith; Mary Beth Rios; Hagop Kantarjian
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Loss of Nuclear p16 Protein Expression Is Not Associated with Promoter Methylation but Defines a Subgroup of Aggressive Endometrial Carcinomas with Poor Prognosis1
Helga B. Salvesen; Soma Das; Lars A. Akslen
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Prognostic Significance of Tissue Prostate-specific Antigen in Endocrine-treated Prostate Carcinomas1
Reinhard Stege; Mirtha Grande; Kjell Carlström; Bernhard Tribukait; Åke Pousette
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Platelet and Coagulation Activation with Vascular Endothelial Growth Factor Generation in Soft Tissue Sarcomas
Henk M. W. Verheul; Klaas Hoekman; Florea Lupu; Henk J. Broxterman; Paul van der Valk; Ajay K. Kakkar; Herbert M. Pinedo
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Increased Expression of S100A6 (Calcyclin), a Calcium-binding Protein of the S100 Family, in Human Colorectal Adenocarcinomas1
Keiko Komatsu; Akiko Andoh; Shingo Ishiguro; Noriko Suzuki; Hiroko Hunai; Yoshiko Kobune-Fujiwara; Masao Kameyama; Jun Miyoshi; Hitoshi Akedo; Hiroyuki Nakamura
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Prognostic Significance of DNA Ploidy, S-Phase Fraction, and Tissue Levels of Aspartic, Cysteine, and Serine Proteases in Operable Gastric Carcinoma1
Antonio Russo; Viviana Bazan; Manuela Migliavacca; Ines Zanna; Carla Tubiolo; Francesca Maria Tumminello; Gabriella Dardanoni; Massimo Cajozzo; Pietro Bazan; Giuseppe Modica; Mario Latteri; Rosa Maria Tomasino; Giuseppe Colucci; Nicola Gebbia; Gaetano Leto
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In Vitro Adenoviral Vector p53-mediated Transduction and Killing Correlates with Expression of Coxsackie-Adenovirus Receptor and ανβ5 Integrin in SUDHL-1 Cells Derived from Anaplastic Large-Cell Lymphoma1
Francesco Turturro; Prem Seth; Charles J. Link, Jr.
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Experimental Therapeutics, Preclinical Pharmacology

EGF Receptor and p21WAF1 Expression are Reciprocally Altered as ME-180 Cervical Carcinoma Cells Progress from High to Low Cisplatin Sensitivity1
Nicholas J. Donato; Margot Perez; Hyunseok Kang; Zahid H. Siddik; Yi-He Ling; Roman Perez-Soler
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Drug-induced Apoptosis in Lung Cancer Cells Is Not Mediated by the Fas/FasL (CD95/APO1) Signaling Pathway1
Carlos G. Ferreira; Christos Tolis; Simone W. Span; Godefridus J. Peters; Thea van Lopik; Alain J. Kummer; Herbert M. Pinedo; Giuseppe Giaccone
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Induction of Apoptosis in Oral Cancer Cells by an Anti-bcl-2 Ribozyme Delivered by an Adenovirus Vector1
Sandra A. Gibson; Christopher Pellenz; Robert E. Hutchison; Frederick R. Davey; Edward J. Shillitoe
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Induction of Apoptosis and Inhibition of c-erbB-2 in Breast Cancer Cells by Flavopiridol1
Yiwei Li; Mahbubur Bhuiyan; Samir Alhasan; Adrian M. Senderowicz; Fazlul H. Sarkar
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The Potential of Soybean Foods as a Chemoprevention Approach for Human Urinary Tract Cancer1
Shu-Jem Su; Trai-Ming Yeh; Huan-Yao Lei; Nan-Haw Chow
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Effects of the bcr/abl Kinase Inhibitors AG957 and NSC 680410 on Chronic Myelogenous Leukemia Cells in Vitro1
Phyllis A. Svingen; Ayalew Tefferi; Timothy J. Kottke; Gurmeet Kaur; Ven L. Narayanan; Edward A. Sausville; Scott H. Kaufmann
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E1A-mediated Paclitaxel Sensitization in HER-2/neu-overexpressing Ovarian Cancer SKOV3.ip1 through Apoptosis Involving the Caspase-3 Pathway1
Naoto T. Ueno; Chandra Bartholomeusz; John L. Herrmann; Zeev Estrov; Ruping Shao; Michael Andreeff; Janet Price; Ralph W. Paul; Pervin Anklesaria; Dihua Yu; Mien-Chie Hung
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Anti-HER2 Antibody and Heregulin Suppress Growth of HER2-Overexpressing Human Breast Cancer Cells through Different Mechanisms1
Xiao-Feng Le; Amanda McWatters; Jon Wiener; Ji-Yuan Wu; Gordon B. Mills; Robert C. Bast, Jr.
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Cellular ATP Depletion by LY309887 as a Predictor of Growth Inhibition in Human Tumor Cell Lines1
Xiaohong Lu; Julie Errington; Victor J. Chen; Nicola J. Curtin; Alan V. Boddy; David R. Newell
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Adenovirus-mediated Expression of p53 or p21 in a Papillary Serous Endometrial Carcinoma Cell Line (SPEC-2) Results in Both Growth Inhibition and Apoptotic Cell Death: Potential Application of Gene Therapy to Endometrial Cancer
Lois Ramondetta; Gorden B. Mills; Thomas W. Burke; Judith K. Wolf
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Balb/c Mice as a Preclinical Model for Raltitrexed-induced Gastrointestinal Toxicity1
S. J. Clarke; D. C. Farrugia; G. W. Aherne; D. M. Pritchard; J. Benstead; A. L. Jackman
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Histology and Sensitivity to Anticancer Drugs of Two Human Non-Small Cell Lung Carcinomas Implanted in the Pleural Cavity of Nude Mice
Laurence Kraus-Berthier; Michel Jan; Nicolas Guilbaud; Monique Naze; Alain Pierré; Ghanem Atassi
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Maternal Exposure to Tamoxifen during Pregnancy Increases Carcinogen-induced Mammary Tumorigenesis among Female Rat Offspring1
Leena Hilakivi-Clarke; Elizabeth Cho; Ighovie Onojafe; Dezhong Joshua Liao; Robert Clarke
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Delayed Administration of Sodium Thiosulfate in Animal Models Reduces Platinum Ototoxicity without Reduction of Antitumor Activity1
Leslie L. Muldoon; Michael A. Pagel; Robert A. Kroll; Robert E. Brummett; Nancy D. Doolittle; Eleanor G. Zuhowski; Merrill J. Egorin; Edward A. Neuwelt
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Letters to the Editor

Sydney E. Salmon3
Raymond Alexanian; Kenneth Anderson; Bart Barlogie; James Berenson; William S. Dalton; Robert A. Kyle
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Correspondence re: T. Davis et al., Therapy of B-Cell Lymphoma with Anti-CD20 Antibodies Can Result in Loss of CD20 Antigen Expression. Clin. Cancer Res., 5: 611–615,1999.
Lori Kunkel
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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