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Volume 6, Issue 1

1 January 2000

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Advances in Brief
Clinical Trials
Molecular Oncology, Markers, Clinical Correlates
Experimental Therapeutics, Preclinical Pharmacology
Letters to the Editor

Advances in Brief

Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper, Antiangiogenic Agent: Phase I Study 1

George J. Brewer; Robert D. Dick; Damanjit K. Grover; Virginia LeClaire; Michael Tseng; Max Wicha; Kenneth Pienta; Bruce G. Redman; Thierry Jahan; Vernon K. Sondak; Myla Strawderman; Gerald LeCarpentier; Sofia D. Merajver

Cyclin E Expression, a Potential Prognostic Marker for Non-Small Cell Lung Cancers

Takayuki Mishina; Hirotoshi Dosaka-Akita; Fumihiro Hommura; Motoi Nishi; Tetsuya Kojima; Shigeaki Ogura; Michio Shimizu; Hiroyuki Katoh; Yoshikazu Kawakami

Effects of the Polyamine Analogues N¹-Ethyl-N¹¹-((cyclopropyl)methyl)-4,8-diazaundecane and N¹-Ethyl-N¹¹-((cycloheptyl)methyl)-4,8- diazaundecane in Human Prostate Cancer Cells 1

Diane E. McCloskey; Patrick M. Woster; Robert A. Casero, Jr.; Nancy E. Davidson

Clinical Trials

Specific Cytolytic T-Cell Responses to Human CEA from Patients Immunized with Recombinant Avipox-CEA Vaccine

MingZhu Zhu; John Marshall; David Cole; Jeffrey Schlom; Kwong Y. Tsang

Human Autoantibodies to Carcinoembryonic Antigen (CEA) Induced by a Vaccinia-CEA Vaccine 1

Robert M. Conry; Karen O. Allen; Seung-won Lee; Susan E. Moore; Denise R. Shaw; Albert F. LoBuglio

A Phase I and Pharmacokinetic Study of the Mitochondrial-specific Rhodacyanine Dye Analog MKT 077 1

Carolyn D. Britten; Eric K. Rowinsky; Sharyn D. Baker; Geoffrey R. Weiss; Lon Smith; Joseph Stephenson; Mace Rothenberg; Leslie Smetzer; Jeffrey Cramer; William Collins; Daniel D. Von Hoff; S. Gail Eckhardt

TP53 Mutation and p53 Overexpression for Prediction of Response to Neoadjuvant Treatment in Breast Cancer Patients 1

Daniela Kandioler-Eckersberger; Carmen Ludwig; Margarethe Rudas; Sonja Kappel; Elisabeth Janschek; Catharina Wenzel; Hermine Schlagbauer-Wadl; Martina Mittlböck; Michael Gnant; Günter Steger; Raimund Jakesz

A Phase I and Pharmacokinetic Study of Melphalan Using a 24-hour Continuous Infusion in Patients with Advanced Malignancies

Frédéric Pinguet; Stéphane Culine; Françoise Bressolle; Cécile Astre; Marie-Pierre Serre; Claude Chevillard; Michel Fabbro

A Phase I and Pharmacokinetic Study of Docetaxel Administered in Combination with Continuous Intravenous Infusion of 5-Fluorouracil in Patients with Advanced Solid Tumors 1

Eric Van Den Neste; Dominique de Valeriola; Joseph Kerger; Harry Bleiberg; Zlatko Kusenda; Christiane Brassinne; Sylvie Bartholomeus; Jean Selleslags; Philippe Hennebert; Hilda Wythouck; Isabelle Cazenave; Florence Lefresne-Soulas; Martine Piccart

Cyclophosphamide and Carboplatin and Selective Consolidation in Advanced Seminoma

Robert J. Amato; Randall Millikan; Dania Daliani; Lori Wood; Christopher Logothetis; Alan Pollack

Phase I Trial of Exisulind (Sulindac Sulfone, FGN-1) as a Chemopreventive Agent in Patients with Familial Adenomatous Polyposis 1

Rosalind van Stolk; Gary Stoner; William L. Hayton; Kenneth Chan; Barry DeYoung; Laura Kresty; Brian H. Kemmenoe; Paul Elson; Lisa Rybicki; James Church; Kim Provencher; Denise McLain; Ernest Hawk; Ben Fryer; Gary Kelloff; Ram Ganapathi; G. Thomas Budd

Patients Treated with Antitumor Drugs Displaying Neurological Deficits Are Characterized by a Low Circulating Level of Nerve Growth Factor 1

Stefano De Santis; Andrea Pace; Loredana Bove; Francesco Cognetti; Francesca Properzi; Marco Fiore; Viviana Triaca; Antonella Savarese; Maria Domenica Simone; Bruno Jandolo; Luigi Manzione; Luigi Aloe

Molecular Oncology, Markers, Clinical Correlates

Significance of Integrin α5 Gene Expression as a Prognostic Factor in Node-negative Non-Small Cell Lung Cancer 1

Masashi Adachi; Toshihiko Taki; Masahiko Higashiyama; Nobuoki Kohno; Haruhiko Inufusa; Masayuki Miyake

Identification and Localization of the Cytokine SDF1 and Its Receptor, CXC Chemokine Receptor 4, to Regions of Necrosis and Angiogenesis in Human Glioblastoma

Sandra A. Rempel; Steve Dudas; Shugang Ge; Jorge A. Gutiérrez

Correlations Among p53, Her-2/neu, and ras Overexpression and Aneuploidy by Multiparameter Flow Cytometry in Human Breast Cancer: Evidence for a Common Phenotypic Evolutionary Pattern in Infiltrating Ductal Carcinomas 1

Charles A. Smith; Agnese A. Pollice; Ling-Ping Gu; Kathryn A. Brown; Sarita G. Singh; Laura E. Janocko; Ronald Johnson; Thomas Julian; David Hyams; Norman Wolmark; Lillian Sweeney; Jan F. Silverman; Stanley E. Shackney

Expression of survivin and Its Relationship to Loss of Apoptosis in Breast Carcinomas

Keitaro Tanaka; Shinji Iwamoto; Goki Gon; Takehiro Nohara; Mitsuhiko Iwamoto; Nobuhiko Tanigawa

Cyclooxygenase-2 Expression Is Related to Prostaglandin Biosynthesis and Angiogenesis in Human Gastric Cancer

Kazuhiko Uefuji; Takashi Ichikura; Hidetaka Mochizuki

The Prognostic Value of Angiogenesis by Chalkley Counting in a Confirmatory Study Design on 836 Breast Cancer Patients 1

Steinbjørn Hansen; Dorthe A. Grabau; Flemming B. Sørensen; Martin Bak; Werner Vach; Carsten Rose

Serum β-2 Microglobulin Levels Are a Significant Prognostic Factor in Philadelphia Chromosome-positive Chronic Myelogenous Leukemia

Jose Rodriguez; Jorge Cortes; Moshe Talpaz; Susan O’Brien; Terry L. Smith; Mary Beth Rios; Hagop Kantarjian

Loss of Nuclear p16 Protein Expression Is Not Associated with Promoter Methylation but Defines a Subgroup of Aggressive Endometrial Carcinomas with Poor Prognosis 1

Helga B. Salvesen; Soma Das; Lars A. Akslen

Prognostic Significance of Tissue Prostate-specific Antigen in Endocrine-treated Prostate Carcinomas 1

Reinhard Stege; Mirtha Grande; Kjell Carlström; Bernhard Tribukait; Åke Pousette

Platelet and Coagulation Activation with Vascular Endothelial Growth Factor Generation in Soft Tissue Sarcomas

Henk M. W. Verheul; Klaas Hoekman; Florea Lupu; Henk J. Broxterman; Paul van der Valk; Ajay K. Kakkar; Herbert M. Pinedo

Increased Expression of S100A6 (Calcyclin), a Calcium-binding Protein of the S100 Family, in Human Colorectal Adenocarcinomas 1

Keiko Komatsu; Akiko Andoh; Shingo Ishiguro; Noriko Suzuki; Hiroko Hunai; Yoshiko Kobune-Fujiwara; Masao Kameyama; Jun Miyoshi; Hitoshi Akedo; Hiroyuki Nakamura

Prognostic Significance of DNA Ploidy, S-Phase Fraction, and Tissue Levels of Aspartic, Cysteine, and Serine Proteases in Operable Gastric Carcinoma 1

Antonio Russo; Viviana Bazan; Manuela Migliavacca; Ines Zanna; Carla Tubiolo; Francesca Maria Tumminello; Gabriella Dardanoni; Massimo Cajozzo; Pietro Bazan; Giuseppe Modica; Mario Latteri; Rosa Maria Tomasino; Giuseppe Colucci; Nicola Gebbia; Gaetano Leto

In Vitro Adenoviral Vector p53-mediated Transduction and Killing Correlates with Expression of Coxsackie-Adenovirus Receptor and α_νβ₅ Integrin in SUDHL-1 Cells Derived from Anaplastic Large-Cell Lymphoma 1

Francesco Turturro; Prem Seth; Charles J. Link, Jr.

Experimental Therapeutics, Preclinical Pharmacology

EGF Receptor and p21WAF1 Expression are Reciprocally Altered as ME-180 Cervical Carcinoma Cells Progress from High to Low Cisplatin Sensitivity 1

Nicholas J. Donato; Margot Perez; Hyunseok Kang; Zahid H. Siddik; Yi-He Ling; Roman Perez-Soler

Drug-induced Apoptosis in Lung Cancer Cells Is Not Mediated by the Fas/FasL (CD95/APO1) Signaling Pathway 1

Carlos G. Ferreira; Christos Tolis; Simone W. Span; Godefridus J. Peters; Thea van Lopik; Alain J. Kummer; Herbert M. Pinedo; Giuseppe Giaccone

Induction of Apoptosis in Oral Cancer Cells by an Anti-bcl-2 Ribozyme Delivered by an Adenovirus Vector 1

Sandra A. Gibson; Christopher Pellenz; Robert E. Hutchison; Frederick R. Davey; Edward J. Shillitoe

Induction of Apoptosis and Inhibition of c-erbB-2 in Breast Cancer Cells by Flavopiridol 1

Yiwei Li; Mahbubur Bhuiyan; Samir Alhasan; Adrian M. Senderowicz; Fazlul H. Sarkar

The Potential of Soybean Foods as a Chemoprevention Approach for Human Urinary Tract Cancer 1

Shu-Jem Su; Trai-Ming Yeh; Huan-Yao Lei; Nan-Haw Chow

Effects of the bcr/abl Kinase Inhibitors AG957 and NSC 680410 on Chronic Myelogenous Leukemia Cells in Vitro1

Phyllis A. Svingen; Ayalew Tefferi; Timothy J. Kottke; Gurmeet Kaur; Ven L. Narayanan; Edward A. Sausville; Scott H. Kaufmann

E1A-mediated Paclitaxel Sensitization in HER-2/neu-overexpressing Ovarian Cancer SKOV3.ip1 through Apoptosis Involving the Caspase-3 Pathway 1

Naoto T. Ueno; Chandra Bartholomeusz; John L. Herrmann; Zeev Estrov; Ruping Shao; Michael Andreeff; Janet Price; Ralph W. Paul; Pervin Anklesaria; Dihua Yu; Mien-Chie Hung

Anti-HER2 Antibody and Heregulin Suppress Growth of HER2-Overexpressing Human Breast Cancer Cells through Different Mechanisms 1

Xiao-Feng Le; Amanda McWatters; Jon Wiener; Ji-Yuan Wu; Gordon B. Mills; Robert C. Bast, Jr.

Cellular ATP Depletion by LY309887 as a Predictor of Growth Inhibition in Human Tumor Cell Lines 1

Xiaohong Lu; Julie Errington; Victor J. Chen; Nicola J. Curtin; Alan V. Boddy; David R. Newell

Adenovirus-mediated Expression of p53 or p21 in a Papillary Serous Endometrial Carcinoma Cell Line (SPEC-2) Results in Both Growth Inhibition and Apoptotic Cell Death: Potential Application of Gene Therapy to Endometrial Cancer

Lois Ramondetta; Gorden B. Mills; Thomas W. Burke; Judith K. Wolf

Balb/c Mice as a Preclinical Model for Raltitrexed-induced Gastrointestinal Toxicity 1

S. J. Clarke; D. C. Farrugia; G. W. Aherne; D. M. Pritchard; J. Benstead; A. L. Jackman

Histology and Sensitivity to Anticancer Drugs of Two Human Non-Small Cell Lung Carcinomas Implanted in the Pleural Cavity of Nude Mice

Laurence Kraus-Berthier; Michel Jan; Nicolas Guilbaud; Monique Naze; Alain Pierré; Ghanem Atassi

Maternal Exposure to Tamoxifen during Pregnancy Increases Carcinogen-induced Mammary Tumorigenesis among Female Rat Offspring 1

Leena Hilakivi-Clarke; Elizabeth Cho; Ighovie Onojafe; Dezhong Joshua Liao; Robert Clarke

Delayed Administration of Sodium Thiosulfate in Animal Models Reduces Platinum Ototoxicity without Reduction of Antitumor Activity 1

Leslie L. Muldoon; Michael A. Pagel; Robert A. Kroll; Robert E. Brummett; Nancy D. Doolittle; Eleanor G. Zuhowski; Merrill J. Egorin; Edward A. Neuwelt

Letters to the Editor

Sydney E. Salmon 3

Raymond Alexanian; Kenneth Anderson; Bart Barlogie; James Berenson; William S. Dalton; Robert A. Kyle

Correspondence re: T. Davis et al., Therapy of B-Cell Lymphoma with Anti-CD20 Antibodies Can Result in Loss of CD20 Antigen Expression. Clin. Cancer Res., 5: 611–615,1999.

Lori Kunkel

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