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Editorials

Understanding Barriers to Drug Delivery: High Resolution in Vivo Imaging Is Key

Rakesh K. Jain

Extract

View articletitled, Understanding Barriers to Drug Delivery: High Resolution in Vivo Imaging Is Key

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Clinical Trials Involving Multidrug Resistance Transcription Units in Retroviral Vectors

Albert B. Deisseroth

Extract

View articletitled, Clinical Trials Involving Multidrug Resistance Transcription Units in Retroviral Vectors

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Advances in Brief

Quantitation of the Change in GADD153 Messenger RNA Level as a Molecular Marker of Tumor Response in Head and Neck Cancer 1

Gerrit Los; Khalid Benbatoul; Dennis P. Gately; Racine Barton; Randolph Christen; K. Thomas Robbins; Daniel Vicario; Saeeda Kirmani; Lisa A. Orloff; Robert Weisman; Stephen B. Howell

Abstract

View articletitled, Quantitation of the Change in GADD153 Messenger RNA Level as a Molecular Marker of Tumor Response in Head and Neck Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

Paclitaxel Chemotherapy after Autologous Stem-Cell Transplantation and Engraftment of Hematopoietic Cells Transduced with a Retrovirus Containing the Multidrug Resistance Complementary DNA (MDR1) in Metastatic Breast Cancer Patients

Abstract

View articletitled, Paclitaxel Chemotherapy after Autologous Stem-Cell Transplantation and Engraftment of Hematopoietic Cells Transduced with a Retrovirus Containing the Multidrug Resistance Complementary DNA (MDR1) in Metastatic Breast Cancer Patients

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A Phase I and Pharmacokinetic Study of Temozolomide and Cisplatin in Patients with Advanced Solid Malignancies 1

Carolyn D. Britten; Eric K. Rowinsky; Sharyn D. Baker; Sanjiv S. Agarwala; John R. Eckardt; Rebecca Barrington; Sami G. Diab; Lisa A. Hammond; Tom Johnson; Miguel Villalona-Calero; Uwe Fraass; Paul Statkevich; Daniel D. Von Hoff; S. Gail Eckhardt

Abstract

View articletitled, A Phase I and Pharmacokinetic Study of Temozolomide and Cisplatin in Patients with Advanced Solid Malignancies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Induction of Spermidine/Spermine N¹-Acetyltransferase (SSAT) Is a Common Event in the Response of Human Primary Non-Small Cell Lung Carcinomas to Exposure to the New Antitumor Polyamine Analogue N¹,N¹¹-Bis(ethyl)norspermine¹

Edward W. Gabrielson; Anthony E. Pegg; Robert A. Casero, Jr.

Abstract

View articletitled, The Induction of Spermidine/Spermine N1-Acetyltransferase (SSAT) Is a Common Event in the Response of Human Primary Non-Small Cell Lung Carcinomas to Exposure to the New Antitumor Polyamine Analogue N1,N11-Bis(ethyl)norspermine1

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Evaluation of Tamoxifen plus Letrozole with Assessment of Pharmacokinetic Interaction in Postmenopausal Women with Metastatic Breast Cancer 1

James N. Ingle; Vera J. Suman; Patricia A. Johnson; James E. Krook; James A. Mailliard; Richard H. Wheeler; Charles L. Loprinzi; Edith A. Perez; V. Craig Jordan; Mitchell Dowsett

Abstract

View articletitled, Evaluation of Tamoxifen plus Letrozole with Assessment of Pharmacokinetic Interaction in Postmenopausal Women with Metastatic Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Hyperthermic Isolated Limb Perfusion with Tumor Necrosis Factor-α and Melphalan in Patients with Locally Advanced Soft Tissue Sarcomas: Treatment Response and Clinical Outcome Related to Changes in Proliferation and Apoptosis 1

Boudewijn E. C. Plaat; Willemina M. Molenaar; Mirjam F. Mastik; Jan Koudstaal; Eva van den Berg; Heimen Schraffordt Koops; Harald J. Hoekstra

Abstract

View articletitled, Hyperthermic Isolated Limb Perfusion with Tumor Necrosis Factor-α and Melphalan in Patients with Locally Advanced Soft Tissue Sarcomas: Treatment Response and Clinical Outcome Related to Changes in Proliferation and Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Study of LGD1069 in Adults with Advanced Cancer

Naiyer A. Rizvi; John L. Marshall; William Dahut; Elizabeth Ness; Joseph A. Truglia; Gordon Loewen; George M. Gill; Edgar H. Ulm; Rita Geiser; Dinah Jaunakais; Michael J. Hawkins

Abstract

View articletitled, A Phase I Study of LGD1069 in Adults with Advanced Cancer

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Minimal Residual Disease in Patients with Hairy Cell Leukemia in Complete Remission Treated with 2-Chlorodeoxyadenosine or 2′-Deoxycoformycin and Prediction of Early Relapse 1

Martin S. Tallman; David Hakimian; Kenneth J. Kopecky; Susan Wheaton; Eric Wollins; Kathy Foucar; Peter A. Cassileth; Thomas Habermann; Michael Grever; Jacob M. Rowe; LoAnn C. Peterson

Abstract

View articletitled, Minimal Residual Disease in Patients with Hairy Cell Leukemia in Complete Remission Treated with 2-Chlorodeoxyadenosine or 2′-Deoxycoformycin and Prediction of Early Relapse<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Up-Regulation of Retinoic Acid Receptor β Expression in Renal Cancers in Vivo Correlates with Response to 13-cis-Retinoic Acid and Interferon-α-2a 1

William J. Berg; David M. Nanus; Abraham Leung; Karen T. Brown; Brian Hutchinson; Madhu Mazumdar; Xiao-Chun Xu; Reuben Lotan; Victor E. Reuter; Robert J. Motzer

Abstract

View articletitled, Up-Regulation of Retinoic Acid Receptor β Expression in Renal Cancers in Vivo Correlates with Response to 13-cis-Retinoic Acid and Interferon-α-2a<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Complete Pathological Remission Is Possible with Systemic Combination Chemotherapy for Inoperable Hepatocellular Carcinoma

Thomas W. T. Leung; Yehuda Z. Patt; Wan-yee Lau; Stephen K. W. Ho; Simon C. H. Yu; Anthony T. C. Chan; Tony S. K. Mok; Winnie Yeo; Choong-tsek Liew; Nancy W. Y. Leung; Amanda M. Y. Tang; Philip J. Johnson

Abstract

View articletitled, Complete Pathological Remission Is Possible with Systemic Combination Chemotherapy for Inoperable Hepatocellular Carcinoma

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Phase I Study of the Novel Cyclic AMP (cAMP) Analogue 8-Chloro-cAMP in Patients with Cancer: Toxicity, Hormonal, and Immunological Effects

David J. Propper; Mark P. Saunders; Amanda J. Salisbury; Louise Long; Ken J. O’Byrne; Jeremy P. Braybrooke; Mitchell Dowsett; Marion Taylor; Denis C. Talbot; Trivadi S. Ganesan; Adrian L. Harris

Abstract

View articletitled, Phase I Study of the Novel Cyclic AMP (cAMP) Analogue 8-Chloro-cAMP in Patients with Cancer: Toxicity, Hormonal, and Immunological Effects

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Pharmacological Analysis of Etoposide in Elderly Patients with Lung Cancer 1

Masahiko Ando; Hironobu Minami; Yuichi Ando; Shuzo Sakai; Yohei Shimono; Seiji Sugiura; Hideo Saka; Kaoru Shimokata; Yoshinori Hasegawa

Abstract

View articletitled, Pharmacological Analysis of Etoposide in Elderly Patients with Lung Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effect of Hepatic Dysfunction due to Liver Metastases on the Pharmacokinetics of Capecitabine and Its Metabolites

Chris Twelves; Robert Glynne-Jones; Jim Cassidy; Johannes Schüller; Timothy Goggin; Brigitte Roos; Ludger Banken; Masahiro Utoh; Erhard Weidekamm; Bruno Reigner

Abstract

View articletitled, Effect of Hepatic Dysfunction due to Liver Metastases on the Pharmacokinetics of Capecitabine and Its Metabolites

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Doxorubicin Gradients in Human Breast Cancer

Jan Lankelma; Henk Dekker; Rafael Fernández Luque; Sylvia Luykx; Klaas Hoekman; Paul van der Valk; Paul J. van Diest; Herbert M. Pinedo

Abstract

View articletitled, Doxorubicin Gradients in Human Breast Cancer

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Ovarian Cancer BRCA1 Gene Therapy: Phase I and II Trial Differences in Immune Response and Vector Stability 1

David L. Tait; Patrice S. Obermiller; Allison R. Hatmaker; Sheryl Redlin-Frazier; Jeffrey T. Holt

Abstract

View articletitled, Ovarian Cancer BRCA1 Gene Therapy: Phase I and II Trial Differences in Immune Response and Vector Stability<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Adenovirus-mediated Wild-Type p53 Gene Transfer as a Surgical Adjuvant in Advanced Head and Neck Cancers 1

Gary L. Clayman; Douglas K. Frank; Patricia A. Bruso; Helmuth Goepfert

Abstract

View articletitled, Adenovirus-mediated Wild-Type p53 Gene Transfer as a Surgical Adjuvant in Advanced Head and Neck Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I and Pharmacologic Study of a 3-Hour Infusion of Paclitaxel followed by Cisplatinum and 5-Fluorouracil in Patients with Advanced Solid Tumors

Kapil N. Bhalla; Gondi N. Kumar; U. Kristina Walle; Ana Maria Ibrado; Tahir Javed; Robert K. Stuart; Carolyn Reed; Susan G. Arbuck; Thomas Walle

Abstract

View articletitled, Phase I and Pharmacologic Study of a 3-Hour Infusion of Paclitaxel followed by Cisplatinum and 5-Fluorouracil in Patients with Advanced Solid Tumors

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Phase II Trial of High-Dose Chemotherapy with Autologous Stem Cell Transplant for Stage IV Breast Cancer with Minimal Metastatic Disease

Yago Nieto; Pablo J. Cagnoni; Elizabeth J. Shpall; Steve Matthes; Anna Barón; Roy B. Jones; Scott I. Bearman

Abstract

View articletitled, Phase II Trial of High-Dose Chemotherapy with Autologous Stem Cell Transplant for Stage IV Breast Cancer with Minimal Metastatic Disease

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Therapy of Advanced Prostate Cancer with Granulocyte Macrophage Colony-stimulating Factor 1

Eric J. Small; David M. Reese; Bonnie Um; Sarah Whisenant; Shannon C. Dixon; William D. Figg

Abstract

View articletitled, Therapy of Advanced Prostate Cancer with Granulocyte Macrophage Colony-stimulating Factor<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

tie-1 Protein Tyrosine Kinase: A Novel Independent Prognostic Marker for Gastric Cancer 1

Wen-chang Lin; Anna F-Y. Li; Chin-Wen Chi; Wen-Wei Chung; Chen Lung Huang; Wing-Yiu Lui; Hsing-Jien Kung; Chew-Wun Wu

Abstract

View articletitled, tie-1 Protein Tyrosine Kinase: A Novel Independent Prognostic Marker for Gastric Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of nm23 in the Primary Tumor and the Metastatic Regional Lymph Nodes of Patients with Gastric Cardiac Cancer 1

Nan-Yung Hsu; Kuan-Chih Chow; Wei-Jen Chen; Cheng-Ching Lin; Fong-Fu Chou; Chao-Long Chen

Abstract

View articletitled, Expression of nm23 in the Primary Tumor and the Metastatic Regional Lymph Nodes of Patients with Gastric Cardiac Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Prognostic Impact of BCL2 Protein Expression in Acute Myelogenous Leukemia Varies with Cytogenetics 1

Steven M. Kornblau; Peter F. Thall; Zeev Estrov; Monica Walterscheid; Shilpen Patel; Alexandra Theriault; Michael J. Keating; Hagop Kantarjian; Elihu Estey; Michael Andreeff

Abstract

View articletitled, The Prognostic Impact of BCL2 Protein Expression in Acute Myelogenous Leukemia Varies with Cytogenetics<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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BRK/Sik Expression in the Gastrointestinal Tract and in Colon Tumors 1

Xavier Llor; Michael S. Serfas; Wenjun Bie; Valeri Vasioukhin; Marina Polonskaia; Jason Derry; Catherine M. Abbott; Angela L. Tyner

Abstract

View articletitled, BRK/Sik Expression in the Gastrointestinal Tract and in Colon Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunoenzymatically Determined Pepsinogen C Concentration in Breast Tumor Cytosols: An Independent Favorable Prognostic Factor in Node-positive Patients 1

Andreas Scorilas; Eleftherios P. Diamandis; Michael A. Levesque; Anastasia Papanastasiou-Diamandi; M. Javad Khosravi; Maurizia Giai; Riccardo Ponzone; Riccardo Roagna; Piero Sismondi; Carlos López-Otin

Abstract

View articletitled, Immunoenzymatically Determined Pepsinogen C Concentration in Breast Tumor Cytosols: An Independent Favorable Prognostic Factor in Node-positive Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Epidermal Growth Factor Receptor Expression and Gene Amplification in High-Grade Non-Brainstem Gliomas of Childhood 1

Markus Bredel; Ian F. Pollack; Ronald L. Hamilton; C. David James

Abstract

View articletitled, Epidermal Growth Factor Receptor Expression and Gene Amplification in High-Grade Non-Brainstem Gliomas of Childhood<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Apoptotic and Mitotic Indices Predict Survival Rates in Lymph Node-negative Colon Carcinomas 1

Frank A. Sinicrope; John Hart; Hai-An Hsu; Michael Lemoine; Fabrizio Michelassi; L. Clifton Stephens

Abstract

View articletitled, Apoptotic and Mitotic Indices Predict Survival Rates in Lymph Node-negative Colon Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Paradoxical Increase in Retinoblastoma Protein in Colorectal Carcinomas May Protect Cells from Apoptosis 1

Hirofumi Yamamoto; Jae-Won Soh; Takushi Monden; Micheal G. Klein; Li Ming Zhang; Haim Shirin; Nadir Arber; Naohiro Tomita; Ira Schieren; C. A. Stein; I. Bernard Weinstein

Abstract

View articletitled, Paradoxical Increase in Retinoblastoma Protein in Colorectal Carcinomas May Protect Cells from Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Differential Expression of Antiapoptotic Gene BAG-1 in Human Breast Normal and Cancer Cell Lines and Tissues 1

Xiaolong Yang; Yawei Hao; Zhihu Ding; Alan Pater; Shou-Ching Tang

Abstract

View articletitled, Differential Expression of Antiapoptotic Gene BAG-1 in Human Breast Normal and Cancer Cell Lines and Tissues<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Role of Vascular Endothelial Growth Factor C Expression in the Development of Lymph Node Metastasis in Gastric Cancer

Yutaka Yonemura; Yoshio Endo; Hideto Fujita; Sachio Fushida; Itasu Ninomiya; Etsurou Bandou; Keizou Taniguchi; Kouichi Miwa; Sigekazu Ohoyama; Kazuo Sugiyama; Takuma Sasaki

Abstract

View articletitled, Role of Vascular Endothelial Growth Factor C Expression in the Development of Lymph Node Metastasis in Gastric Cancer

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Detection of Disseminated Colorectal Cancer Cells in Lymph Nodes, Blood and Bone Marrow

Jürgen Weitz; Peter Kienle; Achim Magener; Moritz Koch; Andrea Schrödel; Frank Willeke; Frank Autschbach; Jeannine Lacroix; Thomas Lehnert; Christian Herfarth; Magnus von Knebel Doeberitz

Abstract

View articletitled, Detection of Disseminated Colorectal Cancer Cells in Lymph Nodes, Blood and Bone Marrow

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Increased Cyclin D1 Expression Is Associated with Features of Malignancy and Disease Recurrence in Ovarian Tumors

Federica Barbieri; Monica Cagnoli; Nicola Ragni; Gianni Foglia; Cristina Bruzzo; Francesco Pedullà; Angela Alama

Abstract

View articletitled, Increased Cyclin D1 Expression Is Associated with Features of Malignancy and Disease Recurrence in Ovarian Tumors

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Prognostic Significance of the Detection of Circulating Malignant Cells by Reverse Transcriptase-Polymerase Chain Reaction in Long-Term Clinically Disease-free Melanoma Patients 1

Begoña Mellado; Lorena Gutierrez; Teresa Castel; Dolors Colomer; Montserrat Fontanillas; Josefa Castro; Jordi Estapé

Abstract

View articletitled, Prognostic Significance of the Detection of Circulating Malignant Cells by Reverse Transcriptase-Polymerase Chain Reaction in Long-Term Clinically Disease-free Melanoma Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Genetic Susceptibility Associated with Rare HRAS1 Variable Number of Tandem Repeats Alleles in Spanish Non-Small Cell Lung Cancer Patients 1

Rafael Rosell; Roser Calvo; José J. Sánchez; Joan Maurel; Mónica Guillot; Mariano Monzó; Laura Núñez; Agustí Barnadas

Abstract

View articletitled, Genetic Susceptibility Associated with Rare HRAS1 Variable Number of Tandem Repeats Alleles in Spanish Non-Small Cell Lung Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Prognostic Significance of p16^INK4a/p14^ARF and p15^INK4b Deletions in Adult Acute Lymphoblastic Leukemia

Stefan Faderl; Hagop M. Kantarjian; Taghi Manshouri; Chin-Yung Chan; Sherry Pierce; Kimberly J. Hays; Jorge Cortes; Deborah Thomas; Zeev Estrov; Maher Albitar

Abstract

View articletitled, The Prognostic Significance of p16INK4a/p14ARF and p15INK4b Deletions in Adult Acute Lymphoblastic Leukemia

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Second Esophageal Tumors in Patients with Head and Neck Squamous Cell Carcinoma: An Assessment of Clonal Relationships

Joseph Califano; Paul L. Leong; Wayne M. Koch; Claus F. Eisenberger; David Sidransky; William H. Westra

Abstract

View articletitled, Second Esophageal Tumors in Patients with Head and Neck Squamous Cell Carcinoma: An Assessment of Clonal Relationships

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Experimental Therapeutics, Preclinical Pharmacology

Adjuvant Treatment of Canine Osteosarcoma with the Human Cytotoxic T-Cell Line TALL-104 1

Sophie Visonneau; Alessandra Cesano; K. Ann Jeglum; Daniela Santoli

Abstract

View articletitled, Adjuvant Treatment of Canine Osteosarcoma with the Human Cytotoxic T-Cell Line TALL-104<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Sequential Dependent Enhancement of Caspase Activation and Apoptosis by Flavopiridol on Paclitaxel-treated Human Gastric and Breast Cancer Cells 1

Monica Motwani; Thomas M. Delohery; Gary K. Schwartz

Abstract

View articletitled, Sequential Dependent Enhancement of Caspase Activation and Apoptosis by Flavopiridol on Paclitaxel-treated Human Gastric and Breast Cancer Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Curcumin Inhibits Tyrosine Kinase Activity of p185^neu and Also Depletes p185^neu 1

Ruey-Long Hong; William H. Spohn; Mien-Chie Hung

Abstract

View articletitled, Curcumin Inhibits Tyrosine Kinase Activity of p185neu and Also Depletes p185neu<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Synergistic Effects of Retinoic Acid and 8-Chloro-Adenosine 3′,5′-Cyclic Monophosphate on the Regulation of Retinoic Acid Receptor β and Apoptosis: Involvement of Mitochondria

Rakesh K. Srivastava; Aparna R. Srivastava; Yoon S. Cho-Chung; Dan L. Longo

Abstract

View articletitled, Synergistic Effects of Retinoic Acid and 8-Chloro-Adenosine 3′,5′-Cyclic Monophosphate on the Regulation of Retinoic Acid Receptor β and Apoptosis: Involvement of Mitochondria

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Marked Antiangiogenic and Antitumor Efficacy of AG3340 in Chemoresistant Human Non-Small Cell Lung Cancer Tumors: Single Agent and Combination Chemotherapy Studies

David R. Shalinsky; John Brekken; Helen Zou; Laura A. Bloom; Charles D. McDermott; Scott Zook; Nissi M. Varki; Krzysztof Appelt

Abstract

View articletitled, Marked Antiangiogenic and Antitumor Efficacy of AG3340 in Chemoresistant Human Non-Small Cell Lung Cancer Tumors: Single Agent and Combination Chemotherapy Studies

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Immunization of Chimpanzees with Tumor Antigen MUC1 Mucin Tandem Repeat Peptide Elicits Both Helper and CytotoxicT-Cell Responses 1

Simon M. Barratt-Boyes; Anda Vlad; Olivera J. Finn

Abstract

View articletitled, Immunization of Chimpanzees with Tumor Antigen MUC1 Mucin Tandem Repeat Peptide Elicits Both Helper and CytotoxicT-Cell Responses<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antitumor Activity of ZD1694 (Tomudex) against Human Head and Neck Cancer in Nude Mouse Models: Role of Dosing Schedule and Plasma Thymidine 1

Shousong Cao; John J. McGuire; Youcef M. Rustum

Abstract

View articletitled, Antitumor Activity of ZD1694 (Tomudex) against Human Head and Neck Cancer in Nude Mouse Models: Role of Dosing Schedule and Plasma Thymidine<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

Insulin and Insulin-like Growth Factor-I (IGF-I) Receptor Overexpression in Breast Cancers Leads to Insulin/IGF-I Hybrid Receptor Overexpression: Evidence for a Second Mechanism of IGF-I Signaling 1

Giuseppe Pandini; Riccardo Vigneri; Angela Costantino; Francesco Frasca; Antonio Ippolito; Yoko Fujita-Yamaguchi; Kenneth Siddle; Ira D. Goldfine; Antonino Belfiore

Abstract

View articletitled, Insulin and Insulin-like Growth Factor-I (IGF-I) Receptor Overexpression in Breast Cancers Leads to Insulin/IGF-I Hybrid Receptor Overexpression: Evidence for a Second Mechanism of IGF-I Signaling <a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Issues

Editorials

Advances in Brief

Clinical Trials

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Cancer Biology, Immunology, Cytokines

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