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Volume 5, Issue 5

1 May 1999

All Issues

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Minireview
Advances in Brief
Clinical Trials
Molecular Oncology, Markers, Clinical Correlates
Experimental Therapeutics, Preclinical Pharmacology
Cancer Biology, Immunology, Cytokines

Minireview

Development of Difluoromethylornithine (DFMO) as a Chemoprevention Agent 1

Frank L. Meyskens, Jr.; Eugene W. Gerner

Abstract

View articletitled, Development of Difluoromethylornithine (DFMO) as a Chemoprevention Agent<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Advances in Brief

Phase I Study of ⁹⁰Y-labeled B72.3 Intraperitoneal Administration in Patients with Ovarian Cancer: Effect of Dose and EDTA Coadministration on Pharmacokinetics and Toxicity 1

Michael G. Rosenblum; Claire F. Verschraegen; James L. Murray; Andrzej P. Kudelka; Jacalyn Gano; Lawrence Cheung; John J. Kavanagh

Abstract

View articletitled, Phase I Study of 90Y-labeled B72.3 Intraperitoneal Administration in Patients with Ovarian Cancer: Effect of Dose and EDTA Coadministration on Pharmacokinetics and Toxicity<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Centrosome Abnormalities in Pancreatic Ductal Carcinoma

Norihiro Sato; Kazuhiro Mizumoto; Masafumi Nakamura; Kenjiro Nakamura; Masahiro Kusumoto; Hideaki Niiyama; Takahiro Ogawa; Masao Tanaka

Abstract

View articletitled, Centrosome Abnormalities in Pancreatic Ductal Carcinoma

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Molecular Detection of Telomerase-positive Circulating Epithelial Cells in Metastatic Breast Cancer Patients

Jean-Charles Soria; Laurent R. Gauthier; Eric Raymond; Christine Granotier; Luc Morat; Jean-Pierre Armand; François D. Boussin; Laure Sabatier

Abstract

View articletitled, Molecular Detection of Telomerase-positive Circulating Epithelial Cells in Metastatic Breast Cancer Patients

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Overexpression of the Cyclin-dependent Kinase Inhibitor p16 Is Associated with Tumor Recurrence in Human Prostate Cancer 1

Cheryl T. Lee; Paola Capodieci; Iman Osman; Melissa Fazzari; Joseph Ferrara; Howard I. Scher; Carlos Cordon-Cardo

Abstract

View articletitled, Overexpression of the Cyclin-dependent Kinase Inhibitor p16 Is Associated with Tumor Recurrence in Human Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Receptor for Interleukin 13 Is a Marker and Therapeutic Target for Human High-Grade Gliomas 1

Waldemar Debinski; Denise M. Gibo; Stanley W. Hulet; James R. Connor; G. Yancey Gillespie

Abstract

View articletitled, Receptor for Interleukin 13 Is a Marker and Therapeutic Target for Human High-Grade Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Comparison of Features of Human Lung Cancer Cell Lines and Their Corresponding Tumors 1

Ignacio I. Wistuba; David Bryant; Carmen Behrens; Sara Milchgrub; Arvind K. Virmani; Raheela Ashfaq; John D. Minna; Adi F. Gazdar

Abstract

View articletitled, Comparison of Features of Human Lung Cancer Cell Lines and Their Corresponding Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Significance of Elevated Cyclooxygenase 2 Expression in Primary, Resected Lung Adenocarcinomas 1

Hiroyuki Achiwa; Yasushi Yatabe; Toyoaki Hida; Tetsuo Kuroishi; Ken-ichi Kozaki; Shigeo Nakamura; Makoto Ogawa; Takahiko Sugiura; Tetsuya Mitsudomi; Takashi Takahashir

Abstract

View articletitled, Prognostic Significance of Elevated Cyclooxygenase 2 Expression in Primary, Resected Lung Adenocarcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cisplatin-induced Activation of Mitogen-activated Protein Kinases in Ovarian Carcinoma Cells: Inhibition of Extracellular Signal-regulated Kinase Activity Increases Sensitivity to Cisplatin 1

Diane L. Persons; Eugenia M. Yazlovitskaya; Wei Cui; Jill C. Pelling

Abstract

View articletitled, Cisplatin-induced Activation of Mitogen-activated Protein Kinases in Ovarian Carcinoma Cells: Inhibition of Extracellular Signal-regulated Kinase Activity Increases Sensitivity to Cisplatin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Recombinant Adenovirus Expressing Wild-Type p53 Is Antiangiogenic: A Proposed Mechanism for Bystander Effect 1

Masahiko Nishizaki; Toshiyoshi Fujiwara; Tohru Tanida; Akio Hizuta; Hiroyuki Nishimori; Takashi Tokino; Yusuke Nakamura; Michael Bouvet; Jack A. Roth; Noriaki Tanaka

Abstract

View articletitled, Recombinant Adenovirus Expressing Wild-Type p53 Is Antiangiogenic: A Proposed Mechanism for Bystander Effect<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

Locoregional Regulatory Peptide Receptor Targeting with the Diffusible Somatostatin Analogue ⁹⁰Y-Labeled DOTA⁰-d-Phe¹-Tyr³-octreotide (DOTATOC): A Pilot Study in Human Gliomas 1

Adrian Merlo; Oliver Hausmann; Morten Wasner; Philipp Steiner; Andreas Otte; Eduard Jermann; Peter Freitag; Jean-Claude Reubi; Jan Müller-Brand; Otmar Gratzl; Helmut R. Mäcke

Abstract

View articletitled, Locoregional Regulatory Peptide Receptor Targeting with the Diffusible Somatostatin Analogue 90Y-Labeled DOTA0-d-Phe1-Tyr3-octreotide (DOTATOC): A Pilot Study in Human Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Efficacy and Safety of Simultaneous Immunomagnetic CD34+ Cell Selection and Breast Cancer Cell Purging in Peripheral Blood Progenitor Cell Samples Used for Hematopoietic Rescue after High-Dose Therapy 1

Michael Mohr; Eva Hilgenfeld; Thomas Fietz; Berthold Hoppe; Michael Koenigsmann; Marianne Hoffmann; Wolfgang U. Knauf; Uwe Cassens; Walter Sibrowski; Joachim Kienast; Eckhard Thiel; Wolfgang E. Berdel

Abstract

View articletitled, Efficacy and Safety of Simultaneous Immunomagnetic CD34+ Cell Selection and Breast Cancer Cell Purging in Peripheral Blood Progenitor Cell Samples Used for Hematopoietic Rescue after High-Dose Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Vascular Stroma Formation in Carcinoma in Situ, Invasive Carcinoma, and Metastatic Carcinoma of the Breast 1

Lawrence F. Brown; Anthony J. Guidi; Stuart J. Schnitt; Livingston Van De Water; Maria Luisa Iruela-Arispe; Tet-Kin Yeo; Kathi Tognazzi; Harold F. Dvorak

Abstract

View articletitled, Vascular Stroma Formation in Carcinoma in Situ, Invasive Carcinoma, and Metastatic Carcinoma of the Breast<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Paradoxical Correlations of Cyclin-dependent Kinase Inhibitors p21waf1/cip1 and p27kip1 in Metastatic Colorectal Carcinoma

Jonathan D. heng; Bruce A. Werness; James S. Babb; Neal J. Meropol

Abstract

View articletitled, Paradoxical Correlations of Cyclin-dependent Kinase Inhibitors p21waf1/cip1 and p27kip1 in Metastatic Colorectal Carcinoma

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Alterations in Expression of Basic Fibroblast Growth Factor (FGF) 2 and Its Receptor FGFR-1 in Human Prostate Cancer 1

Dipak Giri; Frederic Ropiquet; Michael Ittmann

Abstract

View articletitled, Alterations in Expression of Basic Fibroblast Growth Factor (FGF) 2 and Its Receptor FGFR-1 in Human Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of the Hyaluronan Receptor, CD44S, in Epithelial Ovarian Cancer Is an Independent Predictor of Survival

Sanjiv Kayastha; Andrew N.; Freedman M.; Steven Piver; Jhansi Mukkamalla; Maritza Romero-Guittierez; Bruce A. Werness

Abstract

View articletitled, Expression of the Hyaluronan Receptor, CD44S, in Epithelial Ovarian Cancer Is an Independent Predictor of Survival

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Estrogen Receptor Methylation Is Associated with Improved Survival in Adult Acute Myeloid Leukemia 1

Qing Li; Kenneth J. Kopecky; Avinash Mohan; Cheryl L. Willman; Frederick R. Appelbaum; James K. Weick; Jean-Pierre J. Issa

Abstract

View articletitled, Estrogen Receptor Methylation Is Associated with Improved Survival in Adult Acute Myeloid Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Disrupted p53 Function as Predictor of Treatment Failure and Poor Prognosis in B- and T-Cell Non-Hodgkin’s Lymphoma 1

Michael B. Møller; Anne-Marie Gerdes; Karsten Skjødt; Leif S. Mortensen; Niels T. Pedersen

Abstract

View articletitled, Disrupted p53 Function as Predictor of Treatment Failure and Poor Prognosis in B- and T-Cell Non-Hodgkin’s Lymphoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Endothelial Cell Nitric Oxide Synthase in Peritumoral Microvessels Is a Favorable Prognostic Indicator in Premenopausal Breast Cancer Patients 1

Kirsten Mortensen; Susanne Holck; Ib Jarle Christensen; Jan Skouv; David M. Hougaard; Jens Blom; Lars-Inge Larsson

Abstract

View articletitled, Endothelial Cell Nitric Oxide Synthase in Peritumoral Microvessels Is a Favorable Prognostic Indicator in Premenopausal Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Detection of Melanoma Cells in the Blood of Melanoma Patients by Melanoma-inhibitory Activity (MIA) Reverse Transcription-PCR 1

Marcus Mühlbauer; Nicole Langenbach; Wilhelm Stolz; Ruediger Hein; M. Landthaler; Reinhard Buettner; Anja-Katrin Bosserhoff

Abstract

View articletitled, Detection of Melanoma Cells in the Blood of Melanoma Patients by Melanoma-inhibitory Activity (MIA) Reverse Transcription-PCR<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Macrophage Infiltration and Heme Oxygenase-1 Expression Correlate with Angiogenesis in Human Gliomas 1

Akihiro Nishie; Mayumi Ono; Tadahisa Shono; Junichi Fukushi; Michihiro Otsubo; Hitoshi Onoue; Yushi Ito; Takanori Inamura; Kiyonobu Ikezaki; Masashi Fukui; Toru Iwaki; Michihiko Kuwano

Abstract

View articletitled, Macrophage Infiltration and Heme Oxygenase-1 Expression Correlate with Angiogenesis in Human Gliomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Matrix Metalloproteinase Production by Bone Marrow Mononuclear Cells from Normal Individuals and Patients with Acute and Chronic Myeloid Leukemia or Myelodysplastic Syndromes 1

Christian Ries; Florian Loher; Chuanbing Zang; Manfred G. Ismair; Petro E. Petrides

Abstract

View articletitled, Matrix Metalloproteinase Production by Bone Marrow Mononuclear Cells from Normal Individuals and Patients with Acute and Chronic Myeloid Leukemia or Myelodysplastic Syndromes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increased Serum Angiogenin Concentration in Colorectal Cancer Is Correlated with Cancer Progression

Shouji Shimoyama; Kazuki Yamasaki; Masaki Kawahara; Michio Kaminishi

Abstract

View articletitled, Increased Serum Angiogenin Concentration in Colorectal Cancer Is Correlated with Cancer Progression

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Significance of Thymidine Phosphorylase as a Marker of Protumor Monocytes in Breast Cancer

Masakazu Toi; Takayuki Ueno; Hiroshi Matsumoto; Hisashi Saji; Nobuaki Funata; Morio Koike; Takeshi Tominaga

Abstract

View articletitled, Significance of Thymidine Phosphorylase as a Marker of Protumor Monocytes in Breast Cancer

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Prognostic Significance of Allelic Imbalances on Chromosome 9p in Stage I Non-Small Cell Lung Carcinoma 1

Yoshio Tomizawa; Jun-ichi Adachi; Takashi Kohno; Kunihiro Hamada; Ryusei Saito; Masayuki Noguchi; Yoshihiro Matsuno; Setsuo Hirohashi; Naohito Yamaguchi; Jun Yokota

Abstract

View articletitled, Prognostic Significance of Allelic Imbalances on Chromosome 9p in Stage I Non-Small Cell Lung Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Detection of Mutations of p53 Tumor Suppressor Gene in Pancreatic Juice and Its Application to Diagnosis of Patients with Pancreatic Cancer: Comparison with K-ras Mutation 1

Yasushi Yamaguchi; Hiroyuki Watanabe; Songür Yrdiran; Koushirou Ohtsubo; Yoshiharu Motoo; Takasi Okai; Norio Sawabu

Abstract

View articletitled, Detection of Mutations of p53 Tumor Suppressor Gene in Pancreatic Juice and Its Application to Diagnosis of Patients with Pancreatic Cancer: Comparison with K-ras Mutation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Telomere Stability Is Frequently Impaired in High-Risk Groups of Patients with Myelodysplastic Syndromes 1

Junko H. Ohyashiki; Hiroshi Iwama; Naoyuki Yahata; Keiko Ando; Shigefumi Hayashi; Jerry W. Shay; Kazuma Ohyashiki

Abstract

View articletitled, Telomere Stability Is Frequently Impaired in High-Risk Groups of Patients with Myelodysplastic Syndromes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Predictive Value of Preclinical Toxicology Studies for Platinum Anticancer Drugs 1^{, 2}

Diana L. Clark; Paul A. Andrews; David D. Smith; Joseph J. DeGeorge; Robert L. Justice; Julie G. Beitz

Abstract

View articletitled, Predictive Value of Preclinical Toxicology Studies for Platinum Anticancer Drugs<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a><a href="javascript:;" reveal-id="FN2" data-open="FN2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">, 2</a>

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An Improved Nonisotopic Test to Screen a Large Series of New Inhibitor Molecules of Poly(ADP-ribose) Polymerase Activity for Therapeutic Applications 1

Patrice Decker; Everson Alves Miranda; Gilbert de Murcia; Sylviane Muller

Abstract

View articletitled, An Improved Nonisotopic Test to Screen a Large Series of New Inhibitor Molecules of Poly(ADP-ribose) Polymerase Activity for Therapeutic Applications<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Primary T-Cell and Activated Macrophage Response Associated with Tumor Protection Using Peptide/Poly-N-Acetyl Glucosamine Vaccination 1

Nathalie Maitre; Jason M. Brown; Marina Demcheva; Joseph R. Kelley; Mark A. Lockett; John Vournakis; David J. Cole

Abstract

View articletitled, Primary T-Cell and Activated Macrophage Response Associated with Tumor Protection Using Peptide/Poly-N-Acetyl Glucosamine Vaccination<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Treatment of Neoplastic Meningitis with Intrathecal Temozolomide 1

John H. Sampson; Gary E. Archer; Alan T. Villavicencio; Roger E. McLendon; Allan H. Friedman; W. Robert Bishop; Darell D. Bigner; Henry S. Friedman

Abstract

View articletitled, Treatment of Neoplastic Meningitis with Intrathecal Temozolomide<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cellular Pharmacology of the Combination of the DNA Topoisomerase I Inhibitor SN-38 and the Diaminocyclohexane Platinum Derivative Oxaliplatin 1

Nadia Zeghari-Squalli; Eric Raymond; Esteban Cvitkovic; François Goldwasser

Abstract

View articletitled, Cellular Pharmacology of the Combination of the DNA Topoisomerase I Inhibitor SN-38 and the Diaminocyclohexane Platinum Derivative Oxaliplatin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

Activation of Nuclear Factor-κB in Human Metastatic Melanoma Cells and the Effect of Oxidative Stress 1

Frank L. Meyskens, Jr.; Julie A. Buckmeier; Susan E. McNulty; Niloufar B. Tohidian

Abstract

View articletitled, Activation of Nuclear Factor-κB in Human Metastatic Melanoma Cells and the Effect of Oxidative Stress<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Autologous High-Killing Cytotoxic T Lymphocytes against Human Lung Cancer Are Induced Using Interleukin (IL)-1β, IL-2, IL-4, and IL-6: Possible Involvement of Dendritic Cells 1

Yasuo Saijo; Xin Hong; Masashi Tanaka; Ryushi Tazawa; Shu Qin Liu; Kaoru Saijo; Tadao Ohno; Kaoru Koike; Kazuhiro Ohkuda; Ken Satoh; Toshihiro Nukiwa

Abstract

View articletitled, Autologous High-Killing Cytotoxic T Lymphocytes against Human Lung Cancer Are Induced Using Interleukin (IL)-1β, IL-2, IL-4, and IL-6: Possible Involvement of Dendritic Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Suppression of Telomerase, Reexpression of KAI1, and Abrogation of Tumorigenicity by Nerve Growth Factor in Prostate Cancer Cell Lines 1

Sandra Sigala; Isabella Faraoni; Daniela Botticini; Marcelo Paez-Pereda; Cristina Missale; Enzo Bonmassar; PierFranco Spano

Abstract

View articletitled, Suppression of Telomerase, Reexpression of KAI1, and Abrogation of Tumorigenicity by Nerve Growth Factor in Prostate Cancer Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Mechanisms of Apoptosis in T Cells from Patients with Renal Cell Carcinoma 1

Robert G. Uzzo; Patricia Rayman; Vladimir Kolenko; Peter E. Clark; Tracy Bloom; A. Michelle Ward; Luis Molto; Charles Tannenbaum; Lydia J. Worford; Ronald Bukowski; Raymond Tubbs; Eric D. Hsi; Neil H. Bander; Andrew C. Novick; James H. Finke

Abstract

View articletitled, Mechanisms of Apoptosis in T Cells from Patients with Renal Cell Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Loss of Heterozygosity of the Rb Gene Correlates with pRb Protein Expression and Associates with p53 Alteration in Human Esophageal Cancer 1

Eric Poe Xing; Guang-Yu Yang; Li-Dong Wang; Stephanie Tao Shi; Chung S. Yang

Abstract

View articletitled, Loss of Heterozygosity of the Rb Gene Correlates with pRb Protein Expression and Associates with p53 Alteration in Human Esophageal Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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