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Volume 5, Issue 4

1 April 1999

All Issues

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorial
Advances in Brief
Clinical Trials
Molecular Oncology, Markers, Clinical Correlates
Experimental Therapeutics, Preclinical Pharmacology
Cancer Biology, Immunology, Cytokines

Editorial

Metabolic Jeopardy with High-Dose Cyclophosphamide?—Not So Fast

William P. Petros; O. Michael Colvin

Extract

View articletitled, Metabolic Jeopardy with High-Dose Cyclophosphamide?—Not So Fast

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Advances in Brief

Sensitive Detection of Squamous Cells in Bone Marrow and Blood of Head and Neck Cancer Patients by E48 Reverse Transcriptase-Polymerase Chain Reaction

Ruud H. Brakenhoff; Joep G. W. Stroomer; Corlinda ten Brink; Remco de Bree; Sjerp M. Weima; Gordon B. Snow; Guus A. M. S. van Dongen

Abstract

View articletitled, Sensitive Detection of Squamous Cells in Bone Marrow and Blood of Head and Neck Cancer Patients by E48 Reverse Transcriptase-Polymerase Chain Reaction

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Clinical Trials

Phase I Trial of Docetaxel with Filgrastim Support in Pediatric Patients with Refractory Solid Tumors: A Collaborative Pediatric Oncology Branch, National Cancer Institute and Children‘s Cancer Group Trial 1

Nita L. Seibel; Susan M. Blaney; Michelle O‘Brien; Mark Krailo; Ray Hutchinson; Revonda B. Mosher; Frank M. Balis; Gregory H. Reaman

Abstract

View articletitled, Phase I Trial of Docetaxel with Filgrastim Support in Pediatric Patients with Refractory Solid Tumors: A Collaborative Pediatric Oncology Branch, National Cancer Institute and Children‘s Cancer Group Trial<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Phase I Single-Dose Trial of Gadolinium Texaphyrin (Gd-Tex), a Tumor Selective Radiation Sensitizer Detectable by Magnetic Resonance Imaging 1

David I. Rosenthal; Pamela Nurenberg; Carlos R. Becerra; Eugene P. Frenkel; David P. Carbone; Bert L. Lum; Richard Miller; Julie Engel; Stuart Young; Dale Miles; Markus F. Renschler

Abstract

View articletitled, A Phase I Single-Dose Trial of Gadolinium Texaphyrin (Gd-Tex), a Tumor Selective Radiation Sensitizer Detectable by Magnetic Resonance Imaging<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Nonpredictable Pharmacokinetic Behavior of High-Dose Cyclophosphamide in Combination with Cisplatin and 1,3-Bis(2-chloroethyl)-1-nitrosourea 1

Yago Nieto; Xuesheng Xu; Pablo J. Cagnoni; Steve Matthes; Elizabeth J. Shpall; Scott I. Bearman; James Murphy; Roy B. Jones

Abstract

View articletitled, Nonpredictable Pharmacokinetic Behavior of High-Dose Cyclophosphamide in Combination with Cisplatin and 1,3-Bis(2-chloroethyl)-1-nitrosourea<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Trial of Methotrexate-Albumin in a Weekly Intravenous Bolus Regimen in Cancer Patients 1

Gernot Hartung; Gerd Stehle; Hannsjörg Sinn; Andreas Wunder; Hans Hermann Schrenk; Steffen Heeger; Marion Kränzle; Lutz Edler; Eva Frei; Heinz Herbert Fiebig; Dieter Ludwig Heene; Wolfgang Maier-Borst; Wolfgang Queisser

Abstract

View articletitled, Phase I Trial of Methotrexate-Albumin in a Weekly Intravenous Bolus Regimen in Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Oxaliplatin Pharmacokinetics during a Four-Hour Infusion

Wolfgang Kern; Jan Braess; Bettina Böttger; Cornelia Christine Kaufmann; Wolfgang Hiddemann; Eberhard Schleyer

Abstract

View articletitled, Oxaliplatin Pharmacokinetics during a Four-Hour Infusion

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Paclitaxel Steady-State Plasma Concentration as a Determinant of Disease Outcome and Toxicity in Lung Cancer Patients Treated with Paclitaxel and Cisplatin 1

Eric K. Rowinsky; Micheal Jiroutek; Philip Bonomi; David Johnson; Sharyn D. Baker

Abstract

View articletitled, Paclitaxel Steady-State Plasma Concentration as a Determinant of Disease Outcome and Toxicity in Lung Cancer Patients Treated with Paclitaxel and Cisplatin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Vascular Endothelial Growth Factor Is a Marker of Tumor Invasion and Metastasis in Squamous Cell Carcinomas of the Head and Neck 1

Edward R. Sauter; Mark Nesbit; James C. Watson; Andres Klein-Szanto; Samuel Litwin; Meenhard Herlyn

Abstract

View articletitled, Vascular Endothelial Growth Factor Is a Marker of Tumor Invasion and Metastasis in Squamous Cell Carcinomas of the Head and Neck<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Highly Metastatic Human Prostate Cancer Growing within the Prostate of Athymic Mice Overexpresses Vascular Endothelial Growth Factor 1

M. Derya Balbay; Curtis A. Pettaway; Hiroki Kuniyasu; Keiji Inoue; Edilberto Ramirez; Emily Li; Isaiah J. Fidler; Colin P. N. Dinney

Abstract

View articletitled, Highly Metastatic Human Prostate Cancer Growing within the Prostate of Athymic Mice Overexpresses Vascular Endothelial Growth Factor<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Correlation of Abnormal RB, p16^ink4a, and p53 Expression with 3p Loss of Heterozygosity, Other Genetic Abnormalities, and Clinical Features in 103 Primary Non-Small Cell Lung Cancers 1

Joseph Geradts; Kwun M. Fong; Paul V. Zimmerman; Robert Maynard; John D. Minna

Abstract

View articletitled, Correlation of Abnormal RB, p16ink4a, and p53 Expression with 3p Loss of Heterozygosity, Other Genetic Abnormalities, and Clinical Features in 103 Primary Non-Small Cell Lung Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Significance of Clinical Parameters and Biological Markers in Patients with Squamous Cell Carcinoma of the Head and Neck Treated with Concurrent Chemoradiotherapy 1

Akihiro Homma; Yasushi Furuta; Nobuhiko Oridate; Yuko Nakano; Gen Kohashi; Katsunori Yagi; Tatsumi Nagahashi; Satoshi Fukuda; Kazuaki Inoue; Yukio Inuyama

Abstract

View articletitled, Prognostic Significance of Clinical Parameters and Biological Markers in Patients with Squamous Cell Carcinoma of the Head and Neck Treated with Concurrent Chemoradiotherapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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O⁶-Methylguanine-DNA Methyltransferase-deficient Phenotype in Human Gliomas: Frequency and Time to Tumor Progression after Alkylating Agent-based Chemotherapy 1

John R. Silber; A. Blank; Michael S. Bobola; Saadi Ghatan; Douglas D. Kolstoe; Mitchel S. Berger

Abstract

View articletitled, O6-Methylguanine-DNA Methyltransferase-deficient Phenotype in Human Gliomas: Frequency and Time to Tumor Progression after Alkylating Agent-based Chemotherapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Predictive Value of c-erbB-2 and Cathepsin-D for Greek Breast Cancer Patients Using Univariate and Multivariate Analysis

Andreas Scorilas; Julia Yotis; Charilaos Pateras; Theoni Trangas; Maroulio Talieri

Abstract

View articletitled, Predictive Value of c-erbB-2 and Cathepsin-D for Greek Breast Cancer Patients Using Univariate and Multivariate Analysis

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Vascular Endothelial Growth Factor Levels in Ovarian Cyst Fluid Correlate with Malignancy 1

Darcie Hazelton; Roberto F. Nicosia; Santo V. Nicosia

Abstract

View articletitled, Vascular Endothelial Growth Factor Levels in Ovarian Cyst Fluid Correlate with Malignancy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Prognostic Score for Hormone-Refractory Prostate Cancer: Analysis of Two Cancer and Leukemia Group B Studies 1

Robin T. Vollmer; Philip W. Kantoff; Nancy A. Dawson; Nicholas J. Vogelzang

Abstract

View articletitled, A Prognostic Score for Hormone-Refractory Prostate Cancer: Analysis of Two Cancer and Leukemia Group B Studies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Microsatellite Instability Is Uncommon in Breast Cancer 1

Ramaswamy Anbazhagan; Hiroaki Fujii; Edward Gabrielson

Abstract

View articletitled, Microsatellite Instability Is Uncommon in Breast Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Marked Inhibition of Tumor Growth in a Malignant Glioma Tumor Model by a Novel Synthetic Matrix MetalloproteinaseInhibitor AG3340 1

Angela Price; Qiao Shi; Donald Morris; M. Elizabeth Wilcox; Penny M. A. Brasher; N. Barry Rewcastle; David Shalinsky; Helen Zou; Krzysztof Appelt; Randall N. Johnston; V. Wee Yong; Dylan Edwards; Peter Forsyth

Abstract

View articletitled, Marked Inhibition of Tumor Growth in a Malignant Glioma Tumor Model by a Novel Synthetic Matrix MetalloproteinaseInhibitor AG3340<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Evaluation of 5-Aminosalicylic Acid (5-ASA) for Cancer Chemoprevention: Lack of Efficacy against Nascent Adenomatous Polyps in the Apc^Min Mouse 1

Steve R. Ritland; Jonathan A. Leighton; Rhoda Elison Hirsch; Jason D. Morrow; Amy L. Weaver; Sandra J. Gendler

Abstract

View articletitled, Evaluation of 5-Aminosalicylic Acid (5-ASA) for Cancer Chemoprevention: Lack of Efficacy against Nascent Adenomatous Polyps in the ApcMin Mouse<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Recombinant Immunotoxins Directed against the c-erb-2/HER2/neu Oncogene Product: In Vitro Cytotoxicity, Pharmacokinetics, and in Vivo Efficacy Studies in Xenograft Models 1

Michael G. Rosenblum; Laura K. Shawver; John W. Marks; Jody Brink; Lawrence Cheung; Beatrice Langton-Webster

Abstract

View articletitled, Recombinant Immunotoxins Directed against the c-erb-2/HER2/neu Oncogene Product: In Vitro Cytotoxicity, Pharmacokinetics, and in Vivo Efficacy Studies in Xenograft Models<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cooperative Inhibitory Effect of Novel Mixed Backbone Oligonucleotide Targeting Protein Kinase A in Combination with Docetaxel and Anti-Epidermal Growth Factor-Receptor Antibody on Human Breast Cancer Cell Growth 1

Giampaolo Tortora; Rosa Caputo; Grazia Pomatico; Stefano Pepe; A. Raffaele Bianco; Sudhir Agrawal; John Mendelsohn; Fortunato Ciardiello

Abstract

View articletitled, Cooperative Inhibitory Effect of Novel Mixed Backbone Oligonucleotide Targeting Protein Kinase A in Combination with Docetaxel and Anti-Epidermal Growth Factor-Receptor Antibody on Human Breast Cancer Cell Growth<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Dihydropyrimidine Dehydrogenase Activity and Messenger RNA Level May Be Related to the Antitumor Effect of 5-Fluorouracil on Human Tumor Xenografts in Nude Mice

Yoichiro Ishikawa; Tetsuro Kubota; Yoshihide Otani; Masahiko Watanabe; Tatsuo Teramoto; Koichiro Kumai; Masaki Kitajima; Teiji Takechi; Hiroyuki Okabe; Masakazu Fukushima

Abstract

View articletitled, Dihydropyrimidine Dehydrogenase Activity and Messenger RNA Level May Be Related to the Antitumor Effect of 5-Fluorouracil on Human Tumor Xenografts in Nude Mice

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Antitumor Activity of Poly(l-glutamic acid)-Paclitaxel 1 on Syngeneic and Xenografted Tumors²

Chun Li; Janet E. Price; Luka Milas; Nancy R. Hunter; Shi Ke; Dong-Fang Yu; Chusilp Charnsangavej; Sidney Wallace

Abstract

View articletitled, Antitumor Activity of Poly(l-glutamic acid)-Paclitaxel<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a> on Syngeneic and Xenografted Tumors<a href="javascript:;" reveal-id="FN2" data-open="FN2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">2</a>

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Molecular Modeling and Preclinical Evaluation of the Humanized NR-LU-13 Antibody 1

Scott S. Graves; Stephen C. Goshorn; Diane M. Stone; Don B. Axworthy; John M. Reno; Becky Bottino; Stephen Searle; Andrew Henry; Jan Pedersen; Anthony R. Rees; Randell T. Libby

Abstract

View articletitled, Molecular Modeling and Preclinical Evaluation of the Humanized NR-LU-13 Antibody<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antitumor Activity of Sequential Treatment with Topotecan and Anti-Epidermal Growth Factor Receptor Monoclonal Antibody C225 1

Fortunato Ciardiello; Roberto Bianco; Vincenzo Damiano; Sonya De Lorenzo; Stefano Pepe; Sabino De Placido; Zhen Fan; John Mendelsohn; A. Raffaele Bianco; Giampaolo Tortora

Abstract

View articletitled, Antitumor Activity of Sequential Treatment with Topotecan and Anti-Epidermal Growth Factor Receptor Monoclonal Antibody C225<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Comparison of Activation of CPT-11 by Rabbit and Human Carboxylesterases for Use in Enzyme/Prodrug Therapy 1

Mary K. Danks; Christopher L. Morton; Erik J. Krull; Pamela J. Cheshire; Lois B. Richmond; Clayton W. Naeve; Cynthia A. Pawlik; Peter J. Houghton; Philip M. Potter

Abstract

View articletitled, Comparison of Activation of CPT-11 by Rabbit and Human Carboxylesterases for Use in Enzyme/Prodrug Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cancer Biology, Immunology, Cytokines

Isolation of Human Tumor-specific Antibodies by Selection of an Antibody Phage Library on Melanoma Cells 1

Jörg-Michael Kupsch; Nick Harold Tidman; Norbert V. Kang; Hazel Truman; Stephen Hamilton; Nimesha Patel; Julia A. Newton Bishop; Irene May Leigh; James Scott Crowe

Abstract

View articletitled, Isolation of Human Tumor-specific Antibodies by Selection of an Antibody Phage Library on Melanoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Loss of HLA Haplotype in Lung Cancer Cell Lines: Implications for Immunosurveillance of Altered HLA Class I/II Phenotypes in Lung Cancer

Akio Hiraki; Toshihiko Kaneshige; Katsuyuki Kiura; Hiroshi Ueoka; Hiromichi Yamane; Motoyuki Tanaka; Mine Harada

Abstract

View articletitled, Loss of HLA Haplotype in Lung Cancer Cell Lines: Implications for Immunosurveillance of Altered HLA Class I/II Phenotypes in Lung Cancer

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Cooperation between p53 and hMLH1 in a Human Colocarcinoma Cell Line in Response to DNA Damage 1

Faina Vikhanskaya; Gennaro Colella; Monica Valenti; Silvio Parodi; Maurizio D’Incalci; Massimo Broggini

Abstract

View articletitled, Cooperation between p53 and hMLH1 in a Human Colocarcinoma Cell Line in Response to DNA Damage<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Editorial

Advances in Brief

Clinical Trials

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Antitumor Activity of Poly(l-glutamic acid)-Paclitaxel1 on Syngeneic and Xenografted Tumors2

Cancer Biology, Immunology, Cytokines

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Antitumor Activity of Poly(l-glutamic acid)-Paclitaxel 1 on Syngeneic and Xenografted Tumors²