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Editorial

Surrogate Anatomic/Functional Sites for Evaluating Cancer Risk: An Extension of the Field Effect

Levy Kopelovich; Donald Earl Henson; Adi F. Gazdar; Barbara Dunn; Sudhir Srivastava; Gary J. Kelloff; Peter Greenwald

Extract

View articletitled, Surrogate Anatomic/Functional Sites for Evaluating Cancer Risk: An Extension of the Field Effect

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Advances in Brief

Treatment of Therapy-Refractory B-Lineage Acute Lymphoblastic Leukemia with an Apoptosis-inducing CD19-directed Tyrosine Kinase Inhibitor 1

Fatih M. Uckun; Yoav Messinger; Chun-Lin Chen; Karen O’Neill; Dorothea E. Myers; Frederick Goldman; Carole Hurvitz; James T. Casper; Alexandra Levine

Abstract

View articletitled, Treatment of Therapy-Refractory B-Lineage Acute Lymphoblastic Leukemia with an Apoptosis-inducing CD19-directed Tyrosine Kinase Inhibitor<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Serum Bone Sialoprotein in Patients with Primary Breast Cancer Is a Prognostic Marker for Subsequent Bone Metastasis

Ingo J. Diel; Erich-Franz Solomayer; Markus J. Seibel; Johannes Pfeilschifter; Hartwig Maisenbacher; Christina Gollan; Martin Pecherstorfer; Renate Conradi; Gudrun Kehr; Erwin Boehm; Franz P. Armbruster; Gunther Bastert

Abstract

View articletitled, Serum Bone Sialoprotein in Patients with Primary Breast Cancer Is a Prognostic Marker for Subsequent Bone Metastasis

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Anti-CD19 Antibodies Inhibit the Function of the P-gp Pump in Multidrug-resistant B Lymphoma Cells 1

Maria-Ana Ghetie; Victor Ghetie; Ellen S. Vitetta

Abstract

View articletitled, Anti-CD19 Antibodies Inhibit the Function of the P-gp Pump in Multidrug-resistant B Lymphoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Bypassing Immunization: Optimized Design of “Designer T Cells” against Carcinoembryonic Antigen (CEA)-expressing Tumors, and Lack of Suppression by Soluble CEA 1

K. F. Nolan; C.-O. Yun; Y. Akamatsu; J. C. Murphy; S.-O. Leung; E. J. Beecham; R. P. Junghans

Abstract

View articletitled, Bypassing Immunization: Optimized Design of “Designer T Cells” against Carcinoembryonic Antigen (CEA)-expressing Tumors, and Lack of Suppression by Soluble CEA<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

Phase I Clinical Study of Fish Oil Fatty Acid Capsules for Patients with Cancer Cachexia: Cancer and Leukemia Group B Study 9473 1

C. Patrick Burns; Susan Halabi; Gerald H. Clamon; Vera Hars; Brett A. Wagner; Raymond J. Hohl; Eric Lester; Jeffrey J. Kirshner; Vincent Vinciguerra; Electra Paskett

Abstract

View articletitled, Phase I Clinical Study of Fish Oil Fatty Acid Capsules for Patients with Cancer Cachexia: Cancer and Leukemia Group B Study 9473<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I and Pharmacokinetic Study of Tomudex Combined with 5-Fluorouracil Plus Levofolinic Acid in Advanced Head and Neck Cancer and Colorectal Cancer

Francesco Caponigro; Antonio Avallone; Howard McLeod; Giacomo Cartenì; Ferdinando De Vita; Rossana Casaretti; Janine Morsman; Robert Blackie; Alfredo Budillon; Luigi De Lucia; Adriano Gravina; Giuseppe Catalano; Pasquale Comella; Giuseppe Comella

Abstract

View articletitled, Phase I and Pharmacokinetic Study of Tomudex Combined with 5-Fluorouracil Plus Levofolinic Acid in Advanced Head and Neck Cancer and Colorectal Cancer

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Phase I Study of Topotecan Administered as a 21-Day Continuous Infusion in Children with Recurrent Solid Tumors: A Report from the Children’s Cancer Group 1

Haydar Frangoul; Matthew M. Ames; Revonda B. Mosher; Joel M. Reid; Mark D. Krailo; Nita L. Seibel; Dennis W. W. Shaw; Peter G. Steinherz; James A. Whitlock; John S. Holcenberg

Abstract

View articletitled, Phase I Study of Topotecan Administered as a 21-Day Continuous Infusion in Children with Recurrent Solid Tumors: A Report from the Children’s Cancer Group<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Study of Irinotecan Combined with Carboplatin in Previously Untreated Solid Cancers

Minoru Fukuda; Mikio Oka; Hiroshi Soda; Kenji Terashi; Shigeru Kawabata; Katsumi Nakatomi; Hiroshi Takatani; Junji Tsurutani; Kazuhiro Tsukamoto; Yuji Noguchi; Masaaki Fukuda; Akitoshi Kinoshita; Shigeru Kohno

Abstract

View articletitled, Phase I Study of Irinotecan Combined with Carboplatin in Previously Untreated Solid Cancers

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Oral Administration of Recombinant Human Granulocyte Macrophage Colony-stimulating Factor in the Management of Radiotherapy-induced Esophagitis 1

Michael I. Koukourakis; Christodoulos S. Flordellis; Alexandra Giatromanolaki; Sophia Koukouraki; Andreas Kapsoritakis; Spyros Potamianos; George Retalis; Euthimios Sivridis; Bassam Salsaa; Adrian L. Harris; Michael I. Maragoudakis

Abstract

View articletitled, Oral Administration of Recombinant Human Granulocyte Macrophage Colony-stimulating Factor in the Management of Radiotherapy-induced Esophagitis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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c-raf-1 Depletion and Tumor Responses in Patients Treated with the c-raf-1 Antisense Oligodeoxynucleotide ISIS 5132 (CGP 69846A)1

Peter J. O’Dwyer; James P. Stevenson; Maryann Gallagher; Amy Cassella; Irina Vasilevskaya; Brett P. Monia; Jon Holmlund; F. Andrew Dorr; Kang-Shen Yao

Abstract

View articletitled, c-raf-1 Depletion and Tumor Responses in Patients Treated with the c-raf-1 Antisense Oligodeoxynucleotide ISIS 5132 (CGP 69846A)<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Study of Subcutaneously Administered Recombinant Human Interleukin 12 in Patients with Advanced Renal Cell Cancer

Johanna E. A. Portielje; Wim H. J. Kruit; Martin Schuler; Joachim Beck; Cor H. J. Lamers; Gerrit Stoter; Christoph Huber; Maureen de Boer-Dennert; Ashok Rakhit; Reinder L. H. Bolhuis; Walter E. Aulitzky

Abstract

View articletitled, Phase I Study of Subcutaneously Administered Recombinant Human Interleukin 12 in Patients with Advanced Renal Cell Cancer

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A Phase I Study of Recombinant Interferon-β in Patients with Advanced Malignant Disease

Farhad Ravandi; Zeev Estrov; Razelle Kurzrock; James B. Breitmeyer; Birgit J. Maschek; Moshe Talpaz

Abstract

View articletitled, A Phase I Study of Recombinant Interferon-β in Patients with Advanced Malignant Disease

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Monoclonal Antibody Therapy with Edrecolomab in Breast Cancer Patients: Monitoring of Elimination of Disseminated Cytokeratin-positive Tumor Cells in Bone Marrow 1

Stephan Braun; Florian Hepp; Christina R. M. Kentenich; Wolfgang Janni; Klaus Pantel; Gert Riethmüller; Fritz Willgeroth; Harald L. Sommer

Abstract

View articletitled, Monoclonal Antibody Therapy with Edrecolomab in Breast Cancer Patients: Monitoring of Elimination of Disseminated Cytokeratin-positive Tumor Cells in Bone Marrow<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

Increased Expression of COX-2 in Nontumor Liver Tissue Is Associated with Shorter Disease-free Survival in Patients with Hepatocellular Carcinoma 1

Motoi Kondo; Hirofumi Yamamoto; Hiroaki Nagano; Jiro Okami; Yasuhiro Ito; Junzo Shimizu; Hidetoshi Eguchi; Atsushi Miyamoto; Keizo Dono; Koji Umeshita; Nariaki Matsuura; Ken-ichi Wakasa; Shoji Nakamori; Masato Sakon; Morito Monden

Abstract

View articletitled, Increased Expression of COX-2 in Nontumor Liver Tissue Is Associated with Shorter Disease-free Survival in Patients with Hepatocellular Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Linkage Analysis of 153 Prostate Cancer Families Over a 30-cM Region Containing the Putative Susceptibility Locus HPCX1

Ethan M. Lange; Hong Chen; Kristin Brierley; Erin E. Perrone; Cathryn H. Bock; Elizabeth Gillanders; Michael E. Ray; Kathleen A. Cooney

Abstract

View articletitled, Linkage Analysis of 153 Prostate Cancer Families Over a 30-cM Region Containing the Putative Susceptibility Locus HPCX<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Hematogenous Dissemination of Hepatocytes and Tumor Cells after Surgical Resection of Hepatocellular Carcinoma: A Quantitative Analysis 1

Ivy H. N. Wong; Wan Y. Lau; Thomas Leung; Winnie Yeo; Philip J. Johnson

Abstract

View articletitled, Hematogenous Dissemination of Hepatocytes and Tumor Cells after Surgical Resection of Hepatocellular Carcinoma: A Quantitative Analysis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of p53, bcl-2, E-Cadherin, Matrix Metalloproteinase-9, and Tissue Inhibitor of Metalloproteinases-1 in Paired Primary Tumors and Brain Metastasis

Susanne M. Arnold; A. Byron Young; Rita K. Munn; Roy A. Patchell; Nuwan Nanayakkara; William R. Markesbery

Abstract

View articletitled, Expression of p53, bcl-2, E-Cadherin, Matrix Metalloproteinase-9, and Tissue Inhibitor of Metalloproteinases-1 in Paired Primary Tumors and Brain Metastasis

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Prostate-specific Membrane Antigen Levels in Sera from Healthy Men and Patients with Benign Prostate Hyperplasia or Prostate Cancer 1

Mary Lou Beckett; Lisa H. Cazares; Antonia Vlahou; Paul F. Schellhammer; George L. Wright, Jr.

Abstract

View articletitled, Prostate-specific Membrane Antigen Levels in Sera from Healthy Men and Patients with Benign Prostate Hyperplasia or Prostate Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Caspase 2 and Caspase 3 as Predictors of Complete Remission and Survival in Adults with Acute Lymphoblastic Leukemia

Stefan Faderl; Peter F. Thall; Hagop M. Kantarjian; Moshe Talpaz; David Harris; Quin Van; Miloslav Beran; Steven M. Kornblau; Sherry Pierce; Zeev Estrov

Abstract

View articletitled, Caspase 2 and Caspase 3 as Predictors of Complete Remission and Survival in Adults with Acute Lymphoblastic Leukemia

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Heterogeneous Nuclear Ribonucleoprotein A2/B1 Up-Regulation in Bronchial Lavage Specimens: A Clinical Marker of Early Lung Cancer Detection 1

Patricia Fielding; Lesley Turnbull; Wendy Prime; Martin Walshaw; John K. Field

Abstract

View articletitled, Heterogeneous Nuclear Ribonucleoprotein A2/B1 Up-Regulation in Bronchial Lavage Specimens: A Clinical Marker of Early Lung Cancer Detection<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prognostic Significance of p53 Expression in Advanced-Stage Ovarian Serous Borderline Tumors

David M. Gershenson; Michael Deavers; Sheri Diaz; Guillermo Tortolero-Luna; Brigitte E. Miller; Robert C. Bast, Jr.; Gordon B. Mills; Elvio G. Silva

Abstract

View articletitled, Prognostic Significance of p53 Expression in Advanced-Stage Ovarian Serous Borderline Tumors

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Significance of FHIT Expression in Chronic Myelogenous Leukemia

Hagop M. Kantarjian; Moshe Talpaz; Susan O’Brien; Taghi Manshouri; Jorge Cortes; Francis Giles; Mary Beth Rios; Carlo M. Croce; Maher Albitar

Abstract

View articletitled, Significance of FHIT Expression in Chronic Myelogenous Leukemia

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Retinoblastoma-related p107 and pRb2/p130 Proteins in Malignant Lymphomas: Distinct Mechanisms of Cell Growth Control 1

Lorenzo Leoncini; Cristiana Bellan; Antonio Cossu; Pier Paolo Claudio; Stefano Lazzi; Caterina Cinti; Gabriele Cevenini; Tiziana Megha; Lorella Laurini; Pietro Luzi; Giulio Fraternali Orcioni; Milena Piccioli; Stefano Pileri; Costantino Giardino; Piero Tosi; Antonio Giordano

Abstract

View articletitled, Retinoblastoma-related p107 and pRb2/p130 Proteins in Malignant Lymphomas: Distinct Mechanisms of Cell Growth Control<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increased Expression of Ornithine Decarboxylase Messenger RNA in Human Esophageal Carcinoma 1

Ken-ichi Mafune; Yoichi Tanaka; Koshi Mimori; Masaki Mori; Kaiyo Takubo; Masatoshi Makuuchi

Abstract

View articletitled, Increased Expression of Ornithine Decarboxylase Messenger RNA in Human Esophageal Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Predictive Value of Cell Cycle Markers p53, MDM2, p21, and Ki-67 in Superficial Bladder Tumor Recurrence 1

Christian Pfister; Lynne Moore; Pierre Allard; Hélène Larue; Louis Lacombe; Bernard Têtu; François Meyer; Yves Fradet

Abstract

View articletitled, Predictive Value of Cell Cycle Markers p53, MDM2, p21, and Ki-67 in Superficial Bladder Tumor Recurrence<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Analysis of Oncogene and Tumor Suppressor Gene Alterations in Pediatric Malignant Astrocytomas Reveals Reduced Survival for Patients with PTEN Mutations 1

Corey Raffel; Lori Frederick; Judith R. O’Fallon; Pamela Atherton-Skaff; Arie Perry; Robert B. Jenkins; C. David James

Abstract

View articletitled, Analysis of Oncogene and Tumor Suppressor Gene Alterations in Pediatric Malignant Astrocytomas Reveals Reduced Survival for Patients with PTEN Mutations<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Type I and Type III Collagen Metabolites as Predictors of Clinical Outcome in Epithelial Ovarian Cancer

Markku Santala; Marja Simojoki; Juha Risteli; Leila Risteli; Antti Kauppila

Abstract

View articletitled, Type I and Type III Collagen Metabolites as Predictors of Clinical Outcome in Epithelial Ovarian Cancer

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Prognostic Value of p53, Glutathione S-Transferase π, and Thymidylate Synthase for Neoadjuvant Cisplatin-based Chemotherapy in Head and Neck Cancer 1

Hideaki Shiga; Elizabeth I. Heath; Audrey A. Rasmussen; Bruce Trock; Patrick G. Johnston; Arlene A. Forastiere; Miles Langmacher; Alfred Baylor; Michele Lee; Kevin J. Cullen

Abstract

View articletitled, Prognostic Value of p53, Glutathione S-Transferase π, and Thymidylate Synthase for Neoadjuvant Cisplatin-based Chemotherapy in Head and Neck Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and MMP-2 Immunolocalization in Human Prostate: Change in Cellular Localization Associated with High-Grade Prostatic Intraepithelial Neoplasia 1

Jyoti Upadhyay; Bijan Shekarriz; Jeffrey A. Nemeth; Zhong Dong; Glenn D. Cummings; Rafael Fridman; Wael Sakr; David J. Grignon; Michael L. Cher

Abstract

View articletitled, Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and MMP-2 Immunolocalization in Human Prostate: Change in Cellular Localization Associated with High-Grade Prostatic Intraepithelial Neoplasia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Immunohistochemical Expression of Fatty Acid Synthase, Apoptotic-regulating Genes, Proliferating Factors, and ras Protein Product in Colorectal Adenomas, Carcinomas, and Adjacent Nonneoplastic Mucosa

Paolo Visca; Piero Luigi Alò; Franca Del Nonno; Claudio Botti; Giorgio Trombetta; Ferdinando Marandino; Stefania Filippi; Ugo Di Tondo; Raffaele Perrone Donnorso

Abstract

View articletitled, Immunohistochemical Expression of Fatty Acid Synthase, Apoptotic-regulating Genes, Proliferating Factors, and ras Protein Product in Colorectal Adenomas, Carcinomas, and Adjacent Nonneoplastic Mucosa

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The Dynamics of Prostate-specific Antigen after Definitive Radiation Therapy for Prostate Cancer

Robin T. Vollmer; Gustavo S. Montana

Abstract

View articletitled, The Dynamics of Prostate-specific Antigen after Definitive Radiation Therapy for Prostate Cancer

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Evaluation of Four Antibodies in Detecting p53 Protein for Predicting Clinicopathological and Prognostic Significance in Colorectal Adenocarcinoma 1

Hong Zhang

Abstract

View articletitled, Evaluation of Four Antibodies in Detecting p53 Protein for Predicting Clinicopathological and Prognostic Significance in Colorectal Adenocarcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Prognostic Model That Makes Quantitative Estimates of Probability of Relapse for Breast Cancer Patients 1

Michelino De Laurentiis; Sabino De Placido; Angelo R. Bianco; Gary M. Clark; Peter M. Ravdin

Abstract

View articletitled, A Prognostic Model That Makes Quantitative Estimates of Probability of Relapse for Breast Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Genetic Alterations in ERBB2-amplified Breast Carcinomas 1^,2

Jorma Isola; Lisa Chu; Sandy DeVries; Kouji Matsumura; Karen Chew; Britt Marie Ljung; Frederic M. Waldman

Abstract

View articletitled, Genetic Alterations in ERBB2-amplified Breast Carcinomas<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a><a href="javascript:;" reveal-id="FN2" data-open="FN2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">,2</a>

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Long-Template DNA Polymerase Chain Reaction for the Detection of the bcr/abl Translocation in Patients with Chronic Myelogenous Leukemia 1

Cornelius F. Waller; Gereon Dennebaum; Christoph Feldmann; Winand Lange

Abstract

View articletitled, Long-Template DNA Polymerase Chain Reaction for the Detection of the bcr/abl Translocation in Patients with Chronic Myelogenous Leukemia<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The p16-Cyclin D1/CDK4-pRb Pathway and Clinical Outcome in Epithelial Ovarian Cancer 1

Tomoaki Kusume; Hiroshi Tsuda; Masami Kawabata; Takeshi Inoue; Naohiko Umesaki; Tomoko Suzuki; Kumio Yamamoto

Abstract

View articletitled, The p16-Cyclin D1/CDK4-pRb Pathway and Clinical Outcome in Epithelial Ovarian Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Increased Detection of Circulating Tumor Cells in the Blood of Colorectal Carcinoma Patients Using Two Reverse Transcription-PCR Assays and Multiple Blood Samples 1

Richard Q. Wharton; Sonja K. Jonas; Clare Glover; Zulfi A. J. Khan; Antonios Klokouzas; Helen Quinn; Michael Henry; Timothy G. Allen-Mersh

Abstract

View articletitled, Increased Detection of Circulating Tumor Cells in the Blood of Colorectal Carcinoma Patients Using Two Reverse Transcription-PCR Assays and Multiple Blood Samples<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Combination of EGFR, HER-2/neu, and HER-3 Is a Stronger Predictor for the Outcome of Oral Squamous Cell Carcinoma Than Any Individual Family Members 1

Weiya Xia; Yiu-Keung Lau; Hua-Zhong Zhang; Fen-Yuan Xiao; Dennis A. Johnston; Ai-Ru Liu; Lei Li; Ruth L. Katz; Mien-Chie Hung

Abstract

View articletitled, Combination of EGFR, HER-2/neu, and HER-3 Is a Stronger Predictor for the Outcome of Oral Squamous Cell Carcinoma Than Any Individual Family Members<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Variability of Adenovirus Receptor Density Influences Gene Transfer Efficiency and Therapeutic Response in Head and Neck Cancer 1

Daqing Li; Ling Duan; Paul Freimuth; Bert W. O’Malley, Jr.

Abstract

View articletitled, Variability of Adenovirus Receptor Density Influences Gene Transfer Efficiency and Therapeutic Response in Head and Neck Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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p16^INK4a Expression Adenovirus Vector to Suppress Pancreas Cancer Cell Proliferation 1

Susumu Kobayashi; Hiroshi Shirasawa; Hiroshi Sashiyama; Hiroshi Kawahira; Kentaro Kaneko; Takehide Asano; Takenori Ochiai

Abstract

View articletitled, p16INK4a Expression Adenovirus Vector to Suppress Pancreas Cancer Cell Proliferation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Extraneuronal Monoamine Transporter Expression and DNA Repair Vis-à-Vis 2-Chloroethyl-3-sarcosinamide-1-nitrosourea Cytotoxicity in Human Tumor Cell Lines 1

Zhong-Ping Chen; Joanna Remack; Thomas P. Brent; Gérard Mohr; Lawrence C. Panasci

Abstract

View articletitled, Extraneuronal Monoamine Transporter Expression and DNA Repair Vis-à-Vis 2-Chloroethyl-3-sarcosinamide-1-nitrosourea Cytotoxicity in Human Tumor Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effect of Docetaxel on the Therapeutic Ratio of Fractionated Radiotherapy in Vivo1

Kathryn A. Mason; Kazushi Kishi; Nancy Hunter; Lara Buchmiller; Tetsuo Akimoto; Ritsuko Komaki; Luka Milas

Abstract

View articletitled, Effect of Docetaxel on the Therapeutic Ratio of Fractionated Radiotherapy in Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Wild-Type p53 Can Induce p21 and Apoptosis in Neuroblastoma Cells But the DNA Damage-induced G₁ Checkpoint Function 1

Pamela P. McKenzie; Sylvie M. Guichard; David S. Middlemas; Richard A. Ashmun; Mary K. Danks; Linda C. Harris

Abstract

View articletitled, Wild-Type p53 Can Induce p21 and Apoptosis in Neuroblastoma Cells But the DNA Damage-induced G1 Checkpoint Function <a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Factors Limiting Adenovirus-mediated Gene Transfer into Human Lung and Pancreatic Cancer Cell Lines 1

A. Scott Pearson; Patricia E. Koch; Neely Atkinson; Momiao Xiong; Robert W. Finberg; Jack A. Roth; Bingliang Fang

Abstract

View articletitled, Factors Limiting Adenovirus-mediated Gene Transfer into Human Lung and Pancreatic Cancer Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Vaccine Implications of Folate Binding Protein, a Novel Cytotoxic T Lymphocyte-recognized Antigen System in Epithelial Cancers 1

George E. Peoples; Brett W. Anderson; Tom V. Lee; James L. Murray; Andrezj P. Kudelka; J. Taylor Wharton; Constantin G. Ioannides

Abstract

View articletitled, Vaccine Implications of Folate Binding Protein, a Novel Cytotoxic T Lymphocyte-recognized Antigen System in Epithelial Cancers<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Efficacy of Adenovirus-mediated CD/5-FC and HSV-1 Thymidine Kinase/Ganciclovir Suicide Gene Therapies Concomitant with p53 Gene Therapy 1

Yunjie Xie; Jeff D. Gilbert; Jae Ho Kim; Svend O. Freytag

Abstract

View articletitled, Efficacy of Adenovirus-mediated CD/5-FC and HSV-1 Thymidine Kinase/Ganciclovir Suicide Gene Therapies Concomitant with p53 Gene Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Induction of Differentiation-dependent Apoptosis in Human Esophageal Squamous Cell Carcinoma by Adenovirus-mediated p21^sdi1 Gene Transfer 1

Yoshihiko Kadowaki; Toshiyoshi Fujiwara; Takuya Fukazawa; Jianghua Shao; Tatsuji Yasuda; Takahiro Itoshima; Shunsuke Kagawa; Laurie G. Hudson; Jack A. Roth; Noriaki Tanaka

Abstract

View articletitled, Induction of Differentiation-dependent Apoptosis in Human Esophageal Squamous Cell Carcinoma by Adenovirus-mediated p21sdi1 Gene Transfer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Enhanced Efficacy of a Novel Controlled Release Paclitaxel Formulation (PACLIMER Delivery System) for Local-Regional Therapy of Lung Cancer Tumor Nodules in Mice 1

Elizabeth Harper; Wenbin Dang; Rena G. Lapidus; Robert I. Garver, Jr.

Abstract

View articletitled, Enhanced Efficacy of a Novel Controlled Release Paclitaxel Formulation (PACLIMER Delivery System) for Local-Regional Therapy of Lung Cancer Tumor Nodules in Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Adjuvant Therapy for Melanoma in Dogs: Results of Randomized Clinical Trials Using Surgery, Liposome-encapsulated Muramyl Tripeptide, and Granulocyte Macrophage Colony-stimulating Factor 1

E. Gregory MacEwen; Ilene D. Kurzman; David M. Vail; Richard R. Dubielzig; Karen Everlith; Bruce R. Madewell; Carlos O. Rodriguez, Jr.; Brenda Phillips; Courtney H. Zwahlen; Joyce Obradovich; Robert C. Rosenthal; Leslie E. Fox; Mona Rosenberg; Carolyn Henry; Janean Fidel

Abstract

View articletitled, Adjuvant Therapy for Melanoma in Dogs: Results of Randomized Clinical Trials Using Surgery, Liposome-encapsulated Muramyl Tripeptide, and Granulocyte Macrophage Colony-stimulating Factor<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Ch14.18-GM-CSF Fusion Protein Is Effective at Mediating Antibody-dependent Cellular Cytotoxicity and Complement-dependent Cytotoxicity in Vitro1

Ayse Batova; Arvid Kamps; Stephen D. Gillies; Ralph A. Reisfeld; Alice L. Yu

Abstract

View articletitled, The Ch14.18-GM-CSF Fusion Protein Is Effective at Mediating Antibody-dependent Cellular Cytotoxicity and Complement-dependent Cytotoxicity in Vitro<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Specificity of α-Cyano-β-Hydroxy-β-Methyl-N-[4-(Trifluoromethoxy)Phenyl]-Propenamide as an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Sutapa Ghosh; Yaguo Zheng; Xiao Jun; Sandeep Mahajan; Chen Mao; Elise A. Sudbeck; Fatih M. Uckun

Abstract

View articletitled, Specificity of α-Cyano-β-Hydroxy-β-Methyl-N-[4-(Trifluoromethoxy)Phenyl]-Propenamide as an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

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Effectiveness of the Angiogenesis Inhibitor TNP-470 in Reducing the Growth of Human Neuroblastoma in Nude Mice Inversely Correlates with Tumor Burden 1

Howard M. Katzenstein; Alfred W. Rademaker; Christof Senger; Helen R. Salwen; Nadine N. Nguyen; Paul S. Thorner; Louis Litsas; Susan L. Cohn

Abstract

View articletitled, Effectiveness of the Angiogenesis Inhibitor TNP-470 in Reducing the Growth of Human Neuroblastoma in Nude Mice Inversely Correlates with Tumor Burden<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The p16 Status of Tumor Cell Lines Identifies Small Molecule Inhibitors Specific for Cyclin-dependent Kinase 4 1

Akihito Kubo; Kazuhiko Nakagawa; Ravi K. Varma; Nicholas K. Conrad; Jin Quan Cheng; Wen-Ching Lee; Joseph R. Testa; Bruce E. Johnson; Frederic J. Kaye; Michael J. Kelley

Abstract

View articletitled, The p16 Status of Tumor Cell Lines Identifies Small Molecule Inhibitors Specific for Cyclin-dependent Kinase 4<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Potentiation of Platinum Antitumor Effects in Human Lung Tumor Xenografts by the Angiogenesis Inhibitor Squalamine: Effects on Tumor Neovascularization 1

Joan H. Schiller; Gerard Bittner

Abstract

View articletitled, Potentiation of Platinum Antitumor Effects in Human Lung Tumor Xenografts by the Angiogenesis Inhibitor Squalamine: Effects on Tumor Neovascularization<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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MST-16, a Novel Bis-dioxopiperazine Anticancer Agent, Ameliorates Doxorubicin-induced Acute Toxicity While Maintaining Antitumor Efficacy

Motofumi Yoshida; Yoshihiko Maehara; Keizo Sugimachi

Abstract

View articletitled, MST-16, a Novel Bis-dioxopiperazine Anticancer Agent, Ameliorates Doxorubicin-induced Acute Toxicity While Maintaining Antitumor Efficacy

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Cancer Biology, Immunology, Cytokines

Overexpression of nm23-H2/NDP Kinase B in a Human Oral Squamous Cell Carcinoma Cell Line Results in Reduced Metastasis, Differentiated Phenotype in the Metastatic Site, and Growth Factor-independent Proliferative Activity in Culture 1

Hidetaka Miyazaki; Mitsugu Fukuda; Yasushi Ishijima; Yohko Takagi; Tadahiro Iimura; Akihide Negishi; Renzo Hirayama; Naoshi Ishikawa; Teruo Amagasa; Narimichi Kimura

Abstract

View articletitled, Overexpression of nm23-H2/NDP Kinase B in a Human Oral Squamous Cell Carcinoma Cell Line Results in Reduced Metastasis, Differentiated Phenotype in the Metastatic Site, and Growth Factor-independent Proliferative Activity in Culture<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Overexpression of Edg-2/vzg-1 Induces Apoptosis and Anoikisin Ovarian Cancer Cells in a Lysophosphatidic Acid-independent Manner 1

Tatsuro Furui; Ruth LaPushin; Muling Mao; Humera Khan; Steve R. Watt; Mary-Ann V. Watt; Yiling Lu; Xianjun Fang; Shinichi Tsutsui; Zahid H. Siddik; Robert C. Bast, Jr.; Gordon B. Mills

Abstract

View articletitled, Overexpression of Edg-2/vzg-1 Induces Apoptosis and Anoikisin Ovarian Cancer Cells in a Lysophosphatidic Acid-independent Manner<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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