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Editorials

p53 Prognostication: Paradigm or Paradox?

Jack A. Roth

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Drug Resistance: Still on the Learning Curve

Susan E. Bates

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Intrathecal Depot Cytarabine Therapy: A Welcome Addition to a Limited Armamentarium

W. Archie Bleyer

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Advances in Brief

Rapid Activation of MDR1 Gene Expression in Human Metastatic Sarcoma after in Vivo Exposure to Doxorubicin 1

Amir Abolhoda; Amy E. Wilson; Howard Ross; Peter V. Danenberg; Michael Burt; Kathleen W. Scotto

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Phase I Study of an Antisense Oligonucleotide to Protein Kinase C-α (ISIS 3521/CGP 64128A 1) in Patients with Cancer²

Alan R. Yuen; Joanne Halsey; George A. Fisher; Jon T. Holmlund; Richard S. Geary; T. Jesse Kwoh; Andrew Dorr; Branimir I. Sikic

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Vascular Endothelial Growth Factor Levels and Induction of Permeability in Malignant Pleural Effusions 1

Brian K. Zebrowski; Seiji Yano; Wenbiao Liu; Raymond M. Shaheen; Daniel J. Hicklin; Joe B. Putnam, Jr.; Lee M. Ellis

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Clinical Trials

A Phase I and Pharmacological Study of Protracted Infusions of Crisnatol Mesylate in Patients with Solid Malignancies 1

Miguel A. Villalona-Calero; Thierry Petit; John Kuhn; Patrick Cobb; Maura Kraynak; S. Gail Eckhardt; Ronald Drengler; Cecelia Simmons; Pedro Santabarbara; Daniel D. Von Hoff; Eric K. Rowinsky

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Coadministration of Oral Cyclosporin A Enables Oral Therapy with Paclitaxel

Jetske M. Meerum Terwogt; Mirte M. Malingré; Jos H. Beijnen; Wim W. ten Bokkel Huinink; Hilde Rosing; Franciska J. Koopman; Olaf van Tellingen; Martha Swart; Jan H. M. Schellens

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Phase I and Imaging Trial of a Monoclonal Antibody Directed against Gastrin-releasing Peptide in Patients with Lung Cancer 1

Arvind Chaudhry; Jorge A. Carrasquillo; Ingalill L. Avis; Noriyuki Shuke; James C. Reynolds; Richard Bartholomew; Steven M. Larson; Frank Cuttitta; Bruce E. Johnson; James L. Mulshine

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A Randomized Controlled Trial Comparing Intrathecal Sustained-release Cytarabine (DepoCyt) to Intrathecal Methotrexate in Patients with Neoplastic Meningitis from Solid Tumors 1

Michael J. Glantz; Kurt A. Jaeckle; Marc C. Chamberlain; Surasak Phuphanich; Lawrence Recht; Lode J. Swinnen; Bernard Maria; Susan LaFollette; G. Berry Schumann; Bernard F. Cole; Stephen B. Howell

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Classification and Regression Tree Analysis of 1000 Consecutive Patients with Unknown Primary Carcinoma 1

Kenneth R. Hess; Marie C. Abbruzzese; Renato Lenzi; Martin N. Raber; James L. Abbruzzese

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A Feasibility Study of Multiple Cycle Therapy with Melphalan, Thiotepa, and Paclitaxel followed by Mitoxantrone, Thiotepa, and Paclitaxel with Autologous Hematopoietic Cell Support for Metastatic Breast Cancer

Wendy W. Hu; Gwynn D. Long; Keith E. Stockerl-Goldstein; Laura J. Johnston; Nelson J. Chao; Robert S. Negrin; Karl G. Blume

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A Phase I Study of Paclitaxel, Etoposide, and Cisplatin in Extensive Stage Small Cell Lung Cancer 1

Karen Kelly; Zhaoxing Pan; Marie E. Wood; James Murphy; Paul A. Bunn, Jr.

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A Predictive Model for Relapse in High-Risk Primary Breast Cancer Patients Treated with High-Dose Chemotherapy and Autologous Stem-Cell Transplant

Yago Nieto; Pablo J. Cagnoni; Elizabeth J. Shpall; Xuesheng Xu; James Murphy; James Vredenburgh; Nelson J. Chao; Scott I. Bearman; Roy B. Jones

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AIDS-related Kaposi’s Sarcoma: A Phase II Study of Liposomal Doxorubicin 1

Tony W. Cheung; Scot C. Remick; Nozar Azarnia; Jo Ann Proper; Jose R. Barrueco; Bruce J. Dezube; for the TLC d-99 Study Group

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α-Difluoromethylornithine as Treatment for Metastatic Breast Cancer Patients

Joyce A. O’Shaughnessy; Laurence M. Demers; Stephen E. Jones; James Arseneau; Pankaj Khandelwal; Timothy George; Robert Gersh; David Mauger; Andrea Manni

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Molecular Oncology, Markers, Clinical Correlates

Discovery of Differentially Expressed Genes Associated with Paclitaxel Resistance Using cDNA Array Technology: Analysis of Interleukin (IL) 6, IL-8, and Monocyte Chemotactic Protein 1 in the Paclitaxel-resistant Phenotype 1

Zhenfeng Duan; Aynn J. Feller; Richard T. Penson; Bruce. A. Chabner; Michael V. Seiden

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Prospective Assessment of Allelic Losses at 4p14–16 in Colorectal Cancer: Two Mutational Patterns and a Locus Associated with Poorer Survival 1

Rosa Arribas; Maria Ribas; Rosa-Ana Risques; Laia Masramon; Silvia Tórtola; Eugenio Marcuello; Gemma Aiza; Rosa Miró; Gabriel Capellà; Miguel A. Peinado

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Expression of Nuclear Receptor Interacting Proteins TIF-1, SUG-1, Receptor Interacting Protein 140, and Corepressor SMRT in Tamoxifen-resistant Breast Cancer

Christina M. W. Chan; Anne E. Lykkesfeldt; Malcolm G. Parker; Mitchell Dowsett

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Aberrant Fragile Histidine Triad Gene Transcripts in Primary Hepatocellular Carcinoma and Liver Cirrhosis 1

Laura Gramantieri; Pasquale Chieco; Maddalena Di Tomaso; Livia Masi; Fabio Piscaglia; Stefano Brillanti; Stefano Gaiani; Marco Valgimigli; Alighieri Mazziotti; Luigi Bolondi

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Allelic Loss in Esophageal Squamous Cell Carcinoma Patients with and without Family History of Upper Gastrointestinal Tract Cancer

Nan Hu; Mark J. Roth; Michael R. Emmert-Buck; Ze-Zhong Tang; Mihael Polymeropolous; Quan-Hong Wang; Alisa M. Goldstein; Xiao-You Han; Sanford M. Dawsey; Ti Ding; Carol Giffen; Philip R. Taylor

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Immunohistochemical Expression of Somatostatin Type 2A Receptor in Neuroendocrine Tumors

Noriko Kimura; Monika Pilichowska; Fumiko Date; Itaru Kimura; Marcus Schindler

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Human Ovarian Cancer, Cell Lines, and Primary Ascites Cells Express the Human Mullerian Inhibiting Substance (MIS) Type II Receptor, Bind, and Are Responsive to MIS 1

Peter T. Masiakos; David T. MacLaughlin; Shyamala Maheswaran; Jose Teixeira; Arlan F. Fuller, Jr.; Paresh C. Shah; David J. Kehas; Mary K. Kenneally; David M. Dombkowski; Thanh U. Ha; Frederic I. Preffer; Patricia K. Donahoe

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TP53 Accumulation Predicts Improved Survival in Patients Resistant to Systemic Cisplatin-based Chemotherapy forMuscle-invasive Bladder Cancer 1

K. N. Qureshi; T. R. L. Griffiths; M. C. Robinson; C. Marsh; J. T. Roberts; R. R. Hall; J. Lunec; D. E. Neal

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Apoptosis and Expression of Apoptosis Regulating Proteins bcl-2, mcl-1, bcl-X, and bax in Malignant Mesothelioma 1

Ylermi Soini; Vuokko Kinnula; Riitta Kaarteenaho-Wiik; Esko Kurttila; Kaija Linnainmaa; Paavo Pääkkö

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Different Patterns of Angiogenesis in Sarcomas and Carcinomas 1

James Tomlinson; Sanford H. Barsky; Scott Nelson; Samuel Singer; Behnaz Pezeshki; Maggie C. Lee; Frederick Eilber; Mai Nguyen

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Characterization of p53 Mutations in Colorectal Liver Metastases and Correlation with Clinical Parameters 1

Appolonia Tullo; Anna M. D’Erchia; Kazuo Honda; Ragai R. Mitry; Michael D. Kelly; Nagy A. Habib; Cecilia Saccone; Elisabetta Sbisà

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Circulating Soluble Fas Concentration in Breast Cancer Patients

Takayuki Ueno; Masakazu Toi; Takeshi Tominaga

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Evaluation of Soluble CD44v6 as a Potential Serum Marker for Head and Neck Squamous Cell Carcinoma

Nicole L. W. Van Hal; Guus A. M. S. Van Dongen; Corlinda B. M. Ten Brink; Karl-Heinz Heider; Irene Rech-Weichselbraun; Gordon B. Snow; Ruud H. Brakenhoff

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Importance of Nuclear Morphology in Breast Cancer Prognosis

William H. Wolberg; W. Nick Street; Olvi L. Mangasarian

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Genetically Fluorescent Melanoma Bone and Organ Metastasis Models 1

Meng Yang; Ping Jiang; Zili An; Eugene Baranov; Lingna Li; Satoshi Hasegawa; Maraya Al-Tuwaijri; Takashi Chishima; Hiroshi Shimada; A. R. Moossa; Robert M. Hoffman

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Five Novel Immunogenic Antigens in Meningioma: Cloning, Expression Analysis, and Chromosomal Mapping 1

Nicole Comtesse; Dirk Heckel; Alexander Rácz; Nicole Brass; Brenda Glass; Eckart Meese

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Deletion of Chromosome 1p and Loss of Expression of Alkaline Phosphatase Indicate Progression of Meningiomas

Patrick Müller; Wolfram Henn; Isolde Niedermayer; Ralf Ketter; Wolfgang Feiden; Wolf-Ingo Steudel; Klaus D. Zang; Heike Steilen-Gimbel

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Androgen Receptor Gene Alterations and Chromosomal Gains and Losses in Prostate Carcinomas Appearing During Finasteride Treatment for Benign Prostatic Hyperplasia 1

Pasi A. Koivisto; Johanna Schleutker; Heikki Helin; Conny Ehren-van Eekelen; Olli-Pekka Kallioniemi; Jan Trapman

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Experimental Therapeutics, Preclinical Pharmacology

A Human Prolactin Antagonist, hPRL-G129R, Inhibits Breast Cancer Cell Proliferation through Induction of Apoptosis 1

Wen Y. Chen; Preveen Ramamoorthy; Nian-yi Chen; Robert Sticca; Thomas E. Wagner

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Antitumor Activity of CEP-751 (KT-6587) on Human Neuroblastoma and Medulloblastoma Xenografts 1

Audrey E. Evans; Kristin D. Kisselbach; Darrell J. Yamashiro; Naohiko Ikegaki; Anna Marie Camoratto; Craig A. Dionne; Garrett M. Brodeur

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BAY 12-9566, A Novel Inhibitor of Matrix Metalloproteinases with Antiangiogenic Activity 1

Carmen Gatto; Monica Rieppi; Patrizia Borsotti; Silvia Innocenti; Roberta Ceruti; Teresa Drudis; Eugenio Scanziani; Anna M. Casazza; Giulia Taraboletti; Raffaella Giavazzi

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Radiotherapy and Dosimetry of ⁶⁴Cu-TETA-Tyr³-Octreotate in a Somatostatin Receptor-positive, Tumor-bearing Rat Model 1

Jason S. Lewis; Michael R. Lewis; P. Duffy Cutler; Ananth Srinivasan; Michelle A. Schmidt; Sally W. Schwarz; Margaret M. Morris; J. Philip Miller; Carolyn J. Anderson

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Synergy of Topotecan in Combination with Vincristine for Treatment of Pediatric Solid Tumor Xenografts 1

Joyce Thompson; E. Olusegun George; Catherine A. Poquette; Pamela J. Cheshire; Lois B. Richmond; Siebold S. N. de Graaf; Margaret Ma; Clinton F. Stewart; Peter J. Houghton

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Enhanced Antitumor Activity of Paclitaxel in Combination with the Anticarcinoma Immunoconjugate BR96-Doxorubicin

Pamela A. Trail; David Willner; Albert B. Bianchi; Arris J. Henderson; Mark D. TrailSmith; Emel Girit; Shirley Lasch; Ingegerd Hellström; Karl Erik Hellström

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A Cell Type-specific and Gap Junction-independent Mechanism for the Herpes Simplex Virus-1 Thymidine Kinase Gene/Ganciclovir-mediated Bystander Effect 1

Frédéric Princen; Pierre Robe; Chantal Lechanteur; Marc Mesnil; Jean-Michel Rigo; Jacques Gielen; Marie-Paule Merville; Vincent Bours

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Direct Comparison of Liposomal Doxorubicin with or without Polyethylene Glycol Coating in C-26 Tumor-bearing Mice: Is Surface Coating with Polyethylene Glycol Beneficial?1

Ruey-Long Hong; Chang-Jen Huang; Yun-Long Tseng; Victor Fei Pang; Shui-Tsung Chen; Jun-Jen Liu; Fu-Hsiung Chang

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The Outcome of Heregulin-induced Activation of Ovarian Cancer Cells Depends on the Relative Levels of HER-2 and HER-3 Expression 1

Fengji Xu; Yinhua Yu; Xiao-Feng Le; Cinda Boyer; Gordon B. Mills; Robert C. Bast, Jr.

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Expression of Bisecting GlcNAc in Pediatric Brain Tumors and Its Association with Tumor Cell Response to Vinblastine 1

Abdelhadi Rebbaa; Pauline M. Chou; Ivica Vucic; Bernard L. Mirkin; Tadanori Tomita; Eric G. Bremer

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The Antiangiogenic Agent Linomide Inhibits the Growth Rate of von Hippel-Lindau Paraganglioma Xenografts to Mice

David J. Gross; Israel Reibstein; Lola Weiss; Shimon Slavin; Ilan Stein; Michal Neeman; Rinat Abramovitch; Laura E. Benjamin

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Eradication of Human Medulloblastoma Tumor Xenografts with a Combination of O⁶-Benzyl-2′-deoxyguanosine and 1,3-Bis(2-chloroethyl)-1-nitrosourea 1

Demetrius M. Kokkinakis; Robert C. Moschel; Anthony E. Pegg; S. Clifford Schold

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Pharmacokinetics of PK1 and Doxorubicin in Experimental Colon Tumor Models with Differing Responses to PK1 1

Paul M. Loadman; Mike C. Bibby; John A. Double; Waleed M. Al-Shakhaa; Ruth Duncan

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Simplified Production of a Recombinant Human Angiostatin Derivative That Suppresses Intracerebral Glial Tumor Growth 1

Patricio I. Meneses; Lauren E. Abrey; Katherine A. Hajjar; S. Humayun Gultekin; Robert M. Duvoisin; Kenneth I. Berns; Myrna R. Rosenfeld

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Cancer Biology, Immunology, Cytokines

Antagonistic Effect of NK4, a Novel Hepatocyte Growth Factor Variant, on in Vitro Angiogenesis of Human Vascular Endothelial Cells 1

Wen G. Jiang; Steve E. Hiscox; Christian Parr; Tracey A. Martin; Kunio Matsumoto; Toshikazu Nakamura; Robert E. Mansel

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Lysophosphatidic Acid Induces Urokinase Secretion by Ovarian Cancer Cells 1

Terri B. Pustilnik; Veronica Estrella; Jon R. Wiener; Muling Mao; Astrid Eder; Mary-Anne V. Watt; Robert C. Bast, Jr.; Gordon B. Mills

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Constitutive and Inducible Interleukin 8 Expression by Hypoxia and Acidosis Renders Human Pancreatic Cancer Cells More Tumorigenic and Metastatic 1

Qian Shi; James L. Abbruzzese; Suyun Huang; Isaiah J. Fidler; Qinghua Xiong; Keping Xie

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Letters to the Editor

Correspondence 1 re: S. Shimoyama et al., Increased Serum Angiogenin Concentration in Colorectal Cancer Is Correlated with Cancer Progression. Clin. Cancer Res., 5: 1125–1130, 1999.

Sagrario Montero; Belén Lloveras; Hernán Cortés-Funes; Ramon Colomer

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Correspondence re: G. Tallini et al., RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotype. Clin. Cancer Res., 4:287–294, 1998.

Paula Soares; Manuel Sobrinho-Simões

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Issues

Editorials

Advances in Brief

Phase I Study of an Antisense Oligonucleotide to Protein Kinase C-α (ISIS 3521/CGP 64128A1) in Patients with Cancer2

Clinical Trials

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Cancer Biology, Immunology, Cytokines

Letters to the Editor

Correspondence1 re: S. Shimoyama et al., Increased Serum Angiogenin Concentration in Colorectal Cancer Is Correlated with Cancer Progression. Clin. Cancer Res., 5: 1125–1130, 1999.

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Phase I Study of an Antisense Oligonucleotide to Protein Kinase C-α (ISIS 3521/CGP 64128A 1) in Patients with Cancer²

Correspondence 1 re: S. Shimoyama et al., Increased Serum Angiogenin Concentration in Colorectal Cancer Is Correlated with Cancer Progression. Clin. Cancer Res., 5: 1125–1130, 1999.