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Volume 5, Issue 10

October 1999

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorials
Advances in Brief
Clinical Trials
Molecular Oncology, Markers, Clinical Correlates
Experimental Therapeutics, Preclinical Pharmacology
Cancer Biology, Immunology, Cytokines
Letters to the Editor
Errata
Seventh Conference on Radioimmunodetection and Radioimmunotherapy of Cancer
Session I: Radiochemistry of Antibodies
Session II: Radiation Biology, Physics and Dosimetry
Session III: Experimental Studies of Antibody Targeting
Session IV: New Approaches to Improved Radiopharmaceuticals and Targeting
Session V: Experimental Radioimmunotherapy, Including Pre-Targeting
Session VI: Clinical Radioimmunotherapy: Solid Tumors
Session VII: Clinical Radioimmunotherapy: Lymphomas

Editorials

Oral Cancer Chemotherapy: The Promise and the Pitfalls

Howard L. McLeod; William E. Evans

Dihydropyrimidine Dehydrogenase: Its Role in 5-Fluorouracil Clinical Toxicity and Tumor Resistance

Robert B. Diasio; Martin R. Johnson

Advances in Brief

Prostate-specific Membrane Antigen Is Produced in Tumor-associated Neovasculature 1

Sam S. Chang; Denise S. O’Keefe; Dean J. Bacich; Victor E. Reuter; Warren D. W. Heston; Paul B. Gaudin

Differences in Ki67 and c-erbB2 Expression between Screen-detected and True Interval Breast Cancers

Moira Crosier; David Scott; Ronald G. Wilson; Clive D. M. Griffiths; Felicity E. B. May; Bruce R. Westley

Detection of Microsatellite Alterations in Plasma DNA of Non-Small Cell Lung Cancer Patients: A Prospect for Early Diagnosis 1

Gabriella Sozzi; Katia Musso; Cathy Ratcliffe; Peter Goldstraw; Marco A. Pierotti; Ugo Pastorino

Myeloma Cells Release Soluble Interleukin-6Rα in Relation to Disease Progression by Two Distinct Mechanisms: Alternative Splicing and Proteolytic Cleavage 1

Wilfrid Thabard; Sophie Barillé; Madeleine Collette; Jean-Luc Harousseau; Marie-Josée Rapp; Régis Bataille; Martine Amiot

Association between Keratin and Vimentin Expression, Malignant Phenotype, and Survival in Postmenopausal Breast Cancer Patients 1

Patricia A. Thomas; Dawn A. Kirschmann; James R. Cerhan; Robert Folberg; Elisabeth A. Seftor; Thomas A. Sellers; Mary J. C. Hendrix

Mechanisms of Inactivation of p14^ARF, p15^INK4b, and p16^INK4a Genes in Human Esophageal Squamous Cell Carcinoma 1

Eric Poe Xing; Yan Nie; Yunlong Song; Guang-Yu Yang; Yuyang Christine Cai; Li-Dong Wang; Chung S. Yang

Sensitization of Tumor Cells to Ribotoxic Stress-induced Apoptotic Cell Death: A New Therapeutic Strategy

Stephan Rüller; Christian Stahl; Gotje Köhler; Bodo Eickhoff; Jörg Breder; Max Schlaak; Jürgen van der Bosch

Interferon-α-mediated Down-Regulation of Angiogenesis-related Genes and Therapy of Bladder Cancer Are Dependent on Optimization of Biological Dose and Schedule 1

Joel W. Slaton; Paul Perrotte; Keiji Inoue; Colin P. N. Dinney; Isaiah J. Fidler

Clinical Trials

Selective in Vivo Mobilization with Granulocyte Macrophage Colony-stimulating Factor (GM-CSF)/Granulocyte-CSF ascompared to G-CSF Alone of Dendritic Cell Progenitors from Peripheral Blood Progenitor Cells in Patients with Advanced Breast Cancer Undergoing Autologous Transplantation 1

David Avigan; Zekui Wu; Jianlin Gong; Robin Joyce; James Levine; Anthony Elias; Paul Richardson; Joya Milano; Leslie Kennedy; Kenneth Anderson; Donald Kufe

Inter- and Intrapatient Variability in Etoposide Kinetics with Oral and Intravenous Drug Administration 1

Kenneth Hande; Mark Messenger; Judy Wagner; Mary Krozely; Sanjeev Kaul

A Phase I Trial of Humanized Monoclonal Antibody HuM195 (anti-CD33) with Low-Dose Interleukin 2 in Acute Myelogenous Leukemia 1

S. E. Kossman; D. A. Scheinberg; J. G. Jurcic; J. Jimenez; P. C. Caron

Phase I Trial of a MART-1 Peptide Vaccine with Incomplete Freund’s Adjuvant for Resected High-Risk Melanoma 1

Flora Wang; Elizabeth Bade; Catherine Kuniyoshi; Lucy Spears; Georgia Jeffery; Verna Marty; Susan Groshen; Jeffrey Weber

Phase I Study of Direct Intralesional Gene Transfer of HLA-B7 into Metastatic Renal Carcinoma Lesions 1

Brian I. Rini; Linda M. Selk; Nicholas J. Vogelzang

Immunogenicity of a Fucosyl-GM1-Keyhole Limpet Hemocyanin Conjugate Vaccine in Patients with Small Cell Lung Cancer 1

Maura N. Dickler; Govindaswami Ragupathi; Nancy X. Liu; Cristina Musselli; Damian J. Martino; Vincent A. Miller; Mark G. Kris; Fred-Thomas Brezicka; Philip O. Livingston; Stefan C. Grant

Interferon-γ and CXC Chemokine Induction by Interleukin 12 in Renal Cell Carcinoma 1

Ronald M. Bukowski; Patricia Rayman; Luis Molto; Charles S. Tannenbaum; Thomas Olencki; David Peereboom; Raymond Tubbs; Denise McLain; G. Thomas Budd; Thomas Griffin; Andrew Novick; Thomas A. Hamilton; James Finke

Molecular Oncology, Markers, Clinical Correlates

Comparison of Telomerase and CD44 Expression as Diagnostic Tumor Markers in Lesions of the Thyroid

Kenjiro Aogi; Kenji Kitahara; Virginia Urquidi; David Tarin; Steve Goodison

Drug Resistance-associated Markers P-Glycoprotein, Multidrug Resistance-associated Protein 1, Multidrug Resistance-associated Protein 2, and Lung Resistance Protein as Prognostic Factors in Ovarian Carcinoma

Henriette J. G. Arts; Dionyssios Katsaros; Elisabeth G. E. de Vries; Marco Massobrio; Franco Genta; Silvio Danese; Riccardo Arisio; Rick J. Scheper; Marcel Kool; George L. Scheffer; Pax H. B. Willemse; Ate G. J. van der Zee; Albert J. H. Suurmeijer

Serum Concentrations of Vascular Endothelial Growth Factor in Vulvar Cancer 1

Lukas Hefler; Clemens Tempfer; Andreas Obermair; Katrin Frischmuth; Gerhard Sliutz; Alexander Reinthaller; Sepp Leodolter; Christian Kainz

Cyclin D1 and p16^INK4A Expression Predict Reduced Survival in Carcinoma of the Anterior Tongue 1

Ronaldo J. Bova; David I. Quinn; Jane S. Nankervis; Ian E. Cole; Brian F. Sheridan; Michael J. Jensen; Gary J. Morgan; Christopher J. Hughes; Robert L. Sutherland

Cell Proliferation in Prostate Cancer Patients with Lymph Node Metastasis: A Marker for Progression

Liang Cheng; Thomas M. Pisansky; Thomas J. Sebo; Bradley C. Leibovich; Dharamdas M. Ramnani; Amy L. Weaver; Beth G. Scherer; Michael L. Blute; Horst Zincke; David G. Bostwick

Relative Expression of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in Mouse Renal Cell Carcinoma Cells Regulates Their Metastatic Potential

Hideaki Miyake; Isao Hara; Kazuo Gohji; Kazuki Yamanaka; Shoji Hara; Soichi Arakawa; Motowo Nakajima; Sadao Kamidono

Prognostic Relevance of p53 Alterations and Mib-1 Proliferation Index in Subgroups of Primary Liposarcomas 1

Regine Schneider-Stock; Anke Ziegeler; Carsten Haeckel; Dagmar-S. Franke; Janusz Rys; Albert Roessner

Relationship between Intratumoral Dihydropyrimidine Dehydrogenase Activity and Gene Expression in Human Colorectal Cancer

Hiroyuki Uetake; Wataru Ichikawa; Teiji Takechi; Masakazu Fukushima; Zenro Nihei; Kenichi Sugihara

Characterization of Cytokeratin 20 Expression in Pancreatic and Colorectal Cancer 1

Stefan Wildi; Jörg Kleeff; Haruhisa Maruyama; Christoph A. Maurer; Helmut Friess; Markus W. Büchler; Arthur D. Lander; Murray Korc

Lack of Independent Prognostic Significance of p21 and p27 Expression in Advanced Ovarian Cancer: An Immunohistochemical Study 1

Mark Baekelandt; Ruth Holm; Claes G. Tropé; Jahn M. Nesland; Gunnar B. Kristensen

Measurement of Neovascularization Is an Independent Prognosticator of Survival in Node-negative Breast Cancer Patients with Long-Term Follow-Up 1

Sabino De Placido; Chiara Carlomagno; Fortunato Ciardiello; Michelino De Laurentiis; Stefano Pepe; Angela Ruggiero; Giampaolo Tortora; Luigi Panico; Antonio D’Antonio; Guido Pettinato; Giuseppe Petrella; A. Raffaele Bianco

Bcl-2, Bcl-X, Bax, and Bak Expression in Short- and Long-Lived Patients with Diffuse Large B-Cell Lymphomas 1

Osnat Bairey; Yael Zimra; Mati Shaklai; Elimelech Okon; Esther Rabizadeh

Angiogenic Growth Factors in Preinvasive Breast Disease 1

Sue C. Heffelfinger; Mary Ann Miller; Rawia Yassin; Robin Gear

Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 Growth Factor Receptors and Their Ligands, Neuregulin-1 α, Neuregulin-1 β, and Betacellulin, in Normal Endometrium and Endometrial Cancer

Radhika Srinivasan; Eleanor Benton; Frances McCormick; Hillary Thomas; William J. Gullick

Experimental Therapeutics, Preclinical Pharmacology

Inverse Relationship between Epidermal Growth Factor Receptor Expression and Radiocurability of Murine Carcinomas 1

Tetsuo Akimoto; Nancy R. Hunter; Lara Buchmiller; Kathy Mason; K. Kian Ang; Luka Milas

Progression to Androgen Independence Is Delayed by Adjuvant Treatment with Antisense Bcl-2 Oligodeoxynucleotides after Castration in the LNCaP Prostate Tumor Model 1

Martin Gleave; Anthony Tolcher; Hideaki Miyake; Colleen Nelson; Bob Brown; Eliana Beraldi; James Goldie

Inhibitors of Topoisomerase II as pH-dependent Modulators of Etoposide-mediated Cytotoxicity 1

Seppo W. Langer; Günther Schmidt; Morten Sørensen; Maxwell Sehested; Peter Buhl Jensen

Pharmacologic Disruption of Base Excision Repair Sensitizes Mismatch Repair-deficient and -proficient Colon Cancer Cells to Methylating Agents 1

Lili Liu; Pietro Taverna; Cecilia M. Whitacre; Satadal Chatterjee; Stanton L. Gerson

Rapid Esterase-sensitive Breakdown of Polysorbate 80 and Its Impact on the Plasma Pharmacokinetics of Docetaxel and Metabolites in Mice

Olaf van Tellingen; Jos H. Beijnen; Jaap Verweij; Esther J. Scherrenburg; Willem J. Nooijen; Alex Sparreboom

Flavopiridol Induces Cell Cycle Arrest and p53-independent Apoptosis in Non-Small Cell Lung Cancer Cell Lines 1

Geoffrey I. Shapiro; Darlene A. Koestner; Christian B. Matranga; Barrett J. Rollins

Doxorubicin Encapsulated in Sterically Stabilized Liposomes Exhibits Renal and Biliary Clearance Properties That Are Independent of Valspodar (PSC 833) under Conditions That Significantly Inhibit Nonencapsulated Drug Excretion 1

Rajesh Krishna; Natashia McIntosh; K. Wayne Riggs; Lawrence D. Mayer

X-Ray Irradiation Induces Thymidine Phosphorylase and Enhances the Efficacy of Capecitabine (Xeloda) in Human Cancer Xenografts

Noriaki Sawada; Tohru Ishikawa; Fumiko Sekiguchi; Yutaka Tanaka; Hideo Ishitsuka

In Vivo Toxicity and Pharmacokinetic Features of the Janus Kinase 3 Inhibitor WHI-P131 [4-(4′Hydroxyphenyl)-Amino-6,7-Dimethoxyquinazoline]1

Fatih M. Uckun; Onur Ek; Xin-Ping Liu; Chun-Lin Chen

Antibodies to Vascular Endothelial Growth Factor Enhance the Efficacy of Cancer Immunotherapy by Improving Endogenous Dendritic Cell Function 1

Dmitry I. Gabrilovich; Tadao Ishida; Sorena Nadaf; Joyce E. Ohm; David P. Carbone

Cancer Biology, Immunology, Cytokines

Tamoxifen-induced Apoptosis in Breast Cancer Cells Relates to Down-Regulation of bcl-2, but not bax and bcl-X_L, without Alteration of p53 Protein Levels 1

Guo-Jun Zhang; Izo Kimijima; Masamitsu Onda; Masahiko Kanno; Hisayoshi Sato; Takanori Watanabe; Atsuo Tsuchiya; Rikiya Abe; Seiichi Takenoshita

Letters to the Editor

Correspondence re: P. Salven et al., Leukocytes and Platelets of Patients with Cancer Contain High Levels of Vascular Endothelial Growth Factor. Clin. Cancer Res., 5: 487–491, 1999.

Eberhard Gunsilius; Andreas L. Petzer; Guenther Gastl

Errata

Errata

Seventh Conference on Radioimmunodetection and Radioimmunotherapy of Cancer

Introduction to the Seventh Conference on Radioimmunodetection and Radioimmunotherapy of Cancer ¹

David M. Goldenberg

Tribute to David A. Goodwin and Claude F. Meares, Recipients of the Immunomedics Science Award ¹

Gerald L. DeNardo

Session I: Radiochemistry of Antibodies

Biodistribution Study of ¹⁸⁸Re-Labeled Trisuccin-HuCC49 and Trisuccin-HuCC49ΔCh2 Conjugates in Athymic Nude Mice Bearing Intraperitoneal Colon Cancer Xenografts ¹

Ahmad Safavy; M. B. Khazaeli; Kamellia Safavy; Matthew S. Mayo; Donald J. Buchsbaum

Radiolabeling of an Anti-Carcinoembryonic Antigen Antibody Fab′ Fragment (CEA-Scan) with the Positron-emitting Radionuclide Tc-94m ¹

Gary L. Griffiths; David M. Goldenberg; Frank Roesch; Hans J. Hansen

I-131 Anti-B1 Therapy/Tracer Uptake Ratio Using a New Procedure for Fusion of Tracer Images to Computed Tomography Images ¹

Kenneth F. Koral; Jia Li; Yuni Dewaraja; Carla L. Barrett; Denise D. Regan; Kenneth R. Zasadny; Stephen G. Rommelfanger; Isaac R. Francis; Mark S. Kaminski; Richard L. Wahl

Session II: Radiation Biology, Physics and Dosimetry

Effect of ⁶⁷Cu-2IT-BAT-Lym-1 Therapy on BCL-2 Gene and Protein Expression in a Lymphoma Mouse Model ¹

Linda A. Kroger; Sally J. DeNardo; Gerald L. DeNardo; Cheng Yi Xiong; Michelle D. Winthrop; Paul H. Gumerlock

A Method for Patient-specific Absorbed Dose Estimation for Internal β Emitters ¹

Lawrence E. Williams; An Liu; Andrew A. Raubitschek; Jeffrey Y. C. Wong

Validation of an Analytical Expression for the Absorbed Dose from a Spherical β Source Geometry and Its Application to Micrometastatic Radionuclide Therapy ¹

Mehrdad Sarfaraz; Barry W. Wessels

Can Current Models Explain the Lack of Liver Complications in Y-90 Microsphere Therapy?¹

Ellen D. Yorke; Andrew Jackson; Richard A. Fox; Barry W. Wessels; Bruce N. Gray

Studies on the Red Marrow Dosimetry in Radioimmunotherapy: An Experimental Investigation of Factors Influencing the Radiation-induced Myelotoxicity in Therapy with β-, Auger/Conversion Electron-, or α-Emitters ¹

Thomas M. Behr; George Sgouros; Michael G. Stabin; Martin Béhé; Christa Angerstein; Rosalyn D. Blumenthal; Christos Apostolidis; Roger Molinet; Robert M. Sharkey; Lothar Koch; David M. Goldenberg; Wolfgang Becker

A Strategy to Reduce Red Marrow Dose for Intraperitoneal Radioimmunotherapy ¹

Daniel J. Macey; R. F. Meredith

Session III: Experimental Studies of Antibody Targeting

Targeting Strategies for Cancer Radiotherapy ¹

Donald J. Buchsbaum; Buck E. Rogers; M. B. Khazaeli; Matthew S. Mayo; Diane E. Milenic; S. V. S. Kashmiri; Carolyn J. Anderson; Lara L. Chappell; Martin W. Brechbiel; David T. Curiel

Ion Exchange Tumor Targeting: A New Approach ¹

Anders R. Holmberg; Meir Wilchek; Marcela Márquez; Jan-Erik Westlin; Jin Du; Sten Nilsson

Comparison of ¹²⁵I- and ¹¹¹In-labeled Monoclonal Antibody BR96 for Tumor Targeting in Combination with Extracorporeal Immunoadsorption ¹

Michael Garkavij; Jan Tennvall; Tomas Ohlsson; Lars Lindgren; Cecilia Hindorf; Hans-Olov Sjögren; Sven-Erik Strand

Epithelial Mucin-1 (MUC1) Expression and MA5 Anti-MUC1 Monoclonal Antibody Targeting in Multiple Myeloma ¹

J. Burton; D. Mishina; T. Cardillo; K. Lew; A. Rubin; D. M. Goldenberg; D. V. Gold

Idiotypic-Anti-idiotypic Antibody Interactions in Experimental Radioimmunotargeting ¹

Per Sandström; Amanda Johansson; Anders Ullén; Sandra Rathsman; Katrine Riklund-Åhlström; Torgny Stigbrand

Targeting Human Cancer Xenografts with Monoclonal Antibodies Labeled Using Radioiodinated, Diethylenetriaminepentaacetic Acid-appended Peptides ¹

Rhona Stein; Serengulam V. Govindan; M. Jules Mattes; Lisa B. Shih; Gary L. Griffiths; Hans J. Hansen; David M. Goldenberg

Session IV: New Approaches to Improved Radiopharmaceuticals and Targeting

Development of a Hyperimmune Anti-MUC-1 Single Chain Antibody Fragments Phage Display Library for Targeting Breast Cancer ¹

Michelle D. Winthrop; Sally J. DeNardo; Gerald L. DeNardo

Humanization of Immu31, an α-Fetoprotein-specific Antibody ¹

Zhengxing Qu; Michele J. Losman; Kristian C. Eliassen; Hans J. Hansen; David M. Goldenberg; Shui-on Leung

Generation and Monitoring of Cell Lines Producing Humanized Antibodies ¹

Michele J. Losman; Zhengxing Qu; Indira S. Krishnan; Jingrong Wang; Hans J. Hansen; David M. Goldenberg; Shui-on Leung

The Effects of Domain Deletion, Glycosylation, and Long IgG₃ Hinge on the Biodistribution and Serum Stability Properties of a Humanized IgG₁ Immunoglobulin, hLL2, and Its Fragments ¹

Shui-on Leung; Zhengxing Qu; Hans J. Hansen; Lisa B. Shih; Jingrong Wang; Michele J. Losman; David M. Goldenberg; Robert M. Sharkey

Generation and Characterization of a Single Gene-encoded Single-Chain-Tetravalent Antitumor Antibody ¹

Ameurfina D. Santos; S. V. S. Kashmiri; Patricia Horan Hand; Jeffrey Schlom; Eduardo A. Padlan

Cholecystokinin-B/Gastrin Receptor Binding Peptides: Preclinical Development and Evaluation of Their Diagnostic and Therapeutic Potential ¹

Thomas M. Behr; Martin Béhé; Christa Angerstein; Stefan Gratz; Roland Mach; Lars Hagemann; Niels Jenner; Maik Stiehler; Karin Frank-Raue; Friedhelm Raue; Wolfgang Becker

The Effect of Various Therapeutic Solutions including Colloidal Chromic ³²P via an Intratumoral Injection on the Tumor Physiological Parameters of AsPC-1 Human Pancreatic Tumor Xenografts in Nude Mice ¹

Intae Lee; Young H. Lee

Retargeting Interleukin 13 for Radioimmunodetection and Radioimmunotherapy of Human High-grade Gliomas ¹

Waldemar Debinski; Jeffrey P. Thompson

Internal Radionuclide Therapy of Primary Osteosarcoma in Dogs, Using ¹⁵³Sm-Ethylene-diamino-tetramethylene-phosphonate (EDTMP)¹

Magne Aas; Lars Moe; Hans Gamlem; Arne Skretting; Nina Ottesen; Øyvind S. Bruland

Session V: Experimental Radioimmunotherapy, Including Pre-Targeting

Comparison of Multiple Bolus and Continuous Injections of ¹³¹I-labeled CC49 for Therapy in a Colon Cancer Xenograft Model ¹

Donald J. Buchsbaum; M. B. Khazaeli; Matthew S. Mayo; Peter L. Roberson

Radioimmunotherapy Using Vascular Targeted ²¹³Bi: The Role of Tumor Necrosis Factor α in the Development of Pulmonary Fibrosis ¹

Ila A. Davis; Stephen J. Kennel

Validation of ²¹³Bi-α Radioimmunotherapy for Multiple Myeloma ¹

Olivier Couturier; Alain Faivre-Chauvet; Igor V. Filippovich; Philippe Thédrez; Catherine Saï-Maurel; Manuel Bardiès; Anil K. Mishra; Magali Gauvrit; Guy Blain; Christos Apostolidis; Roger Molinet; Jean-Charles Abbe; Regis Bataille; John Wijdenes; Jean-François Chatal; Michel Chérel

Growth and Characterization of LNCaP Prostate Cancer Cell Spheroids ¹

Åse M. Ballangrud; Wei-Hong Yang; Ann Dnistrian; Nina M. Lampen; George Sgouros

Immunohistology of Carcinoembryonic Antigen (CEA)-expressing Tumors Grafted in Nude Mice after Radioimmunotherapy with ¹³¹I-labeled Bivalent Hapten and Anti-CEA × Antihapten Bispecific Antibody ¹

Emmanuel Gautherot; Françoise Kraeber-Bodéré; Laurent Daniel; Maryse Fiche; Éric Rouvier; Catherine Saï-Maurel; Philippe Thedrez; Jean-François Chatal; Jacques Barbet

Toxicity and Efficacy of Radioimmunotherapy in Carcinoembryonic Antigen-producing Medullary Thyroid Cancer Xenograft: Comparison of Iodine 131-labeled F(ab′)₂ and Pretargeted Bivalent Hapten and Evaluation of Repeated Injections ¹

Françoise Kraeber-Bodéré; Alain Faivre-Chauvet; Catherine Saï-Maurel; Loïc Campion; Maryse Fiche; Emmanuel Gautherot; Jean Le Boterff; Jacques Barbet; Jean-François Chatal; Philippe Thédrez

Radioimmunotherapy in Medullary Thyroid Cancer Using Bispecific Antibody and Iodine 131-labeled Bivalent Hapten: Preliminary Results of a Phase I/II Clinical Trial ¹

Françoise Kraeber-Bodéré; Stephane Bardet; Cornelis A. Hoefnagel; Maria R. Vieira; Jean-Philippe Vuillez; Arnaud Murat; Theresa C. Ferreira; Manuel Bardiès; Ludovic Ferrer; Isabelle Resche; Emmanuel Gautherot; Eric Rouvier; Jacques Barbet; Jean-François Chatal

Assessment of Combined Radioimmunotherapy and Chemotherapy for Treatment of Medullary Thyroid Cancer ¹

Rhona Stein; Malik Juweid; Cun-Hui Zhang; David M. Goldenberg

Maximum Tolerated Dose and Large Tumor Radioimmunotherapy Studies of ⁶⁴Cu-labeled Monoclonal Antibody 1A3 in a Colon Cancer Model ¹

Judith M. Connett; Thomas L. Buettner; Carolyn J. Anderson

Antibody Phage Libraries for the Next Generation of Tumor Targeting Radioimmunotherapeutics ¹

Sally J. DeNardo; Gerald L. DeNardo; David G. DeNardo; Cheng-Yi Xiong; Xu-Bao Shi; Michelle D. Winthrop; Linda A. Kroger; Paul Carter

Session VI: Clinical Radioimmunotherapy: Solid Tumors

Strategies for Developing Effective Radioimmunotherapy for Solid Tumors ¹

Gerald L. DeNardo; Robert T. O'Donnell; Linda A. Kroger; Carol M. Richman; Desiree S. Goldstein; Sui Shen; Sally J. DeNardo

Initial Clinical Experience Evaluating Yttrium-90-Chimeric T84.66 Anticarcinoembryonic Antigen Antibody and Autologous Hematopoietic Stem Cell Support in Patients with Carcinoembryonic Antigen-producing Metastatic Breast Cancer ¹

Jeffrey Y. C. Wong; George Somlo; Tamara Odom-Maryon; Lawrence E. Williams; An Liu; Dave Yamauchi; Anna M. Wu; Paul Yazaki; Sharon Wilczynski; John E. Shively; Stephen Forman; James H. Doroshow; Andrew A. Raubitschek

Radioimmunotherapy of Small Volume Disease of Colorectal Cancer Metastatic to the Liver: Preclinical Evaluation in Comparison to Standard Chemotherapy and Initial Results of a Phase I Clinical Study ¹

Thomas M. Behr; Alexandra L. Salib; Torsten Liersch; Martin Béhé; Christa Angerstein; Rosalyn D. Blumenthal; Afshin Fayyazi; Robert M. Sharkey; Bernhard Ringe; Heinz Becker; Bernhard Wörmann; Wolfgang Hiddemann; David M. Goldenberg; Wolfgang Becker

Dosimetry-based Therapy in Metastatic Breast Cancer Patients Using ⁹⁰Y Monoclonal Antibody 170H.82 with Autologous Stem Cell Support and Cyclosporin A ¹

Carol M. Richman; Sally J. DeNardo; Robert T. O'Donnell; Desiree S. Goldstein; Sui Shen; David L. Kukis; Linda A. Kroger; Aina Yuan; Graeme R. Boniface; Irwin J. Griffith; Gerald L. DeNardo

A Phase II Study of Intraperitoneal Radioimmunotherapy with Iodine-131-labeled Monoclonal Antibody OC-125 in Patients with Residual Ovarian Carcinoma ¹

Marc-André Mahé; Pierre Fumoleau; Michel Fabbro; Jean-Paul Guastalla; Patrick Faurous; Pierre Chauvot; Lucienne Chetanoud; Jean-Marc Classe; Philippe Rouanet; Jean-François Chatal

Phase II Study of Interferon-enhanced ¹³¹I-Labeled High Affinity CC49 Monoclonal Antibody Therapy in Patients with Metastatic Prostate Cancer ¹

Ruby F. Meredith; M. B. Khazaeli; Daniel J. Macey; William E. Grizzle; Matthew Mayo; Jeffrey Schlom; Charles D. Russell; Albert F. LoBuglio

Radioimmunotherapy of Small Cell Lung Carcinoma with the Two-Step Method Using a Bispecific Anti-Carcinoembryonic Antigen/Anti-Diethylenetriaminepentaacetic Acid (DTPA) Antibody and Iodine-131 Di-DTPA Hapten: Results of a Phase I/II Trial ¹

Jean-Philippe Vuillez; Françoise Kraeber-Bodéré; Denis Moro; Manuel Bardiès; Jean-Yves Douillard; Emmanuel Gautherot; Eric Rouvier; Jacques Barbet; Frederic Garban; Philippe Moreau; Jean-François Chatal

Phase I Radioimmunotherapy of Metastatic Renal Cell Carcinoma with ¹³¹I-labeled Chimeric Monoclonal Antibody G250 ¹

Martijn G. Steffens; Otto C. Boerman; Pieter H. M. de Mulder; Wim J. G. Oyen; Wil C. A. M. Buijs; J. Alfred Witjes; Wim J. M. van den Broek; Jeannette C. Oosterwijk-Wakka; Frans M. J. Debruyne; Frans H. M. Corstens; Egbert Oosterwijk

Loco-Regional Radioimmunotherapy of High-Grade Malignant Gliomas Using Specific Monoclonal Antibodies Labeled with ⁹⁰Y: A Phase I Study ¹

Pietro Riva; Giancarlo Franceschi; Massimo Frattarelli; Simonetta Lazzari; Nada Riva; Giuliano Giuliani; Michela Casi; Gabriella Sarti; Giuliano Guiducci; Gianluigi Giorgetti; Rossella Gentile; Monica Santimaria; Eduard Jermann; Helmut R. Maeke

Session VII: Clinical Radioimmunotherapy: Lymphomas

Radioimmunotherapy of Relapsed Non-Hodgkin's Lymphoma with Zevalin, a ⁹⁰Y-labeled Anti-CD20 Monoclonal Antibody ¹

Gregory A. Wiseman; Christine A. White; Thomas E. Witzig; Leo I. Gordon; Christos Emmanouilides; Andrew Raubitschek; Nalini Janakiraman; John Gutheil; Russell J. Schilder; Stewart Spies; Daniel H. S. Silverman; Antonio J. Grillo-López

Radioimmunotherapy Using ¹³¹I-labeled Anti-CD22 Monoclonal Antibody (LL2) in Patients with Previously Treated B-cell Lymphomas ¹

Ola Lindén; Jan Tennvall; Eva Cavallin-Ståhl; Lennart Darte; Michael Garkavij; Karl-Johan Lindner; Michael Ljungberg; Tomas Ohlsson; Katarina Sjögreen; Karin Wingårdh; Sven-Erik Strand

Pharmacokinetics, Dosimetry, and Initial Therapeutic Results with ¹³¹I- and ¹¹¹In-⁹⁰Y-Labeled Humanized LL2 Anti-CD22 Monoclonal Antibody in Patients with Relapsed, Refractory Non-Hodgkin's Lymphoma ¹

Malik E. Juweid; Edward Stadtmauer; George Hajjar; Robert M. Sharkey; Samer Suleiman; Selina Luger; Lawrence C. Swayne; Abass Alavi; David M. Goldenberg

Low- versus High-Dose Radioimmunotherapy with Humanized Anti-CD22 or Chimeric Anti-CD20 Antibodies in a Broad Spectrum of B Cell-associated Malignancies ¹

Thomas M. Behr; Bernhard Wörmann; Martin Gramatzki; Joachim Riggert; Stefan Gratz; Martin Béhé; Frank Griesinger; Robert M. Sharkey; Hans-J. Kolb; Wolfgang Hiddemann; David M. Goldenberg; Wolfgang Becker

Pharmacokinetics of Radiolabeled Polyclonal Antiferritin in Patients with Hodgkin's Disease ¹

Jing Lai; Syed M. Quadri; Paul E. Borchardt; Leigh Harris; Robin Wucher; Eileen Askew; Louis Schweichler; Huibert M. Vriesendorp

Fractionated Radiolabeled Antiferritin Therapy for Patients with Recurrent Hodgkin's Disease ¹

Huibert M. Vriesendorp; Syed M. Quadri; Cynthia T. Wyllie; Jing Lai; Paul E. Borchardt; Leigh Harris; Robin Wucher; Eileen Askew; Louis Schweichler

⁶⁷Copper-2-Iminothiolane-6-[p-(Bromoacetamido)benzyl]-TETA-Lym-1 for Radioimmunotherapy of Non-Hodgkin's Lymphoma ¹

Robert T. O'Donnell; Gerald L. DeNardo; David L. Kukis; Kathleen R. Lamborn; Sui Shen; Aina Yuan; Desiree S. Goldstein; Gary R. Mirick; Sally J. DeNardo

Importance of Timing of Radioimmunotherapy after Granulocyte Colony-Stimulating Factor Administration for Peripheral Blood Stem Cell Harvest ¹

Malik E. Juweid; Rosalyn D. Blumenthal; Walter Lew; George Hajjar; Arnold D. Rubin; David M. Goldenberg

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