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Volume 5, Issue 1

1 January 1999

All Issues

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorial
Advances in Brief
Clinical Trials
Molecular Oncology, Markers, Clinical Correlates
Experimental Therapeutics, Preclinical Pharmacology
Errata

Editorial

John Mendelsohn

Extract

View articletitled, Editorial

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Topotecan: What Dose, What Schedule, What Route?1

Seamus O’Reilly

Extract

View articletitled, Topotecan: What Dose, What Schedule, What Route?<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Doxorubicin-Polymer Conjugates: Further Demonstration of the Concept of Enhanced Permeability and Retention

Franco M. Muggia

Extract

View articletitled, Doxorubicin-Polymer Conjugates: Further Demonstration of the Concept of Enhanced Permeability and Retention

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Advances in Brief

Immunological Effects of Interleukin 12 Administered by Bolus Intravenous Injection to Patients with Cancer 1

Michael J. Robertson; Christine Cameron; Michael B. Atkins; Michael S. Gordon; Michael T. Lotze; Matthew L. Sherman; Jerome Ritz

Abstract

View articletitled, Immunological Effects of Interleukin 12 Administered by Bolus Intravenous Injection to Patients with Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Deletions of Chromosome 4 at Multiple Sites Are Frequent in Malignant Mesothelioma and Small Cell Lung Carcinoma 1

Narayan Shivapurkar; Arvind K. Virmani; Ignacio I. Wistuba; Sara Milchgrub; Bruce Mackay; John D. Minna; Adi F. Gazdar

Abstract

View articletitled, Deletions of Chromosome 4 at Multiple Sites Are Frequent in Malignant Mesothelioma and Small Cell Lung Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Relative Expression of E-Cadherin and Type IV Collagenase Genes Predicts Disease Outcome in Patients with Resectable Pancreatic Carcinoma 1

Hiroki Kuniyasu; Lee M. Ellis; Douglas B. Evans; James L. Abbruzzese; Claudia J. Fenoglio; Corazon D. Bucana; Karen R. Cleary; Eiichi Tahara; Isaiah J. Fidler

Abstract

View articletitled, Relative Expression of E-Cadherin and Type IV Collagenase Genes Predicts Disease Outcome in Patients with Resectable Pancreatic Carcinoma<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) α and TGFα/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis 1

Peter Nørgaard; Brian Law; Heather Joseph; David L. Page; Yu Shyr; Debbie Mays; Jennifer A. Pietenpol; Nancy E. Kohl; Allen Oliff; Robert J. Coffey, Jr.; Hans Skovgaard Poulsen; Harold L. Moses

Abstract

View articletitled, Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) α and TGFα/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Interleukin-6 Modulated Conditionally Replicative Adenovirus as an Antitumor/Cytotoxic Agent for Cancer Therapy 1

Claudine Rancourt; Alain Piché; Jesús Gomez-Navarro; Minghui Wang; Ronald D. Alvarez; Gene P. Siegal; Gerald M. Fuller; Simon A. Jones; David T. Curiel

Abstract

View articletitled, Interleukin-6 Modulated Conditionally Replicative Adenovirus as an Antitumor/Cytotoxic Agent for Cancer Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Pretreatment with a Monoclonal Antibody/Interleukin-2 Fusion Protein Directed against DNA Enhances the Delivery of Therapeutic Molecules to Solid Tumors 1

Jason L. Hornick; Leslie A. Khawli; Peisheng Hu; Jahangir Sharifi; Chand Khanna; Alan L. Epstein

Abstract

View articletitled, Pretreatment with a Monoclonal Antibody/Interleukin-2 Fusion Protein Directed against DNA Enhances the Delivery of Therapeutic Molecules to Solid Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cyclic-AMP Induction of Gap Junctional Intercellular Communication Increases Bystander Effect in Suicide Gene Therapy 1

George D. Carystinos; Maha M. Katabi; Dale W. Laird; Jacques Galipeau; Helen Chan; Moulay A. Alaoui-Jamali; Gerald Batist

Abstract

View articletitled, Cyclic-AMP Induction of Gap Junctional Intercellular Communication Increases Bystander Effect in Suicide Gene Therapy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Clinical Trials

A Comparison of Clinical Pharmacodynamics of Different Administration Schedules of Oral Topotecan (Hycamtin)

Cees J. H. Gerrits; Jan H. M. Schellens; Howard Burris; John R. Eckardt; Andre S. T. Planting; Maria E. L. van der Burg; Gail I. Rodriguez; Walter J. Loos; Vera van Beurden; Ian Hudson; Daniel D. Von Hoff; Jaap Verweij

Abstract

View articletitled, A Comparison of Clinical Pharmacodynamics of Different Administration Schedules of Oral Topotecan (Hycamtin)

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Immunization of Melanoma Patients with BEC2-Keyhole Limpet Hemocyanin plus BCG Intradermally Followed by Intravenous Booster Immunizations with BEC2 to Induce Anti-GD3 Ganglioside Antibodies 1

Tzy-Jyun Yao; Michael Meyers; Philip O. Livingston; Alan N. Houghton; Paul B. Chapman

Abstract

View articletitled, Immunization of Melanoma Patients with BEC2-Keyhole Limpet Hemocyanin plus BCG Intradermally Followed by Intravenous Booster Immunizations with BEC2 to Induce Anti-GD3 Ganglioside Antibodies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic Agents—Drug-Polymer Conjugates 1

Paul A. Vasey; Stan B. Kaye; Rosemary Morrison; Chris Twelves; Peter Wilson; Ruth Duncan; Alison H. Thomson; Lilian S. Murray; Tom E. Hilditch; Tom Murray; Sally Burtles; D. Fraier; E. Frigerio; Jim Cassidy; on behalf of the Cancer Research Campaign Phase I/II Committee

Abstract

View articletitled, Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic Agents—Drug-Polymer Conjugates<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Hepatic Transcatheter Arterial Chemoembolization Alternating with Systemic Protracted Continuous Infusion 5-Fluorouracil for Gastrointestinal Malignancies Metastatic to Liver: A Phase II Trial of the Puget Sound Oncology Consortium (PSOC 1104)1

Linda M. Bavisotto; Nilesh H. Patel; Sandra J. Althaus; Douglas M. Coldwell; Hanh V. Nghiem; Tove Thompson; Barry Storer; Charles R. Thomas, Jr.

Abstract

View articletitled, Hepatic Transcatheter Arterial Chemoembolization Alternating with Systemic Protracted Continuous Infusion 5-Fluorouracil for Gastrointestinal Malignancies Metastatic to Liver: A Phase II Trial of the Puget Sound Oncology Consortium (PSOC 1104)<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phase I Studies with the Nonclassical Antifolate Nolatrexed Dihydrochloride (AG337, THYMITAQ) Administered Orally for 5 Days 1

Andy N. Hughes; Imran Rafi; Melanie J. Griffin; A. Hilary Calvert; David R. Newell; Joanne A. Calvete; Amanda Johnston; Neil Clendeninn; Alan V. Boddy

Abstract

View articletitled, Phase I Studies with the Nonclassical Antifolate Nolatrexed Dihydrochloride (AG337, THYMITAQ) Administered Orally for 5 Days<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Molecular Oncology, Markers, Clinical Correlates

The Nuclear Factor-κB RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells 1

Weixin Wang; James L. Abbruzzese; Douglas B. Evans; Lillie Larry; Karen R. Cleary; Paul J. Chiao

Abstract

View articletitled, The Nuclear Factor-κB RelA Transcription Factor Is Constitutively Activated in Human Pancreatic Adenocarcinoma Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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p53 Codon 72 Polymorphism in Taiwanese Lung Cancer Patients: Association with Lung Cancer Susceptibility and Prognosis 1

Yi-Ching Wang; Chih-Yi Chen; Shin-Kuang Chen; Yuan-Yen Chang; Pinpin Lin

Abstract

View articletitled, p53 Codon 72 Polymorphism in Taiwanese Lung Cancer Patients: Association with Lung Cancer Susceptibility and Prognosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Changes of Angiogenesis and Tumor Cell Apoptosis during Colorectal Carcinogenesis

Toshiharu Aotake; Cai-De Lu; Yukio Chiba; Ryusuke Muraok; Nobuhiko Tanigawa

Abstract

View articletitled, Changes of Angiogenesis and Tumor Cell Apoptosis during Colorectal Carcinogenesis

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Overexpression of Ornithine Decarboxylase in Prostate Cancer and Prostatic Fluid in Humans 1

Rajiv R. Mohan; Anjana Challa; Sanjay Gupta; David G. Bostwick; Nihal Ahmad; Rajesh Agarwal; Susan R. Marengo; Saeid B. Amini; Francisco Paras; Gregory T. MacLennan; Martin I. Resnick; Hasan Mukhtar

Abstract

View articletitled, Overexpression of Ornithine Decarboxylase in Prostate Cancer and Prostatic Fluid in Humans<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Elevated Levels of Circulating Plasma Matrix Metalloproteinase 9 in Non-Small Cell Lung Cancer Patients 1

Toshihiko Iizasa; Takehiko Fujisawa; Makoto Suzuki; Shin-ichirou Motohashi; Kazuhiro Yasufuku; Tomohisa Yasukawa; Masayuki Baba; Mitsutoshi Shiba

Abstract

View articletitled, Elevated Levels of Circulating Plasma Matrix Metalloproteinase 9 in Non-Small Cell Lung Cancer Patients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Thrombospondins I and II Messenger RNA Expression in Lung Carcinoma: Relationship with p53 Alterations, Angiogenic Growth Factors, and Vascular Density 1

Gabriella Fontanini; Laura Boldrini; Alessandra Calcinai; Silvana Chinè; Marco Lucchi; Alfredo Mussi; Carlo Alberto Angeletti; Fulvio Basolo; Generoso Bevilacqua

Abstract

View articletitled, Thrombospondins I and II Messenger RNA Expression in Lung Carcinoma: Relationship with p53 Alterations, Angiogenic Growth Factors, and Vascular Density<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimental Therapeutics, Preclinical Pharmacology

Simultaneous Protection of G156A Methylguanine DNA Methyltransferase Gene-transduced Hematopoietic Progenitors and Sensitization of Tumor Cells Using O⁶-Benzylguanine and Temozolomide 1

Jane S. Reese; Brian M. Davis; Lili Liu; Stanton L. Gerson

Abstract

View articletitled, Simultaneous Protection of G156A Methylguanine DNA Methyltransferase Gene-transduced Hematopoietic Progenitors and Sensitization of Tumor Cells Using O6-Benzylguanine and Temozolomide<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Without Prior Stimulation, Tumor-associated Lymphocytes from Malignant Effusions Lyse Autologous Tumor Cells in the Presence of Bispecific Antibody HEA125xOKT3 1

Gudrun Strauß; Brigitte Gückel; Diethelm Wallwiener; Gerhard Moldenhauer

Abstract

View articletitled, Without Prior Stimulation, Tumor-associated Lymphocytes from Malignant Effusions Lyse Autologous Tumor Cells in the Presence of Bispecific Antibody HEA125xOKT3<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antiangiogenic Effects of Camptothecin Analogues 9-Amino-20(S)-camptothecin, Topotecan, and CPT-11 Studied in the Mouse Cornea Model 1

James J. O’Leary; Richard L. Shapiro; Chris J. Ren; Neal Chuang; Henry W. Cohen; Milan Potmesil

Abstract

View articletitled, Antiangiogenic Effects of Camptothecin Analogues 9-Amino-20(S)-camptothecin, Topotecan, and CPT-11 Studied in the Mouse Cornea Model<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Interleukin 10 (IL-10) Inhibition of Primary Human Prostate Cell-induced Angiogenesis: IL-10 Stimulation of Tissue Inhibitor of Metalloproteinase-1 and Inhibition of Matrix Metalloproteinase (MMP)-2/MMP-9 Secretion

Mark E. Stearns; Johng Rhim; Min Wang

Abstract

View articletitled, Interleukin 10 (IL-10) Inhibition of Primary Human Prostate Cell-induced Angiogenesis: IL-10 Stimulation of Tissue Inhibitor of Metalloproteinase-1 and Inhibition of Matrix Metalloproteinase (MMP)-2/MMP-9 Secretion

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Attenuation of WAF1/Cip1 Expression by an Antisense Adenovirus Expression Vector Sensitizes Glioblastoma Cells to Apoptosis Induced by Chemotherapeutic Agents 1,3-Bis(2-chloroethyl)-1-nitrosourea and Cisplatin 1

Sanbao Ruan; M. Fatih Okcu; Rey-Chen Pong; Michael Andreeff; Victor Levin; Jer-Tsong Hsieh; Wei Zhang

Abstract

View articletitled, Attenuation of WAF1/Cip1 Expression by an Antisense Adenovirus Expression Vector Sensitizes Glioblastoma Cells to Apoptosis Induced by Chemotherapeutic Agents 1,3-Bis(2-chloroethyl)-1-nitrosourea and Cisplatin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Selective Modulation of Collagenase 1 Gene Expression by the Chemotherapeutic Agent Doxorubicin 1

Ulrike Benbow; Rangan Maitra; Joshua W. Hamilton; Constance E. Brinckerhoff

Abstract

View articletitled, Selective Modulation of Collagenase 1 Gene Expression by the Chemotherapeutic Agent Doxorubicin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Lack of Evidence for a Polymorphism at Codon 160 of Human O⁶-Alkylguanine-DNA Alkyltransferase Gene in Normal Tissue and Cancer 1

Michael H. Wu; Karen E. Lohrbach; Olufunmilayo I. Olopade; Demetrius M. Kokkinakis; Henry S. Friedman; M. Eileen Dolan

Abstract

View articletitled, Lack of Evidence for a Polymorphism at Codon 160 of Human O6-Alkylguanine-DNA Alkyltransferase Gene in Normal Tissue and Cancer<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Synergistic Interaction between Paclitaxel and 8-Chloro-adenosine 3′,5′-Monophosphate in Human Ovarian Carcinoma Cell Lines 1

Hayley M. McDaid; Patrick G. Johnston

Abstract

View articletitled, Synergistic Interaction between Paclitaxel and 8-Chloro-adenosine 3′,5′-Monophosphate in Human Ovarian Carcinoma Cell Lines<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Errata

Extract

View articletitled, Errata

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