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Volume 4, Issue 11

1 November 1998

Front Matter
Table of Contents
Back Matter
Editorial Board

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorial
Advances in Brief
Research Articles

Editorial

Therapeutic innovation: the up-front window.

E Frei, 3rd

Advances in Brief

Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas.

W M Lin; E Forgacs; D P Warshal; I T Yeh; J S Martin; R Ashfaq; C Y Muller

Association between cyclin D1 (CCND1) gene amplification and human papillomavirus infection in human laryngeal squamous cell carcinoma.

P Cattani; S Hohaus; A Bellacosa; M Genuardi; S Cavallo; V Rovella; G Almadori; G Cadoni; J Galli; M Maurizi; G Fadda; G Neri

Research Articles

Metabolic and hemodynamic evaluation of brain metastases from small cell lung cancer with positron emission tomography.

U Lassen; P Andersen; G Daugaard; S Holm; M Jensen; C Svarer; H S Poulsen; O B Paulson

Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma.

P S Multani; S O'Day; L M Nadler; M L Grossbard

Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients.

T Utsunomiya; S Yonezawa; H Sakamoto; H Kitamura; S Hokita; T Aiko; S Tanaka; T Irimura; Y S Kim; E Sato

Expression of p21WAF1 predicts outcome of esophageal cancer patients treated by surgery alone or by combined therapy modalities.

M Sarbia; M Stahl; A zur Hausen; K Zimmermann; L Wang; U Fink; H Heep; P Dutkowski; R Willers; W Müller; S Seeber; H E Gabbert

Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer.

G Gasparini; P C Brooks; E Biganzoli; P B Vermeulen; E Bonoldi; L Y Dirix; G Ranieri; R Miceli; D A Cheresh

Antagonistic effects of systemic interleukin 2 on immune Tcell-mediated graft-versus-leukemia reactivity.

V Schirrmacher; S Müerköster; V Umansky

Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect.

K Reiss; C D'Ambrosio; X Tu; C Tu; R Baserga

Alpha-cyano-beta-hydroxy-beta-methyl-N-[4-(trifluoromethoxy)phenyl] propenamide: an inhibitor of the epidermal growth factor receptor tyrosine kinase with potent cytotoxic activity against breast cancer cells.

S Ghosh; Y Zheng; X Jun; R K Narla; S Mahajan; C Navara; C Mao; E A Sudbeck; F M Uckun

Selection of tumor antigens as targets for immune attack using immunohistochemistry: protein antigens.

S Zhang; H S Zhang; C Cordon-Cardo; G Ragupathi; P O Livingston

A phase II "window" study of topotecan in untreated patients with high risk adult acute lymphoblastic leukemia.

S D Gore; E K Rowinsky; C B Miller; C Griffin; T L Chen; M Borowitz; R C Donehower; K L Burks; D K Armstrong; P J Burke; M R Grever; S H Kaufmann

Phase I study of the pharmacokinetics of a radioimmunoconjugate, 90Y-T101, in patients with CD5-expressing leukemia and lymphoma.

F M Foss; A Raubitscheck; J L Mulshine; T A Fleisher; J C Reynolds; C H Paik; R D Neumann; C Boland; P Perentesis; M R Brown; J M Frincke; C P Lollo; S M Larson; J A Carrasquillo

Phase I clinical and pharmacokinetic study of titanocene dichloride in adults with advanced solid tumors.

A Korfel; M E Scheulen; H J Schmoll; O Gründel; A Harstrick; M Knoche; L M Fels; M Skorzec; F Bach; J Baumgart; G Sass; S Seeber; E Thiel; W E Berdel

Dendritic cell-based vaccines in the setting of peripheral blood stem cell transplantation: CD34+ cell-depleted mobilized peripheral blood can serve as a source of potent dendritic cells.

D Choi; M Perrin; S Hoffmann; A E Chang; V Ratanatharathorn; J Uberti; K T McDonagh; J J Mulé

Chemotherapy immediately following autologous stem-cell transplantation in patients with advanced breast cancer.

Z Rahman; J Kavanagh; R Champlin; R Giles; E Hanania; S Fu; Z Zu; R Mehra; F Holmes; A Kudelka; D Claxton; C Verschraegen; J Gajewski; M Andreeff; S Heimfeld; R Berenson; D Ellerson; L Calvert; E Mechetner; T Holzmayer; A Dayne; J Hamer; C Bachier; J Ostrove; A Deisseroth

Superiority of sequential versus concurrent administration of paclitaxel with etoposide in advanced non-small cell lung cancer: comparison of two Phase II trials.

E Felip; B Massuti; C Camps; D Benito; D Isla; J L González-Larriba; M P López-Cabrerizo; O Salamanca; J Puerto-Pica; A Moyano; J Baselga; R Rosell

Phase I/II radioimmunotherapy trial with iodine-131-labeled monoclonal antibody G250 in metastatic renal cell carcinoma.

C R Divgi; N H Bander; A M Scott; J A O'Donoghue; G Sgouros; S Welt; R D Finn; F Morrissey; P Capitelli; J M Williams; D Deland; A Nakhre; E Oosterwijk; S Gulec; M C Graham; S M Larson; L J Old

Photodynamic therapy using mono-L-aspartyl chlorin e6 (Npe6) for the treatment of cutaneous disease: a Phase I clinical study.

S W Taber; V H Fingar; C T Coots; T J Wieman

Irinotecan (CPT-11) metabolism and disposition in cancer patients.

A Sparreboom; M J de Jonge; P de Bruijn; E Brouwer; K Nooter; W J Loos; R J van Alphen; R H Mathijssen; G Stoter; J Verweij

A Phase I study of capecitabine in combination with oral leucovorin in patients with intractable solid tumors.

J Cassidy; L Dirix; D Bissett; B Reigner; T Griffin; D Allman; B Osterwalder; A T Van Oosterom

A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies.

M Hidalgo; G Rodriguez; J G Kuhn; T Brown; G Weiss; J P MacGovren; D D Von Hoff; E K Rowinsky

Elevated serum levels of Trichosanthes japonica agglutinin-I binding alkaline phosphatase in relation to high-risk groups for hepatocellular carcinomas.

K Fukushima; T Hada; K Higashino; K Yamashita

Identification of high-risk patients by assessment of nuclear Ki-67 expression in a prospective study of endometrial carcinomas.

H B Salvesen; O E Iversen; L A Akslen

Loss of heterozygosity at 11q23 in squamous cell carcinoma of the head and neck is associated with recurrent disease.

A D Lazar; M R Winter; C P Nogueira; P S Larson; E M Finnemore; R W Dolan; N Fuleihan; A Chakravarti; A Zietman; C L Rosenberg

High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.

R A Cooper; D P Wilks; J P Logue; S E Davidson; R D Hunter; S A Roberts; C M West

Detection of microscopic neuroblastoma in marrow by histology, immunocytology, and reverse transcription-PCR of multiple molecular markers.

I Y Cheung; D Barber; N K Cheung

Detection of human telomerase reverse transcriptase messenger RNA in voided urine samples as a useful diagnostic tool for bladder cancer.

H Ito; S Kyo; T Kanaya; M Takakura; K Koshida; M Namiki; M Inoue

Cytotoxicity and DNA fragmentation associated with sequential gemcitabine and 5-fluoro-2'-deoxyuridine in HT-29 colon cancer cells.

Q Ren; V Kao; J L Grem

DNA vaccination with HuD inhibits growth of a neuroblastoma in mice.

A F Carpentier; M R Rosenfeld; J Y Delattre; R G Whalen; J B Posner; J Dalmau

A single-chain immunotoxin against carcinoembryonic antigen that suppresses growth of colorectal carcinoma cells.

Y Akamatsu; J C Murphy; K F Nolan; P Thomas; R J Kreitman; S O Leung; R P Junghans

Improved efficacy and enlarged spectrum of activity of a novel anthracycline disaccharide analogue of doxorubicin against human tumor xenografts.

G Pratesi; M De Cesare; C Caserini; P Perego; L Dal Bo; D Polizzi; R Supino; M Bigioni; S Manzini; E Iafrate; C Salvatore; A Casazza; F Arcamone; F Zunino

Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells.

J A Houghton; R Ebanks; F G Harwood; D M Tillman

Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo.

P A Bunn, Jr; B A Helfrich; D G Brenner; D C Chan; D J Dykes; A J Cohen; Y E Miller

Antileukemia activity of a natural killer cell line against human leukemias.

Y Yan; P Steinherz; H G Klingemann; D Dennig; B H Childs; J McGuirk; R J O'Reilly

Growth inhibitory effects of 1,25-dihydroxyvitamin D3 and its synthetic analogue, 1alpha,25-dihydroxy-16-ene-23yne-26,27-hexafluoro-19-nor-cholecalcifero l (Ro 25-6760), on a human colon cancer xenograft.

S R Evans; A M Schwartz; E I Shchepotin; M Uskokovic; I B Shchepotin

Alpha-fetoprotein derived from a human hepatoma prevents growth of estrogen-dependent human breast cancer xenografts.

J A Bennett; S Zhu; A Pagano-Mirarchi; T A Kellom; H I Jacobson

Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells.

D S Schrump; W Matthews; G A Chen; A Mixon; N K Altorki

Pharmacokinetics of O6-benzylguanine and its active metabolite 8-oxo-O6-benzylguanine in plasma and cerebrospinal fluid after intrathecal administration of O6-benzylguanine in the nonhuman primate.

S L Berg; D J Murry; C L McCully; K Godwin; F M Balis

Dipyridamole potentiates antipurine antifolate activity in the presence of hypoxanthine in tumor cells but not in normal tissues in vitro.

E Marshman; D R Newell; A H Calvert; A M Dickinson; H R Patel; F C Campbell; N J Curtin

Polynucleotide immunization of nonhuman primates against carcinoembryonic antigen.

R M Conry; S A White; P N Fultz; M B Khazaeli; T V Strong; K O Allen; D L Barlow; S E Moore; P N Coan; I Davis; D T Curiel; A F LoBuglio

Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium.

S D Drenning; A J Marcovitch; D E Johnson; M F Melhem; D J Tweardy; J R Grandis

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