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15 February 2025
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Cover Image
Cover Image
The cover shows a section of a tumor specimen from a patient with advanced head and neck squamous cell carcinoma. Immunohistochemical staining with multiplexed immunofluorescence highlights the tumor microenvironment spatial architecture and various immune cell populations surrounding the tumor. For details, see the article by Hanna and colleagues on page 619 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Obituary
Clinical Trials: Targeted Therapy
Duvelisib with Docetaxel for Patients with Anti–PD-1 Refractory, Recurrent, or Metastatic Head and Neck Squamous Cell Carcinoma
Glenn J. Hanna; L. B. Oakley; R. Shi; A. ONeill; K. Y. Shin; N. Scarfo; K. Sehgal; M. J. Dennis; N. Quinn; V. Y. Jo; K. Wong; A. Shvyrkova; V. Kushnarev; B. U. Shanthappa; A. Tkachuk; K. Kryukov; A. Sarachakov; V. Svekolkin; J. Lennerz; S. Waters; R. I. Haddad
A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
J. Andrew Livingston; Jean-Yves Blay; Jonathan Trent; Claudia Valverde; Mark Agulnik; Mrinal Gounder; Axel Le Cesne; Meredith McKean; Michael J. Wagner; Silvia Stacchiotti; Samuel Agresta; Alfonso Quintás-Cardama; Sarah A. Reilly; Kathleen Healy; Denice Hickman; Tina Zhao; Alex Ballesteros-Perez; Alexis Khalil; Michael P. Collins; Jessica Piel; Kim Horrigan; Ariel Lefkovith; Scott Innis; Alexander J. Lazar; Gregory M. Cote; Andrew J. Wagner
Phase I/II Trial of Exportin 1 Inhibitor Selinexor plus Docetaxel in Previously Treated, Advanced KRAS-Mutant Non–Small Cell Lung Cancer
Mitchell S. von Itzstein; Timothy F. Burns; Jonathan E. Dowell; Leora Horn; D. Ross Camidge; Sally J. York; Keith D. Eaton; Kelly Kyle; Farjana Fattah; Jialiang Liu; Hong Mu-Mosley; Arjun Gupta; Urooba Nadeem; Ang Gao; Song Zhang; David E. Gerber
Clinical Trials: Immunotherapy
The Prostaglandin EP4 Antagonist Vorbipiprant Combined with PD-1 Blockade for Refractory Microsatellite-Stable Metastatic Colorectal Cancer: A Phase Ib/IIa Trial
Filippo Pietrantonio; Federica Morano; Monica Niger; Filippo Ghelardi; Claudia Chiodoni; Michele Palazzo; Federico Nichetti; Paolo Manca; Eleonora Cristarella; Valentina Doldi; Nadia Zaffaroni; Giovanna Sabella; Nadia Brambilla; Elena Benincasa; Giampaolo Giacovelli; Cristina Vitalini; Federica Girolami; Lucio C. Rovati
Bladder Preservation with Durvalumab plus Tremelimumab and Concurrent Radiotherapy in Patients with Localized Muscle-Invasive Bladder Cancer (IMMUNOPRESERVE): A Phase II Spanish Oncology GenitoUrinary Group Trial
Xavier Garcia-del-Muro; Begoña P. Valderrama; Ana Medina-Colmenero; Olatz Etxaniz; Regina Gironés Sarrió; María José Juan-Fita; Marcel Costa-García; Rafael Moreno; Isabel Miras Rodríguez; Irene Ortiz; Andrés Cuéllar; Ferran Ferrer; Francesc Vigués; Roberto de Haro Piedra; Arturo Candal Gomez; Salvador Villà; José Luis Pontones; Yasmina Murria; Guillermo Lendínez-Cano; Ramon Alemany
Next-Generation Sequencing–Based MSI Scoring Predicts Benefit in Mismatch Repair–Deficient Tumors Treated with Nivolumab: Follow-up on NCI-MATCH Arm Z1D
Jonathan D. Schoenfeld; Nilofer S. Azad; Jacob Gross; Li Chen; Michael J. Overman; Katrina Kao; Latifa Jackson; Donna Brunnquell; Xiangning Bu; Christina Coppola; Ping Guan; Jennifer Lee; David Sims; Rebecca Fuchs; Jason L. Weirather; Kathleen L. Pfaff; Lauren Gunasti; Srin Ranasinghe; Stanley R. Hamilton; Victoria Wang; Peter J. O’Dwyer; Catherine J. Wu; Scott J. Rodig; David R. Patton; Lyndsay Harris
Research Briefs: Precision Medicine and Therapeutics
Precision Medicine and Imaging
Complete Remissions of HER2-Positive Trastuzumab-Resistant Xenografts Using a Potent [225Ac]Ac-Labeled Anti-HER2 Antibody–Drug Radioconjugate
Jessica Pougoue Ketchemen; Fabrice Ngoh Njotu; Hanan Babeker; Alissar Monzer; Emmanuel Nwangele; Anjong Florence Tikum; Nikita Henning; Nava Hassani; Sarah Frye; Randy Perron; Chris Byrne; Candice Didychuk; Qi Qi; Laura Bannister; Alireza Doroudi; Humphrey Fonge
Human Papilloma Virus Circulating Cell-Free DNA Kinetics in Patients with Cervical Cancer Undergoing Definitive Chemoradiation
Aaron Seo; Weihong Xiao; Olsi Gjyshi; Kyoko Yoshida-Court; Peng Wei; David Swanson; Tatiana Cisneros Napravnik; Adam Grippin; Aradhana M. Venkatesan; Megan C. Jacobsen; David T. Fuentes; Erica Lynn; Julie Sammouri; Anuja Jhingran; Melissa Joyner; Lilie L. Lin; Lauren E. Colbert; Maura L. Gillison; Ann H. Klopp
Circulating Tumor DNA Dynamics and Clinical Outcome in Metastatic Colorectal Cancer Patients Undergoing Front-Line Chemotherapy
Michele Ghidini; Jens Claus Hahne; Chiara Senti; Timon Heide; Paula Z. Proszek; Ridwan Shaikh; Paul Carter; Mike Hubank; Francesco Trevisani; Ornella Garrone; Maria Rosa Cappelletti; Daniele Generali; Monica Cattaneo; Nicoletta Gnocchi; Gianvito Donati; Angela Gobbi; Giulia Grizzi; Andrea Lampis; Raghad Elghadi; Giulia Tanzi; Gianluca Tomasello; Margherita Ratti; David J. Pinato; Matteo Fassan; Georgios Vlachogiannis; Andrea Sottoriva; Alessio Cortellini; Rodolfo Passalacqua; Nicola Valeri
HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma
Naomi Yamamoto; Stephanie Dobersch; Ian Loveless; Annie N. Samraj; Gun Ho Jang; Miki Haraguchi; Liang-I. Kang; Marianna B. Ruzinova; Kiran R. Vij; Jacqueline L. Mudd; Thomas Walsh; Rachael A. Safyan; Elena Gabriela Chiorean; Sunil R. Hingorani; Nathan M. Bolton; Li Li; Ryan C. Fields; David G. DeNardo; Faiyaz Notta; Howard C. Crawford; Nina G. Steele; Sita Kugel
Translational Cancer Mechanisms and Therapy
Smoking-Associated Carcinogen–Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation
Ritesh K. Aggarwal; Simone Sidoli; Jingli Wang; Srabani Sahu; Rahul Sanawar; Varun Gupta; Srinivas Aluri; Vineeth Sukrithan; Charan T.R. Vegivinti; Phaedon D. Zavras; Divij Verma; Shanisha Gordon-Mitchell; Beamon Agarwal; Tanya Verma; Daniel T. Starczynowski; Ulrich G. Steidl; Aditi Shastri; Balazs Halmos; Lindsay M. LaFave; Haiying Cheng; Amit Verma; Yiyu Zou
Human Pancreatic Cancer Single-Cell Atlas Reveals Association of CXCL10+ Fibroblasts and Basal Subtype Tumor Cells
Ian M. Loveless; Samantha B. Kemp; Kailee M. Hartway; Jacob T. Mitchell; Yuesong Wu; Samuel D. Zwernik; Daniel James Salas-Escabillas; Sydney Brender; Madison George; Yetunde Makinwa; Thais Stockdale; Kendyll Gartrelle; Rohit G. Reddy; Daniel W. Long; Allison Wombwell; Julie M. Clark; Albert M. Levin; David Kwon; Ling Huang; Ralph Francescone; Débora B. Vendramini-Costa; Ben Z. Stanger; Adam Alessio; Andrew M. Waters; Yuehua Cui; Elana J. Fertig; Luciane T. Kagohara; Brian Theisen; Howard C. Crawford; Nina G. Steele
Correction
Correction: Targeting the Phosphoinositide 3-Kinase p110-α Isoform Impairs Cell Proliferation, Survival, and Tumor Growth in Small Cell Lung Cancer
Anna Wojtalla; Barbara Fischer; Nataliya Kotelevets; Francesco A. Mauri; Jens Sobek; Hubert Rehrauer; Carlos Wotzkow; Mario P. Tschan; Michael J. Seckl; Uwe Zangemeister-Wittke; Alexandre Arcaro
Editor's Note
Editor’s Note: HHLA2, a New Immune Checkpoint Member of the B7 Family, Is Widely Expressed in Human Lung Cancer and Associated with EGFR Mutational Status
Haiying Cheng; Murali Janakiram; Alain Borczuk; Juan Lin; Wanglong Qiu; Huijie Liu; Jordan M. Chinai; Balazs Halmos; Roman Perez-Soler; Xingxing Zang
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